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The map label for this gene is ptpA [H]

Identifier: 55981149

GI number: 55981149

Start: 1126049

End: 1126534

Strand: Reverse

Name: ptpA [H]

Synonym: TTHA1180

Alternate gene names: 55981149

Gene position: 1126534-1126049 (Counterclockwise)

Preceding gene: 55981150

Following gene: 55981148

Centisome position: 60.9

GC content: 69.55

Gene sequence:

>486_bases
ATGGACCGGCCCGTGCGCGTCCTCTTCGTCTGCCTGGGAAACATCTGCCGTAGCCCCATGGCCGAGGGCATCTTCCGCAA
GCTCCTGAAGGAGCGGGGCCTCGAGGACCGCTTTGAGGTGGACTCGGCGGGCACCGGGGCCTGGCACGTGGGCGAGCCCA
TGGACCCCCGGGCGAGGCGGGTGTTGGAGGAGGAGGGGGCCTACTTCCCCCACGTGGCCCGGAGGCTCACCCGGGAGGAC
GTCCTGGCCTACGACCACATCCTGGTCATGGACCGGGAGAACCTGGAGGAGGTCCTGAGGCGCTTCCCCGAGGCCCGGGG
CAAGGTGCGCCTGGTGCTGGAGGAGCTCGGCGGGGGCGAGGTCCAGGACCCCTACTACGGGGATCTGGAGGATTTCCGGG
AGGTCTACTGGACCCTGGAGGCGGCCTTGCAGGCCTTCTTGGACCGGCATGGATCCCCTAGCCCTGCTGCGGAAGGCCGG
GCTTGA

Upstream 100 bases:

>100_bases
GGGCGGGGGACGGAGGTGGGGGCGGAGGTGCCTTACTGAATCTCCCACCGCGGCGAAGGCCTGGAAAGGGTCTTTCCGCC
GCGAACGGTATCATGGGGGC

Downstream 100 bases:

>100_bases
GGCGGAAGGCCCGGCCCTCCCCCTCCACGGGGGGGACATCTCCCGGGTGTGGCGGGTGGGGCGGTTCGTGGTGAAGACGG
CCCAGGACCCCCCGCCCGGC

Product: low molecular weight phosphotyrosine protein phosphatase

Products: NA

Alternate protein names: PTPase [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MDRPVRVLFVCLGNICRSPMAEGIFRKLLKERGLEDRFEVDSAGTGAWHVGEPMDPRARRVLEEEGAYFPHVARRLTRED
VLAYDHILVMDRENLEEVLRRFPEARGKVRLVLEELGGGEVQDPYYGDLEDFREVYWTLEAALQAFLDRHGSPSPAAEGR
A

Sequences:

>Translated_161_residues
MDRPVRVLFVCLGNICRSPMAEGIFRKLLKERGLEDRFEVDSAGTGAWHVGEPMDPRARRVLEEEGAYFPHVARRLTRED
VLAYDHILVMDRENLEEVLRRFPEARGKVRLVLEELGGGEVQDPYYGDLEDFREVYWTLEAALQAFLDRHGSPSPAAEGR
A
>Mature_161_residues
MDRPVRVLFVCLGNICRSPMAEGIFRKLLKERGLEDRFEVDSAGTGAWHVGEPMDPRARRVLEEEGAYFPHVARRLTRED
VLAYDHILVMDRENLEEVLRRFPEARGKVRLVLEELGGGEVQDPYYGDLEDFREVYWTLEAALQAFLDRHGSPSPAAEGR
A

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=149, Percent_Identity=39.5973154362416, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI6005988, Length=149, Percent_Identity=39.5973154362416, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI96304457, Length=75, Percent_Identity=45.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1788375, Length=135, Percent_Identity=39.2592592592593, Blast_Score=80, Evalue=5e-17,
Organism=Escherichia coli, GI87081812, Length=144, Percent_Identity=38.1944444444444, Blast_Score=75, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325330, Length=157, Percent_Identity=35.031847133758, Blast_Score=104, Evalue=7e-24,
Organism=Drosophila melanogaster, GI78706766, Length=147, Percent_Identity=37.4149659863946, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI78706768, Length=147, Percent_Identity=37.4149659863946, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI78706764, Length=125, Percent_Identity=39.2, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI78711846, Length=156, Percent_Identity=33.974358974359, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI78706770, Length=148, Percent_Identity=37.8378378378378, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI78706772, Length=148, Percent_Identity=37.8378378378378, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648069, Length=150, Percent_Identity=32.6666666666667, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 18441; Mature: 18441

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRPVRVLFVCLGNICRSPMAEGIFRKLLKERGLEDRFEVDSAGTGAWHVGEPMDPRARR
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCHHHHH
VLEEEGAYFPHVARRLTREDVLAYDHILVMDRENLEEVLRRFPEARGKVRLVLEELGGGE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
VQDPYYGDLEDFREVYWTLEAALQAFLDRHGSPSPAAEGRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDRPVRVLFVCLGNICRSPMAEGIFRKLLKERGLEDRFEVDSAGTGAWHVGEPMDPRARR
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCHHHHH
VLEEEGAYFPHVARRLTREDVLAYDHILVMDRENLEEVLRRFPEARGKVRLVLEELGGGE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
VQDPYYGDLEDFREVYWTLEAALQAFLDRHGSPSPAAEGRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]