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The map label for this gene is lysS

Identifier: 55981010

GI number: 55981010

Start: 987915

End: 989393

Strand: Reverse

Name: lysS

Synonym: TTHA1041

Alternate gene names: 55981010

Gene position: 989393-987915 (Counterclockwise)

Preceding gene: 55981011

Following gene: 55981009

Centisome position: 53.49

GC content: 65.92

Gene sequence:

>1479_bases
ATGAACGACCAGACCCGCCAGCGCCTGCTCAACCTGGAAGCCTTGGTGGAGGCGGGGTTTGCCCCCTACCCCTACCGCTT
CCCCAAGACCCACAGCGCCGAGGCCATCCTCAAGGCCAAGCGGGGCGCCCCCCCTGAGTCCGAGTGGCCGGAGGAGGAGG
TGGCCGTGGCCGGGCGCCTCGTGGCCTTGAGGCGCATGGGCAAGGTGACCTTCGCCCACCTCCTGGACGAGACGGGAAGG
ATCCAGCTCTACTTCCAGAGGGACCTCACGCCCAAATACGAGCTCCTCAAGAAGCTGGACGTGGGGGACATCCTGGGGGT
GAGGGGGCACCCCTTCACCACCAAGACGGGGGAGGTGACGGTCAAGGTCCTGGACTGGACGCCCCTGGTCAAGAGCCTCC
ACCCCCTCCCCGACAAGTGGCACGGCCTCCGGGACAAGGAGGTCCGCTACCGCCAGCGCTATCTGGACCTCATCGTCAAC
CCCGAGGTGCGGGAGGTCTTCCGCCGCCGCTCGGAGATCGTCCGCTACATCCGGCGCTTCTTTGAGGCCAAGGGGTTTTT
GGAGGTGGAGACCCCCATCCTCCAGCCCACCACGGGCGGGGCGGAGGCCAGGCCCTTCAAGACCTACCACAACGCCCTAG
ACCACGAGTTCTACCTCCGCATCTCCTTGGAGCTCTACCTCAAGCGCCTCCTCGTCGGGGGGTACGAGAAGGTCTTTGAG
ATCGGGCGCAACTTCCGCAACGAGGGCATTGACCACAACCACAACCCCGAGTTCACCATGCTGGAGGCCTACTGGGCCTA
CGCCGACTACCAGGACATGGCGGGCCTGGTGGAGGAGCTCCTTTCGGGCCTCGTCCTCCACCTCTTCGGGAGCCACGAGG
TCCCCTACCAAGGGCGGGTGCTGAACTTCAAGCCGCCCTTCAGGCGCATCTCCTTCGTGGAGGCCCTGAAGGAGAAGGCG
GGCCTTCCCTTTGACCCCCTGGACCTGGAGCGCCTAAGGCTTTGGGCCGACGCCCACCACCCCGAGCTTTCCCAGGTGCC
GAACTACAAGCTTCTGGACAAGCTTTTCGGCATCTACGTGGAGCCCGAGCTCCAGGACCCCACCTTTGTCTTTGACTTCC
CCCTGGCCATCAGCCCCCTGGCCAAAAGGCACCGGGAGAAGCCGGGCCTCGTGGAGCGCTGGGACCTCTACGCCGGGGGG
ATGGAGCTTGCTCCCTGTTACTCCGAGCTCAACGACCCCTTGGACCAAAGGGAGCGCTTCCTGGAGCAGGCGAGGCGCCG
CAAGGAGGGGGACGAGGAGGCCCCCGAGCCCGACGAGGACTTCCTCCTGGCCCTGGAGTACGGGATGCCCCCGGCGGCGG
GGCTGGGCCTCGGGATAGACCGCCTCGCCATGCTCCTCACCGACCAGCCCTCTCTAAGGGACGTCCTCCTCTTCCCCCTC
CTCAAGCCCAAGAAGGAGGCGGTGGAAGAAGGGGTCTAA

Upstream 100 bases:

>100_bases
GGCAAGGCCCTTTTGGGCCACCGGGTGGGGGACGTGCTCTCCCTGGACACCCCCAAGGGCAGGCGGGAGTTCCGGGTGGT
GGCCATCCACGGTTGAGGCC

Downstream 100 bases:

>100_bases
ATGGCCGAAGGCGCCGCCCGGTTGAGCCTCGCCGTCGCCCTCCTCGTGTTGGGGCTCAAGGCCCTCGCCTACCTTCTCAC
GGGCTCGGTGGCCCTGCTCT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MNDQTRQRLLNLEALVEAGFAPYPYRFPKTHSAEAILKAKRGAPPESEWPEEEVAVAGRLVALRRMGKVTFAHLLDETGR
IQLYFQRDLTPKYELLKKLDVGDILGVRGHPFTTKTGEVTVKVLDWTPLVKSLHPLPDKWHGLRDKEVRYRQRYLDLIVN
PEVREVFRRRSEIVRYIRRFFEAKGFLEVETPILQPTTGGAEARPFKTYHNALDHEFYLRISLELYLKRLLVGGYEKVFE
IGRNFRNEGIDHNHNPEFTMLEAYWAYADYQDMAGLVEELLSGLVLHLFGSHEVPYQGRVLNFKPPFRRISFVEALKEKA
GLPFDPLDLERLRLWADAHHPELSQVPNYKLLDKLFGIYVEPELQDPTFVFDFPLAISPLAKRHREKPGLVERWDLYAGG
MELAPCYSELNDPLDQRERFLEQARRRKEGDEEAPEPDEDFLLALEYGMPPAAGLGLGIDRLAMLLTDQPSLRDVLLFPL
LKPKKEAVEEGV

Sequences:

>Translated_492_residues
MNDQTRQRLLNLEALVEAGFAPYPYRFPKTHSAEAILKAKRGAPPESEWPEEEVAVAGRLVALRRMGKVTFAHLLDETGR
IQLYFQRDLTPKYELLKKLDVGDILGVRGHPFTTKTGEVTVKVLDWTPLVKSLHPLPDKWHGLRDKEVRYRQRYLDLIVN
PEVREVFRRRSEIVRYIRRFFEAKGFLEVETPILQPTTGGAEARPFKTYHNALDHEFYLRISLELYLKRLLVGGYEKVFE
IGRNFRNEGIDHNHNPEFTMLEAYWAYADYQDMAGLVEELLSGLVLHLFGSHEVPYQGRVLNFKPPFRRISFVEALKEKA
GLPFDPLDLERLRLWADAHHPELSQVPNYKLLDKLFGIYVEPELQDPTFVFDFPLAISPLAKRHREKPGLVERWDLYAGG
MELAPCYSELNDPLDQRERFLEQARRRKEGDEEAPEPDEDFLLALEYGMPPAAGLGLGIDRLAMLLTDQPSLRDVLLFPL
LKPKKEAVEEGV
>Mature_492_residues
MNDQTRQRLLNLEALVEAGFAPYPYRFPKTHSAEAILKAKRGAPPESEWPEEEVAVAGRLVALRRMGKVTFAHLLDETGR
IQLYFQRDLTPKYELLKKLDVGDILGVRGHPFTTKTGEVTVKVLDWTPLVKSLHPLPDKWHGLRDKEVRYRQRYLDLIVN
PEVREVFRRRSEIVRYIRRFFEAKGFLEVETPILQPTTGGAEARPFKTYHNALDHEFYLRISLELYLKRLLVGGYEKVFE
IGRNFRNEGIDHNHNPEFTMLEAYWAYADYQDMAGLVEELLSGLVLHLFGSHEVPYQGRVLNFKPPFRRISFVEALKEKA
GLPFDPLDLERLRLWADAHHPELSQVPNYKLLDKLFGIYVEPELQDPTFVFDFPLAISPLAKRHREKPGLVERWDLYAGG
MELAPCYSELNDPLDQRERFLEQARRRKEGDEEAPEPDEDFLLALEYGMPPAAGLGLGIDRLAMLLTDQPSLRDVLLFPL
LKPKKEAVEEGV

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=509, Percent_Identity=44.2043222003929, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI194272210, Length=509, Percent_Identity=44.2043222003929, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI45439306, Length=354, Percent_Identity=25.9887005649718, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI40789249, Length=244, Percent_Identity=26.6393442622951, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790571, Length=494, Percent_Identity=46.7611336032389, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1789256, Length=493, Percent_Identity=46.4503042596349, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI87082379, Length=324, Percent_Identity=34.5679012345679, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788173, Length=248, Percent_Identity=27.0161290322581, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17535925, Length=499, Percent_Identity=43.0861723446894, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17535927, Length=499, Percent_Identity=43.0861723446894, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71994340, Length=499, Percent_Identity=43.0861723446894, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17551876, Length=346, Percent_Identity=26.0115606936416, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32566633, Length=279, Percent_Identity=27.2401433691756, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320242, Length=491, Percent_Identity=43.1771894093686, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324256, Length=479, Percent_Identity=29.8538622129436, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323011, Length=353, Percent_Identity=26.628895184136, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325153, Length=231, Percent_Identity=29.4372294372294, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24640849, Length=484, Percent_Identity=44.2148760330579, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24640851, Length=484, Percent_Identity=44.2148760330579, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24584738, Length=289, Percent_Identity=30.1038062283737, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_THET2 (Q72JT9)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_004654.1
- HSSP:   P0A8N3
- ProteinModelPortal:   Q72JT9
- SMR:   Q72JT9
- STRING:   Q72JT9
- GeneID:   2776391
- GenomeReviews:   AE017221_GR
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   GHPQMMS
- PhylomeDB:   Q72JT9
- ProtClustDB:   PRK00484
- BioCyc:   TTHE262724:TT_C0679-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 56922; Mature: 56922

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDQTRQRLLNLEALVEAGFAPYPYRFPKTHSAEAILKAKRGAPPESEWPEEEVAVAGRL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VALRRMGKVTFAHLLDETGRIQLYFQRDLTPKYELLKKLDVGDILGVRGHPFTTKTGEVT
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
VKVLDWTPLVKSLHPLPDKWHGLRDKEVRYRQRYLDLIVNPEVREVFRRRSEIVRYIRRF
EEEECCCHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FEAKGFLEVETPILQPTTGGAEARPFKTYHNALDHEFYLRISLELYLKRLLVGGYEKVFE
HHCCCCEEECCCEECCCCCCCCCCCHHHHHHHCCCEEEEEEEHHHHHHHHHHCCHHHHHH
IGRNFRNEGIDHNHNPEFTMLEAYWAYADYQDMAGLVEELLSGLVLHLFGSHEVPYQGRV
HHHHHHHCCCCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LNFKPPFRRISFVEALKEKAGLPFDPLDLERLRLWADAHHPELSQVPNYKLLDKLFGIYV
ECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHCEEE
EPELQDPTFVFDFPLAISPLAKRHREKPGLVERWDLYAGGMELAPCYSELNDPLDQRERF
CCCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
LEQARRRKEGDEEAPEPDEDFLLALEYGMPPAAGLGLGIDRLAMLLTDQPSLRDVLLFPL
HHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHC
LKPKKEAVEEGV
CCCHHHHHHCCC
>Mature Secondary Structure
MNDQTRQRLLNLEALVEAGFAPYPYRFPKTHSAEAILKAKRGAPPESEWPEEEVAVAGRL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VALRRMGKVTFAHLLDETGRIQLYFQRDLTPKYELLKKLDVGDILGVRGHPFTTKTGEVT
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
VKVLDWTPLVKSLHPLPDKWHGLRDKEVRYRQRYLDLIVNPEVREVFRRRSEIVRYIRRF
EEEECCCHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FEAKGFLEVETPILQPTTGGAEARPFKTYHNALDHEFYLRISLELYLKRLLVGGYEKVFE
HHCCCCEEECCCEECCCCCCCCCCCHHHHHHHCCCEEEEEEEHHHHHHHHHHCCHHHHHH
IGRNFRNEGIDHNHNPEFTMLEAYWAYADYQDMAGLVEELLSGLVLHLFGSHEVPYQGRV
HHHHHHHCCCCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LNFKPPFRRISFVEALKEKAGLPFDPLDLERLRLWADAHHPELSQVPNYKLLDKLFGIYV
ECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHCEEE
EPELQDPTFVFDFPLAISPLAKRHREKPGLVERWDLYAGGMELAPCYSELNDPLDQRERF
CCCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
LEQARRRKEGDEEAPEPDEDFLLALEYGMPPAAGLGLGIDRLAMLLTDQPSLRDVLLFPL
HHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHC
LKPKKEAVEEGV
CCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA