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The map label for this gene is ribBA [H]

Identifier: 55981031

GI number: 55981031

Start: 1008529

End: 1009728

Strand: Reverse

Name: ribBA [H]

Synonym: TTHA1062

Alternate gene names: 55981031

Gene position: 1009728-1008529 (Counterclockwise)

Preceding gene: 55981032

Following gene: 55981030

Centisome position: 54.59

GC content: 69.33

Gene sequence:

>1200_bases
ATGGAAGGGATCGCCAGCGTCAAGGAACTTCTGGAGGAGCTCAAGGCGGGCCGCCCCGTGATCTTGGTGGACGACGAGGA
CCGGGAGAACGAGGGCGACCTGATCATGGCGGCGGAGCACGTGACCCCGGAGTGGGTGAACTTCATGCTCAAGGAGTGCC
GGGGCCTCCTCTGCGTGGCCCTCACGGAGGAGAGGGCCAAGGCCCTGGACCTCCCCCTCATGGTGGAGAGGAACCAGGAC
CCCCAGGGCACCCGCTTCACCGTGAGCGTGGACGCCCGGGGGACGACCACGGGGATCAGCGCCTTTGAGCGGGCGGCCAC
CATCCGGCTCCTCGCCGACCCCGAGGCCACGGCCCAGGACTTCCGCCGCCCGGGGCACGTCTTTCCCCTGGTGGCGAGGC
CCGGGGGGGTCTTGCGCCGCGCCGGGCACACGGAGGCCACGGTGGACCTGTTGCGCCTCGCCGGCCTCACCCCGGTGGGC
AGCCTCATTGAGATCCTCAAGGAGGACGGCACCATGGCCCGCCTGCCCGACCTCCTGGCCTTCGCTAGGAGGCACGGCCT
CAAGGTGGGCACCATCGCCGACCTCATCCGCTACCGCCTGGAGAAGGGGGACCTCTACGTGCGGCGGGAGGCGGAGGCCC
TCCTTCCCACCCGCTTTGGGGAGTTCCGCATCCTGGGCTACCGCGACACCCTCACGGGGGAGGAGCACGCCGCCTTGGTC
ATGGGAAGCTGGGCGCCGGAGGAGCCCGTCCTCGTGCGCATGCACTCCGAGTGCCTCACCGGGGACGCCCTCCACTCCCT
GCGGTGCGACTGCGGCTTCCAGAGGGACCTGGCCCTACAGCGGATCGCCGAGGAGGGGAAGGGGGTCTTGGTCTACCTGA
GGCAGGAGGGGCGGGGGATCGGCCTCGTGAACAAGATCAAGGCCTACCACCTCCAGGACCAAGGGCTGGACACGGTGGAG
GCCAACCTGGCCCTGGGGTTTCCCCCGGACCTCCGGGACTACGGCGTGGGGGCCCAGATCCTCTACGACCTCGGGGTGCG
GAAGATGCGCCTCCTCACCAACAACCCGCGCAAGGTCCGGGCCCTCTCCGGCTTCGGCATAGAGATCGTGGAGCGCATCC
CCTTGAGGGCCGGGGACAACCCCCACAACGAGCGCTACCTCCAGGCCAAGAAGGAGAAGCTCGGGCACTGGATGGATTGA

Upstream 100 bases:

>100_bases
TCGAGGTGACCAACCTGGGGAGGCTTCGGGTGGGGGACGGGGTGAACCTCGAGGTGGACCTCATCGCCCGTTACGTGGCG
CGGCTTTTGGGGAGAGCGTG

Downstream 100 bases:

>100_bases
GGCCGCCTTGCGCGGGCGTGGAGGCCCCGGCGAAAGGTCTCCGGGAGGAGGAGGGTAGCATAGGGGCATGCTCCCCCTCA
GGGTCCTGGTCCTCCTCCTG

Product: GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MEGIASVKELLEELKAGRPVILVDDEDRENEGDLIMAAEHVTPEWVNFMLKECRGLLCVALTEERAKALDLPLMVERNQD
PQGTRFTVSVDARGTTTGISAFERAATIRLLADPEATAQDFRRPGHVFPLVARPGGVLRRAGHTEATVDLLRLAGLTPVG
SLIEILKEDGTMARLPDLLAFARRHGLKVGTIADLIRYRLEKGDLYVRREAEALLPTRFGEFRILGYRDTLTGEEHAALV
MGSWAPEEPVLVRMHSECLTGDALHSLRCDCGFQRDLALQRIAEEGKGVLVYLRQEGRGIGLVNKIKAYHLQDQGLDTVE
ANLALGFPPDLRDYGVGAQILYDLGVRKMRLLTNNPRKVRALSGFGIEIVERIPLRAGDNPHNERYLQAKKEKLGHWMD

Sequences:

>Translated_399_residues
MEGIASVKELLEELKAGRPVILVDDEDRENEGDLIMAAEHVTPEWVNFMLKECRGLLCVALTEERAKALDLPLMVERNQD
PQGTRFTVSVDARGTTTGISAFERAATIRLLADPEATAQDFRRPGHVFPLVARPGGVLRRAGHTEATVDLLRLAGLTPVG
SLIEILKEDGTMARLPDLLAFARRHGLKVGTIADLIRYRLEKGDLYVRREAEALLPTRFGEFRILGYRDTLTGEEHAALV
MGSWAPEEPVLVRMHSECLTGDALHSLRCDCGFQRDLALQRIAEEGKGVLVYLRQEGRGIGLVNKIKAYHLQDQGLDTVE
ANLALGFPPDLRDYGVGAQILYDLGVRKMRLLTNNPRKVRALSGFGIEIVERIPLRAGDNPHNERYLQAKKEKLGHWMD
>Mature_399_residues
MEGIASVKELLEELKAGRPVILVDDEDRENEGDLIMAAEHVTPEWVNFMLKECRGLLCVALTEERAKALDLPLMVERNQD
PQGTRFTVSVDARGTTTGISAFERAATIRLLADPEATAQDFRRPGHVFPLVARPGGVLRRAGHTEATVDLLRLAGLTPVG
SLIEILKEDGTMARLPDLLAFARRHGLKVGTIADLIRYRLEKGDLYVRREAEALLPTRFGEFRILGYRDTLTGEEHAALV
MGSWAPEEPVLVRMHSECLTGDALHSLRCDCGFQRDLALQRIAEEGKGVLVYLRQEGRGIGLVNKIKAYHLQDQGLDTVE
ANLALGFPPDLRDYGVGAQILYDLGVRKMRLLTNNPRKVRALSGFGIEIVERIPLRAGDNPHNERYLQAKKEKLGHWMD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=58.4615384615385, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1789420, Length=194, Percent_Identity=50, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=201, Percent_Identity=46.2686567164179, Blast_Score=175, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6319438, Length=191, Percent_Identity=45.0261780104712, Blast_Score=142, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44433; Mature: 44433

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGIASVKELLEELKAGRPVILVDDEDRENEGDLIMAAEHVTPEWVNFMLKECRGLLCVA
CCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
LTEERAKALDLPLMVERNQDPQGTRFTVSVDARGTTTGISAFERAATIRLLADPEATAQD
EEHHHHHHCCCCEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHEEEEEEECCCHHHHH
FRRPGHVFPLVARPGGVLRRAGHTEATVDLLRLAGLTPVGSLIEILKEDGTMARLPDLLA
HCCCCCEEEEEECCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
FARRHGLKVGTIADLIRYRLEKGDLYVRREAEALLPTRFGEFRILGYRDTLTGEEHAALV
HHHHCCCEEHHHHHHHHHHHCCCCEEEEECHHHHCCCCCCCEEEEEECCCCCCCCCEEEE
MGSWAPEEPVLVRMHSECLTGDALHSLRCDCGFQRDLALQRIAEEGKGVLVYLRQEGRGI
EECCCCCCCEEEEECHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCC
GLVNKIKAYHLQDQGLDTVEANLALGFPPDLRDYGVGAQILYDLGVRKMRLLTNNPRKVR
CHHHHHHHEEECCCCCCEEECCEEECCCCCHHHCCCCHHHHHHHCHHHEEHHCCCCCEEE
ALSGFGIEIVERIPLRAGDNPHNERYLQAKKEKLGHWMD
EECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEGIASVKELLEELKAGRPVILVDDEDRENEGDLIMAAEHVTPEWVNFMLKECRGLLCVA
CCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
LTEERAKALDLPLMVERNQDPQGTRFTVSVDARGTTTGISAFERAATIRLLADPEATAQD
EEHHHHHHCCCCEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHEEEEEEECCCHHHHH
FRRPGHVFPLVARPGGVLRRAGHTEATVDLLRLAGLTPVGSLIEILKEDGTMARLPDLLA
HCCCCCEEEEEECCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
FARRHGLKVGTIADLIRYRLEKGDLYVRREAEALLPTRFGEFRILGYRDTLTGEEHAALV
HHHHCCCEEHHHHHHHHHHHCCCCEEEEECHHHHCCCCCCCEEEEEECCCCCCCCCEEEE
MGSWAPEEPVLVRMHSECLTGDALHSLRCDCGFQRDLALQRIAEEGKGVLVYLRQEGRGI
EECCCCCCCEEEEECHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCC
GLVNKIKAYHLQDQGLDTVEANLALGFPPDLRDYGVGAQILYDLGVRKMRLLTNNPRKVR
CHHHHHHHEEECCCCCCEEECCEEECCCCCHHHCCCCHHHHHHHCHHHEEHHCCCCCEEE
ALSGFGIEIVERIPLRAGDNPHNERYLQAKKEKLGHWMD
EECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA