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The map label for this gene is murC [H]

Identifier: 55981054

GI number: 55981054

Start: 1032123

End: 1033463

Strand: Direct

Name: murC [H]

Synonym: TTHA1085

Alternate gene names: 55981054

Gene position: 1032123-1033463 (Clockwise)

Preceding gene: 55981053

Following gene: 55981055

Centisome position: 55.8

GC content: 74.05

Gene sequence:

>1341_bases
ATGAGAAAGGCGCACATCATGGGCATTGAAGGCGTGGGCATGAGCGCCCTCGCCCGGCTCCTCATGGCGGAAGGGGTGGC
GGTGACGGGGTGCGACCTCGCCCCAGGCCCTAGGGCAAGGCGGCTCGGAGTTCCCGTGCACCACGGGCACGACCCCGGCC
ACCTCGCCGACGAGGACACCCTGGTGGTCCCCACCCCCGTGCCCCCGGACCACCCCGAGGTGGTGGAGGCCCGGAAGAGG
GGCCTTAGGGTCCTCCGCAGGATGGAGCTCCTCGCCCACTTCCTCGCGCAAAGGCCCTCCGCGGGCGTGACCGGCACCCA
CGGCAAGACCACCACCACGGGGATGCTCGCGGCCATCCTCCTGGAGGCGGGCCTGGACCCCTGGGTCTTCCTGGGGGGGG
AGCTCGCCCTCCTCCCCGGCAACGCCCGCCCCGGCCGGGGGCCCCGGGTGGCCGAGGTGGACGAGTCGGACCCCCTCTTC
CGGGAGGTCCGGGTGAGCGTCGCCGTGGCCACCAACCTGGAGGCGGACCACGTGGCCCCCCGGGGGGAGCGGGCCCCCAA
CTACCACGAAAGCCTCGAGGCCCTAAAGGAGGCCATGCGGGGCTTCCTCGCGGGCGCAAAGACCGTTGTGGTCCCCGCAA
TGGACCCGGGCCTCCTCGCCCTCACCGAGGGGCTTCCCCGGAGGCTCTTCGGCCCCGGGGGGGAGGTCTGGGCGGAGGCG
GTGGACCTAAGCCCCTCCGGGGCCTCCTTCCGCCTCGTCCACCGGGAAGGCCCCCTGGGGGAGGTCCACCTGCGGGTGCC
GGGGAGGCACAACGTCCACAACGCCCTCGCCGCCGCCCTCGCCGCCCTGGCCCTGGGGGCGTCCCCGGAGGCCATCTCCC
GGGGGCTTTCCCGCTTCCCCGGCGTGGGGCGGCGGTTTGAGCGGGTGGGGGAGGTGGGCGGGGCCTGGGTGGTGGACGAC
TACGCCCACCACCCCACCGAGGTCCAGGCCACCCTGGAGGCGGCCCTCCTCTCCGGGCGGCGGGTCCGCGTCTTCTTCCA
GCCCCACCGCCTCCTCCGCACCCAGGAGCTCTGGGAGGCCTTCGCCCAGGCCCTCAAGGGGGCCCACGAGGTGGTGGTCC
TGCCCGTCTACACCGCGGGAGAGCGGGGCCGGGAAAGCCCCGAGGCCCTCTCCGACCGCATCGCAAAGAGGCTTGAGGAC
CTGGGCCGGCCCGCGCGCCGCATGGACAAGGAAGAGGCCCTGGCCTACGCCCGCGCCACGGCAAGGCCCGAGGACCTCCT
CCTCTTCATGGGGGCCGGGGACGTGACCCTTCTCGCGCGGAGGCTCGTCCATGAGGGTTGA

Upstream 100 bases:

>100_bases
TCGAGGCCCTGGAGGACCTGGAGGCGCGCCGAAGGGCCATGGCCCGCCTCTCCCCCGAGGGGGCGGCGGCGCGCCTCGCC
GACCTTCTGGAGGCGTTCCT

Downstream 100 bases:

>100_bases
ACGGGTGCTGCTCAAGGACTACACCACCCTGGGGGTAGGGGGGCCGGCGGAGCTTTGGACCGTGGAGACCCGGGAGGAGC
TCAAGCGGGCCACCGAGGCC

Product: UDP-N-acetylmuramate--alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MRKAHIMGIEGVGMSALARLLMAEGVAVTGCDLAPGPRARRLGVPVHHGHDPGHLADEDTLVVPTPVPPDHPEVVEARKR
GLRVLRRMELLAHFLAQRPSAGVTGTHGKTTTTGMLAAILLEAGLDPWVFLGGELALLPGNARPGRGPRVAEVDESDPLF
REVRVSVAVATNLEADHVAPRGERAPNYHESLEALKEAMRGFLAGAKTVVVPAMDPGLLALTEGLPRRLFGPGGEVWAEA
VDLSPSGASFRLVHREGPLGEVHLRVPGRHNVHNALAAALAALALGASPEAISRGLSRFPGVGRRFERVGEVGGAWVVDD
YAHHPTEVQATLEAALLSGRRVRVFFQPHRLLRTQELWEAFAQALKGAHEVVVLPVYTAGERGRESPEALSDRIAKRLED
LGRPARRMDKEEALAYARATARPEDLLLFMGAGDVTLLARRLVHEG

Sequences:

>Translated_446_residues
MRKAHIMGIEGVGMSALARLLMAEGVAVTGCDLAPGPRARRLGVPVHHGHDPGHLADEDTLVVPTPVPPDHPEVVEARKR
GLRVLRRMELLAHFLAQRPSAGVTGTHGKTTTTGMLAAILLEAGLDPWVFLGGELALLPGNARPGRGPRVAEVDESDPLF
REVRVSVAVATNLEADHVAPRGERAPNYHESLEALKEAMRGFLAGAKTVVVPAMDPGLLALTEGLPRRLFGPGGEVWAEA
VDLSPSGASFRLVHREGPLGEVHLRVPGRHNVHNALAAALAALALGASPEAISRGLSRFPGVGRRFERVGEVGGAWVVDD
YAHHPTEVQATLEAALLSGRRVRVFFQPHRLLRTQELWEAFAQALKGAHEVVVLPVYTAGERGRESPEALSDRIAKRLED
LGRPARRMDKEEALAYARATARPEDLLLFMGAGDVTLLARRLVHEG
>Mature_446_residues
MRKAHIMGIEGVGMSALARLLMAEGVAVTGCDLAPGPRARRLGVPVHHGHDPGHLADEDTLVVPTPVPPDHPEVVEARKR
GLRVLRRMELLAHFLAQRPSAGVTGTHGKTTTTGMLAAILLEAGLDPWVFLGGELALLPGNARPGRGPRVAEVDESDPLF
REVRVSVAVATNLEADHVAPRGERAPNYHESLEALKEAMRGFLAGAKTVVVPAMDPGLLALTEGLPRRLFGPGGEVWAEA
VDLSPSGASFRLVHREGPLGEVHLRVPGRHNVHNALAAALAALALGASPEAISRGLSRFPGVGRRFERVGEVGGAWVVDD
YAHHPTEVQATLEAALLSGRRVRVFFQPHRLLRTQELWEAFAQALKGAHEVVVLPVYTAGERGRESPEALSDRIAKRLED
LGRPARRMDKEEALAYARATARPEDLLLFMGAGDVTLLARRLVHEG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=467, Percent_Identity=35.5460385438972, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1790680, Length=472, Percent_Identity=28.1779661016949, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 47916; Mature: 47916

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAHIMGIEGVGMSALARLLMAEGVAVTGCDLAPGPRARRLGVPVHHGHDPGHLADEDT
CCCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LVVPTPVPPDHPEVVEARKRGLRVLRRMELLAHFLAQRPSAGVTGTHGKTTTTGMLAAIL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
LEAGLDPWVFLGGELALLPGNARPGRGPRVAEVDESDPLFREVRVSVAVATNLEADHVAP
HHCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHEEEEEEECCCHHCCCC
RGERAPNYHESLEALKEAMRGFLAGAKTVVVPAMDPGLLALTEGLPRRLFGPGGEVWAEA
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCHHHCCCCHHHHHHH
VDLSPSGASFRLVHREGPLGEVHLRVPGRHNVHNALAAALAALALGASPEAISRGLSRFP
HCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
GVGRRFERVGEVGGAWVVDDYAHHPTEVQATLEAALLSGRRVRVFFQPHRLLRTQELWEA
CCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHH
FAQALKGAHEVVVLPVYTAGERGRESPEALSDRIAKRLEDLGRPARRMDKEEALAYARAT
HHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHC
ARPEDLLLFMGAGDVTLLARRLVHEG
CCCCCEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MRKAHIMGIEGVGMSALARLLMAEGVAVTGCDLAPGPRARRLGVPVHHGHDPGHLADEDT
CCCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LVVPTPVPPDHPEVVEARKRGLRVLRRMELLAHFLAQRPSAGVTGTHGKTTTTGMLAAIL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
LEAGLDPWVFLGGELALLPGNARPGRGPRVAEVDESDPLFREVRVSVAVATNLEADHVAP
HHCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHEEEEEEECCCHHCCCC
RGERAPNYHESLEALKEAMRGFLAGAKTVVVPAMDPGLLALTEGLPRRLFGPGGEVWAEA
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCHHHCCCCHHHHHHH
VDLSPSGASFRLVHREGPLGEVHLRVPGRHNVHNALAAALAALALGASPEAISRGLSRFP
HCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
GVGRRFERVGEVGGAWVVDDYAHHPTEVQATLEAALLSGRRVRVFFQPHRLLRTQELWEA
CCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHH
FAQALKGAHEVVVLPVYTAGERGRESPEALSDRIAKRLEDLGRPARRMDKEEALAYARAT
HHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHC
ARPEDLLLFMGAGDVTLLARRLVHEG
CCCCCEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA