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The map label for this gene is htrA [H]

Identifier: 55981289

GI number: 55981289

Start: 1257627

End: 1258841

Strand: Reverse

Name: htrA [H]

Synonym: TTHA1320

Alternate gene names: 55981289

Gene position: 1258841-1257627 (Counterclockwise)

Preceding gene: 55981290

Following gene: 55981288

Centisome position: 68.05

GC content: 69.14

Gene sequence:

>1215_bases
ATGAACCTGGGACGTTCCTTTGTGGGCTTTCTGGTGCTCTCCCTGATGGCGGGGGCGGTGCTCTGGTGGGGGGTCTCCAA
CGGCCAGGCCCCAAGCTCCCAGGCGGCCAAGGCCGCCGACGAGGGGCTTTTGGAGTACGAGCGGAACACCGTGGAGATCG
TGGAGCGCTACGGGGACGGGGTGGTCTACGTCTCCGTGGTCACCCGGCCGCAAAGCGTCCAGCTTCCCCCGGGGTTTGAG
TTCTTCGCCCCCTTCCTCCAGGTGCCGCCCCAGCGGGGCACGGGCTCGGGCTTCGTCATTGACAAGGAGGGGTACATCTT
CACCAACTACCACGTGGTGGAGGGGGCGGACCGGATCACGGTGAAGTTCCACAACGACCCCAAGGAGTACCAGGCCCGGC
TGGTGGGGGCGGCCCCGCCCCTGGACGTGGCCCTCCTCAAGGTGGACGCCCCCAAGGAGCGCCTGGTGCCCTTGGTCCTG
GGGGACTCCGACCAGATTCGGGTGGGGCAGAAGGCCATCGCCATGGGGAACCCCTTCGGGCTGGAGTTCACCGTGACCCA
GGGGATCGTCTCCGCCATCCGGGAGAACCCGGGGGCGATCGGGGACGAGTCGGGCCTCGTGCCCCAGGTGATCCAGACGG
ACGCCGCCATCAACCCCGGCAACTCCGGGGGGCCCCTCCTCAACTCCCGGGGCGAGGTCATCGGCATCAACACCGCCATC
CTCACCCCCACGGGCCAGTTCGGCGCGGCCCAGTTCGCCGGGGTGGGGTTCGCCTTGCCCATCAACCTGGTGAAGCAGTA
CCTCCCCGAGATGCGGGCGGGGAAGATCCTCACCGCCGAGGAGATCGTGCGGAGCCGGCCCCGGCTTGGGGTTTCCATCA
TTCCCCTCTCCTTCTACCCGGAGAGGCTCCGCCAGCAGTATGGCCTCCCCGACACCGGCCTCATGGTCCAGGAGGTGGAG
CGGAATAGCCCCGCCCAGAAGGCGGGCCTCAAGCCCCCCACCCGCTTTGCCTACATCCAGCTGCCCACGGGGGAGGCCCT
CCAGGTGGGGGTGGACGGGGACGTGCTCCTGGAGGCGGACGGGGTGCCCCTCACCTCCATCGCCCAGCTCCGCCAGGTCC
TCTACGCCAAGAAGCCCGGCGAGGCGGTGACCCTCAAGGTCTGGCGGCAAGGCCGGACCCTCACCCTCCGGGTGGTGCCC
CAGGTCCTGCGGTAG

Upstream 100 bases:

>100_bases
CACCTGGAGGACCGGATCCTGGTCCACGAGAACCGCACCGTGGTCTTCGTCTAATGGCGGGCTAACCGGGGGGGCGTAGG
GTGGAACTGGGAGGTGTGGC

Downstream 100 bases:

>100_bases
ATGGGGCTTTGGGAGAAGGCGCCCCTCAGGCTTAGGCGCTACCTCGTCTACCGCCGCGAGGGGGGGTGGCCCCCCCTCGC
CTTGGGGCCCTCCGTAACGG

Product: periplasmic serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNLGRSFVGFLVLSLMAGAVLWWGVSNGQAPSSQAAKAADEGLLEYERNTVEIVERYGDGVVYVSVVTRPQSVQLPPGFE
FFAPFLQVPPQRGTGSGFVIDKEGYIFTNYHVVEGADRITVKFHNDPKEYQARLVGAAPPLDVALLKVDAPKERLVPLVL
GDSDQIRVGQKAIAMGNPFGLEFTVTQGIVSAIRENPGAIGDESGLVPQVIQTDAAINPGNSGGPLLNSRGEVIGINTAI
LTPTGQFGAAQFAGVGFALPINLVKQYLPEMRAGKILTAEEIVRSRPRLGVSIIPLSFYPERLRQQYGLPDTGLMVQEVE
RNSPAQKAGLKPPTRFAYIQLPTGEALQVGVDGDVLLEADGVPLTSIAQLRQVLYAKKPGEAVTLKVWRQGRTLTLRVVP
QVLR

Sequences:

>Translated_404_residues
MNLGRSFVGFLVLSLMAGAVLWWGVSNGQAPSSQAAKAADEGLLEYERNTVEIVERYGDGVVYVSVVTRPQSVQLPPGFE
FFAPFLQVPPQRGTGSGFVIDKEGYIFTNYHVVEGADRITVKFHNDPKEYQARLVGAAPPLDVALLKVDAPKERLVPLVL
GDSDQIRVGQKAIAMGNPFGLEFTVTQGIVSAIRENPGAIGDESGLVPQVIQTDAAINPGNSGGPLLNSRGEVIGINTAI
LTPTGQFGAAQFAGVGFALPINLVKQYLPEMRAGKILTAEEIVRSRPRLGVSIIPLSFYPERLRQQYGLPDTGLMVQEVE
RNSPAQKAGLKPPTRFAYIQLPTGEALQVGVDGDVLLEADGVPLTSIAQLRQVLYAKKPGEAVTLKVWRQGRTLTLRVVP
QVLR
>Mature_404_residues
MNLGRSFVGFLVLSLMAGAVLWWGVSNGQAPSSQAAKAADEGLLEYERNTVEIVERYGDGVVYVSVVTRPQSVQLPPGFE
FFAPFLQVPPQRGTGSGFVIDKEGYIFTNYHVVEGADRITVKFHNDPKEYQARLVGAAPPLDVALLKVDAPKERLVPLVL
GDSDQIRVGQKAIAMGNPFGLEFTVTQGIVSAIRENPGAIGDESGLVPQVIQTDAAINPGNSGGPLLNSRGEVIGINTAI
LTPTGQFGAAQFAGVGFALPINLVKQYLPEMRAGKILTAEEIVRSRPRLGVSIIPLSFYPERLRQQYGLPDTGLMVQEVE
RNSPAQKAGLKPPTRFAYIQLPTGEALQVGVDGDVLLEADGVPLTSIAQLRQVLYAKKPGEAVTLKVWRQGRTLTLRVVP
QVLR

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=372, Percent_Identity=32.258064516129, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4506141, Length=374, Percent_Identity=29.9465240641711, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI24308541, Length=314, Percent_Identity=30.2547770700637, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI7019477, Length=360, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1789629, Length=358, Percent_Identity=36.0335195530726, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786356, Length=306, Percent_Identity=37.5816993464052, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789630, Length=322, Percent_Identity=31.055900621118, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646839, Length=299, Percent_Identity=30.1003344481605, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43514; Mature: 43514

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLGRSFVGFLVLSLMAGAVLWWGVSNGQAPSSQAAKAADEGLLEYERNTVEIVERYGDG
CCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCC
VVYVSVVTRPQSVQLPPGFEFFAPFLQVPPQRGTGSGFVIDKEGYIFTNYHVVEGADRIT
EEEEEEEECCCEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEEEEECCCCEEE
VKFHNDPKEYQARLVGAAPPLDVALLKVDAPKERLVPLVLGDSDQIRVGQKAIAMGNPFG
EEECCCHHHHHEEEECCCCCCCEEEEEECCCHHHEEEEEECCCCCEEECCEEEECCCCCC
LEFTVTQGIVSAIRENPGAIGDESGLVPQVIQTDAAINPGNSGGPLLNSRGEVIGINTAI
EEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEE
LTPTGQFGAAQFAGVGFALPINLVKQYLPEMRAGKILTAEEIVRSRPRLGVSIIPLSFYP
ECCCCCCCCHHHCCCCEEECHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCEEEEECCCCH
ERLRQQYGLPDTGLMVQEVERNSPAQKAGLKPPTRFAYIQLPTGEALQVGVDGDVLLEAD
HHHHHHCCCCCCCHHHHHHHCCCCHHHCCCCCCCEEEEEEECCCCEEEEECCCCEEEEEC
GVPLTSIAQLRQVLYAKKPGEAVTLKVWRQGRTLTLRVVPQVLR
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECHHHHC
>Mature Secondary Structure
MNLGRSFVGFLVLSLMAGAVLWWGVSNGQAPSSQAAKAADEGLLEYERNTVEIVERYGDG
CCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCC
VVYVSVVTRPQSVQLPPGFEFFAPFLQVPPQRGTGSGFVIDKEGYIFTNYHVVEGADRIT
EEEEEEEECCCEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEEEEECCCCEEE
VKFHNDPKEYQARLVGAAPPLDVALLKVDAPKERLVPLVLGDSDQIRVGQKAIAMGNPFG
EEECCCHHHHHEEEECCCCCCCEEEEEECCCHHHEEEEEECCCCCEEECCEEEECCCCCC
LEFTVTQGIVSAIRENPGAIGDESGLVPQVIQTDAAINPGNSGGPLLNSRGEVIGINTAI
EEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEE
LTPTGQFGAAQFAGVGFALPINLVKQYLPEMRAGKILTAEEIVRSRPRLGVSIIPLSFYP
ECCCCCCCCHHHCCCCEEECHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCEEEEECCCCH
ERLRQQYGLPDTGLMVQEVERNSPAQKAGLKPPTRFAYIQLPTGEALQVGVDGDVLLEAD
HHHHHHCCCCCCCHHHHHHHCCCCHHHCCCCCCCEEEEEEECCCCEEEEECCCCEEEEEC
GVPLTSIAQLRQVLYAKKPGEAVTLKVWRQGRTLTLRVVPQVLR
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]