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The map label for this gene is czcR [H]

Identifier: 55981331

GI number: 55981331

Start: 1299630

End: 1300313

Strand: Direct

Name: czcR [H]

Synonym: TTHA1362

Alternate gene names: 55981331

Gene position: 1299630-1300313 (Clockwise)

Preceding gene: 55981330

Following gene: 55981332

Centisome position: 70.26

GC content: 70.18

Gene sequence:

>684_bases
ATGAAGCGGATCCTCCTCATAGAGGACGACCCCGAGGTGGCCCGGCTCGTGGAGGCCGAGCTTAAGGAGGCCGGCTTCCA
GGTGGACTGGGCCAAGACGGGGATGGAGGGGCTGATCCGGCACCGGGAGGGCAAGCCCGACCTCGTGGTCCTGGACCTCG
GCCTCCCCGACCTGGACGGGGCGGAGGTGGCGCGAAGGATCCGGGCCACGGACGACACCCCCATCCTCGTCCTCACGGCC
CAGGACGCGGTGGACCGCAAGGTGAGCCTCCTCACGGGCGGGGCCGACGACTACCTGGTGAAGCCCTTCCACCCGGCGGA
GCTCCTGGCCCGCATCCAGGTGCAGCTTAGGCACAAGGAGGGGAGCGAGGTCCTCGCCGTGGGCCAGCTGGAGCTCTACC
CCGGGAAGCGCCAGGTCTTCTTCCGGGAGCGGGAGGTCCGCCTCTCCCCCAAGGAGTTTGACCTCCTCCACCTCCTCATG
AGCCGGCCCGGACGGGTCTTCCCCCGCCCCGAGATTGAGGAAAGGGTCTGGGGCAGGCCCTTGGGCAAGGACTCCAACGT
CCTGGACGTTCACATGGCCAACCTCCGGGCCAAGCTCCGGGAGGCGGGGGCCTACGGGTACCTGCGCACGGTCCGGGGCG
TGGGCTACGCCGTGCGGCCGGGAAGGAGGGAGGAGGAGGGCTAG

Upstream 100 bases:

>100_bases
CGGAGGGGGACGTGCTCCTCCTTTTGGGGAAGGAGCGGGTAAGCCTGGTCCGGCTCCTCCAAGAGGCCTACGGCGTGGCC
CTTCCGGGGAGGCTTTGGCC

Downstream 100 bases:

>100_bases
GTGCTCTCCTTCCGCGCCCGGCTCTTCCTGGCCTTCGCCCTTTTGTGGCTCCTTTTCCTGGGCGGGGCCTGGTACCTGGC
GGGACGCAGCGTGGACCAGG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKRILLIEDDPEVARLVEAELKEAGFQVDWAKTGMEGLIRHREGKPDLVVLDLGLPDLDGAEVARRIRATDDTPILVLTA
QDAVDRKVSLLTGGADDYLVKPFHPAELLARIQVQLRHKEGSEVLAVGQLELYPGKRQVFFREREVRLSPKEFDLLHLLM
SRPGRVFPRPEIEERVWGRPLGKDSNVLDVHMANLRAKLREAGAYGYLRTVRGVGYAVRPGRREEEG

Sequences:

>Translated_227_residues
MKRILLIEDDPEVARLVEAELKEAGFQVDWAKTGMEGLIRHREGKPDLVVLDLGLPDLDGAEVARRIRATDDTPILVLTA
QDAVDRKVSLLTGGADDYLVKPFHPAELLARIQVQLRHKEGSEVLAVGQLELYPGKRQVFFREREVRLSPKEFDLLHLLM
SRPGRVFPRPEIEERVWGRPLGKDSNVLDVHMANLRAKLREAGAYGYLRTVRGVGYAVRPGRREEEG
>Mature_227_residues
MKRILLIEDDPEVARLVEAELKEAGFQVDWAKTGMEGLIRHREGKPDLVVLDLGLPDLDGAEVARRIRATDDTPILVLTA
QDAVDRKVSLLTGGADDYLVKPFHPAELLARIQVQLRHKEGSEVLAVGQLELYPGKRQVFFREREVRLSPKEFDLLHLLM
SRPGRVFPRPEIEERVWGRPLGKDSNVLDVHMANLRAKLREAGAYGYLRTVRGVGYAVRPGRREEEG

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=216, Percent_Identity=38.4259259259259, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=40.6392694063927, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=36.9369369369369, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=39.7260273972603, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787375, Length=217, Percent_Identity=33.1797235023041, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=35.2941176470588, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=34.841628959276, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=35.4260089686099, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=35.4545454545455, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.9649122807018, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=35.3448275862069, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI145693140, Length=239, Percent_Identity=32.2175732217573, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=31.3559322033898, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=26.2222222222222, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=32.7731092436975, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=27.1929824561404, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789149, Length=124, Percent_Identity=28.2258064516129, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1788191, Length=110, Percent_Identity=32.7272727272727, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25656; Mature: 25656

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILLIEDDPEVARLVEAELKEAGFQVDWAKTGMEGLIRHREGKPDLVVLDLGLPDLDG
CCEEEEEECCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCCCH
AEVARRIRATDDTPILVLTAQDAVDRKVSLLTGGADDYLVKPFHPAELLARIQVQLRHKE
HHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHEECCC
GSEVLAVGQLELYPGKRQVFFREREVRLSPKEFDLLHLLMSRPGRVFPRPEIEERVWGRP
CCEEEEEEEEEECCCCCEEEEEECCEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCC
LGKDSNVLDVHMANLRAKLREAGAYGYLRTVRGVGYAVRPGRREEEG
CCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHCCEEECCCCCCCCC
>Mature Secondary Structure
MKRILLIEDDPEVARLVEAELKEAGFQVDWAKTGMEGLIRHREGKPDLVVLDLGLPDLDG
CCEEEEEECCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCCCH
AEVARRIRATDDTPILVLTAQDAVDRKVSLLTGGADDYLVKPFHPAELLARIQVQLRHKE
HHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHEECCC
GSEVLAVGQLELYPGKRQVFFREREVRLSPKEFDLLHLLMSRPGRVFPRPEIEERVWGRP
CCEEEEEEEEEECCCCCEEEEEECCEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCC
LGKDSNVLDVHMANLRAKLREAGAYGYLRTVRGVGYAVRPGRREEEG
CCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]