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The map label for this gene is trpS [H]

Identifier: 55981196

GI number: 55981196

Start: 1164910

End: 1165923

Strand: Reverse

Name: trpS [H]

Synonym: TTHA1227

Alternate gene names: 55981196

Gene position: 1165923-1164910 (Counterclockwise)

Preceding gene: 55981204

Following gene: 55981195

Centisome position: 63.03

GC content: 66.07

Gene sequence:

>1014_bases
ATGAAGCGGGTGCTTTCCGGCATCCAGCCCTCGGGGGAGATCCACATCGGCAACTACCTCGGGGCCATCAAGCAGTGGGT
GGCCATCGGGGAGAAGCTGGGGCGGGACGCCTTCTTCTGCATCGTGGACTACCACGCCCTCACCAACCCCCTCGCCTACG
ACCCCTCTACCCTCGCCCAGCGCACCTTTGAGGCCGCCCTGGTCAACATCGCCGCGGGGCTTGACCCGGAGAAGGTCACC
CTCTTCGTCCAGTCCCACGTGCCCGAGCACACTGAGCTCTCCTGGGTCTTCACCACCTTAACCCCCCTGGGGGACCTCAC
CCGCATGACCCAGTTCAAGGACAAGGCCAGCAAGCAGGAGACCGTCTGGTCTGGCCTCCTCATGTACCCGGTGCTCCAGG
CGGCGGACATCCTCATCTACAAGGCGGACACCGTCCCCGTGGGGGAGGACCAGGTGCAGCACATTGAGCTCACCCGGGAG
ATCGCCCGCCGCTTCAACCACCTCTTCGGGGAGACCTTCCCCGAACCCCAGGCCCTCTTGAACCCAGAGGCCCCCCGGGT
CCCCGGGATTGACGGCAAGGCCAAGATGAGCAAGTCCTTGGGCAACACCATCGGCCTCCTGGAGCCCGAGGAGAGCATCT
GGCAGAAGATCCAGCACCTCCCCGACGACCCCCAGAGGATCCGCCTCTCCGACCCCGGGGACCCCGAGCGCACCATTCTT
TTCACCTACCTCTCCTACTTCGCCCCCAAGGACCTGGTGGAGGCCCTGAAGGAGGAGTACCGGAAGGCGGGGGTGGGGAC
CTACGTGGTGAAGCGGATCCTCTTTGACCACCTCATGGAGGCCCTGCGCCCCATCCGGGAAAGGGCCGAGGCCCTGAAGA
AGGACCCGGACTACGTGATGGATGCCCTTTTGGAGGGCGCCAAGCGGGCCAGGGCCGTGGCCCAGGCGACCATGGAGGAG
GTGCGGGAGAAGGTGGGCCTCCTCCTGCCCAGGAAGCGGCCGGTCCTCCGGTGA

Upstream 100 bases:

>100_bases
ATTCAGGGTCATGTGCCCGCAAGGGCGTGCGGGTTCAAGTCCCGCCCCCGGCACCAGAAGGCCCCCGCGAGGGGGCCTAA
GCTTTTGCTACACTTAGGCC

Downstream 100 bases:

>100_bases
TCCGCATCGCCTTTCCCGGCTTTGAGGGGACCCCGGAGGCCCTGAGGGAGGCCCTGAGGCGGGGCCGGCTTTCCCCAAAG
GAGGTGCCCGTCCTCGCCGT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKRVLSGIQPSGEIHIGNYLGAIKQWVAIGEKLGRDAFFCIVDYHALTNPLAYDPSTLAQRTFEAALVNIAAGLDPEKVT
LFVQSHVPEHTELSWVFTTLTPLGDLTRMTQFKDKASKQETVWSGLLMYPVLQAADILIYKADTVPVGEDQVQHIELTRE
IARRFNHLFGETFPEPQALLNPEAPRVPGIDGKAKMSKSLGNTIGLLEPEESIWQKIQHLPDDPQRIRLSDPGDPERTIL
FTYLSYFAPKDLVEALKEEYRKAGVGTYVVKRILFDHLMEALRPIRERAEALKKDPDYVMDALLEGAKRARAVAQATMEE
VREKVGLLLPRKRPVLR

Sequences:

>Translated_337_residues
MKRVLSGIQPSGEIHIGNYLGAIKQWVAIGEKLGRDAFFCIVDYHALTNPLAYDPSTLAQRTFEAALVNIAAGLDPEKVT
LFVQSHVPEHTELSWVFTTLTPLGDLTRMTQFKDKASKQETVWSGLLMYPVLQAADILIYKADTVPVGEDQVQHIELTRE
IARRFNHLFGETFPEPQALLNPEAPRVPGIDGKAKMSKSLGNTIGLLEPEESIWQKIQHLPDDPQRIRLSDPGDPERTIL
FTYLSYFAPKDLVEALKEEYRKAGVGTYVVKRILFDHLMEALRPIRERAEALKKDPDYVMDALLEGAKRARAVAQATMEE
VREKVGLLLPRKRPVLR
>Mature_337_residues
MKRVLSGIQPSGEIHIGNYLGAIKQWVAIGEKLGRDAFFCIVDYHALTNPLAYDPSTLAQRTFEAALVNIAAGLDPEKVT
LFVQSHVPEHTELSWVFTTLTPLGDLTRMTQFKDKASKQETVWSGLLMYPVLQAADILIYKADTVPVGEDQVQHIELTRE
IARRFNHLFGETFPEPQALLNPEAPRVPGIDGKAKMSKSLGNTIGLLEPEESIWQKIQHLPDDPQRIRLSDPGDPERTIL
FTYLSYFAPKDLVEALKEEYRKAGVGTYVVKRILFDHLMEALRPIRERAEALKKDPDYVMDALLEGAKRARAVAQATMEE
VREKVGLLLPRKRPVLR

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=333, Percent_Identity=39.3393393393393, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI41352700, Length=183, Percent_Identity=49.7267759562842, Blast_Score=178, Evalue=7e-45,
Organism=Escherichia coli, GI1789786, Length=333, Percent_Identity=39.3393393393393, Blast_Score=225, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71982800, Length=334, Percent_Identity=32.3353293413174, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982793, Length=334, Percent_Identity=32.3353293413174, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320474, Length=346, Percent_Identity=33.8150289017341, Blast_Score=169, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24666151, Length=331, Percent_Identity=37.4622356495468, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37988; Mature: 37988

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVLSGIQPSGEIHIGNYLGAIKQWVAIGEKLGRDAFFCIVDYHALTNPLAYDPSTLAQ
CCHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCHHHHHH
RTFEAALVNIAAGLDPEKVTLFVQSHVPEHTELSWVFTTLTPLGDLTRMTQFKDKASKQE
HHHHHHHHHHHHCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVWSGLLMYPVLQAADILIYKADTVPVGEDQVQHIELTREIARRFNHLFGETFPEPQALL
HHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHC
NPEAPRVPGIDGKAKMSKSLGNTIGLLEPEESIWQKIQHLPDDPQRIRLSDPGDPERTIL
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCHHHHH
FTYLSYFAPKDLVEALKEEYRKAGVGTYVVKRILFDHLMEALRPIRERAEALKKDPDYVM
HHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
DALLEGAKRARAVAQATMEEVREKVGLLLPRKRPVLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKRVLSGIQPSGEIHIGNYLGAIKQWVAIGEKLGRDAFFCIVDYHALTNPLAYDPSTLAQ
CCHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCHHHHHH
RTFEAALVNIAAGLDPEKVTLFVQSHVPEHTELSWVFTTLTPLGDLTRMTQFKDKASKQE
HHHHHHHHHHHHCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVWSGLLMYPVLQAADILIYKADTVPVGEDQVQHIELTREIARRFNHLFGETFPEPQALL
HHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHC
NPEAPRVPGIDGKAKMSKSLGNTIGLLEPEESIWQKIQHLPDDPQRIRLSDPGDPERTIL
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCHHHHH
FTYLSYFAPKDLVEALKEEYRKAGVGTYVVKRILFDHLMEALRPIRERAEALKKDPDYVM
HHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
DALLEGAKRARAVAQATMEEVREKVGLLLPRKRPVLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]