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The map label for this gene is 55980929

Identifier: 55980929

GI number: 55980929

Start: 906268

End: 907713

Strand: Direct

Name: 55980929

Synonym: TTHA0960

Alternate gene names: NA

Gene position: 906268-907713 (Clockwise)

Preceding gene: 55980928

Following gene: 55980930

Centisome position: 48.99

GC content: 66.87

Gene sequence:

>1446_bases
ATGGCAAGGACCGGAGCGGAGTACATCGAGGCCTTGAAGACCCGTCCCCCCAACCTCTGGTACAAGGGGGAGAAGGTGGA
GGACCCCACCACCCACCCCGTCTTCCGGGGGATCGTGCGCACCATGGCCGCCCTCTACGACCTGCAGCACGACCCCCGCT
ACCGGGAGGTCCTCACCTACGAGGAGGAGGGGAAGCGGCACGGGATGAGCTTCCTCATCCCCAAGACCAAGGAGGACCTG
AAGCGGAGGGGGCAGGCCTACAAGCTCTGGGCCGACCAGAACCTGGGGATGATGGGGCGGAGCCCCGACTACCTCAACGC
CGTGGTCATGGCCTACGCGGCGAGCGCGGACTACTTCGGAGAGTTCGCCGAGAACGTCCGGAACTACTACCGGTACCTCC
GGGACCAGGACCTCGCCACCACCCACGCCCTCACCAACCCCCAGGTGAACCGGGCGAGGCCTCCCTCGGGCCAGCCCGAC
CCCTACATCCCCGTGGGGGTGGTGAAGCAGACGGAGAAGGGGATCGTGGTCCGGGGGGCCCGGATGACGGCCACCTTCCC
CCTGGCGGACGAGGTCCTCATCTTCCCCTCCACCCTCCTCCAGGCGGGAAGCGAGAAGTACGCCCTGGCCTTCGCCCTTC
CCACCTCCACCCCGGGCCTCCACTTCGTCTGCCGGGAGGCCCTGGTGGGCGGGGACAGCCCCTTTGACCACCCCCTCTCC
AGCCGGGTGGAGGAGATGGACTGCCTGGTGATCTTTGACGACGTCCTCGTCCCCTGGGAGAGGGTCTTCATCCTGGGGAA
CGTGGAGCTCTGCAACAACGCCTACGCGGCCACGGGCGCCCTGAACCACATGGCCCACCAGGTGGTGGCCCTGAAGACGG
CGAAGACCGAGGCCTTCCTTGGGGTGGCGGCCCTCATGGCCGAGGGCATCGGGGCGGACGTCTACGGCCACGTGCAGGAG
AAGATCGCCGAGATCATCGTCTACCTCGAGGCCATGCGCGCCTTCTGGACGAGGGCGGAGGAGGAGGCCAAGGAGAACGC
CTACGGCCTCTTGGTCCCGGACCGGGGCGCCTTGGACGGGGCCAGGAACCTCTACCCGAGGCTTTACCCCAGGATCCGGG
AGATCCTTGAGCAGATCGGGGCTTCCGGCCTCATCACCCTCCCCTCGGAGAAGGACTTCAAGGGGCCCCTCGGCCCCTTC
CTGGAGAAGTTCCTCCAGGGGGCGGCCCTCGAGGCCAAGGAGCGGGTGGCCCTCTTCCGCCTGGCCTGGGACATGACCCT
CTCCGGCTTCGGGGCGAGGCAGGAGCTCTACGAGCGCTTCTTCTTCGGCGACCCCGTGCGCATGTACCAGACCCTCTACA
ACGTCTACAACAAGGAGCCCTACAAGGAGAGGATCCGCGCTTTCCTCAAGGAAAGCCTCAAGGTCTTTGAGGAGGTCCAG
GCGTGA

Upstream 100 bases:

>100_bases
CGGCACCTATGCCCTGGACTTCTACACCGACCTCAAGACCATCGCCCTTCCCCTCCGCCCCCCGCACGTGCCCAAGTTCG
GGAAGTAAGGGAGGTAGCCC

Downstream 100 bases:

>100_bases
AAGAGGCCTTCAAGGAGGCCCTCGCCCGCTTCGCCAGCGGGGTCACGGTGGTGGCGGCCAGGCTTGGGGAGGAGGAAAGG
GGGATGACGGCCACCGCCTT

Product: 4-hydroxyphenylacetate-3-hydroxylase

Products: NA

Alternate protein names: 4-HPA 3-hydroxylase; 4-HPA 3-monooxygenase large component

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MARTGAEYIEALKTRPPNLWYKGEKVEDPTTHPVFRGIVRTMAALYDLQHDPRYREVLTYEEEGKRHGMSFLIPKTKEDL
KRRGQAYKLWADQNLGMMGRSPDYLNAVVMAYAASADYFGEFAENVRNYYRYLRDQDLATTHALTNPQVNRARPPSGQPD
PYIPVGVVKQTEKGIVVRGARMTATFPLADEVLIFPSTLLQAGSEKYALAFALPTSTPGLHFVCREALVGGDSPFDHPLS
SRVEEMDCLVIFDDVLVPWERVFILGNVELCNNAYAATGALNHMAHQVVALKTAKTEAFLGVAALMAEGIGADVYGHVQE
KIAEIIVYLEAMRAFWTRAEEEAKENAYGLLVPDRGALDGARNLYPRLYPRIREILEQIGASGLITLPSEKDFKGPLGPF
LEKFLQGAALEAKERVALFRLAWDMTLSGFGARQELYERFFFGDPVRMYQTLYNVYNKEPYKERIRAFLKESLKVFEEVQ
A

Sequences:

>Translated_481_residues
MARTGAEYIEALKTRPPNLWYKGEKVEDPTTHPVFRGIVRTMAALYDLQHDPRYREVLTYEEEGKRHGMSFLIPKTKEDL
KRRGQAYKLWADQNLGMMGRSPDYLNAVVMAYAASADYFGEFAENVRNYYRYLRDQDLATTHALTNPQVNRARPPSGQPD
PYIPVGVVKQTEKGIVVRGARMTATFPLADEVLIFPSTLLQAGSEKYALAFALPTSTPGLHFVCREALVGGDSPFDHPLS
SRVEEMDCLVIFDDVLVPWERVFILGNVELCNNAYAATGALNHMAHQVVALKTAKTEAFLGVAALMAEGIGADVYGHVQE
KIAEIIVYLEAMRAFWTRAEEEAKENAYGLLVPDRGALDGARNLYPRLYPRIREILEQIGASGLITLPSEKDFKGPLGPF
LEKFLQGAALEAKERVALFRLAWDMTLSGFGARQELYERFFFGDPVRMYQTLYNVYNKEPYKERIRAFLKESLKVFEEVQ
A
>Mature_480_residues
ARTGAEYIEALKTRPPNLWYKGEKVEDPTTHPVFRGIVRTMAALYDLQHDPRYREVLTYEEEGKRHGMSFLIPKTKEDLK
RRGQAYKLWADQNLGMMGRSPDYLNAVVMAYAASADYFGEFAENVRNYYRYLRDQDLATTHALTNPQVNRARPPSGQPDP
YIPVGVVKQTEKGIVVRGARMTATFPLADEVLIFPSTLLQAGSEKYALAFALPTSTPGLHFVCREALVGGDSPFDHPLSS
RVEEMDCLVIFDDVLVPWERVFILGNVELCNNAYAATGALNHMAHQVVALKTAKTEAFLGVAALMAEGIGADVYGHVQEK
IAEIIVYLEAMRAFWTRAEEEAKENAYGLLVPDRGALDGARNLYPRLYPRIREILEQIGASGLITLPSEKDFKGPLGPFL
EKFLQGAALEAKERVALFRLAWDMTLSGFGARQELYERFFFGDPVRMYQTLYNVYNKEPYKERIRAFLKESLKVFEEVQA

Specific function: Utilizes FADH(2) supplied by hpaC, to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3,4-dihydroxyphenylacetic acid (DHPA)

COG id: COG2368

COG function: function code Q; Aromatic ring hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPAB_THET8 (Q5SJP8)

Other databases:

- EMBL:   AP008226
- RefSeq:   YP_144226.1
- PDB:   2YYG
- PDB:   2YYI
- PDB:   2YYJ
- PDB:   2YYK
- PDB:   2YYL
- PDB:   2YYM
- PDBsum:   2YYG
- PDBsum:   2YYI
- PDBsum:   2YYJ
- PDBsum:   2YYK
- PDBsum:   2YYL
- PDBsum:   2YYM
- ProteinModelPortal:   Q5SJP8
- SMR:   Q5SJP8
- STRING:   Q5SJP8
- GeneID:   3170066
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA0960
- NMPDR:   fig|300852.3.peg.1073
- eggNOG:   COG2368
- HOGENOM:   HBG366849
- OMA:   DISLTHT
- ProtClustDB:   CLSK2761911
- BioCyc:   TTHE300852:TTHA0960-MONOMER
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100
- InterPro:   IPR004925
- InterPro:   IPR012687
- Gene3D:   G3DSA:2.40.110.10
- Gene3D:   G3DSA:1.20.140.10
- PIRSF:   PIRSF000331
- TIGRFAMs:   TIGR02309

Pfam domain/function: PF03241 HpaB; SSF56645 AcylCoA_dehyd_NM; SSF47203 AcylCoADH_C_like

EC number: NA

Molecular weight: Translated: 54304; Mature: 54173

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: BINDING 142-142 BINDING 185-185

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTGAEYIEALKTRPPNLWYKGEKVEDPTTHPVFRGIVRTMAALYDLQHDPRYREVLTY
CCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCC
EEEGKRHGMSFLIPKTKEDLKRRGQAYKLWADQNLGMMGRSPDYLNAVVMAYAASADYFG
HHHHHHCCCEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCHHHHH
EFAENVRNYYRYLRDQDLATTHALTNPQVNRARPPSGQPDPYIPVGVVKQTEKGIVVRGA
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCEEEECC
RMTATFPLADEVLIFPSTLLQAGSEKYALAFALPTSTPGLHFVCREALVGGDSPFDHPLS
EEEEECCCCCCHHCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHH
SRVEEMDCLVIFDDVLVPWERVFILGNVELCNNAYAATGALNHMAHQVVALKTAKTEAFL
HHHHHCCEEEEEHHHHCCCCCEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVAALMAEGIGADVYGHVQEKIAEIIVYLEAMRAFWTRAEEEAKENAYGLLVPDRGALDG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
ARNLYPRLYPRIREILEQIGASGLITLPSEKDFKGPLGPFLEKFLQGAALEAKERVALFR
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
LAWDMTLSGFGARQELYERFFFGDPVRMYQTLYNVYNKEPYKERIRAFLKESLKVFEEVQ
HHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
A
C
>Mature Secondary Structure 
ARTGAEYIEALKTRPPNLWYKGEKVEDPTTHPVFRGIVRTMAALYDLQHDPRYREVLTY
CCCHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCC
EEEGKRHGMSFLIPKTKEDLKRRGQAYKLWADQNLGMMGRSPDYLNAVVMAYAASADYFG
HHHHHHCCCEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCHHHHH
EFAENVRNYYRYLRDQDLATTHALTNPQVNRARPPSGQPDPYIPVGVVKQTEKGIVVRGA
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCEEEECC
RMTATFPLADEVLIFPSTLLQAGSEKYALAFALPTSTPGLHFVCREALVGGDSPFDHPLS
EEEEECCCCCCHHCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHH
SRVEEMDCLVIFDDVLVPWERVFILGNVELCNNAYAATGALNHMAHQVVALKTAKTEAFL
HHHHHCCEEEEEHHHHCCCCCEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVAALMAEGIGADVYGHVQEKIAEIIVYLEAMRAFWTRAEEEAKENAYGLLVPDRGALDG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
ARNLYPRLYPRIREILEQIGASGLITLPSEKDFKGPLGPFLEKFLQGAALEAKERVALFR
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
LAWDMTLSGFGARQELYERFFFGDPVRMYQTLYNVYNKEPYKERIRAFLKESLKVFEEVQ
HHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA