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The map label for this gene is icd

Identifier: 55981504

GI number: 55981504

Start: 1460972

End: 1462462

Strand: Reverse

Name: icd

Synonym: TTHA1535

Alternate gene names: 55981504

Gene position: 1462462-1460972 (Counterclockwise)

Preceding gene: 55981506

Following gene: 55981501

Centisome position: 79.06

GC content: 65.59

Gene sequence:

>1491_bases
ATGCCCCTGATCACCACGGAAACCGGCAAGAAGATGCACGTTCTCGAGGACGGGCGCAAGCTCATCACCGTCATCCCCGG
AGACGGCATCGGGCCCGAGTGCGTGGAGGCTACCCTCAAGGTCCTAGAGGCGGCCAAGGCCCCCCTGGCCTACGAGGTGC
GAGAGGCGGGGGCGAGCGTCTTCCGGCGGGGCATCGCCTCGGGCGTTCCCCAGGAGACCATTGAGTCCATCCGCAAGACC
CGGGTGGTCCTGAAGGGTCCCCTGGAAACCCCGGTGGGCTACGGGGAGAAGAGCGCCAACGTCACCCTAAGGAAGCTCTT
TGAGACCTACGCCAACGTCCGCCCCGTGCGGGAGTTCCCCAACGTCCCCACCCCCTATGCGGGCCGGGGCATTGACCTCG
TGGTGGTGCGGGAGAACGTGGAGGACCTCTACGCCGGGATTGAGCACATGCAGACCCCGAGCGTGGCCCAGACCCTCAAG
CTCATCTCCTGGAAGGGATCGGAGAAGATCGTCCGCTTCGCCTTTGAGCTGGCCCGGGCCGAGGGGCGGAAGAAGGTCCA
CTGCGCCACCAAGTCCAACATCATGAAGCTCGCCGAAGGGACCCTGAAGCGGGCCTTTGAGCAGGTGGCCCAGGAGTACC
CCGACATAGAAGCGGTCCACATCATCGTGGACAACGCTGCCCACCAGCTGGTGAAAAGGCCCGAGCAGTTTGAGGTGATC
GTCACCACCAACATGAACGGAGACATCCTCTCCGACCTCACCTCGGGGCTCATTGGGGGCCTGGGCTTCGCTCCCTCGGC
CAACATCGGCAACGAGGTGGCCATCTTTGAGGCCGTCCACGGTTCCGCCCCCAAGTACGCCGGGAAGAACGTCATCAACC
CCACCGCGGTCCTCCTCTCGGCGGTGATGATGCTCCGCTACCTGGAGGAGTTCGCCACGGCGGACCTTATAGAGAACGCC
CTCCTCTACACCCTCGAGGAGGGCCGGGTCCTCACGGGGGACGTGGTGGGCTACGACCGGGGGGCCAAGACCACGGAGTA
CACCGAGGCCATCATCCAGAACCTGGGCAAGACCCCAAGGAAGACCCAGGTGCGGGGCTACAAGCCCTTCCGCCTGCCCC
AGGTGGACGGGGCCATCGCCCCCATCGTCCCTAGGAGCCGCCGGGTTGTGGGGGTGGACGTCTTCGTGGAAACCAACCTC
CTGCCCGAGGCCCTGGGAAAGGCCCTGGAGGACCTTGCCGCGGGCACCCCCTTCCGGCTCAAGATGATCTCCAACCGGGG
CACCCAGGTCTACCCCCCCACCGGCGGGCTCACGGACCTGGTGGACCACTACCGCTGCCGCTTCCTCTACACGGGGGAGG
GGGAGGCTAAGGACCCGGAGATCCTGGACCTCGTAAGCCGGGTGGCAAGCCGCTTCCGCTGGATGCACCTGGAGAAGCTC
CAGGAATTTGACGGCGAGCCCGGCTTCACCAAGGCCCAAGGGGAAGACTAA

Upstream 100 bases:

>100_bases
GCCCCCACCACGACCACCCGGGCCACGCCCCGAGTTTACAAGGCCTCAAGCCCCGTGGTGTAGTGTAAAGGGGGGCGATT
CCGCCCCCGGAGGTGAACCC

Downstream 100 bases:

>100_bases
GGCCACCCCATGCCGGCTTGGGCCGGCATGGGGCCCGGCATGGCCCCGAGCCTGATGCGGCGCCTAGACCAGGGCGAAGC
GGGCCTCGAGGGCCGGAAGG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MPLITTETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESIRKT
RVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQTLK
LISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVI
VTTNMNGDILSDLTSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFATADLIENA
LLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGKTPRKTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVETNL
LPEALGKALEDLAAGTPFRLKMISNRGTQVYPPTGGLTDLVDHYRCRFLYTGEGEAKDPEILDLVSRVASRFRWMHLEKL
QEFDGEPGFTKAQGED

Sequences:

>Translated_496_residues
MPLITTETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESIRKT
RVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQTLK
LISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVI
VTTNMNGDILSDLTSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFATADLIENA
LLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGKTPRKTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVETNL
LPEALGKALEDLAAGTPFRLKMISNRGTQVYPPTGGLTDLVDHYRCRFLYTGEGEAKDPEILDLVSRVASRFRWMHLEKL
QEFDGEPGFTKAQGED
>Mature_495_residues
PLITTETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESIRKTR
VVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQTLKL
ISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIV
TTNMNGDILSDLTSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFATADLIENAL
LYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGKTPRKTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVETNLL
PEALGKALEDLAAGTPFRLKMISNRGTQVYPPTGGLTDLVDHYRCRFLYTGEGEAKDPEILDLVSRVASRFRWMHLEKLQ
EFDGEPGFTKAQGED

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family

Homologues:

Organism=Homo sapiens, GI5031777, Length=337, Percent_Identity=45.6973293768546, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI4758582, Length=341, Percent_Identity=37.2434017595308, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI28178838, Length=316, Percent_Identity=38.6075949367089, Blast_Score=212, Evalue=8e-55,
Organism=Homo sapiens, GI28178816, Length=343, Percent_Identity=36.4431486880466, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI28178821, Length=339, Percent_Identity=35.693215339233, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI28178819, Length=203, Percent_Identity=39.4088669950739, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1787381, Length=408, Percent_Identity=35.7843137254902, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1788101, Length=332, Percent_Identity=35.2409638554217, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI87081683, Length=352, Percent_Identity=34.375, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71986051, Length=351, Percent_Identity=42.1652421652422, Blast_Score=275, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI25144293, Length=363, Percent_Identity=38.5674931129477, Blast_Score=234, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17505779, Length=340, Percent_Identity=35.8823529411765, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17550882, Length=340, Percent_Identity=35.2941176470588, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324709, Length=342, Percent_Identity=44.4444444444444, Blast_Score=279, Evalue=9e-76,
Organism=Saccharomyces cerevisiae, GI6324291, Length=343, Percent_Identity=38.4839650145773, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322097, Length=359, Percent_Identity=34.2618384401114, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319830, Length=367, Percent_Identity=31.0626702997275, Blast_Score=126, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24643268, Length=338, Percent_Identity=44.0828402366864, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24643270, Length=338, Percent_Identity=44.0828402366864, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24661184, Length=342, Percent_Identity=43.859649122807, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI281362242, Length=359, Percent_Identity=38.1615598885794, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24648872, Length=359, Percent_Identity=38.1615598885794, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI161078633, Length=340, Percent_Identity=33.2352941176471, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24650122, Length=340, Percent_Identity=33.2352941176471, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161078635, Length=340, Percent_Identity=33.2352941176471, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI161078637, Length=340, Percent_Identity=33.2352941176471, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI161078639, Length=334, Percent_Identity=32.9341317365269, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20130355, Length=335, Percent_Identity=28.955223880597, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45550436, Length=280, Percent_Identity=22.8571428571429, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): IDH_THET8 (P33197)

Other databases:

- EMBL:   M94317
- EMBL:   AP008226
- RefSeq:   YP_144801.1
- PDB:   2D1C
- PDBsum:   2D1C
- ProteinModelPortal:   P33197
- SMR:   P33197
- STRING:   P33197
- GeneID:   3168917
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA1535
- NMPDR:   fig|300852.3.peg.1847
- eggNOG:   COG0473
- HOGENOM:   HBG518924
- OMA:   DNIMKMT
- ProtClustDB:   PRK09222
- BioCyc:   TTHE300852:TTHA1535-MONOMER
- InterPro:   IPR019818
- InterPro:   IPR001804
- Gene3D:   G3DSA:3.40.718.10
- PANTHER:   PTHR11835

Pfam domain/function: PF00180 Iso_dh

EC number: =1.1.1.42

Molecular weight: Translated: 54439; Mature: 54308

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00470 IDH_IMDH

Important sites: BINDING 104-104 BINDING 114-114 BINDING 137-137 BINDING 224-224

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLITTETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASV
CCCEECCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FRRGIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFP
HHHHHHCCCCHHHHHHHHHCEEHEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCC
NVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARA
CCCCCCCCCCEEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
EGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVI
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHCCCCCEEEE
VTTNMNGDILSDLTSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLS
EEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHH
AVMMLRYLEEFATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGKTPR
HHHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCEEECCCCCCCHHHHHHHHHHCCCCCC
KTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVETNLLPEALGKALEDLAAGTPFRL
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEE
KMISNRGTQVYPPTGGLTDLVDHYRCRFLYTGEGEAKDPEILDLVSRVASRFRWMHLEKL
EEECCCCCEEECCCCCHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QEFDGEPGFTKAQGED
HHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PLITTETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASV
CCEECCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FRRGIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFP
HHHHHHCCCCHHHHHHHHHCEEHEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCC
NVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARA
CCCCCCCCCCEEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
EGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVI
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHCCCCCEEEE
VTTNMNGDILSDLTSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLS
EEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHH
AVMMLRYLEEFATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGKTPR
HHHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCEEECCCCCCCHHHHHHHHHHCCCCCC
KTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVETNLLPEALGKALEDLAAGTPFRL
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEE
KMISNRGTQVYPPTGGLTDLVDHYRCRFLYTGEGEAKDPEILDLVSRVASRFRWMHLEKL
EEECCCCCEEECCCCCHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QEFDGEPGFTKAQGED
HHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1539996