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The map label for this gene is truD [H]

Identifier: 55981500

GI number: 55981500

Start: 1455479

End: 1456549

Strand: Reverse

Name: truD [H]

Synonym: TTHA1531

Alternate gene names: 55981500

Gene position: 1456549-1455479 (Counterclockwise)

Preceding gene: 55981501

Following gene: 55981498

Centisome position: 78.74

GC content: 67.79

Gene sequence:

>1071_bases
ATGGACCTGGTCTTTCGCCCCGAGCGCTACCCCTTCCTCACCCAAGACCTCCCCGGGGTGGGCGGGGAGATCCGGGTGGA
GCCCGAGGACTTCCAGGTGGAGGAGGTGCCCGCCTACCTCCCCAAGGGGGAGGGGGAGCACCTCTACCTCCTTCTGGAGA
AGGAGGGCCGCACCACCCGGGAGGTCTTGGAGTTCCTGCGGGACGAGGTGGGGGTGCCCGAGAAGGAGATCGGGGTGGCG
GGCCTAAAGGACAAGCGCGCCAAAACCCGCCAGTGGTTCTCCATCCCGAGGAAGTACGAGGACGCCCTCTGCCTTCTGGA
GAACCTCCAGGGCGTGAGGCTCCTTGCCGCCGACCTCCACACCAACAAGCTCAGGACGGGGCACCTCAAGGGGAACCGCT
TCCATATCCTCATCCGCCGCCCCAAAGGGGGGGTGGCGGAGGCGGAGGCGGTCCTAAAGCGCCTCGCGGAGAAGGGCGTC
CCCAACTACTACGGCCCCCAGCGCTTCGGCCTTGGGGGGCTAAACCCGGTTAGGGGCTACAAGCTAGTGAAGGAGGGAAA
GGGCCGGGGAAGCCCCTGGCTCAAGCGCTTCCTCATCGGAAGCCTCCAGAGCCTCCTCTTCAACGACTGGGTGGCCCTGA
GGATGGCCCTGGGCCTCTACGACCGGGTGGTCCCCGGGGACTGGGCCAAAAAGCACGCCACGGGAGGGGAGTTCCTGGTG
GAAGACCCGGGGGAGGCCGAGCGCGCCCTAAGGCTTGAGATCAGCGCCACGGGCCCCCTCTTCGGCAAGAAGTACCCCGA
GGCCCAAGGGGAGGCGAGGGCCATAGAGGACGAGGTCCTCGCCCGCTACGGCCTCAAGCGGGAGGAGTTCAGGGCTAGGC
GGGGCGCCCGGAGGCCCATCCGGGTCCCCCTCGCGGAGTGGAAGGTGGAGGAGGCCCCGGAGGGGCTTTGGCTTTCCTTC
TTCCTGCCCAAGGGGAGCTACGCCACGAGCCTTCTTCGGGAGGTGATGAAGGTGGAGGCCCTAGACCACCTGGAAGCCGA
ACCGGCCCCCGAGGACGCCGAGGGCCTCTAG

Upstream 100 bases:

>100_bases
CCGAGGCCGGGGTGGAGCTTGGCTCCGAGGCCTTCTTCCGCTACGGCTTCGGCGTCCTGGAGTCTTGGCTAAAGGCCCTT
CCCTAGGCGAGAATAGGGGG

Downstream 100 bases:

>100_bases
CCGGGCCTCCACCCCTTCCCGGTCCTCGGGGAGGCCGGTGAGGAGGAGGTAGAGGAGGCCGGAAAGCTCCCCGAGGACCA
GAAAACCCGTCTGGGCCCGC

Product: hypothetical protein

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MDLVFRPERYPFLTQDLPGVGGEIRVEPEDFQVEEVPAYLPKGEGEHLYLLLEKEGRTTREVLEFLRDEVGVPEKEIGVA
GLKDKRAKTRQWFSIPRKYEDALCLLENLQGVRLLAADLHTNKLRTGHLKGNRFHILIRRPKGGVAEAEAVLKRLAEKGV
PNYYGPQRFGLGGLNPVRGYKLVKEGKGRGSPWLKRFLIGSLQSLLFNDWVALRMALGLYDRVVPGDWAKKHATGGEFLV
EDPGEAERALRLEISATGPLFGKKYPEAQGEARAIEDEVLARYGLKREEFRARRGARRPIRVPLAEWKVEEAPEGLWLSF
FLPKGSYATSLLREVMKVEALDHLEAEPAPEDAEGL

Sequences:

>Translated_356_residues
MDLVFRPERYPFLTQDLPGVGGEIRVEPEDFQVEEVPAYLPKGEGEHLYLLLEKEGRTTREVLEFLRDEVGVPEKEIGVA
GLKDKRAKTRQWFSIPRKYEDALCLLENLQGVRLLAADLHTNKLRTGHLKGNRFHILIRRPKGGVAEAEAVLKRLAEKGV
PNYYGPQRFGLGGLNPVRGYKLVKEGKGRGSPWLKRFLIGSLQSLLFNDWVALRMALGLYDRVVPGDWAKKHATGGEFLV
EDPGEAERALRLEISATGPLFGKKYPEAQGEARAIEDEVLARYGLKREEFRARRGARRPIRVPLAEWKVEEAPEGLWLSF
FLPKGSYATSLLREVMKVEALDHLEAEPAPEDAEGL
>Mature_356_residues
MDLVFRPERYPFLTQDLPGVGGEIRVEPEDFQVEEVPAYLPKGEGEHLYLLLEKEGRTTREVLEFLRDEVGVPEKEIGVA
GLKDKRAKTRQWFSIPRKYEDALCLLENLQGVRLLAADLHTNKLRTGHLKGNRFHILIRRPKGGVAEAEAVLKRLAEKGV
PNYYGPQRFGLGGLNPVRGYKLVKEGKGRGSPWLKRFLIGSLQSLLFNDWVALRMALGLYDRVVPGDWAKKHATGGEFLV
EDPGEAERALRLEISATGPLFGKKYPEAQGEARAIEDEVLARYGLKREEFRARRGARRPIRVPLAEWKVEEAPEGLWLSF
FLPKGSYATSLLREVMKVEALDHLEAEPAPEDAEGL

Specific function: Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Homo sapiens, GI50727002, Length=135, Percent_Identity=30.3703703703704, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI148762985, Length=141, Percent_Identity=34.7517730496454, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI148762961, Length=141, Percent_Identity=34.7517730496454, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI148762948, Length=141, Percent_Identity=34.7517730496454, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789102, Length=335, Percent_Identity=33.134328358209, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324817, Length=132, Percent_Identity=35.6060606060606, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355799, Length=135, Percent_Identity=34.0740740740741, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 40183; Mature: 40183

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS50984 TRUD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLVFRPERYPFLTQDLPGVGGEIRVEPEDFQVEEVPAYLPKGEGEHLYLLLEKEGRTTR
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHH
EVLEFLRDEVGVPEKEIGVAGLKDKRAKTRQWFSIPRKYEDALCLLENLQGVRLLAADLH
HHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEHHH
TNKLRTGHLKGNRFHILIRRPKGGVAEAEAVLKRLAEKGVPNYYGPQRFGLGGLNPVRGY
CCCEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
KLVKEGKGRGSPWLKRFLIGSLQSLLFNDWVALRMALGLYDRVVPGDWAKKHATGGEFLV
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEE
EDPGEAERALRLEISATGPLFGKKYPEAQGEARAIEDEVLARYGLKREEFRARRGARRPI
ECCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCE
RVPLAEWKVEEAPEGLWLSFFLPKGSYATSLLREVMKVEALDHLEAEPAPEDAEGL
ECCHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDLVFRPERYPFLTQDLPGVGGEIRVEPEDFQVEEVPAYLPKGEGEHLYLLLEKEGRTTR
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHH
EVLEFLRDEVGVPEKEIGVAGLKDKRAKTRQWFSIPRKYEDALCLLENLQGVRLLAADLH
HHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEHHH
TNKLRTGHLKGNRFHILIRRPKGGVAEAEAVLKRLAEKGVPNYYGPQRFGLGGLNPVRGY
CCCEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
KLVKEGKGRGSPWLKRFLIGSLQSLLFNDWVALRMALGLYDRVVPGDWAKKHATGGEFLV
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEE
EDPGEAERALRLEISATGPLFGKKYPEAQGEARAIEDEVLARYGLKREEFRARRGARRPI
ECCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCE
RVPLAEWKVEEAPEGLWLSFFLPKGSYATSLLREVMKVEALDHLEAEPAPEDAEGL
ECCHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA