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The map label for this gene is guaA [H]

Identifier: 55981521

GI number: 55981521

Start: 1477956

End: 1479467

Strand: Direct

Name: guaA [H]

Synonym: TTHA1552

Alternate gene names: 55981521

Gene position: 1477956-1479467 (Clockwise)

Preceding gene: 55981517

Following gene: 55981522

Centisome position: 79.9

GC content: 70.7

Gene sequence:

>1512_bases
GTGGTCCTGGTCCTGGATTTCGGCTCCCAGTACACGCGGCTCATCGCGAGGAGGCTCCGGGAGCTCCGGGCCTTCTCCCT
CATCCTTCCGGGGGACGCCCCCCTGGAGGAGGTCCTCAAGCACCGCCCCCAGGCCCTCATCCTCTCGGGGGGGCCGAGAA
GCGTCTTTGACCCCGACGCCCCCCGACCCGACCCCAGGCTCTTCTCCTCGGGCCTGCCCCTCCTCGGGATCTGCTACGGC
ATGCAGCTCCTCGCCCAGGAGCTCGGGGGACGGGTGGAGCGGGCGGGCCGGGCCGAGTACGGCAAGGCCCTCCTCACCCG
CCACGAGGGCCCCCTCTTCCGGGGCCTCGAGGGGGAGGTCCAGGTCTGGATGAGCCACCAGGACGCCGTGACCGCCCCGC
CCCCGGGCTGGCGGGTGGTGGCGGAGACGGAGGAGAACCCCGTGGCCGCCATCGCCTCCCCGGACGGGCGGGCCTACGGC
GTCCAGTTCCACCCCGAGGTAGCCCACACCCCCAAGGGGATGCAGATCCTGGAGAACTTCCTGGAGCTTGCCGGGGTCAA
GCGGGACTGGACCCCGGAGCACGTCCTGGAAGAACTCCTCCGGGAGGTGCGGGAGCGGGCGGGGAAGGACCGGGTCCTCC
TCGCCGTCTCCGGGGGGGTGGACTCCTCCACCCTGGCCCTCCTCCTCGCCAAGGCGGGGGTGGACCACCTGGCCGTCTTC
GTGGACCACGGGCTTTTGCGCCTGGGGGAGCGGGAGGAGGTGGAGGGGGCCTTAAGGGCCCTTGGGGTGAACCTCCTGGT
GGTGGACGCCAAGGAGCGCTTCCTGAAGGCCCTAAAGGGCGTGGAGGACCCCGAGGAAAAGCGCAAGATCATCGGGCGGG
AGTTCGTGGCGGCCTTCTCCCAGGTGGCCCGGGAGAGGGGCCCCTTCCGCTTCCTCGCCCAGGGAACCCTCTACCCGGAC
GTCATTGAGTCCGCCGGGGGGCACGGGGCGGCCAAGATCAAGAGCCACCACAACGTGGGCGGCCTCCCCGAGGACCTGGA
GTTTGAGCTCCTAGAGCCCTTTCGCCTCCTCTTCAAGGACGAGGTGCGGGAGCTCGCCCTCCTCCTCGGGCTTCCCGACA
CCCTGCGCCTCCGCCACCCCTTCCCCGGGCCTGGCCTCGCCGTGCGCGTCCTGGGGGAGGTGACGGAGGAGCGCCTGGAG
ATCCTGAGGCGGGCGGACGACATCTTCACGAGCCTCCTCAGGGAGTGGGGCCTCTACGAGAAGGTGGCCCAAGCCCTGGC
GGTCCTCACGCCCGTGAGGAGCGTGGGGGTGGCGGGGGACGAAAGGAAGTACGGGTACGTCCTCGCCCTCAGGGCCGTCA
CCACCGAGGACTTCATGACCGCCGACTGGGCGAGGCTTCCCCTGGAGTTCCTGGACGAGGCGGCCCGGCGGATCACCCGC
AGGGTCCCGGAGATCGGACGGGTGGTCTACGACCTCACCTCCAAGCCCCCGGCCACGATAGAGTGGGAATGA

Upstream 100 bases:

>100_bases
CCACCCGGGGGCAGGACGGGAGCAGGGAAAGGCCCAGGCTCCAAAGCCCCCCGGACTTTTTCCGCCCCTTGGGTTCCAGG
AGGCGTAGTAGACTCTTGGC

Downstream 100 bases:

>100_bases
TGGGCGAACCCGCAAGGCTCAGGCGGCTCACCGCCGAGGAGTACCTGAGGGAGGAGGCCACCTCCCCCGTGAAGCGGGAG
CTGGTGGAGGGGGTTCCCTA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLKHRPQALILSGGPRSVFDPDAPRPDPRLFSSGLPLLGICYG
MQLLAQELGGRVERAGRAEYGKALLTRHEGPLFRGLEGEVQVWMSHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYG
VQFHPEVAHTPKGMQILENFLELAGVKRDWTPEHVLEELLREVRERAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVF
VDHGLLRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVEDPEEKRKIIGREFVAAFSQVARERGPFRFLAQGTLYPD
VIESAGGHGAAKIKSHHNVGGLPEDLEFELLEPFRLLFKDEVRELALLLGLPDTLRLRHPFPGPGLAVRVLGEVTEERLE
ILRRADDIFTSLLREWGLYEKVAQALAVLTPVRSVGVAGDERKYGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITR
RVPEIGRVVYDLTSKPPATIEWE

Sequences:

>Translated_503_residues
MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLKHRPQALILSGGPRSVFDPDAPRPDPRLFSSGLPLLGICYG
MQLLAQELGGRVERAGRAEYGKALLTRHEGPLFRGLEGEVQVWMSHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYG
VQFHPEVAHTPKGMQILENFLELAGVKRDWTPEHVLEELLREVRERAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVF
VDHGLLRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVEDPEEKRKIIGREFVAAFSQVARERGPFRFLAQGTLYPD
VIESAGGHGAAKIKSHHNVGGLPEDLEFELLEPFRLLFKDEVRELALLLGLPDTLRLRHPFPGPGLAVRVLGEVTEERLE
ILRRADDIFTSLLREWGLYEKVAQALAVLTPVRSVGVAGDERKYGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITR
RVPEIGRVVYDLTSKPPATIEWE
>Mature_503_residues
MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLKHRPQALILSGGPRSVFDPDAPRPDPRLFSSGLPLLGICYG
MQLLAQELGGRVERAGRAEYGKALLTRHEGPLFRGLEGEVQVWMSHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYG
VQFHPEVAHTPKGMQILENFLELAGVKRDWTPEHVLEELLREVRERAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVF
VDHGLLRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVEDPEEKRKIIGREFVAAFSQVARERGPFRFLAQGTLYPD
VIESAGGHGAAKIKSHHNVGGLPEDLEFELLEPFRLLFKDEVRELALLLGLPDTLRLRHPFPGPGLAVRVLGEVTEERLE
ILRRADDIFTSLLREWGLYEKVAQALAVLTPVRSVGVAGDERKYGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITR
RVPEIGRVVYDLTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=546, Percent_Identity=38.2783882783883, Blast_Score=303, Evalue=4e-82,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=50.3875968992248, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1789760, Length=186, Percent_Identity=32.258064516129, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787517, Length=212, Percent_Identity=28.7735849056604, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=566, Percent_Identity=34.982332155477, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71992710, Length=566, Percent_Identity=34.982332155477, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI133901714, Length=566, Percent_Identity=34.982332155477, Blast_Score=272, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6323873, Length=514, Percent_Identity=48.8326848249027, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322638, Length=189, Percent_Identity=28.042328042328, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281365319, Length=544, Percent_Identity=38.2352941176471, Blast_Score=295, Evalue=6e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 55818; Mature: 55818

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLKHRPQALILSGGPRSVFDPDA
CEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCCCC
PRPDPRLFSSGLPLLGICYGMQLLAQELGGRVERAGRAEYGKALLTRHEGPLFRGLEGEV
CCCCHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCE
QVWMSHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYGVQFHPEVAHTPKGMQILENF
EEEEECCCCCCCCCCCCEEEEECCCCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHH
LELAGVKRDWTPEHVLEELLREVRERAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVF
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCHHHHHHH
VDHGLLRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVEDPEEKRKIIGREFVAAFS
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QVARERGPFRFLAQGTLYPDVIESAGGHGAAKIKSHHNVGGLPEDLEFELLEPFRLLFKD
HHHHHCCCEEEEECCCCCHHHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EVRELALLLGLPDTLRLRHPFPGPGLAVRVLGEVTEERLEILRRADDIFTSLLREWGLYE
HHHHHHHHHCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KVAQALAVLTPVRSVGVAGDERKYGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITR
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RVPEIGRVVYDLTSKPPATIEWE
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLKHRPQALILSGGPRSVFDPDA
CEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCCCC
PRPDPRLFSSGLPLLGICYGMQLLAQELGGRVERAGRAEYGKALLTRHEGPLFRGLEGEV
CCCCHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCE
QVWMSHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYGVQFHPEVAHTPKGMQILENF
EEEEECCCCCCCCCCCCEEEEECCCCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHH
LELAGVKRDWTPEHVLEELLREVRERAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVF
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCHHHHHHH
VDHGLLRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVEDPEEKRKIIGREFVAAFS
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QVARERGPFRFLAQGTLYPDVIESAGGHGAAKIKSHHNVGGLPEDLEFELLEPFRLLFKD
HHHHHCCCEEEEECCCCCHHHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EVRELALLLGLPDTLRLRHPFPGPGLAVRVLGEVTEERLEILRRADDIFTSLLREWGLYE
HHHHHHHHHCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KVAQALAVLTPVRSVGVAGDERKYGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITR
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RVPEIGRVVYDLTSKPPATIEWE
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA