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The map label for this gene is uvrC [H]

Identifier: 55981517

GI number: 55981517

Start: 1473944

End: 1475716

Strand: Direct

Name: uvrC [H]

Synonym: TTHA1548

Alternate gene names: 55981517

Gene position: 1473944-1475716 (Clockwise)

Preceding gene: 55981515

Following gene: 55981521

Centisome position: 79.68

GC content: 69.54

Gene sequence:

>1773_bases
GTGCGGGCCCAAGACCTCCCTCCCCTTCCCGAGACCCCCGGGGTCTACCTGTGGAAGCGGGGGGAGGAGGTGCTCTACGT
GGGCAAGGCCAAGAGCCTCCGCGCCCGGGTGAAAAGCTACTTCCACGCCGAGGGCAAGGCGAGGCGCATCGCCGAGGAGG
CCACAGGGCTAGACTTCATCGCCACCCGGGACGAGGTGGAGGCCCTCCTCCTCGAGGCCAACCTCATCAAGGCCCACCGC
CCCCTCTACAACGTCCTCCTCAAGGACGACAAGCACTACCCCTTCCTCAAGCTCACCAACGAGCCCTTCCCCACCCTCCT
CGTGGTGCGCCGGGTGGAGGAGGACGGGGCCAAGTACTACGGGCCCTTCCCCGAGGCGGGGGCGCTTCGCCGCATCAAGA
CCCTCATAGACCGCCTCTTCCCCTTGCGCAAGAACTCGGGCTACCCCATGAAAAGGAGGCGCTACCCCTGCCTGAACTAC
AGCATGGGCCGCTGCCTCGCCCCTTGCGTGGGGAAGGCGGACCCAGAGGCCTACCAGGAGGTGGTGCGCCAGGTGGAGGC
GGTCCTCGAGGGCCGGGTGGACGGGCTCCTTCAGGAGCTCGAGGCCAAGATGCGGGAGGCGGCGAGAAGGCTTGAGTTTG
AGCGGGCGGCGGAGATCCGCGACCAGATGGAGGCCCTAAGGGCCTTCTTCTCCACGGACCAGCAGGCCTTTGACCCGGAG
ATGGGGGACCTGGACTTTCTGGGGATGGCCCGCTCCGGGGCCCTCGCCGTGGTGCAGCTCTACCAGGTGCGCTCCGGGCG
GATCCTCGGCCGCATCAGCCGCGTGGTGGAGAAGGAGGAGGCCACGGACGAGGAAATCCTCTGGGCCTTCCTCCGGGACC
ACTACCTGGAGGCCTCCCCCCTCCCCCCCCTCGTCCTCCTCCCCTTCCCCCTGGAGGACCTGGAAAGCCTCGCCGAGCTC
CTCAAGCGCCGCGCGGGGCGGAAGGTGGAGCTTAGGGTGCCGAAGAAGGGGGAGAAGGCGCGGCTCTTGGAACTCGCCGA
AAGGAACGCCCGCCTCGCCTTGGAGACCGAGCTCAAGCTCCGGGAAAGGCGGGGGGAGCACCCTGCCCTCAAGGCCCTCC
AGGACCTCCTGGGGCTTCCCGCCCGCCCCTGGCGCCTCGAGGGCTACGACATAAGCCACCTCCAGGGCCAGGCCCGGGTC
TTCTCCATCGCCGTCTTTGAGGGGGGAAGGCCCAAGCGGCAGGAGTACCGCAGGATGCGCCTCAAGGCGGGGAACGACGA
CTACGCCGCCATGGAGGAAGGGGTCTTCCGCCGCTACACGGGAAGCCTCAAGGACCTTCCCCTCCCCGACCTCCTCCTCA
TTGACGGGGGAGTGGGCCAGGTGCGGGCGGCGGCAAGGGCCCTGGAGCGGGCGGGCCTCAGGCTTCCCCTGGTGGGCCTC
GCCAAGGGGGAGGAGGTCCTGGTCACGCCGGAAGGGCGGGAGCTCCGCCTCCCCCTCACCCACCCGGCCCTGCAGCTTCT
CATCCACCTCCGGGACGAGGCCCACCAAAACGGCCTCCGCTACCACCGGAAGCGGCGGAGCGAGGAGCTTTTCCGGGTCC
TCCAGGGCATCCCCGGGATCGGGGAGAAAAGGAGGCGGCTCCTCTTGGAGCGCTACGGGGGGCTAAGGGCCCTCAAGGAG
GCCCCCCTGGAGGAGCTCGCCCGGCTTCCCGGGATGAGCCTCGAGGCCGCCCGGGCCCTCAAGGCGGCCCTGGCCGAGGA
GGAGCCCGCCTGA

Upstream 100 bases:

>100_bases
GGGGAGGGTGAGGTCCCGCCCTAAGGCGCGGGCGTTCCAGGCCAGGTCCAGGTGGGCGTCCACCAGGAAGGGAGGCACGG
GGAAAGTCTACAATGGGGGC

Downstream 100 bases:

>100_bases
CACCACCTGCGCCCCAAAAGGGCCTCCCCAAGCCTTGGTCCGGGCCCATGTGCGGGCGCACCTCAGATGAGGGCGCTCAC
CGACTGGTTGGTGTGGACGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MRAQDLPPLPETPGVYLWKRGEEVLYVGKAKSLRARVKSYFHAEGKARRIAEEATGLDFIATRDEVEALLLEANLIKAHR
PLYNVLLKDDKHYPFLKLTNEPFPTLLVVRRVEEDGAKYYGPFPEAGALRRIKTLIDRLFPLRKNSGYPMKRRRYPCLNY
SMGRCLAPCVGKADPEAYQEVVRQVEAVLEGRVDGLLQELEAKMREAARRLEFERAAEIRDQMEALRAFFSTDQQAFDPE
MGDLDFLGMARSGALAVVQLYQVRSGRILGRISRVVEKEEATDEEILWAFLRDHYLEASPLPPLVLLPFPLEDLESLAEL
LKRRAGRKVELRVPKKGEKARLLELAERNARLALETELKLRERRGEHPALKALQDLLGLPARPWRLEGYDISHLQGQARV
FSIAVFEGGRPKRQEYRRMRLKAGNDDYAAMEEGVFRRYTGSLKDLPLPDLLLIDGGVGQVRAAARALERAGLRLPLVGL
AKGEEVLVTPEGRELRLPLTHPALQLLIHLRDEAHQNGLRYHRKRRSEELFRVLQGIPGIGEKRRRLLLERYGGLRALKE
APLEELARLPGMSLEAARALKAALAEEEPA

Sequences:

>Translated_590_residues
MRAQDLPPLPETPGVYLWKRGEEVLYVGKAKSLRARVKSYFHAEGKARRIAEEATGLDFIATRDEVEALLLEANLIKAHR
PLYNVLLKDDKHYPFLKLTNEPFPTLLVVRRVEEDGAKYYGPFPEAGALRRIKTLIDRLFPLRKNSGYPMKRRRYPCLNY
SMGRCLAPCVGKADPEAYQEVVRQVEAVLEGRVDGLLQELEAKMREAARRLEFERAAEIRDQMEALRAFFSTDQQAFDPE
MGDLDFLGMARSGALAVVQLYQVRSGRILGRISRVVEKEEATDEEILWAFLRDHYLEASPLPPLVLLPFPLEDLESLAEL
LKRRAGRKVELRVPKKGEKARLLELAERNARLALETELKLRERRGEHPALKALQDLLGLPARPWRLEGYDISHLQGQARV
FSIAVFEGGRPKRQEYRRMRLKAGNDDYAAMEEGVFRRYTGSLKDLPLPDLLLIDGGVGQVRAAARALERAGLRLPLVGL
AKGEEVLVTPEGRELRLPLTHPALQLLIHLRDEAHQNGLRYHRKRRSEELFRVLQGIPGIGEKRRRLLLERYGGLRALKE
APLEELARLPGMSLEAARALKAALAEEEPA
>Mature_590_residues
MRAQDLPPLPETPGVYLWKRGEEVLYVGKAKSLRARVKSYFHAEGKARRIAEEATGLDFIATRDEVEALLLEANLIKAHR
PLYNVLLKDDKHYPFLKLTNEPFPTLLVVRRVEEDGAKYYGPFPEAGALRRIKTLIDRLFPLRKNSGYPMKRRRYPCLNY
SMGRCLAPCVGKADPEAYQEVVRQVEAVLEGRVDGLLQELEAKMREAARRLEFERAAEIRDQMEALRAFFSTDQQAFDPE
MGDLDFLGMARSGALAVVQLYQVRSGRILGRISRVVEKEEATDEEILWAFLRDHYLEASPLPPLVLLPFPLEDLESLAEL
LKRRAGRKVELRVPKKGEKARLLELAERNARLALETELKLRERRGEHPALKALQDLLGLPARPWRLEGYDISHLQGQARV
FSIAVFEGGRPKRQEYRRMRLKAGNDDYAAMEEGVFRRYTGSLKDLPLPDLLLIDGGVGQVRAAARALERAGLRLPLVGL
AKGEEVLVTPEGRELRLPLTHPALQLLIHLRDEAHQNGLRYHRKRRSEELFRVLQGIPGIGEKRRRLLLERYGGLRALKE
APLEELARLPGMSLEAARALKAALAEEEPA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=592, Percent_Identity=38.3445945945946, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1788037, Length=184, Percent_Identity=31.5217391304348, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 67105; Mature: 67105

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAQDLPPLPETPGVYLWKRGEEVLYVGKAKSLRARVKSYFHAEGKARRIAEEATGLDFI
CCCCCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
ATRDEVEALLLEANLIKAHRPLYNVLLKDDKHYPFLKLTNEPFPTLLVVRRVEEDGAKYY
ECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCC
GPFPEAGALRRIKTLIDRLFPLRKNSGYPMKRRRYPCLNYSMGRCLAPCVGKADPEAYQE
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCCCCHHHHHH
VVRQVEAVLEGRVDGLLQELEAKMREAARRLEFERAAEIRDQMEALRAFFSTDQQAFDPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
MGDLDFLGMARSGALAVVQLYQVRSGRILGRISRVVEKEEATDEEILWAFLRDHYLEASP
CCCCHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
LPPLVLLPFPLEDLESLAELLKRRAGRKVELRVPKKGEKARLLELAERNARLALETELKL
CCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHH
RERRGEHPALKALQDLLGLPARPWRLEGYDISHLQGQARVFSIAVFEGGRPKRQEYRRMR
HHHCCCCHHHHHHHHHHCCCCCCCEECCCCHHHHCCCCEEEEEEEECCCCCHHHHHHHHH
LKAGNDDYAAMEEGVFRRYTGSLKDLPLPDLLLIDGGVGQVRAAARALERAGLRLPLVGL
HCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEE
AKGEEVLVTPEGRELRLPLTHPALQLLIHLRDEAHQNGLRYHRKRRSEELFRVLQGIPGI
CCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GEKRRRLLLERYGGLRALKEAPLEELARLPGMSLEAARALKAALAEEEPA
CHHHHHHHHHHHCCHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRAQDLPPLPETPGVYLWKRGEEVLYVGKAKSLRARVKSYFHAEGKARRIAEEATGLDFI
CCCCCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
ATRDEVEALLLEANLIKAHRPLYNVLLKDDKHYPFLKLTNEPFPTLLVVRRVEEDGAKYY
ECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCC
GPFPEAGALRRIKTLIDRLFPLRKNSGYPMKRRRYPCLNYSMGRCLAPCVGKADPEAYQE
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCCCCHHHHHH
VVRQVEAVLEGRVDGLLQELEAKMREAARRLEFERAAEIRDQMEALRAFFSTDQQAFDPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
MGDLDFLGMARSGALAVVQLYQVRSGRILGRISRVVEKEEATDEEILWAFLRDHYLEASP
CCCCHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
LPPLVLLPFPLEDLESLAELLKRRAGRKVELRVPKKGEKARLLELAERNARLALETELKL
CCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHH
RERRGEHPALKALQDLLGLPARPWRLEGYDISHLQGQARVFSIAVFEGGRPKRQEYRRMR
HHHCCCCHHHHHHHHHHCCCCCCCEECCCCHHHHCCCCEEEEEEEECCCCCHHHHHHHHH
LKAGNDDYAAMEEGVFRRYTGSLKDLPLPDLLLIDGGVGQVRAAARALERAGLRLPLVGL
HCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEE
AKGEEVLVTPEGRELRLPLTHPALQLLIHLRDEAHQNGLRYHRKRRSEELFRVLQGIPGI
CCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GEKRRRLLLERYGGLRALKEAPLEELARLPGMSLEAARALKAALAEEEPA
CHHHHHHHHHHHCCHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA