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The map label for this gene is liaR [H]

Identifier: 55981321

GI number: 55981321

Start: 1292060

End: 1292707

Strand: Reverse

Name: liaR [H]

Synonym: TTHA1352

Alternate gene names: 55981321

Gene position: 1292707-1292060 (Counterclockwise)

Preceding gene: 55981333

Following gene: 55981320

Centisome position: 69.89

GC content: 66.36

Gene sequence:

>648_bases
GTGATCCGGGTTCTTCTGGCGGACGACCACGCCCTTTTCCGCCAGGGGCTGAAAAGCCTCCTGGAGGCCGAGGGGGACTT
CCGGGTGGTGGGGGAGGCCAAGGACGGATGGGAGGCCATGCGCCACGCCCTGGAGACCAAGCCCGACGTGATCCTCATGG
ACATCCAGATGCCGGGCCTGGACGGGGTGCAGGCCACCCAGGCCATCCTCAAGGAGTGGCCCCAGGCCAAGGTCATCATG
CTCACCATGTACCGCCAGGACGCCTACGTCTTTGAGGCGGTGAAGGCGGGGGCCCGGGGCTACCTCCTCAAGGACGTGGA
CGCGAGGGAGCTGGTGGACGCCATCCGCCGCGTCCACGCAGGGGAGGTGCTTCTGGACGCGGAGCTTGCCGGGCACATCA
TCCAGGACTTCCGCGCCAAGAAGGAGGCCAGCCAGCCCCTCCACGCCGAGCTTTCCGAGCGCGAGGTCCAGATCCTGAGG
CTGGTGGCCCAGGGGTACACCAACCAGGAGATCGCCGCCGAGCTCCAGCTTTCCGAGAAGACGGTGCGCAACCGCCTTTC
GGAAATTTTCCAGAAGCTTCACCTCAACAACCGGACCCAGGCGGCCCTTTACGCCATCCGGGAGGGGTTGGCGAGGCCCG
AAGAGTGA

Upstream 100 bases:

>100_bases
CCTTTCGGTGCGGCCCAGGCCGTACCCCCCGGGCACCAGTTTCTCCACGCGAAAGGTCAGCACGCCTCTACCCTAGCCCC
TTTGGCGCTATGATGGAAGG

Downstream 100 bases:

>100_bases
GGGTGGAGGACCCGCGGCGCTACCTCCTGGAGCTCGCCCCCCTTGCGGGGGAGGAGGCGAGGGGGGAGTACGTGGCCTCG
AGGCTCCCCGGGGCCCGGAG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MIRVLLADDHALFRQGLKSLLEAEGDFRVVGEAKDGWEAMRHALETKPDVILMDIQMPGLDGVQATQAILKEWPQAKVIM
LTMYRQDAYVFEAVKAGARGYLLKDVDARELVDAIRRVHAGEVLLDAELAGHIIQDFRAKKEASQPLHAELSEREVQILR
LVAQGYTNQEIAAELQLSEKTVRNRLSEIFQKLHLNNRTQAALYAIREGLARPEE

Sequences:

>Translated_215_residues
MIRVLLADDHALFRQGLKSLLEAEGDFRVVGEAKDGWEAMRHALETKPDVILMDIQMPGLDGVQATQAILKEWPQAKVIM
LTMYRQDAYVFEAVKAGARGYLLKDVDARELVDAIRRVHAGEVLLDAELAGHIIQDFRAKKEASQPLHAELSEREVQILR
LVAQGYTNQEIAAELQLSEKTVRNRLSEIFQKLHLNNRTQAALYAIREGLARPEE
>Mature_215_residues
MIRVLLADDHALFRQGLKSLLEAEGDFRVVGEAKDGWEAMRHALETKPDVILMDIQMPGLDGVQATQAILKEWPQAKVIM
LTMYRQDAYVFEAVKAGARGYLLKDVDARELVDAIRRVHAGEVLLDAELAGHIIQDFRAKKEASQPLHAELSEREVQILR
LVAQGYTNQEIAAELQLSEKTVRNRLSEIFQKLHLNNRTQAALYAIREGLARPEE

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=214, Percent_Identity=36.9158878504673, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788521, Length=207, Percent_Identity=33.8164251207729, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787473, Length=205, Percent_Identity=33.1707317073171, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1786747, Length=203, Percent_Identity=31.0344827586207, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790102, Length=203, Percent_Identity=34.4827586206897, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788712, Length=210, Percent_Identity=23.3333333333333, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082052, Length=118, Percent_Identity=32.2033898305085, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788546, Length=199, Percent_Identity=26.6331658291457, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24291; Mature: 24291

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVLLADDHALFRQGLKSLLEAEGDFRVVGEAKDGWEAMRHALETKPDVILMDIQMPGL
CEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCC
DGVQATQAILKEWPQAKVIMLTMYRQDAYVFEAVKAGARGYLLKDVDARELVDAIRRVHA
CCHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GEVLLDAELAGHIIQDFRAKKEASQPLHAELSEREVQILRLVAQGYTNQEIAAELQLSEK
CCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TVRNRLSEIFQKLHLNNRTQAALYAIREGLARPEE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIRVLLADDHALFRQGLKSLLEAEGDFRVVGEAKDGWEAMRHALETKPDVILMDIQMPGL
CEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCC
DGVQATQAILKEWPQAKVIMLTMYRQDAYVFEAVKAGARGYLLKDVDARELVDAIRRVHA
CCHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GEVLLDAELAGHIIQDFRAKKEASQPLHAELSEREVQILRLVAQGYTNQEIAAELQLSEK
CCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TVRNRLSEIFQKLHLNNRTQAALYAIREGLARPEE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]