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The map label for this gene is cutS [H]

Identifier: 55980972

GI number: 55980972

Start: 948980

End: 950197

Strand: Direct

Name: cutS [H]

Synonym: TTHA1003

Alternate gene names: 55980972

Gene position: 948980-950197 (Clockwise)

Preceding gene: 55980971

Following gene: 55980973

Centisome position: 51.3

GC content: 72.09

Gene sequence:

>1218_bases
ATGAGCCTTAAGGCGCGGCTCGCCCTCTTCTTCGCCCTTTCCATCGGGCTCGCCCTCTTCTTCCAAGGGGCCTTGAGCTA
CGTGGCCTTCAAAGGGCTCATAGAGGCCGACCTGGACCGCTCCCTCCTCTTCTACGCCCGCGCCCTCGCCGAGGGACGGC
CTGGCCCCAGGGGCGAGTTCGCCTTCCGCCTGGTCCAAGGCGGGACAAGGACCCAAAGCCCCGGCTTCCCCGACCTACCC
CCCCTTGCCCCGGGGCGGTACTGGAAGGAGGGGTGGCGGGTCTGGGTCATGGAGGCGCCTGGGGGCACCCTCACCCTGGC
CCGGTACGAGCCTGAGGCCCTCCTGGCCCTCTCCCGCTTCCGCCTGGTCCTCTTCGCCTCGGGAGCGGCCCTCACCCTGG
CCTTTGCCCTCCTCGCCGGGCACCTCGCCGGGGTGGCCTTGAGGCCCCTCTCCCGCCTCACGGAGGTGGCGCGGCGGGTG
GCCGACTCCCAGGACCTCTCCCAGCGGGTGCCCCCCGAGGGAGGCGGGGAGCTCAAGACCCTGGCCGAGGCCTTCAACCA
CATGCTGGAGCGCCTCGAGGCCTTCCTGGAGCGGGAAAAGCGCTTCACCCGGGACGCGGCCCACGAGCTCAGGACCCCGG
TGGCCGCCGCTTTGGCCCAGCTGGAGGCGGCGGAAGGGGGCTACCTGTCCGAGGGCGAGGCCCTTCAGGCGACGAAGGAG
GAACTCCTCCGCATGAAGCGCCTGGTGGAGGCCCTCCTCGTCCTGGCGAGGGAAGGCCGGGTGACGCCCGTGCCCTTGGA
CCTTGCCGCCCTCGCCCGGGAGGAGGCCAGGGCCTTCGGGGTGCCCTACCGGGGGCCCGAAACCCTCCCCTACGAGGGCG
ACCCCCTCCTCCTCGCCCAGGCCCTGCGGAACCTCCTCAGAAACGCGTTCCTCCACGGGGAGGGAAAGGGAGTGGAGGTG
CGGCTTTCCCAGGAGGGGGAGGACCTCGTCCTGGAGGTGAGGGACGAGGGCCCGGGGATGCCCGAGGAGGCCCTGAAGGA
GGCGGGCAGGCCCTTTTTCCGGGCCTCCCCCAAACCCGGGGAGGGCCTGGGCCTCTCCGTGGCCAAGAAGGTGGCCGAGG
CCCACGGGGGTGCCCTCGTCCTCGTTCCCCGCAAGCCCACCGGGCTCACGGCCCGCCTCCTCCTGCCGGCTAACCCCCGG
CTAACGGGGACGCCCTAG

Upstream 100 bases:

>100_bases
CCCGAGAAGGTGGGGGCGGTGAAGGTCTACGTCCACTACCTCCGGCAGAAGCTCTTCCCCGAGGTGGTGCGCACCGTGCC
CGGAGGGTACCGGCTCGGCC

Downstream 100 bases:

>100_bases
CCTTGGGCAGCGAGGAGGTGGTCGTTTGCGCAAGGTGTGGTGGATCCTTTTCCTCTCGTCCGCCCTGGCCCAGGGCGCGG
AACTGGCCTCTTGGGTGCGG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSLKARLALFFALSIGLALFFQGALSYVAFKGLIEADLDRSLLFYARALAEGRPGPRGEFAFRLVQGGTRTQSPGFPDLP
PLAPGRYWKEGWRVWVMEAPGGTLTLARYEPEALLALSRFRLVLFASGAALTLAFALLAGHLAGVALRPLSRLTEVARRV
ADSQDLSQRVPPEGGGELKTLAEAFNHMLERLEAFLEREKRFTRDAAHELRTPVAAALAQLEAAEGGYLSEGEALQATKE
ELLRMKRLVEALLVLAREGRVTPVPLDLAALAREEARAFGVPYRGPETLPYEGDPLLLAQALRNLLRNAFLHGEGKGVEV
RLSQEGEDLVLEVRDEGPGMPEEALKEAGRPFFRASPKPGEGLGLSVAKKVAEAHGGALVLVPRKPTGLTARLLLPANPR
LTGTP

Sequences:

>Translated_405_residues
MSLKARLALFFALSIGLALFFQGALSYVAFKGLIEADLDRSLLFYARALAEGRPGPRGEFAFRLVQGGTRTQSPGFPDLP
PLAPGRYWKEGWRVWVMEAPGGTLTLARYEPEALLALSRFRLVLFASGAALTLAFALLAGHLAGVALRPLSRLTEVARRV
ADSQDLSQRVPPEGGGELKTLAEAFNHMLERLEAFLEREKRFTRDAAHELRTPVAAALAQLEAAEGGYLSEGEALQATKE
ELLRMKRLVEALLVLAREGRVTPVPLDLAALAREEARAFGVPYRGPETLPYEGDPLLLAQALRNLLRNAFLHGEGKGVEV
RLSQEGEDLVLEVRDEGPGMPEEALKEAGRPFFRASPKPGEGLGLSVAKKVAEAHGGALVLVPRKPTGLTARLLLPANPR
LTGTP
>Mature_404_residues
SLKARLALFFALSIGLALFFQGALSYVAFKGLIEADLDRSLLFYARALAEGRPGPRGEFAFRLVQGGTRTQSPGFPDLPP
LAPGRYWKEGWRVWVMEAPGGTLTLARYEPEALLALSRFRLVLFASGAALTLAFALLAGHLAGVALRPLSRLTEVARRVA
DSQDLSQRVPPEGGGELKTLAEAFNHMLERLEAFLEREKRFTRDAAHELRTPVAAALAQLEAAEGGYLSEGEALQATKEE
LLRMKRLVEALLVLAREGRVTPVPLDLAALAREEARAFGVPYRGPETLPYEGDPLLLAQALRNLLRNAFLHGEGKGVEVR
LSQEGEDLVLEVRDEGPGMPEEALKEAGRPFFRASPKPGEGLGLSVAKKVAEAHGGALVLVPRKPTGLTARLLLPANPRL
TGTP

Specific function: Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=302, Percent_Identity=32.4503311258278, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790551, Length=260, Percent_Identity=30.3846153846154, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789403, Length=441, Percent_Identity=27.6643990929705, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788393, Length=270, Percent_Identity=27.4074074074074, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790861, Length=299, Percent_Identity=31.7725752508361, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789808, Length=288, Percent_Identity=28.125, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=293, Percent_Identity=29.0102389078498, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=253, Percent_Identity=28.0632411067194, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788279, Length=312, Percent_Identity=27.5641025641026, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=24.7491638795987, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790436, Length=206, Percent_Identity=29.6116504854369, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=269, Percent_Identity=29.368029739777, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=217, Percent_Identity=29.0322580645161, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43853; Mature: 43722

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKARLALFFALSIGLALFFQGALSYVAFKGLIEADLDRSLLFYARALAEGRPGPRGEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHH
AFRLVQGGTRTQSPGFPDLPPLAPGRYWKEGWRVWVMEAPGGTLTLARYEPEALLALSRF
EEHEECCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCEEEEEEECHHHHHHHHHH
RLVLFASGAALTLAFALLAGHLAGVALRPLSRLTEVARRVADSQDLSQRVPPEGGGELKT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHH
LAEAFNHMLERLEAFLEREKRFTRDAAHELRTPVAAALAQLEAAEGGYLSEGEALQATKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ELLRMKRLVEALLVLAREGRVTPVPLDLAALAREEARAFGVPYRGPETLPYEGDPLLLAQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
ALRNLLRNAFLHGEGKGVEVRLSQEGEDLVLEVRDEGPGMPEEALKEAGRPFFRASPKPG
HHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHCCCCCEECCCCCC
EGLGLSVAKKVAEAHGGALVLVPRKPTGLTARLLLPANPRLTGTP
CCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SLKARLALFFALSIGLALFFQGALSYVAFKGLIEADLDRSLLFYARALAEGRPGPRGEF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHH
AFRLVQGGTRTQSPGFPDLPPLAPGRYWKEGWRVWVMEAPGGTLTLARYEPEALLALSRF
EEHEECCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCEEEEEEECHHHHHHHHHH
RLVLFASGAALTLAFALLAGHLAGVALRPLSRLTEVARRVADSQDLSQRVPPEGGGELKT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHH
LAEAFNHMLERLEAFLEREKRFTRDAAHELRTPVAAALAQLEAAEGGYLSEGEALQATKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ELLRMKRLVEALLVLAREGRVTPVPLDLAALAREEARAFGVPYRGPETLPYEGDPLLLAQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
ALRNLLRNAFLHGEGKGVEVRLSQEGEDLVLEVRDEGPGMPEEALKEAGRPFFRASPKPG
HHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHCCCCCEECCCCCC
EGLGLSVAKKVAEAHGGALVLVPRKPTGLTARLLLPANPRLTGTP
CCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]