Click here to switch to the map view.

The map label for this gene is acsA [H]

Identifier: 55981254

GI number: 55981254

Start: 1224327

End: 1226216

Strand: Direct

Name: acsA [H]

Synonym: TTHA1285

Alternate gene names: 55981254

Gene position: 1224327-1226216 (Clockwise)

Preceding gene: 55981253

Following gene: 55981261

Centisome position: 66.19

GC content: 71.8

Gene sequence:

>1890_bases
ATGGAACCGGTCTGGTACCCCGACGCGCGCGCCCAAGAAACCTGGCTTGGCCGCTTCATGGCCGAGCTCGGCTTCCAGGA
CTACGAGGCCTTCCACCGCTACAGCGTGGAGGAGGCCGAGGCCTTCTACCACGCCTTCTTCACCCGGCTCGGCGTGCCCT
GGCGGGCCCCGTACACCCGGGTGGTGGAAGGCCACTTCCCCTTCCCCCGCTTCTTCGTGGGGGGAAGGCTCAACCTGGTG
GAGGCCTGCCTGCGCCACGACCCCACCCGGCCCGCCCTCGTCCACGAGACGGAGGACGGCCACGTCCGGAGCCTCACCTA
CGGGGAGGCCCGCCGGGAGGTGGAAAGGCTCGCAGGGGGCCTCCGGGCCCTCGGGGTGGGGCGGGGAGACCGGGTGGGGC
TATGGCTTCCCATGGGCCTCGAGGCGGCCTTGGCCCTCCTCGCCGTGGCCCACCTCGGGGGGATCGCCGTCCCCATCTTC
TCGGGCTACGGGGCGGAGGCCGCCGCCCTCCGCCTCAAGGACGCCGAGGCCAAGCTCCTCATCGTCCAAGACGGCTTCCT
TCGCCGGGGACGCCGGGTGGAGCTCCTCCCCGAGGCCCGGAAGGCCAGGGCCATGGCGGGGACGGAAAAGGTGGCCGTGG
TCCGCCGCCTCGGCCTCCCCCTGGAGGAGGAGGCGGACCTCGCCGCCCTCGCCGGCCCCCTCTCGCCGCCGGAGGAGATG
GAGAGCATGGACCCCTTCATGCTCATCTACACCTCCGGGACCACGGGCCGCCCCAAGGGCACGGTCCACTACCACGCGGG
CTTTCCCTTGAAGGCCGCCCTGGACCTCGCCCTCCTCTTTGACCTGAGGGAGGAGGACCGCCTCTTCTGGTTCACCGACC
TCGGCTGGATGATGGGGCCCTGGGCCATCCTGGGAGGCCTCATCCTCGGGGCCACCGTCTTCCTCTACGACGGGGCGCCG
GACCATCCGGGCCCGGACCGCCTCTGGCGCATGGTGGCGGCCCACCGCCTCACCCACTTAGGCCTCTCCCCCACCCTGGT
GCGGGCCCTCATCCCCTTTGGGGAAGCCCCCGTGGAGGCCCACGACCTCTCCTCCCTCCGGGTCCTCGGCTCCACGGGAG
AGCCCTGGAACCTCGAGCCCTACCTCTGGTTCTTCCGGGTGGTGGGCAAGGAGCGGCTTCCCATCGTGAACTACTCGGGG
GGCACCGAGGTCTCGGGGGGCATCCTGGGGAACGTCCTGGTGAGGCCCATCAAGCCCATGGGGTTCAACACCGCCGTGCC
CGGCATGAAGGCCGCCGTCTTGGACGAGGAGGGGAGGCCCGTGGTGGGCAAGGTGGGGGAGCTCGCCGTCCTCGCCCCCT
GGCCCGGGATGACCAAGGGCTTCTGGCGGGACGAGGCCCGGTACCTGGAGACCTACTTCCAGAAGGTGCCCGGGGTCTGG
GTCCACGGGGACTTCGCCCTCCTGGACGAGGAGGGGCACTTCTTCCTCCTCGGCCGCTCCGACGACACCCTGAAGGTGGC
GGGAAAGCGGGTGGGCCCCGCCGAGGTGGAGACGGCGGCCATGGCCCATCCCGCCCTGCGGGAGTGCGCCGCCATCGGTG
TGCCCCACCCGGTGAAGGGGGAGGCCATCGTCCTCTTCGCCGTGCTGAAGCCGGGCTTCGCCCCCTCGGAGGCCCTGGCC
GAGGAGGTGGCGGAGCGGGTGGCCGAGGCCTTGGGGAAGCCCCTCAGGCCGGAGCGGGTCCTCTTCGTCCCCGACCTGCC
CAAGACGCGCAACGCCAAGGTGATGCGCCGGGTGGTGCGGGCCGCCTTCCTGGGCCAGGACCCCGGGGACCTCTCCGCCT
TGGAGAACCCGGAGGCGGTGGCGGCCATCAAGCGGACCCGGGAGGGTTAA

Upstream 100 bases:

>100_bases
GCGGCTCCTCGCCAAGCGCCCCGAGGACCGGCTCGGCCTTAAGGCGTTTCTCCGCGTCCTCGCCGAGGCCTCGAGGCCAA
ACCCCTCACGGAGGTAACCC

Downstream 100 bases:

>100_bases
AGGGCCCCCGCCCGCCGCTCCAAAGCCCCTTTACGGGTAGGCCCAGCAAAGCCCCGGCGAAGAGGAAGAGGGCCACCCCC
CCGGCCCCGCCCAGGAGGAG

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MEPVWYPDARAQETWLGRFMAELGFQDYEAFHRYSVEEAEAFYHAFFTRLGVPWRAPYTRVVEGHFPFPRFFVGGRLNLV
EACLRHDPTRPALVHETEDGHVRSLTYGEARREVERLAGGLRALGVGRGDRVGLWLPMGLEAALALLAVAHLGGIAVPIF
SGYGAEAAALRLKDAEAKLLIVQDGFLRRGRRVELLPEARKARAMAGTEKVAVVRRLGLPLEEEADLAALAGPLSPPEEM
ESMDPFMLIYTSGTTGRPKGTVHYHAGFPLKAALDLALLFDLREEDRLFWFTDLGWMMGPWAILGGLILGATVFLYDGAP
DHPGPDRLWRMVAAHRLTHLGLSPTLVRALIPFGEAPVEAHDLSSLRVLGSTGEPWNLEPYLWFFRVVGKERLPIVNYSG
GTEVSGGILGNVLVRPIKPMGFNTAVPGMKAAVLDEEGRPVVGKVGELAVLAPWPGMTKGFWRDEARYLETYFQKVPGVW
VHGDFALLDEEGHFFLLGRSDDTLKVAGKRVGPAEVETAAMAHPALRECAAIGVPHPVKGEAIVLFAVLKPGFAPSEALA
EEVAERVAEALGKPLRPERVLFVPDLPKTRNAKVMRRVVRAAFLGQDPGDLSALENPEAVAAIKRTREG

Sequences:

>Translated_629_residues
MEPVWYPDARAQETWLGRFMAELGFQDYEAFHRYSVEEAEAFYHAFFTRLGVPWRAPYTRVVEGHFPFPRFFVGGRLNLV
EACLRHDPTRPALVHETEDGHVRSLTYGEARREVERLAGGLRALGVGRGDRVGLWLPMGLEAALALLAVAHLGGIAVPIF
SGYGAEAAALRLKDAEAKLLIVQDGFLRRGRRVELLPEARKARAMAGTEKVAVVRRLGLPLEEEADLAALAGPLSPPEEM
ESMDPFMLIYTSGTTGRPKGTVHYHAGFPLKAALDLALLFDLREEDRLFWFTDLGWMMGPWAILGGLILGATVFLYDGAP
DHPGPDRLWRMVAAHRLTHLGLSPTLVRALIPFGEAPVEAHDLSSLRVLGSTGEPWNLEPYLWFFRVVGKERLPIVNYSG
GTEVSGGILGNVLVRPIKPMGFNTAVPGMKAAVLDEEGRPVVGKVGELAVLAPWPGMTKGFWRDEARYLETYFQKVPGVW
VHGDFALLDEEGHFFLLGRSDDTLKVAGKRVGPAEVETAAMAHPALRECAAIGVPHPVKGEAIVLFAVLKPGFAPSEALA
EEVAERVAEALGKPLRPERVLFVPDLPKTRNAKVMRRVVRAAFLGQDPGDLSALENPEAVAAIKRTREG
>Mature_629_residues
MEPVWYPDARAQETWLGRFMAELGFQDYEAFHRYSVEEAEAFYHAFFTRLGVPWRAPYTRVVEGHFPFPRFFVGGRLNLV
EACLRHDPTRPALVHETEDGHVRSLTYGEARREVERLAGGLRALGVGRGDRVGLWLPMGLEAALALLAVAHLGGIAVPIF
SGYGAEAAALRLKDAEAKLLIVQDGFLRRGRRVELLPEARKARAMAGTEKVAVVRRLGLPLEEEADLAALAGPLSPPEEM
ESMDPFMLIYTSGTTGRPKGTVHYHAGFPLKAALDLALLFDLREEDRLFWFTDLGWMMGPWAILGGLILGATVFLYDGAP
DHPGPDRLWRMVAAHRLTHLGLSPTLVRALIPFGEAPVEAHDLSSLRVLGSTGEPWNLEPYLWFFRVVGKERLPIVNYSG
GTEVSGGILGNVLVRPIKPMGFNTAVPGMKAAVLDEEGRPVVGKVGELAVLAPWPGMTKGFWRDEARYLETYFQKVPGVW
VHGDFALLDEEGHFFLLGRSDDTLKVAGKRVGPAEVETAAMAHPALRECAAIGVPHPVKGEAIVLFAVLKPGFAPSEALA
EEVAERVAEALGKPLRPERVLFVPDLPKTRNAKVMRRVVRAAFLGQDPGDLSALENPEAVAAIKRTREG

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI28416953, Length=625, Percent_Identity=36.32, Blast_Score=350, Evalue=3e-96,
Organism=Homo sapiens, GI8923896, Length=658, Percent_Identity=33.434650455927, Blast_Score=335, Evalue=8e-92,
Organism=Homo sapiens, GI253970489, Length=671, Percent_Identity=32.9359165424739, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI31982927, Length=648, Percent_Identity=27.6234567901235, Blast_Score=253, Evalue=6e-67,
Organism=Homo sapiens, GI13375727, Length=626, Percent_Identity=28.2747603833866, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI42544132, Length=523, Percent_Identity=27.151051625239, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI38505220, Length=511, Percent_Identity=26.614481409002, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI122937307, Length=523, Percent_Identity=27.5334608030593, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI157311624, Length=495, Percent_Identity=26.2626262626263, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI157311622, Length=495, Percent_Identity=26.2626262626263, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI115511026, Length=496, Percent_Identity=26.008064516129, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI58082049, Length=489, Percent_Identity=25.9713701431493, Blast_Score=133, Evalue=6e-31,
Organism=Escherichia coli, GI1790505, Length=629, Percent_Identity=34.8171701112878, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1786529, Length=631, Percent_Identity=30.5863708399366, Blast_Score=265, Evalue=8e-72,
Organism=Escherichia coli, GI221142682, Length=541, Percent_Identity=24.9537892791128, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1788107, Length=503, Percent_Identity=25.4473161033797, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI145693145, Length=550, Percent_Identity=24.7272727272727, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982997, Length=645, Percent_Identity=31.937984496124, Blast_Score=307, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI71983001, Length=645, Percent_Identity=31.937984496124, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17569507, Length=663, Percent_Identity=24.8868778280543, Blast_Score=217, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32563687, Length=539, Percent_Identity=24.860853432282, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17557194, Length=601, Percent_Identity=24.459234608985, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=566, Percent_Identity=24.0282685512367, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=560, Percent_Identity=23.5714285714286, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=531, Percent_Identity=23.1638418079096, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=406, Percent_Identity=26.3546798029557, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17560140, Length=514, Percent_Identity=24.7081712062257, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=538, Percent_Identity=22.8624535315985, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=33.7480559875583, Blast_Score=351, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6319264, Length=635, Percent_Identity=33.7007874015748, Blast_Score=337, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6319699, Length=502, Percent_Identity=23.9043824701195, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667955, Length=646, Percent_Identity=32.8173374613003, Blast_Score=335, Evalue=8e-92,
Organism=Drosophila melanogaster, GI62472339, Length=557, Percent_Identity=35.7271095152603, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=35.3846153846154, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI21355225, Length=607, Percent_Identity=27.841845140033, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24648260, Length=569, Percent_Identity=25.4833040421793, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI18859661, Length=539, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355181, Length=510, Percent_Identity=25.0980392156863, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281365686, Length=542, Percent_Identity=24.169741697417, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922652, Length=552, Percent_Identity=24.0942028985507, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24653035, Length=365, Percent_Identity=25.2054794520548, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161076582, Length=372, Percent_Identity=24.7311827956989, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356947, Length=371, Percent_Identity=23.1805929919137, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648676, Length=383, Percent_Identity=24.2819843342037, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 69039; Mature: 69039

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPVWYPDARAQETWLGRFMAELGFQDYEAFHRYSVEEAEAFYHAFFTRLGVPWRAPYTR
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHH
VVEGHFPFPRFFVGGRLNLVEACLRHDPTRPALVHETEDGHVRSLTYGEARREVERLAGG
EEECCCCCCHHEECCCHHHHHHHHHCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHCC
LRALGVGRGDRVGLWLPMGLEAALALLAVAHLGGIAVPIFSGYGAEAAALRLKDAEAKLL
HHEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEECCCCEEE
IVQDGFLRRGRRVELLPEARKARAMAGTEKVAVVRRLGLPLEEEADLAALAGPLSPPEEM
EEECHHHHCCCEEEECCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHH
ESMDPFMLIYTSGTTGRPKGTVHYHAGFPLKAALDLALLFDLREEDRLFWFTDLGWMMGP
HCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHH
WAILGGLILGATVFLYDGAPDHPGPDRLWRMVAAHRLTHLGLSPTLVRALIPFGEAPVEA
HHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
HDLSSLRVLGSTGEPWNLEPYLWFFRVVGKERLPIVNYSGGTEVSGGILGNVLVRPIKPM
HCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHCCCCCC
GFNTAVPGMKAAVLDEEGRPVVGKVGELAVLAPWPGMTKGFWRDEARYLETYFQKVPGVW
CCCCCCCCCEEEEECCCCCCCEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEE
VHGDFALLDEEGHFFLLGRSDDTLKVAGKRVGPAEVETAAMAHPALRECAAIGVPHPVKG
EECCEEEEECCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
EAIVLFAVLKPGFAPSEALAEEVAERVAEALGKPLRPERVLFVPDLPKTRNAKVMRRVVR
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHH
AAFLGQDPGDLSALENPEAVAAIKRTREG
HHHCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MEPVWYPDARAQETWLGRFMAELGFQDYEAFHRYSVEEAEAFYHAFFTRLGVPWRAPYTR
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHH
VVEGHFPFPRFFVGGRLNLVEACLRHDPTRPALVHETEDGHVRSLTYGEARREVERLAGG
EEECCCCCCHHEECCCHHHHHHHHHCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHCC
LRALGVGRGDRVGLWLPMGLEAALALLAVAHLGGIAVPIFSGYGAEAAALRLKDAEAKLL
HHEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEECCCCEEE
IVQDGFLRRGRRVELLPEARKARAMAGTEKVAVVRRLGLPLEEEADLAALAGPLSPPEEM
EEECHHHHCCCEEEECCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHH
ESMDPFMLIYTSGTTGRPKGTVHYHAGFPLKAALDLALLFDLREEDRLFWFTDLGWMMGP
HCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHH
WAILGGLILGATVFLYDGAPDHPGPDRLWRMVAAHRLTHLGLSPTLVRALIPFGEAPVEA
HHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
HDLSSLRVLGSTGEPWNLEPYLWFFRVVGKERLPIVNYSGGTEVSGGILGNVLVRPIKPM
HCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHCCCCCC
GFNTAVPGMKAAVLDEEGRPVVGKVGELAVLAPWPGMTKGFWRDEARYLETYFQKVPGVW
CCCCCCCCCEEEEECCCCCCCEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEE
VHGDFALLDEEGHFFLLGRSDDTLKVAGKRVGPAEVETAAMAHPALRECAAIGVPHPVKG
EECCEEEEECCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
EAIVLFAVLKPGFAPSEALAEEVAERVAEALGKPLRPERVLFVPDLPKTRNAKVMRRVVR
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHH
AAFLGQDPGDLSALENPEAVAAIKRTREG
HHHCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA