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The map label for this gene is gdhA [H]

Identifier: 55981546

GI number: 55981546

Start: 1499544

End: 1500803

Strand: Reverse

Name: gdhA [H]

Synonym: TTHA1577

Alternate gene names: 55981546

Gene position: 1500803-1499544 (Counterclockwise)

Preceding gene: 55981547

Following gene: 55981545

Centisome position: 81.14

GC content: 72.94

Gene sequence:

>1260_bases
ATGCCGCTAAAAGCCTACCGGCCCCCCGAGGACCCGGGGCTTTGGGACACCTACCTGGAGTGGCTGGAACGGGCCCTGAA
GGTGGCGGAGGCCCACCCCACCACTCTGGAGTACCTGGCCCACCCCAAGCGCCTGGTCACCCTCTCCCTTCCCGTGGTCA
TGGACGACGGGAAGGTGCGCATCTTCCAGGGCTACCGCGTGGTGCACGACATCGCCCGGGGACCGGCCAAGGGCGGGGTC
CGCCTGGACCCGGGGGTCACCCTGGGCCAGACTGCGGGCCTCGCCGCCTGGATGACCTTGAAGGCGGCCGTCTACGACCT
GCCTTTCGGCGGGGCGGCGGGGGGGATCGCCGTGGACCCCAAGGGGCTTTCCCCGCAGGAGCTGGAGCGCCTGGTGCGCC
GCTACACCGCCGAGCTCGTGGGCCTCATCGGGCCCGACAGCGACATCCTGGGGCCCGACCTCGGGGCGGACCAGCAGGTC
ATGGCCTGGATCATGGACACCTACTCCATGACCGTGGGCTCCACGGTGCCCGGGGTGGTGACGGGGAAGCCCCACGCCCT
GGGGGGGAGCGAGGGGCGGGACGACGCCGCGGGGCTTGGGGCGCTTCTCGTGCTGGAGGCCCTGGCCAAGAGGCGGGGCC
TGGACCTTCGGGGCGCCCGGGTGGTGGTGCAGGGCCTCGGCCAGGTGGGGGCGGCGGTGGCCCTGCACGCCGAGCGCCTG
GGGATGCGGGTGGTGGCCGTGGCCACCTCCATGGGGGGCATGTACGCCCCCGAGGGGCTGGACGTGGCCGAGGTCCTCTC
CACCTACGAGGCCACGGGGTTTTTGCCCCGGCTGGACCTGGCCCCGGAGGAGGTCTTCGGCCTCGAGGCCGAGGTCCTCG
TCCTGGCGGCCCGGGAGGGGGCCTTGGACGGGGACAGGGCCCGGCAGGTCCAGGCCCAGGCGGTGGTGGAGGTGGCCAAC
TTCGGCCTCACCCCCGAGGCCGAGGCCTACCTTTTGGGCAAGGGAGCGCTGGTGGTGCCCGACCTCCTCTCCGGCGGGGG
CGGACTCCTCGCCAGCTACCTGGAGTGGGTGCAGGACCTCAACATGTTCTTCTGGAGCCCGGAGGAGGTGCGCGAGCGCT
TTGAAACCCGTGTGGCCCGGGTGGTGGACGCGGTCTGCCGGCGGGCGGAGCGGGGCGGGCTGGACCTGAGGATGGGCGCC
TTGGCCCTCGCCTTGGAGCGGCTGGACGAGGCCACCCGGCTTCGGGGCGTGTACCCGTGA

Upstream 100 bases:

>100_bases
ACCAACGCCAAGACCGGGGCCTTGGACTACCTTAGGCTCTTCCTGGAGATGAAGGCGGTGGCCGAGCGCTTCTAGGGGTA
TAATCCTCGGCGGTGATGCT

Downstream 100 bases:

>100_bases
GGAGCGGCGATGAAGAGCGAACCCCTTTCCTACCTGGGCAAGGACGGAGGCCCCTGGGAGATCTTCACGGAGCAGGTGGA
CCGGGTCGTCCCCTACCTGG

Product: NAD-dependent glutamate dehydrogenase

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPLKAYRPPEDPGLWDTYLEWLERALKVAEAHPTTLEYLAHPKRLVTLSLPVVMDDGKVRIFQGYRVVHDIARGPAKGGV
RLDPGVTLGQTAGLAAWMTLKAAVYDLPFGGAAGGIAVDPKGLSPQELERLVRRYTAELVGLIGPDSDILGPDLGADQQV
MAWIMDTYSMTVGSTVPGVVTGKPHALGGSEGRDDAAGLGALLVLEALAKRRGLDLRGARVVVQGLGQVGAAVALHAERL
GMRVVAVATSMGGMYAPEGLDVAEVLSTYEATGFLPRLDLAPEEVFGLEAEVLVLAAREGALDGDRARQVQAQAVVEVAN
FGLTPEAEAYLLGKGALVVPDLLSGGGGLLASYLEWVQDLNMFFWSPEEVRERFETRVARVVDAVCRRAERGGLDLRMGA
LALALERLDEATRLRGVYP

Sequences:

>Translated_419_residues
MPLKAYRPPEDPGLWDTYLEWLERALKVAEAHPTTLEYLAHPKRLVTLSLPVVMDDGKVRIFQGYRVVHDIARGPAKGGV
RLDPGVTLGQTAGLAAWMTLKAAVYDLPFGGAAGGIAVDPKGLSPQELERLVRRYTAELVGLIGPDSDILGPDLGADQQV
MAWIMDTYSMTVGSTVPGVVTGKPHALGGSEGRDDAAGLGALLVLEALAKRRGLDLRGARVVVQGLGQVGAAVALHAERL
GMRVVAVATSMGGMYAPEGLDVAEVLSTYEATGFLPRLDLAPEEVFGLEAEVLVLAAREGALDGDRARQVQAQAVVEVAN
FGLTPEAEAYLLGKGALVVPDLLSGGGGLLASYLEWVQDLNMFFWSPEEVRERFETRVARVVDAVCRRAERGGLDLRMGA
LALALERLDEATRLRGVYP
>Mature_418_residues
PLKAYRPPEDPGLWDTYLEWLERALKVAEAHPTTLEYLAHPKRLVTLSLPVVMDDGKVRIFQGYRVVHDIARGPAKGGVR
LDPGVTLGQTAGLAAWMTLKAAVYDLPFGGAAGGIAVDPKGLSPQELERLVRRYTAELVGLIGPDSDILGPDLGADQQVM
AWIMDTYSMTVGSTVPGVVTGKPHALGGSEGRDDAAGLGALLVLEALAKRRGLDLRGARVVVQGLGQVGAAVALHAERLG
MRVVAVATSMGGMYAPEGLDVAEVLSTYEATGFLPRLDLAPEEVFGLEAEVLVLAAREGALDGDRARQVQAQAVVEVANF
GLTPEAEAYLLGKGALVVPDLLSGGGGLLASYLEWVQDLNMFFWSPEEVRERFETRVARVVDAVCRRAERGGLDLRMGAL
ALALERLDEATRLRGVYP

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=336, Percent_Identity=35.7142857142857, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4885281, Length=336, Percent_Identity=35.4166666666667, Blast_Score=211, Evalue=9e-55,
Organism=Escherichia coli, GI1788059, Length=359, Percent_Identity=30.08356545961, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17544676, Length=338, Percent_Identity=33.1360946745562, Blast_Score=199, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324951, Length=398, Percent_Identity=26.8844221105528, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319256, Length=429, Percent_Identity=25.4079254079254, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI45553475, Length=370, Percent_Identity=32.1621621621622, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI45549226, Length=336, Percent_Identity=33.3333333333333, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24649283, Length=332, Percent_Identity=33.1325301204819, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24649460, Length=282, Percent_Identity=34.3971631205674, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 44690; Mature: 44559

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKAYRPPEDPGLWDTYLEWLERALKVAEAHPTTLEYLAHPKRLVTLSLPVVMDDGKVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEEEEEEECCCEE
IFQGYRVVHDIARGPAKGGVRLDPGVTLGQTAGLAAWMTLKAAVYDLPFGGAAGGIAVDP
EEECHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEECC
KGLSPQELERLVRRYTAELVGLIGPDSDILGPDLGADQQVMAWIMDTYSMTVGSTVPGVV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
TGKPHALGGSEGRDDAAGLGALLVLEALAKRRGLDLRGARVVVQGLGQVGAAVALHAERL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GMRVVAVATSMGGMYAPEGLDVAEVLSTYEATGFLPRLDLAPEEVFGLEAEVLVLAAREG
CEEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEECCC
ALDGDRARQVQAQAVVEVANFGLTPEAEAYLLGKGALVVPDLLSGGGGLLASYLEWVQDL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEECHHHCCCHHHHHHHHHHHHHH
NMFFWSPEEVRERFETRVARVVDAVCRRAERGGLDLRMGALALALERLDEATRLRGVYP
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PLKAYRPPEDPGLWDTYLEWLERALKVAEAHPTTLEYLAHPKRLVTLSLPVVMDDGKVR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEEEEEEECCCEE
IFQGYRVVHDIARGPAKGGVRLDPGVTLGQTAGLAAWMTLKAAVYDLPFGGAAGGIAVDP
EEECHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEECC
KGLSPQELERLVRRYTAELVGLIGPDSDILGPDLGADQQVMAWIMDTYSMTVGSTVPGVV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
TGKPHALGGSEGRDDAAGLGALLVLEALAKRRGLDLRGARVVVQGLGQVGAAVALHAERL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GMRVVAVATSMGGMYAPEGLDVAEVLSTYEATGFLPRLDLAPEEVFGLEAEVLVLAAREG
CEEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEECCC
ALDGDRARQVQAQAVVEVANFGLTPEAEAYLLGKGALVVPDLLSGGGGLLASYLEWVQDL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEECHHHCCCHHHHHHHHHHHHHH
NMFFWSPEEVRERFETRVARVVDAVCRRAERGGLDLRMGALALALERLDEATRLRGVYP
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9680336; 10360571; 9135121; 9654452; 10366510 [H]