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The map label for this gene is epsD [H]

Identifier: 55981352

GI number: 55981352

Start: 1318515

End: 1320788

Strand: Direct

Name: epsD [H]

Synonym: TTHA1383

Alternate gene names: 55981352

Gene position: 1318515-1320788 (Clockwise)

Preceding gene: 55981351

Following gene: 55981353

Centisome position: 71.28

GC content: 68.51

Gene sequence:

>2274_bases
ATGAAGAGCGCGTGGATCCGTGCGGCCGTGATCGCCCTCGCAGGGCTAGGGGCTTTTGCCCTTGCGGGGAGCTTTCCCGA
GGAGCCCCGCTTCCAGGCCCCGGTGAACCTCAAGGTCTCGGAATCCCAGGTCAAGGCGGGCCAGACCCTGCCCCTGGACG
TGGTCCTCGAGGCCCTGGCAAGGAGCGTGGGGCTTCAGCCCCTCATCTACCGGGCCTACGACCCAAGCGGGGACCCCGCC
AAGGCCCAGCCCCCCCTGCCCAACATCAAGCTGGACTTCCAGGGCAAGCCCTTCCGGGAGGTCTGGGACCTCCTCTTCGC
CACCTACGGCAACCAGTACAGCCTGGACTACCTCTTCCTGCCCCCCGACGTGGTGGTGGTGGCCCCCACCCAGGTGATCA
CCGCCCTGGTGGACGCCCCGAGCCGCACGGGGGCCATGGAGCGTAGGCCCTACATCGTGGGCATCCCCGAGATCGCCTAC
AAGCGCACGGAGACGGACGCCCAGGGCCAGCCCCGCACGGTCGTCAACATTGAGGGCGCCAAGGCCTGGGTCCAGAACGA
CCTCCTCCCCTTCCTCTCCCGGGAGGCCGCGGGGCTCAACGTGAACTGGATCGTGGTGGAGGAGGGCGGGAGGCTCAAGG
CCGTTCTCTCCGTTCTCGCCACCCCCGAGCAGCACGCCCGCTTCTCCGACATTCTGCAGCGGGCCGGGATTGACTTCCGC
CCCCTCCCCGCCCTGGCCCAGCCCAAGCCCCGGGTGGAGAAGACCTACACCCTCACCTACGCCACCTTCCCCGAACTCCT
CGCCTTCCTCCAGTCCCGCCTCCCCGAGGCCCAGATCAGCGTGGTCCCCACCAACCCCCAAAGGGCCATCGTCCTCGCCA
CCGAGGAGGACCACGCCCGCTTGAGCGAGCTTCTAAAGACGGCCGACGTCCCCAAGACCGTCCGCCGGGTCTACGCCCTG
CAGAACCTCACCTTCGCTGAGGCCCAGGAGCGCCTAAAGCCCCTCCTGGAGAAGGACCTCAAGGGGGCCCGCCTGGAAAG
CCTCCCCGGCAACCCCAAGGCCCTCCTCCTCGAGGCCCCCGAGGCGGAGCACGCCCTCTTCGCCGAGATCCTGAAGGCCC
TGGACGTCCCCCCCCAGGCCCCCCAAGCCCCCCAGGAGGCCACCTTGCGGCGCCTCTACCCCCTGCGCTACGCCAACGCC
GAGCAGGTGGCCCCCTTCCTCGCCCGGGAGGTGCCGGGGATCGTGGTCCAGACCGTTCCCGGCCAGCCCGTCCTCTCGGT
GCGGGGCACGGAGAAGCAGCTCGCCGAGGTGGAAAGCCTCCTCGCCCAGATTGACCGGGCCCCCGAGCAAGGCCCTCCCG
TGTTCCAGCGGGCCTACCAGCTCTCCAACGCCAAGGCGGTGGAGCTCGCCCAGGTGCTCCAGGAGGCGCTCAAGGCCCGG
CAGGCCCAAAACCAGGGCCAGCAGAACCAGGCCCTCCCCACCCGGGAGGCCACGGTGGTGGCCGACCCCAGGACCAACAC
CCTCATCGTCACCGGCACCCAGGAGGACCTCGCCCTGGTGGAGGGCCTCATCCCCAAGCTGGACCAGCCCGTGCCCCAGG
TTTCCTTGCGGGTGCGCATCCAGGAGGTCCAGTCCAACCTGACCCGTAGCCTCGGCCTCAAGTGGAACAGCATCGCCGGC
GGCAACGTGGCGGCCAGCATCCTGGACTCGGGCCTTTCCCTCATCTTTGACTCCACGCGAAGCCTCGCCGCCCTCAACAT
CATGGCCACCCTGGACGCCCTGCAGCAACAGGGCCTCTCCCGGGCCCTCCGGGACGTGAACCAGACCGTCCTCAACAACC
AGACCGCCCGCCTGCAGTCCGGCGAGACCTTCTTCATCCGGCGGGTGGTGAACGACCAGGTGGAACGGGTCCCCTTTGAC
GTGGGGCTCATCGTGGAGGTCACGCCCCAGATCACCGCCGACGGCCAGATCCTCCTCAACATCAAGGCCGAGATCTCGGG
GAACGTCCAGCGCAACCCCGTGGACGGGGACGTGGACCGCTTCACCAAGCAGGTGGTGACCACCACCCTCAGGGTCAAAG
ACGGGGAGACCGTGGTCCTCGGGGGCCTCACCTCCCAGGAGTCCAACCAGAGCCAGCAGGGGGTGCCCCTCCTCATGGAC
ATCCCCCTGATCGGCGAACTCTTCAAGCAGCGGACGAACGAGAGCACCGACAAGGAGCTTTTGGTGGTGATCACCGCCGA
CATCCTCAAGGAGACGGCCTCGGCGAACCCCTAA

Upstream 100 bases:

>100_bases
GCACGGAGGCCGTGGTGCGCCAGGTGGAGGAAGGAAGCGTGACCCTGGCCTTGAAGGAGGAAACCTTGAGCCTGTCCCTC
GTCCAAGCTGGAGGTGGCCA

Downstream 100 bases:

>100_bases
GAGGCCGGGCGTTCCGCAAGGGGGGCCCGTGGGCCCCCCTTTGGCCTACAATGTCCCCATGCGGTTTCTCACGGCAGGCG
AGTCCCACGGGCCCGAGCTT

Product: general secretion pathway protein PilQ

Products: NA

Alternate protein names: Cholera toxin secretion protein epsD [H]

Number of amino acids: Translated: 757; Mature: 757

Protein sequence:

>757_residues
MKSAWIRAAVIALAGLGAFALAGSFPEEPRFQAPVNLKVSESQVKAGQTLPLDVVLEALARSVGLQPLIYRAYDPSGDPA
KAQPPLPNIKLDFQGKPFREVWDLLFATYGNQYSLDYLFLPPDVVVVAPTQVITALVDAPSRTGAMERRPYIVGIPEIAY
KRTETDAQGQPRTVVNIEGAKAWVQNDLLPFLSREAAGLNVNWIVVEEGGRLKAVLSVLATPEQHARFSDILQRAGIDFR
PLPALAQPKPRVEKTYTLTYATFPELLAFLQSRLPEAQISVVPTNPQRAIVLATEEDHARLSELLKTADVPKTVRRVYAL
QNLTFAEAQERLKPLLEKDLKGARLESLPGNPKALLLEAPEAEHALFAEILKALDVPPQAPQAPQEATLRRLYPLRYANA
EQVAPFLAREVPGIVVQTVPGQPVLSVRGTEKQLAEVESLLAQIDRAPEQGPPVFQRAYQLSNAKAVELAQVLQEALKAR
QAQNQGQQNQALPTREATVVADPRTNTLIVTGTQEDLALVEGLIPKLDQPVPQVSLRVRIQEVQSNLTRSLGLKWNSIAG
GNVAASILDSGLSLIFDSTRSLAALNIMATLDALQQQGLSRALRDVNQTVLNNQTARLQSGETFFIRRVVNDQVERVPFD
VGLIVEVTPQITADGQILLNIKAEISGNVQRNPVDGDVDRFTKQVVTTTLRVKDGETVVLGGLTSQESNQSQQGVPLLMD
IPLIGELFKQRTNESTDKELLVVITADILKETASANP

Sequences:

>Translated_757_residues
MKSAWIRAAVIALAGLGAFALAGSFPEEPRFQAPVNLKVSESQVKAGQTLPLDVVLEALARSVGLQPLIYRAYDPSGDPA
KAQPPLPNIKLDFQGKPFREVWDLLFATYGNQYSLDYLFLPPDVVVVAPTQVITALVDAPSRTGAMERRPYIVGIPEIAY
KRTETDAQGQPRTVVNIEGAKAWVQNDLLPFLSREAAGLNVNWIVVEEGGRLKAVLSVLATPEQHARFSDILQRAGIDFR
PLPALAQPKPRVEKTYTLTYATFPELLAFLQSRLPEAQISVVPTNPQRAIVLATEEDHARLSELLKTADVPKTVRRVYAL
QNLTFAEAQERLKPLLEKDLKGARLESLPGNPKALLLEAPEAEHALFAEILKALDVPPQAPQAPQEATLRRLYPLRYANA
EQVAPFLAREVPGIVVQTVPGQPVLSVRGTEKQLAEVESLLAQIDRAPEQGPPVFQRAYQLSNAKAVELAQVLQEALKAR
QAQNQGQQNQALPTREATVVADPRTNTLIVTGTQEDLALVEGLIPKLDQPVPQVSLRVRIQEVQSNLTRSLGLKWNSIAG
GNVAASILDSGLSLIFDSTRSLAALNIMATLDALQQQGLSRALRDVNQTVLNNQTARLQSGETFFIRRVVNDQVERVPFD
VGLIVEVTPQITADGQILLNIKAEISGNVQRNPVDGDVDRFTKQVVTTTLRVKDGETVVLGGLTSQESNQSQQGVPLLMD
IPLIGELFKQRTNESTDKELLVVITADILKETASANP
>Mature_757_residues
MKSAWIRAAVIALAGLGAFALAGSFPEEPRFQAPVNLKVSESQVKAGQTLPLDVVLEALARSVGLQPLIYRAYDPSGDPA
KAQPPLPNIKLDFQGKPFREVWDLLFATYGNQYSLDYLFLPPDVVVVAPTQVITALVDAPSRTGAMERRPYIVGIPEIAY
KRTETDAQGQPRTVVNIEGAKAWVQNDLLPFLSREAAGLNVNWIVVEEGGRLKAVLSVLATPEQHARFSDILQRAGIDFR
PLPALAQPKPRVEKTYTLTYATFPELLAFLQSRLPEAQISVVPTNPQRAIVLATEEDHARLSELLKTADVPKTVRRVYAL
QNLTFAEAQERLKPLLEKDLKGARLESLPGNPKALLLEAPEAEHALFAEILKALDVPPQAPQAPQEATLRRLYPLRYANA
EQVAPFLAREVPGIVVQTVPGQPVLSVRGTEKQLAEVESLLAQIDRAPEQGPPVFQRAYQLSNAKAVELAQVLQEALKAR
QAQNQGQQNQALPTREATVVADPRTNTLIVTGTQEDLALVEGLIPKLDQPVPQVSLRVRIQEVQSNLTRSLGLKWNSIAG
GNVAASILDSGLSLIFDSTRSLAALNIMATLDALQQQGLSRALRDVNQTVLNNQTARLQSGETFFIRRVVNDQVERVPFD
VGLIVEVTPQITADGQILLNIKAEISGNVQRNPVDGDVDRFTKQVVTTTLRVKDGETVVLGGLTSQESNQSQQGVPLLMD
IPLIGELFKQRTNESTDKELLVVITADILKETASANP

Specific function: Required for secretion of cholera toxin through the outer membrane [H]

COG id: COG4964

COG function: function code U; Flp pilus assembly protein, secretin CpaC

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP D family [H]

Homologues:

Organism=Escherichia coli, GI87082242, Length=506, Percent_Identity=26.8774703557312, Blast_Score=93, Evalue=7e-20,
Organism=Escherichia coli, GI1789793, Length=307, Percent_Identity=28.9902280130293, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001775
- InterPro:   IPR005644
- InterPro:   IPR004846
- InterPro:   IPR013356
- InterPro:   IPR004845
- InterPro:   IPR001814 [H]

Pfam domain/function: PF00263 Secretin; PF03958 Secretin_N [H]

EC number: NA

Molecular weight: Translated: 82692; Mature: 82692

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAWIRAAVIALAGLGAFALAGSFPEEPRFQAPVNLKVSESQVKAGQTLPLDVVLEALA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHH
RSVGLQPLIYRAYDPSGDPAKAQPPLPNIKLDFQGKPFREVWDLLFATYGNQYSLDYLFL
HHHCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEE
PPDVVVVAPTQVITALVDAPSRTGAMERRPYIVGIPEIAYKRTETDAQGQPRTVVNIEGA
CCCEEEECHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCEEEEECCH
KAWVQNDLLPFLSREAAGLNVNWIVVEEGGRLKAVLSVLATPEQHARFSDILQRAGIDFR
HHHHHHCHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
PLPALAQPKPRVEKTYTLTYATFPELLAFLQSRLPEAQISVVPTNPQRAIVLATEEDHAR
CCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCHHHH
LSELLKTADVPKTVRRVYALQNLTFAEAQERLKPLLEKDLKGARLESLPGNPKALLLEAP
HHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEECC
EAEHALFAEILKALDVPPQAPQAPQEATLRRLYPLRYANAEQVAPFLAREVPGIVVQTVP
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECC
GQPVLSVRGTEKQLAEVESLLAQIDRAPEQGPPVFQRAYQLSNAKAVELAQVLQEALKAR
CCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QAQNQGQQNQALPTREATVVADPRTNTLIVTGTQEDLALVEGLIPKLDQPVPQVSLRVRI
HHHCCCCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHH
QEVQSNLTRSLGLKWNSIAGGNVAASILDSGLSLIFDSTRSLAALNIMATLDALQQQGLS
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
RALRDVNQTVLNNQTARLQSGETFFIRRVVNDQVERVPFDVGLIVEVTPQITADGQILLN
HHHHHHHHHHHCCCHHEECCCCEEEHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEE
IKAEISGNVQRNPVDGDVDRFTKQVVTTTLRVKDGETVVLGGLTSQESNQSQQGVPLLMD
EEEEECCCEECCCCCCHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCCCCCEEEE
IPLIGELFKQRTNESTDKELLVVITADILKETASANP
CHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHCCCC
>Mature Secondary Structure
MKSAWIRAAVIALAGLGAFALAGSFPEEPRFQAPVNLKVSESQVKAGQTLPLDVVLEALA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHH
RSVGLQPLIYRAYDPSGDPAKAQPPLPNIKLDFQGKPFREVWDLLFATYGNQYSLDYLFL
HHHCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEE
PPDVVVVAPTQVITALVDAPSRTGAMERRPYIVGIPEIAYKRTETDAQGQPRTVVNIEGA
CCCEEEECHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCEEEEECCH
KAWVQNDLLPFLSREAAGLNVNWIVVEEGGRLKAVLSVLATPEQHARFSDILQRAGIDFR
HHHHHHCHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
PLPALAQPKPRVEKTYTLTYATFPELLAFLQSRLPEAQISVVPTNPQRAIVLATEEDHAR
CCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCHHHH
LSELLKTADVPKTVRRVYALQNLTFAEAQERLKPLLEKDLKGARLESLPGNPKALLLEAP
HHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEECC
EAEHALFAEILKALDVPPQAPQAPQEATLRRLYPLRYANAEQVAPFLAREVPGIVVQTVP
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECC
GQPVLSVRGTEKQLAEVESLLAQIDRAPEQGPPVFQRAYQLSNAKAVELAQVLQEALKAR
CCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QAQNQGQQNQALPTREATVVADPRTNTLIVTGTQEDLALVEGLIPKLDQPVPQVSLRVRI
HHHCCCCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHH
QEVQSNLTRSLGLKWNSIAGGNVAASILDSGLSLIFDSTRSLAALNIMATLDALQQQGLS
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
RALRDVNQTVLNNQTARLQSGETFFIRRVVNDQVERVPFDVGLIVEVTPQITADGQILLN
HHHHHHHHHHHCCCHHEECCCCEEEHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEE
IKAEISGNVQRNPVDGDVDRFTKQVVTTTLRVKDGETVVLGGLTSQESNQSQQGVPLLMD
EEEEECCCEECCCCCCHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCCCCCEEEE
IPLIGELFKQRTNESTDKELLVVITADILKETASANP
CHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]