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The map label for this gene is mutL [H]

Identifier: 55981292

GI number: 55981292

Start: 1260152

End: 1261789

Strand: Reverse

Name: mutL [H]

Synonym: TTHA1323

Alternate gene names: 55981292

Gene position: 1261789-1260152 (Counterclockwise)

Preceding gene: 55981293

Following gene: 55981290

Centisome position: 68.21

GC content: 72.83

Gene sequence:

>1638_bases
GTGATCCGCCCCCTCCCTCCGGAGCTTAGGGGCCTCCTCGCCCGGGGCGAGGTGCTCCTTACGGTGAAGGACGCCGTGCG
GGAGCTTCTGGAAAACGCCCTGGACGCTGGGGCCAGGAGGGTGCGGGTGGAGCTTTGGGGCGGGGGGCTTAAGCGGCTTG
TGGTGGAGGACGACGGGGAGGGGATCCCCCTGGAAGACCTCCCCCTCGCCGTGGAGCCCTACGCCACGAGCAAGCTCCAG
GACCTTGAGGGCATCCGCACCCTGGGCTTCCGCGGCCAGGCCCTCTACGCCCTAAGGCAGGCGGCCAGGCTCAGGATCCG
CTCCCGGCCTCGAGGGCAGCTCGGCGGCGGGCTCCTCCTCGCGGAAGGGGAGCGGGTGGAGGTGCGCCCCGTCCCCGCCC
CCCCGGGGACCCGGGTGGAGGTGGAGGGGCTTTTCCTCGGGGAGGGGCGGGACCCCAAGGGGGAGGTCCGGGGGGTCTTG
GAGCTCCTAAAGCGCTACCTCCTCCACCACCCTCGCCTCGCCCTGGCCCTTTTCGCGGAAGGGGAGGCCCGGCTCCTCTT
CCCGGGGGCGGGGCTTGAGGAGGCGGCCCGCCTCGCCTTCGGCCGCCTCCTGGCCAAGCGGCTCCTTCCCCTGGCCTACG
GGGCGGGGGGCCTCGAGGTCCAGGGCCTCGTCTCCCGGCCGGAGGTGAGCCGCACCCGGCCGGACCGGCTCTTCCTCGCG
GTGAACGGGAGGCCGGTGGCCTTCCCCGAGGGGCTTCTCCGGCGGGTGCGCCGCGCCTACCGGGAGCTTCTGCCGGAGGG
GCACTACCCCGTGGGCGTCCTGAACCTCTTCCTCCCCCAGGAGGCCTTTCGCCTGCGCCTGGACGCGAGGAAGGAGGAGG
TGGTCCTTTCTGAGGAGGTGGAGGCCCTGGTGGAGGAGGCCCTCCTCGCCCTCTTCCGGCGGGAGAACCTGGCCCGGGCC
CTCCCCGAGCCCAAGCCCCTCCAGCCCTTAAGCCCCCCCACGGCCTCGGGCCTGCCCCGCCTCCGCTTCCTCGCCCAGTT
CCGGGAGAGCTACCTCCTCGCCGAGGCGGGGGACACCCTCTACGTGGTGGACCAGCACGCCGCCCACGAGCGCATCCTCT
ACGAGGACCTCCTCAAGCGGGTCGCCGAGGGGCCGAAGCCCCTCCCCCGGCCCCTCCTCGTCCCCTTGGCCCCCGAGGAG
GAAGCCCTTTTGGAGGCGGGGCAGGAGGCTTTGGCGGCGCTTTTCCGCTGGGAGCCCTTCGGCCCCGGGAGGGTGCGGCT
CCTCATGGCCCCCGCCTTCCTCCACCCCTACCCCCTTCTCCTCCCCGAGGTCTTCAAGGAGGCCTTGCGCGGGGAGGGGA
GAAGCCTCAAGGCCCTCCTCGCCCGCCTCGCCTGCCTCCCCGCCGTCAAAGCGGGCCACCCCCTGGGAGAGGCCCAAGGC
CAGGCCCTCCTGGACGCCCTCCTCGCCTGCGAGACCCCCTGGGCCTGCCCCCACGGAAGGCCCGTCCTCCTTGCCCTCAA
GGAGGAGGACCTCATCCGCCGCTTCGGACGCCGCTCGGGGGCTCGGGGAGGAGGAGAAGCCCGTCCTCGTCCGCAAGAAG
AAAGCTTCCCGGAAGCACCTCTACCCCGAGAACCTTAA

Upstream 100 bases:

>100_bases
TCGCCTTAGACCCCGACCGCCTCACCCCCCTCGAGGCCCTGAGGTTCCTCCACGAGCTCAAGGCCTTGGCCCTGGGCCTC
CCCCTGGGTAGCATGAAGGG

Downstream 100 bases:

>100_bases
GGGGCACGTCCACCTCCCCCTTGCCCTCCTTGGCGCTTTTTTTGGGGGTGGCGGCGAGGGCGAGGAGGCCGATGGGCACC
TCCCTAAGCTCCTCCGTGTC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MIRPLPPELRGLLARGEVLLTVKDAVRELLENALDAGARRVRVELWGGGLKRLVVEDDGEGIPLEDLPLAVEPYATSKLQ
DLEGIRTLGFRGQALYALRQAARLRIRSRPRGQLGGGLLLAEGERVEVRPVPAPPGTRVEVEGLFLGEGRDPKGEVRGVL
ELLKRYLLHHPRLALALFAEGEARLLFPGAGLEEAARLAFGRLLAKRLLPLAYGAGGLEVQGLVSRPEVSRTRPDRLFLA
VNGRPVAFPEGLLRRVRRAYRELLPEGHYPVGVLNLFLPQEAFRLRLDARKEEVVLSEEVEALVEEALLALFRRENLARA
LPEPKPLQPLSPPTASGLPRLRFLAQFRESYLLAEAGDTLYVVDQHAAHERILYEDLLKRVAEGPKPLPRPLLVPLAPEE
EALLEAGQEALAALFRWEPFGPGRVRLLMAPAFLHPYPLLLPEVFKEALRGEGRSLKALLARLACLPAVKAGHPLGEAQG
QALLDALLACETPWACPHGRPVLLALKEEDLIRRFGRRSGARGGGEARPRPQEESFPEAPLPREP

Sequences:

>Translated_545_residues
MIRPLPPELRGLLARGEVLLTVKDAVRELLENALDAGARRVRVELWGGGLKRLVVEDDGEGIPLEDLPLAVEPYATSKLQ
DLEGIRTLGFRGQALYALRQAARLRIRSRPRGQLGGGLLLAEGERVEVRPVPAPPGTRVEVEGLFLGEGRDPKGEVRGVL
ELLKRYLLHHPRLALALFAEGEARLLFPGAGLEEAARLAFGRLLAKRLLPLAYGAGGLEVQGLVSRPEVSRTRPDRLFLA
VNGRPVAFPEGLLRRVRRAYRELLPEGHYPVGVLNLFLPQEAFRLRLDARKEEVVLSEEVEALVEEALLALFRRENLARA
LPEPKPLQPLSPPTASGLPRLRFLAQFRESYLLAEAGDTLYVVDQHAAHERILYEDLLKRVAEGPKPLPRPLLVPLAPEE
EALLEAGQEALAALFRWEPFGPGRVRLLMAPAFLHPYPLLLPEVFKEALRGEGRSLKALLARLACLPAVKAGHPLGEAQG
QALLDALLACETPWACPHGRPVLLALKEEDLIRRFGRRSGARGGGEARPRPQEESFPEAPLPREP
>Mature_545_residues
MIRPLPPELRGLLARGEVLLTVKDAVRELLENALDAGARRVRVELWGGGLKRLVVEDDGEGIPLEDLPLAVEPYATSKLQ
DLEGIRTLGFRGQALYALRQAARLRIRSRPRGQLGGGLLLAEGERVEVRPVPAPPGTRVEVEGLFLGEGRDPKGEVRGVL
ELLKRYLLHHPRLALALFAEGEARLLFPGAGLEEAARLAFGRLLAKRLLPLAYGAGGLEVQGLVSRPEVSRTRPDRLFLA
VNGRPVAFPEGLLRRVRRAYRELLPEGHYPVGVLNLFLPQEAFRLRLDARKEEVVLSEEVEALVEEALLALFRRENLARA
LPEPKPLQPLSPPTASGLPRLRFLAQFRESYLLAEAGDTLYVVDQHAAHERILYEDLLKRVAEGPKPLPRPLLVPLAPEE
EALLEAGQEALAALFRWEPFGPGRVRLLMAPAFLHPYPLLLPEVFKEALRGEGRSLKALLARLACLPAVKAGHPLGEAQG
QALLDALLACETPWACPHGRPVLLALKEEDLIRRFGRRSGARGGGEARPRPQEESFPEAPLPREP

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=332, Percent_Identity=28.6144578313253, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI4505913, Length=354, Percent_Identity=25.7062146892655, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI310128478, Length=354, Percent_Identity=25.7062146892655, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI4505911, Length=351, Percent_Identity=27.0655270655271, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI189458898, Length=351, Percent_Identity=27.0655270655271, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI189458896, Length=342, Percent_Identity=27.1929824561404, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1790612, Length=365, Percent_Identity=29.8630136986301, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71991825, Length=269, Percent_Identity=33.0855018587361, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17562796, Length=390, Percent_Identity=22.8205128205128, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323819, Length=313, Percent_Identity=28.4345047923323, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323063, Length=192, Percent_Identity=28.6458333333333, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136968, Length=339, Percent_Identity=30.3834808259587, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17136970, Length=356, Percent_Identity=26.4044943820225, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 60104; Mature: 60104

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRPLPPELRGLLARGEVLLTVKDAVRELLENALDAGARRVRVELWGGGLKRLVVEDDGE
CCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCC
GIPLEDLPLAVEPYATSKLQDLEGIRTLGFRGQALYALRQAARLRIRSRPRGQLGGGLLL
CCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEE
AEGERVEVRPVPAPPGTRVEVEGLFLGEGRDPKGEVRGVLELLKRYLLHHPRLALALFAE
ECCCEEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GEARLLFPGAGLEEAARLAFGRLLAKRLLPLAYGAGGLEVQGLVSRPEVSRTRPDRLFLA
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCEEEEE
VNGRPVAFPEGLLRRVRRAYRELLPEGHYPVGVLNLFLPQEAFRLRLDARKEEVVLSEEV
ECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHH
EALVEEALLALFRRENLARALPEPKPLQPLSPPTASGLPRLRFLAQFRESYLLAEAGDTL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEECCCEE
YVVDQHAAHERILYEDLLKRVAEGPKPLPRPLLVPLAPEEEALLEAGQEALAALFRWEPF
EEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCC
GPGRVRLLMAPAFLHPYPLLLPEVFKEALRGEGRSLKALLARLACLPAVKAGHPLGEAQG
CCCCEEEEEECHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
QALLDALLACETPWACPHGRPVLLALKEEDLIRRFGRRSGARGGGEARPRPQEESFPEAP
HHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
LPREP
CCCCC
>Mature Secondary Structure
MIRPLPPELRGLLARGEVLLTVKDAVRELLENALDAGARRVRVELWGGGLKRLVVEDDGE
CCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCC
GIPLEDLPLAVEPYATSKLQDLEGIRTLGFRGQALYALRQAARLRIRSRPRGQLGGGLLL
CCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEE
AEGERVEVRPVPAPPGTRVEVEGLFLGEGRDPKGEVRGVLELLKRYLLHHPRLALALFAE
ECCCEEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GEARLLFPGAGLEEAARLAFGRLLAKRLLPLAYGAGGLEVQGLVSRPEVSRTRPDRLFLA
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCEEEEE
VNGRPVAFPEGLLRRVRRAYRELLPEGHYPVGVLNLFLPQEAFRLRLDARKEEVVLSEEV
ECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHH
EALVEEALLALFRRENLARALPEPKPLQPLSPPTASGLPRLRFLAQFRESYLLAEAGDTL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEECCCEE
YVVDQHAAHERILYEDLLKRVAEGPKPLPRPLLVPLAPEEEALLEAGQEALAALFRWEPF
EEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCC
GPGRVRLLMAPAFLHPYPLLLPEVFKEALRGEGRSLKALLARLACLPAVKAGHPLGEAQG
CCCCEEEEEECHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
QALLDALLACETPWACPHGRPVLLALKEEDLIRRFGRRSGARGGGEARPRPQEESFPEAP
HHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
LPREP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA