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The map label for this gene is degS [H]

Identifier: 55981150

GI number: 55981150

Start: 1126596

End: 1128143

Strand: Reverse

Name: degS [H]

Synonym: TTHA1181

Alternate gene names: 55981150

Gene position: 1128143-1126596 (Counterclockwise)

Preceding gene: 55981151

Following gene: 55981149

Centisome position: 60.99

GC content: 71.58

Gene sequence:

>1548_bases
ATGACGGAGCATAGCCTCTACCGCCTCGTCCGCCTGGCCCAAAGGCTTCTGCCCCCCGCCATCGCCCTGGTGGTCCTGGC
CTTTGAGCTCGCCCTTTCCCCCTTTGACCACACCAGCGCCCTCTTCTGGCTCCGTCTGGGCTTCTACGGCCTCGTGGGAC
CCCTGGTCACCTACGCGGTCCTGGAGTGGATCGCCCAGGAGGTCCTGGAGAAGGCCCGGGCCGAGCGGGCCCTGGAGGAG
GCGAACCGGAGGCTCCTCGCCTCGGAGCGGGTCTTCCGCGAGGCCCTGGCGAGCGAGAACCTGGAGGAGGCGGTGCTGCG
CATCGCCCGGGGCCTGGAGGAGACCCTGGGCTACCCCGTGGCCCTCGAGGCCGAGGGGGTGCGCTCGGGGGAGGGGTGCG
GGGGCCGGCGGGTGGCCCTGCCCGGGCTTAAGGGGCACTTGGAGGCCTGCGGGGACGGGACGGACCAGGTCTTCCTGGAG
GTCCTGGCCCACGAGGTAGCGGGGGCGCTCCAGGCGGTGGTGGCCCGGAGCCGCGACCTCCTCACCCTCTTTGAGGTGGA
CCAGGCCCTGAAGGCCGAGGCCAACCTGGACCGGCTTCTGGAGGGGCTTTTGGACCGGATCCGCGCCTGGGCGGGGGCCG
AGGGGGGTGGGGTCCTCCTTTTGGACGAGGAGGGCTTTCTCCTGGCCCGGGTGGTCCAGGGGCTTGCCCTTCCCTCCCAC
CCCTTCCTCCCCGAGGGGGCCTGGAAGGCGGCGCTCCAGGGCCCGGTCTTCGTGGAAAAGGGGGTCCTGGCCCTCCCCTT
GAAGGCGCGGGAGCCCGTGGGGGTGCTCGTCCTCAAGGGCGAGGACCTCTCCCGGCGCATCCCCTTCCTCTCCTTCCTCG
CCTCCCAGGTGGCCCTGGCGGTGCGGAACGCCCAGGCCTACCTGAAGGCGGAGGAGCTCGCCATCAACGAGGAGCGCACC
CGCATCGCCCGGGAGATCCACGACGGCCTCGCCCAAAGCCTCGCCTTCATGGCCCTGAAGCTGGACCTGGTGGAACGGCT
TTGGGAGAAGGACAAAGAGGCGGCCCTGGGGGCCCTCGCCGAGGTGCGGGAGACCCTTAGGGCCCAGATCCGGGAGGTGC
GCCGGAGCATCTTCGCCCTCCGGCCCATTGACCTGGAGCGCTACGGCTTTTTGGAGTCCTTGCGCCGTTACGCCCAGGCC
TTCGCCGAGCAGGCGGGCTTTAGGGTCCAGCTTTCCCTTCCCGAGCGCGTGGGCCTCTCCCAGGCGAGCGAGCTCGTCCT
CTTCCGCGTCCTGCAGGAGGCCCTCACCAACGCCGCCAAGCACGCCAGGCCCACCCGGGTGGAGGTGGTGTTGGAGCCCT
TGGGGGAGCGGGGGGCGAGGCTCGTGGTGCGGGACAACGGCCGGGGCTTCGCCGTCCCCGAGGCCCAGGGCCTGGGCGGG
TTCGGCCTCACCCAGATGCGCGAAAGGGTGGAGGCCCGGGGCGGAAGGTTCTGGGTGGTCTCGGCGCCGGGGCGGGGGAC
GGAGGTGGGGGCGGAGGTGCCTTACTGA

Upstream 100 bases:

>100_bases
CGCCTCCGGCGGATCTTCCACAAGGCCGGCCTCACCCTGGGGGAGGTCCAGATGCTCCGGGGCCTCCTCCACCAGAGCCG
CTTCGCCCAGAGGAGAAAGG

Downstream 100 bases:

>100_bases
ATCTCCCACCGCGGCGAAGGCCTGGAAAGGGTCTTTCCGCCGCGAACGGTATCATGGGGGCATGGACCGGCCCGTGCGCG
TCCTCTTCGTCTGCCTGGGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTEHSLYRLVRLAQRLLPPAIALVVLAFELALSPFDHTSALFWLRLGFYGLVGPLVTYAVLEWIAQEVLEKARAERALEE
ANRRLLASERVFREALASENLEEAVLRIARGLEETLGYPVALEAEGVRSGEGCGGRRVALPGLKGHLEACGDGTDQVFLE
VLAHEVAGALQAVVARSRDLLTLFEVDQALKAEANLDRLLEGLLDRIRAWAGAEGGGVLLLDEEGFLLARVVQGLALPSH
PFLPEGAWKAALQGPVFVEKGVLALPLKAREPVGVLVLKGEDLSRRIPFLSFLASQVALAVRNAQAYLKAEELAINEERT
RIAREIHDGLAQSLAFMALKLDLVERLWEKDKEAALGALAEVRETLRAQIREVRRSIFALRPIDLERYGFLESLRRYAQA
FAEQAGFRVQLSLPERVGLSQASELVLFRVLQEALTNAAKHARPTRVEVVLEPLGERGARLVVRDNGRGFAVPEAQGLGG
FGLTQMRERVEARGGRFWVVSAPGRGTEVGAEVPY

Sequences:

>Translated_515_residues
MTEHSLYRLVRLAQRLLPPAIALVVLAFELALSPFDHTSALFWLRLGFYGLVGPLVTYAVLEWIAQEVLEKARAERALEE
ANRRLLASERVFREALASENLEEAVLRIARGLEETLGYPVALEAEGVRSGEGCGGRRVALPGLKGHLEACGDGTDQVFLE
VLAHEVAGALQAVVARSRDLLTLFEVDQALKAEANLDRLLEGLLDRIRAWAGAEGGGVLLLDEEGFLLARVVQGLALPSH
PFLPEGAWKAALQGPVFVEKGVLALPLKAREPVGVLVLKGEDLSRRIPFLSFLASQVALAVRNAQAYLKAEELAINEERT
RIAREIHDGLAQSLAFMALKLDLVERLWEKDKEAALGALAEVRETLRAQIREVRRSIFALRPIDLERYGFLESLRRYAQA
FAEQAGFRVQLSLPERVGLSQASELVLFRVLQEALTNAAKHARPTRVEVVLEPLGERGARLVVRDNGRGFAVPEAQGLGG
FGLTQMRERVEARGGRFWVVSAPGRGTEVGAEVPY
>Mature_514_residues
TEHSLYRLVRLAQRLLPPAIALVVLAFELALSPFDHTSALFWLRLGFYGLVGPLVTYAVLEWIAQEVLEKARAERALEEA
NRRLLASERVFREALASENLEEAVLRIARGLEETLGYPVALEAEGVRSGEGCGGRRVALPGLKGHLEACGDGTDQVFLEV
LAHEVAGALQAVVARSRDLLTLFEVDQALKAEANLDRLLEGLLDRIRAWAGAEGGGVLLLDEEGFLLARVVQGLALPSHP
FLPEGAWKAALQGPVFVEKGVLALPLKAREPVGVLVLKGEDLSRRIPFLSFLASQVALAVRNAQAYLKAEELAINEERTR
IAREIHDGLAQSLAFMALKLDLVERLWEKDKEAALGALAEVRETLRAQIREVRRSIFALRPIDLERYGFLESLRRYAQAF
AEQAGFRVQLSLPERVGLSQASELVLFRVLQEALTNAAKHARPTRVEVVLEPLGERGARLVVRDNGRGFAVPEAQGLGGF
GLTQMRERVEARGGRFWVVSAPGRGTEVGAEVPY

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=249, Percent_Identity=29.3172690763052, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787474, Length=204, Percent_Identity=31.3725490196078, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87082311, Length=210, Percent_Identity=31.4285714285714, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56558; Mature: 56427

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHSLYRLVRLAQRLLPPAIALVVLAFELALSPFDHTSALFWLRLGFYGLVGPLVTYAV
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEWIAQEVLEKARAERALEEANRRLLASERVFREALASENLEEAVLRIARGLEETLGYPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCE
ALEAEGVRSGEGCGGRRVALPGLKGHLEACGDGTDQVFLEVLAHEVAGALQAVVARSRDL
EEECCCCCCCCCCCCCEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
LTLFEVDQALKAEANLDRLLEGLLDRIRAWAGAEGGGVLLLDEEGFLLARVVQGLALPSH
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHCCCCCC
PFLPEGAWKAALQGPVFVEKGVLALPLKAREPVGVLVLKGEDLSRRIPFLSFLASQVALA
CCCCCCHHHHHHCCCCEECCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
VRNAQAYLKAEELAINEERTRIAREIHDGLAQSLAFMALKLDLVERLWEKDKEAALGALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVRETLRAQIREVRRSIFALRPIDLERYGFLESLRRYAQAFAEQAGFRVQLSLPERVGLS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHCCHH
QASELVLFRVLQEALTNAAKHARPTRVEVVLEPLGERGARLVVRDNGRGFAVPEAQGLGG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCEECCCCCCCCCC
FGLTQMRERVEARGGRFWVVSAPGRGTEVGAEVPY
CCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TEHSLYRLVRLAQRLLPPAIALVVLAFELALSPFDHTSALFWLRLGFYGLVGPLVTYAV
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEWIAQEVLEKARAERALEEANRRLLASERVFREALASENLEEAVLRIARGLEETLGYPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCE
ALEAEGVRSGEGCGGRRVALPGLKGHLEACGDGTDQVFLEVLAHEVAGALQAVVARSRDL
EEECCCCCCCCCCCCCEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
LTLFEVDQALKAEANLDRLLEGLLDRIRAWAGAEGGGVLLLDEEGFLLARVVQGLALPSH
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHCCCCCC
PFLPEGAWKAALQGPVFVEKGVLALPLKAREPVGVLVLKGEDLSRRIPFLSFLASQVALA
CCCCCCHHHHHHCCCCEECCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
VRNAQAYLKAEELAINEERTRIAREIHDGLAQSLAFMALKLDLVERLWEKDKEAALGALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVRETLRAQIREVRRSIFALRPIDLERYGFLESLRRYAQAFAEQAGFRVQLSLPERVGLS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHCCHH
QASELVLFRVLQEALTNAAKHARPTRVEVVLEPLGERGARLVVRDNGRGFAVPEAQGLGG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCEECCCCCCCCCC
FGLTQMRERVEARGGRFWVVSAPGRGTEVGAEVPY
CCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]