Click here to switch to the map view.

The map label for this gene is cls [H]

Identifier: 55981419

GI number: 55981419

Start: 1377930

End: 1379243

Strand: Direct

Name: cls [H]

Synonym: TTHA1450

Alternate gene names: 55981419

Gene position: 1377930-1379243 (Clockwise)

Preceding gene: 55981418

Following gene: 55981420

Centisome position: 74.49

GC content: 68.95

Gene sequence:

>1314_bases
ATGCTTTGGCTGGCCATGAGGCGTTTCCTCGTTCTGCTCTGGCTCCTCTCCCTGGCCCTGGCGGCGCCCCGCCTCGTGGT
GGAGCCCGAGGACGGGGTCAAGCCCCTCCTGGACCTCATCGCCTCCGCCCGGGAGGAGATCCTGGTCAAGATGTACCTCT
GGACCCCAAGCCGCATGGACGTGGTGGAGGCCCTGGGGGAGGCGGCGAGGCGAGGGGTGCGGGTGCGGGTCCTCCTGGAG
CGGGAGCCCTCGGGGGGGCGGGTGGACCTCGAGGTCTTCCAGGCCCTTAAAGCGCGGGGGGTGGAGGTCAGGCTCACCAC
GCCCTTCCGCTTCGTCTTCGTGCACGAAAAAAGCCTGGTGGTGGACCGCAAGCGGGCCTGGGTGGGCACCATGAACCTCA
CGGGAAGCTCCTTCGCCGCCAACCGCGAGTACGCCCTCATCCTGGACGACCCCGCGCAGGTGGCCGAGATCGCCAAGGTC
TTTGAGGCCGACTGGGAAGGGGAAAGGCTGGACCTCTCCCAAGCCCTGCTCGTCTGGGCGCCAAGCCGCGTCCTGGGCGG
GGTGAAGGAGGGGAACGCCCGGGAAACCCTCCTCGCCCTCATCCGGGGGGCCCAAAGGGAGCTTTTCCTGGAGCACCAGG
CCATGGCCGACCCCGAGGTGGAGGCCGCCCTGAAGGAGGCCCTGGGCCGGGGGGTGCGGGTGCGCCTTCTGGGGAGCCCT
AAGGAGCCCGGGGACACCTACTTCCTCGCGGGGGCCCTGAGGCTCAAGGAGGCGGGGGCCCTGGTGCGCTTCCTCCCCGA
CCCCTACGTCCACGCCAAGGTCCTGGTGCGGGACGGCGAAGAGGCCCTTTTGGGAAGCCTCAACCTGAGCGCCAACTCCA
TCCAGGCCAACCGGGAGCTTGCCGTGCGCTTCACCGCCCGGGAGGCCCCCGAGGCCTTTAGAAGGCTCCTTTTCGTGATG
GAGGGGGACTGGGAAAAGGCCCTTCCGGAAAACCCCTTCGCCCTCCCCCCGGTGGAGGGGGTAATCCCCTGGCAGGAGGC
CCCCCGGTACTTCGGCCGCGTGGCCACGGTGGAGGGGGTGATCCAGGCGGTGGAGGACCGGGGCACGGTGGCCTTCCTCA
AGTTCGGCCCGGGGGAAAGCGACCTCCGGCTGGTGGCTTTCCCGAGAAGCTACGGCCTCTTCGCCCAGCCTTTCCCCCAG
AGTTACCTGGGCAAGAAGGTGCGGGCCAGGGGGCGGATCGTCCTCTACGCCGGCTACTACGAGATCGTCCTGGAAGGCCC
GGAGAACCTGGAGGTGCTGGATGGAGGCCCTTAA

Upstream 100 bases:

>100_bases
ACCGCCCCCACTACGTGCGCTTTACCCTGGAGAAACTCGCGGAAGCGCGGGGCCTTCCCTTCGCCGAGGCGGAGGCCCTC
ACCGACCGGAACGCCCGGGT

Downstream 100 bases:

>100_bases
GGCCCTGGGCTACGAGGTGAGCCCCATAGAGGGGGGCGTCTACGGGGAAAAGCGGCGGGGCGGGGTGGTCTACCAGGTCT
TCTACGCGGAAAAGGGCGAC

Product: hypothetical protein

Products: Biphosphatidylglycerol; Glycerol. [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MLWLAMRRFLVLLWLLSLALAAPRLVVEPEDGVKPLLDLIASAREEILVKMYLWTPSRMDVVEALGEAARRGVRVRVLLE
REPSGGRVDLEVFQALKARGVEVRLTTPFRFVFVHEKSLVVDRKRAWVGTMNLTGSSFAANREYALILDDPAQVAEIAKV
FEADWEGERLDLSQALLVWAPSRVLGGVKEGNARETLLALIRGAQRELFLEHQAMADPEVEAALKEALGRGVRVRLLGSP
KEPGDTYFLAGALRLKEAGALVRFLPDPYVHAKVLVRDGEEALLGSLNLSANSIQANRELAVRFTAREAPEAFRRLLFVM
EGDWEKALPENPFALPPVEGVIPWQEAPRYFGRVATVEGVIQAVEDRGTVAFLKFGPGESDLRLVAFPRSYGLFAQPFPQ
SYLGKKVRARGRIVLYAGYYEIVLEGPENLEVLDGGP

Sequences:

>Translated_437_residues
MLWLAMRRFLVLLWLLSLALAAPRLVVEPEDGVKPLLDLIASAREEILVKMYLWTPSRMDVVEALGEAARRGVRVRVLLE
REPSGGRVDLEVFQALKARGVEVRLTTPFRFVFVHEKSLVVDRKRAWVGTMNLTGSSFAANREYALILDDPAQVAEIAKV
FEADWEGERLDLSQALLVWAPSRVLGGVKEGNARETLLALIRGAQRELFLEHQAMADPEVEAALKEALGRGVRVRLLGSP
KEPGDTYFLAGALRLKEAGALVRFLPDPYVHAKVLVRDGEEALLGSLNLSANSIQANRELAVRFTAREAPEAFRRLLFVM
EGDWEKALPENPFALPPVEGVIPWQEAPRYFGRVATVEGVIQAVEDRGTVAFLKFGPGESDLRLVAFPRSYGLFAQPFPQ
SYLGKKVRARGRIVLYAGYYEIVLEGPENLEVLDGGP
>Mature_437_residues
MLWLAMRRFLVLLWLLSLALAAPRLVVEPEDGVKPLLDLIASAREEILVKMYLWTPSRMDVVEALGEAARRGVRVRVLLE
REPSGGRVDLEVFQALKARGVEVRLTTPFRFVFVHEKSLVVDRKRAWVGTMNLTGSSFAANREYALILDDPAQVAEIAKV
FEADWEGERLDLSQALLVWAPSRVLGGVKEGNARETLLALIRGAQRELFLEHQAMADPEVEAALKEALGRGVRVRLLGSP
KEPGDTYFLAGALRLKEAGALVRFLPDPYVHAKVLVRDGEEALLGSLNLSANSIQANRELAVRFTAREAPEAFRRLLFVM
EGDWEKALPENPFALPPVEGVIPWQEAPRYFGRVATVEGVIQAVEDRGTVAFLKFGPGESDLRLVAFPRSYGLFAQPFPQ
SYLGKKVRARGRIVLYAGYYEIVLEGPENLEVLDGGP

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 48586; Mature: 48586

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWLAMRRFLVLLWLLSLALAAPRLVVEPEDGVKPLLDLIASAREEILVKMYLWTPSRMD
CHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHEEEEEEEECCCHHH
VVEALGEAARRGVRVRVLLEREPSGGRVDLEVFQALKARGVEVRLTTPFRFVFVHEKSLV
HHHHHHHHHHCCEEEEEEEEECCCCCEEEHHHHHHHHHCCCEEEEECCEEEEEEECCHHE
VDRKRAWVGTMNLTGSSFAANREYALILDDPAQVAEIAKVFEADWEGERLDLSQALLVWA
EECCHHEEEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEECHHHHHEEEE
PSRVLGGVKEGNARETLLALIRGAQRELFLEHQAMADPEVEAALKEALGRGVRVRLLGSP
CHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCC
KEPGDTYFLAGALRLKEAGALVRFLPDPYVHAKVLVRDGEEALLGSLNLSANSIQANREL
CCCCCCEEEEEEEEHHHCCCEEEECCCCCEEEEEEEECCCHHHHEECCCCCCCEECCCEE
AVRFTAREAPEAFRRLLFVMEGDWEKALPENPFALPPVEGVIPWQEAPRYFGRVATVEGV
EEEEECHHHHHHHHHHHEEECCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IQAVEDRGTVAFLKFGPGESDLRLVAFPRSYGLFAQPFPQSYLGKKVRARGRIVLYAGYY
HHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHCHHHHCCCCEEEEECEE
EIVLEGPENLEVLDGGP
EEEEECCCCCEEECCCC
>Mature Secondary Structure
MLWLAMRRFLVLLWLLSLALAAPRLVVEPEDGVKPLLDLIASAREEILVKMYLWTPSRMD
CHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHEEEEEEEECCCHHH
VVEALGEAARRGVRVRVLLEREPSGGRVDLEVFQALKARGVEVRLTTPFRFVFVHEKSLV
HHHHHHHHHHCCEEEEEEEEECCCCCEEEHHHHHHHHHCCCEEEEECCEEEEEEECCHHE
VDRKRAWVGTMNLTGSSFAANREYALILDDPAQVAEIAKVFEADWEGERLDLSQALLVWA
EECCHHEEEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEECHHHHHEEEE
PSRVLGGVKEGNARETLLALIRGAQRELFLEHQAMADPEVEAALKEALGRGVRVRLLGSP
CHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCC
KEPGDTYFLAGALRLKEAGALVRFLPDPYVHAKVLVRDGEEALLGSLNLSANSIQANREL
CCCCCCEEEEEEEEHHHCCCEEEECCCCCEEEEEEEECCCHHHHEECCCCCCCEECCCEE
AVRFTAREAPEAFRRLLFVMEGDWEKALPENPFALPPVEGVIPWQEAPRYFGRVATVEGV
EEEEECHHHHHHHHHHHEEECCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IQAVEDRGTVAFLKFGPGESDLRLVAFPRSYGLFAQPFPQSYLGKKVRARGRIVLYAGYY
HHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHCHHHHCCCCEEEEECEE
EIVLEGPENLEVLDGGP
EEEEECCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Phosphatidylglycerol [C]

Specific reaction: 2 Phosphatidylglycerol = Biphosphatidylglycerol + Glycerol. [C]

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA