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The map label for this gene is gmk

Identifier: 55981531

GI number: 55981531

Start: 1485496

End: 1486167

Strand: Reverse

Name: gmk

Synonym: TTHA1562

Alternate gene names: 55981531

Gene position: 1486167-1485496 (Counterclockwise)

Preceding gene: 55981533

Following gene: 55981530

Centisome position: 80.34

GC content: 68.3

Gene sequence:

>672_bases
GTGAAGGGGATGCGGGGCCGCCTTTTCGTGATGACCGGGGCGAGCGGGGTGGGCAAGGGCACGGTGCGGGCGAAGGTGCT
GGAGCGCACCCGGCTCTTCTACTCCATCTCCATGACCACCCGCCCCCCCCGGCCGGGGGAGGTGGACGGGGTGGACTACT
ACTTCGTGGACCGCCCCACCTTTGAGGCCCTCGTCCGCGAGGACGGCTTCTTGGAGTACGCGGAGTACGTGGGCCACCTC
TACGGCACCCCCAGGGCCCCGGTGGAGCGGGCCTTGAGCCGGGGGGAGGACGTCCTCTTGGAGATTGAGGTCCAGGGGGC
GCTCCAGGTGAAGCGGGCCGTGCCCGAGGCGGTCCTGATCTTCCTCCTACCCCCCTCTCTCTCCGAGCTGAAGCGCCGCC
TGGTCTACCGGGGCAAGGACAGCCCCGAGAAGATCCAGAAGCGCCTGGAGCAGGCGGAGTGGGAGATAAGGAACGCCCAC
CTCTTTGACTACGTGGTGGTGAACGACGTCCTCGAGGAGGCCGTGGCCGACTTCCTCGCCATCCTCACCGCGGAGAGGCG
GCGGAGCGGGAGGATGGGGGAGGCTTTGGAGATGGCCCTGCGGCGCGATTTGGCCCTCGAGGCCGAGCTGGACGAGATCC
TAAGGAGGCGGTATGGCGGAACCGGGCATTGA

Upstream 100 bases:

>100_bases
GCGGAAGAAGCGGTCGGGGAAGATCTGGTAAAAGAAGGCGCCTTCGTACCATGCCATGCCTCCGAGTCTAACACCCCGGT
CCTGTGGTATCCTCTCCCGG

Downstream 100 bases:

>100_bases
CAAGCTCTTCGGCATGGTGGACTCCAAGTACCGGCTCACCGTGGTGGTGGCCAAAAGGGCGCAGCAGCTCCTCCGCCACG
GCTTCAAGAACACGGTCTTG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKGMRGRLFVMTGASGVGKGTVRAKVLERTRLFYSISMTTRPPRPGEVDGVDYYFVDRPTFEALVREDGFLEYAEYVGHL
YGTPRAPVERALSRGEDVLLEIEVQGALQVKRAVPEAVLIFLLPPSLSELKRRLVYRGKDSPEKIQKRLEQAEWEIRNAH
LFDYVVVNDVLEEAVADFLAILTAERRRSGRMGEALEMALRRDLALEAELDEILRRRYGGTGH

Sequences:

>Translated_223_residues
MKGMRGRLFVMTGASGVGKGTVRAKVLERTRLFYSISMTTRPPRPGEVDGVDYYFVDRPTFEALVREDGFLEYAEYVGHL
YGTPRAPVERALSRGEDVLLEIEVQGALQVKRAVPEAVLIFLLPPSLSELKRRLVYRGKDSPEKIQKRLEQAEWEIRNAH
LFDYVVVNDVLEEAVADFLAILTAERRRSGRMGEALEMALRRDLALEAELDEILRRRYGGTGH
>Mature_223_residues
MKGMRGRLFVMTGASGVGKGTVRAKVLERTRLFYSISMTTRPPRPGEVDGVDYYFVDRPTFEALVREDGFLEYAEYVGHL
YGTPRAPVERALSRGEDVLLEIEVQGALQVKRAVPEAVLIFLLPPSLSELKRRLVYRGKDSPEKIQKRLEQAEWEIRNAH
LFDYVVVNDVLEEAVADFLAILTAERRRSGRMGEALEMALRRDLALEAELDEILRRRYGGTGH

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=197, Percent_Identity=36.5482233502538, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI226874833, Length=192, Percent_Identity=35.9375, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI4504221, Length=192, Percent_Identity=35.9375, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI38570142, Length=182, Percent_Identity=31.3186813186813, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=30.1587301587302, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI262118255, Length=177, Percent_Identity=27.683615819209, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI262118259, Length=177, Percent_Identity=27.683615819209, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI262118263, Length=177, Percent_Identity=27.683615819209, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4505237, Length=177, Percent_Identity=27.683615819209, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI21361598, Length=184, Percent_Identity=28.2608695652174, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI186700629, Length=179, Percent_Identity=26.2569832402235, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI186972120, Length=179, Percent_Identity=26.2569832402235, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI186700627, Length=179, Percent_Identity=26.2569832402235, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI111154074, Length=150, Percent_Identity=29.3333333333333, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI21536464, Length=189, Percent_Identity=26.984126984127, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI119943108, Length=152, Percent_Identity=30.2631578947368, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI52630447, Length=182, Percent_Identity=27.4725274725275, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI261862237, Length=152, Percent_Identity=30.2631578947368, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=204, Percent_Identity=41.6666666666667, Blast_Score=161, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17508835, Length=188, Percent_Identity=34.5744680851064, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193203132, Length=197, Percent_Identity=32.994923857868, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71988041, Length=178, Percent_Identity=28.6516853932584, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988048, Length=178, Percent_Identity=28.6516853932584, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17557440, Length=188, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17556244, Length=132, Percent_Identity=34.8484848484849, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320662, Length=186, Percent_Identity=38.1720430107527, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21356141, Length=192, Percent_Identity=39.5833333333333, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI161077626, Length=184, Percent_Identity=27.7173913043478, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI116007136, Length=184, Percent_Identity=27.7173913043478, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI85724806, Length=184, Percent_Identity=27.7173913043478, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45554481, Length=184, Percent_Identity=27.7173913043478, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24640542, Length=184, Percent_Identity=27.7173913043478, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45554489, Length=184, Percent_Identity=27.7173913043478, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI221330164, Length=176, Percent_Identity=32.9545454545455, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221330166, Length=176, Percent_Identity=32.9545454545455, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221330162, Length=176, Percent_Identity=32.9545454545455, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281362230, Length=174, Percent_Identity=28.735632183908, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648808, Length=174, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85816281, Length=135, Percent_Identity=31.8518518518519, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI85816106, Length=135, Percent_Identity=31.8518518518519, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45551002, Length=135, Percent_Identity=31.8518518518519, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161078487, Length=174, Percent_Identity=28.735632183908, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281362232, Length=174, Percent_Identity=28.735632183908, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161078485, Length=174, Percent_Identity=28.735632183908, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648810, Length=174, Percent_Identity=28.735632183908, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_THET8 (Q5SI18)

Other databases:

- EMBL:   AP008226
- RefSeq:   YP_144828.1
- HSSP:   P0A5I4
- ProteinModelPortal:   Q5SI18
- SMR:   Q5SI18
- STRING:   Q5SI18
- GeneID:   3169695
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA1562
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   TTHE300852:TTHA1562-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 25339; Mature: 25339

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGMRGRLFVMTGASGVGKGTVRAKVLERTRLFYSISMTTRPPRPGEVDGVDYYFVDRPT
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEEECCCH
FEALVREDGFLEYAEYVGHLYGTPRAPVERALSRGEDVLLEIEVQGALQVKRAVPEAVLI
HHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEEECCHHHHHHHCHHEEEE
FLLPPSLSELKRRLVYRGKDSPEKIQKRLEQAEWEIRNAHLFDYVVVNDVLEEAVADFLA
EECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ILTAERRRSGRMGEALEMALRRDLALEAELDEILRRRYGGTGH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKGMRGRLFVMTGASGVGKGTVRAKVLERTRLFYSISMTTRPPRPGEVDGVDYYFVDRPT
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEEECCCH
FEALVREDGFLEYAEYVGHLYGTPRAPVERALSRGEDVLLEIEVQGALQVKRAVPEAVLI
HHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEEECCHHHHHHHCHHEEEE
FLLPPSLSELKRRLVYRGKDSPEKIQKRLEQAEWEIRNAHLFDYVVVNDVLEEAVADFLA
EECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ILTAERRRSGRMGEALEMALRRDLALEAELDEILRRRYGGTGH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA