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The map label for this gene is sbcD [H]

Identifier: 55981258

GI number: 55981258

Start: 1231605

End: 1232723

Strand: Reverse

Name: sbcD [H]

Synonym: TTHA1289

Alternate gene names: 55981258

Gene position: 1232723-1231605 (Counterclockwise)

Preceding gene: 55981259

Following gene: 55981257

Centisome position: 66.64

GC content: 72.12

Gene sequence:

>1119_bases
ATGCGCCTTCTCCACACCGCCGACTGGCACCTGGGCAAGCTCCTCAAGGGGGTGGACCGGACCCCGGAGATCGCCGCCGC
CCTCCGGGACCTTCTGGGCCTGGTCCGGTCCGAGCGGGTGGACCTGGTGGTGGTCTCCGGGGACCTGTTTGACCGGCCCC
AGGTTTCGGCGGAGGCCGAGGCTTGCGCGGTGGAGTTCTTCATGGAGCTCAAGGCCCTTGGGGTCCCGGCCCTGGTCATC
GCCGGCAACCACGACCCCAAAGAGCGCCTCGAGGCCCTCGCCCCCCTTCTCGGGCTTGCGGGGGCCCGGGTCCGGGGCCG
CCTCCTCTTCGCCGAGGAGGGAGGGGTGGTGGAGGTGGGCGGGGTGCGGGCGGGGCTTCTGCCCTTCGTTTCCGAGCGCC
TCCTCGTCCGGCGCCTCTTCCAGGAGGACGAGGTCCTGCACCGCACCTACGCCGAGGCCCTGCGCCGGGTGCTGGACAAC
CTCAAAAGCCCTCTTCTCCTGGGCCACTTCGCCGTGGAGGGGGCGAGGCCCGGGGGAGGGGAGTTCGTCTTCCACCTGGT
GGGAAGCTACGCCGTCCCCCGGGCGAGCCTGCCTTTGGAGGTCCGCTACCTCGCCCTGGGCCACGTCCACCGGCAACAGC
AGGTGAGCGAGGCCCCCGTGGCCTGGTACCCGGGAAGCCTGGTGCAGCTGGACTTTGGCGAGGGGGAGGGGGCGGAGCGG
GGGGCGCTCCTCGTGGAGCTTCCCCCCTCGGGGCCGCCCCGGGTCCACCCCATCCCGGGGCGGTGGGGGAAGCCCCTCAG
GACCTACCGCCTGCGGCCCGAGGAGCTGGACGGGAGGATGGGCGAGTTGGAGCGCTTTCCCGGCTACCTGCGCCTGGTGG
TGGAGGGGAGGCTTTCCCCCCAGGTCAAGGAGAACCTTTTCCGGGCCCTCCCCCACCTCCTCGCCGTGGAGGGCGCCCCG
CTCCAGGCTGGGGAGGGGAGGCGGGAGGAGGTGCAGGACCTCGGCTTCGTGGAGGGCTACGCCCGCTACCTGGAGGAGCG
GGGAAGGAAGGAGGAGGCCCTGCTGGAGCGCTTCGCTGAGGTGCTGGCGGAGGTGGAGGGTGAGGCCCTTACGGCTTGA

Upstream 100 bases:

>100_bases
GTCCCCCTCTCCACCCTCTTCGCCGCCTTTCTGCTCGCCGGGGGGAAGGGAGAGGGCGGGGATCACGCCCACCCCCACTA
GGGGCGCGTAAGATGGGGCC

Downstream 100 bases:

>100_bases
GCTGGAGGGGTTCGGCCCCTACCGGGAGCGCCAGGCGGTGGACTTCTCCGACGTGGAGCTCTTCGCCATCACCGGGCCCA
CGGGGAGCGGGAAGAGCACC

Product: exonuclease SbcD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MRLLHTADWHLGKLLKGVDRTPEIAAALRDLLGLVRSERVDLVVVSGDLFDRPQVSAEAEACAVEFFMELKALGVPALVI
AGNHDPKERLEALAPLLGLAGARVRGRLLFAEEGGVVEVGGVRAGLLPFVSERLLVRRLFQEDEVLHRTYAEALRRVLDN
LKSPLLLGHFAVEGARPGGGEFVFHLVGSYAVPRASLPLEVRYLALGHVHRQQQVSEAPVAWYPGSLVQLDFGEGEGAER
GALLVELPPSGPPRVHPIPGRWGKPLRTYRLRPEELDGRMGELERFPGYLRLVVEGRLSPQVKENLFRALPHLLAVEGAP
LQAGEGRREEVQDLGFVEGYARYLEERGRKEEALLERFAEVLAEVEGEALTA

Sequences:

>Translated_372_residues
MRLLHTADWHLGKLLKGVDRTPEIAAALRDLLGLVRSERVDLVVVSGDLFDRPQVSAEAEACAVEFFMELKALGVPALVI
AGNHDPKERLEALAPLLGLAGARVRGRLLFAEEGGVVEVGGVRAGLLPFVSERLLVRRLFQEDEVLHRTYAEALRRVLDN
LKSPLLLGHFAVEGARPGGGEFVFHLVGSYAVPRASLPLEVRYLALGHVHRQQQVSEAPVAWYPGSLVQLDFGEGEGAER
GALLVELPPSGPPRVHPIPGRWGKPLRTYRLRPEELDGRMGELERFPGYLRLVVEGRLSPQVKENLFRALPHLLAVEGAP
LQAGEGRREEVQDLGFVEGYARYLEERGRKEEALLERFAEVLAEVEGEALTA
>Mature_372_residues
MRLLHTADWHLGKLLKGVDRTPEIAAALRDLLGLVRSERVDLVVVSGDLFDRPQVSAEAEACAVEFFMELKALGVPALVI
AGNHDPKERLEALAPLLGLAGARVRGRLLFAEEGGVVEVGGVRAGLLPFVSERLLVRRLFQEDEVLHRTYAEALRRVLDN
LKSPLLLGHFAVEGARPGGGEFVFHLVGSYAVPRASLPLEVRYLALGHVHRQQQVSEAPVAWYPGSLVQLDFGEGEGAER
GALLVELPPSGPPRVHPIPGRWGKPLRTYRLRPEELDGRMGELERFPGYLRLVVEGRLSPQVKENLFRALPHLLAVEGAP
LQAGEGRREEVQDLGFVEGYARYLEERGRKEEALLERFAEVLAEVEGEALTA

Specific function: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sbcD family [H]

Homologues:

Organism=Escherichia coli, GI1786598, Length=254, Percent_Identity=26.7716535433071, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 40987; Mature: 40987

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLHTADWHLGKLLKGVDRTPEIAAALRDLLGLVRSERVDLVVVSGDLFDRPQVSAEAE
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHH
ACAVEFFMELKALGVPALVIAGNHDPKERLEALAPLLGLAGARVRGRLLFAEEGGVVEVG
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEC
GVRAGLLPFVSERLLVRRLFQEDEVLHRTYAEALRRVLDNLKSPLLLGHFAVEGARPGGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCC
EFVFHLVGSYAVPRASLPLEVRYLALGHVHRQQQVSEAPVAWYPGSLVQLDFGEGEGAER
HHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCC
GALLVELPPSGPPRVHPIPGRWGKPLRTYRLRPEELDGRMGELERFPGYLRLVVEGRLSP
CEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCHHHHCCCHHHHHHCCCEEEEEEECCCCH
QVKENLFRALPHLLAVEGAPLQAGEGRREEVQDLGFVEGYARYLEERGRKEEALLERFAE
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VLAEVEGEALTA
HHHHHCCCCCCC
>Mature Secondary Structure
MRLLHTADWHLGKLLKGVDRTPEIAAALRDLLGLVRSERVDLVVVSGDLFDRPQVSAEAE
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHH
ACAVEFFMELKALGVPALVIAGNHDPKERLEALAPLLGLAGARVRGRLLFAEEGGVVEVG
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEC
GVRAGLLPFVSERLLVRRLFQEDEVLHRTYAEALRRVLDNLKSPLLLGHFAVEGARPGGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCC
EFVFHLVGSYAVPRASLPLEVRYLALGHVHRQQQVSEAPVAWYPGSLVQLDFGEGEGAER
HHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCC
GALLVELPPSGPPRVHPIPGRWGKPLRTYRLRPEELDGRMGELERFPGYLRLVVEGRLSP
CEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCHHHHCCCHHHHHHCCCEEEEEEECCCCH
QVKENLFRALPHLLAVEGAPLQAGEGRREEVQDLGFVEGYARYLEERGRKEEALLERFAE
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VLAEVEGEALTA
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377; 10568751; 1646786; 8493111 [H]