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The map label for this gene is fadN [H]

Identifier: 55980859

GI number: 55980859

Start: 848967

End: 851258

Strand: Direct

Name: fadN [H]

Synonym: TTHA0890

Alternate gene names: 55980859

Gene position: 848967-851258 (Clockwise)

Preceding gene: 55980858

Following gene: 55980860

Centisome position: 45.9

GC content: 67.58

Gene sequence:

>2292_bases
ATGATCAAGAAGGTAGGCGTGGTAGGCGCGGGGACCATGGGTAGCGGGATCGCCGCCCTGGTGGCCAGCGCCGGGATCCC
GGTGGTGCTCCTGGACATCCCCGGGAAGGAGGACCGGAACGAGTACGCCAAAAGGGGCCTGGAGCGCGCCCTCAAGGCCA
GGCCCGCGGCCTTCATGGACCCCGAGCGGGCCCGCTACATTGAGATCGGCAACACCGAGGACCACCTGGAAAAGCTCAGG
GACTGCGACTGGGTGGTGGAGGCCATCGTTGAGAAGCCAGAACCCAAGCAGGCCCTTTACGCCCGCCTGGAAAACCTTTT
GAAACCCACCGCCATCGTCAGCTCCAACACCAGCGGCATCCCCATGAGGGTTCTCCTGGAGGGGCGCTCCGAGGGCTTCC
GCCGCCGCTTCCTCGGGACGCACTTCTTCAACCCGCCCCGCTACCTCCACCTCCTGGAGCTCATCCCCACCCCGGAGACC
GACCCCAAGGTCCTCGAGGAGATCCGCCGCTTCGGGGAGCGCATTCTGGGCAAGGGGACCGTCCTCGCCAAGGACTCCCC
CGGCTTCATCGCCAACCGCCTCGGGGTTTACGGGATGGTGCAGGCCGTGCGCCTCATGGAGAAGCACGGCCTCACCATTG
ACGAGGTGGACGCCCTCACCGGGCCCCTCCTCGGCCGCCCCAACTCCGCCACCTTCCGCACCGCCGACCTCACGGGCCTG
GACGTGCTCAAGCTCGTGACCGAGGAGCTCGCCCAGGCCACCGGGGAGGACTTCGCCCTTCCCGAGTGGGTCCACCGGCT
CGTGGAGGAGGGCCGCCTCGGAGAGAAGGCGGGGGCCGGGTTCTACAAGCGGGTGAACGGGGAGATCTACACCCTGGACT
ACCGGACCTTGGATTACGCCCCCCGGACCAAGCTGGAGCTTCCCGAGCTTCGCGCCCTCCGGGACCTTCCCCTGAGGGAG
CGCCTTGCCAAGGCCTTGGACCTTCCCGGTAAGTACGGGGCCTTCCTCCGGGAGCTTTTCGCCAGGACCGCCCACTACAC
CCTGGAGAAGGCCCCGGAGATCGCCTACGACCTCGTCTCCGTGGACCAGGCCCTGGAGTGGGGCTTCGGGTGGGAGGAGG
GGCCCTTCAAGAACATGGACGCCGTGGGGCTTTCCCGGGTGGAGGCCCTTTTCGCCGAATACGGCCTGGAGGTTCCCGAG
CTCCTCGGGAAGGCCCAGGGCACCTTCTACAAAGACGGCGCCTACCTGGGGTTTGACGGGGCCTACCACCCCTTGCCCAA
GCGGGAGGGCGTCATCTCCCTAAAGGCCCTCAAGTCCGAGGGCAAGACCCTCTTGGAGGGCAAGGAGGCGGCCCTTCTGG
ACCTGGGGGATGGGGTGGCCCTTCTGGAGTTCCGCACCAAGATGAACGCCATCGGGGAGGGGGTCATCCGCATGCTCCAG
AAGAGCCTGGAGTTTGTGGAGGAGAAGGGTTACCTGGGCCTCGTCATCGGCAACGAGGACCCGAGGGCCTTCTCCGCCGG
GGCCAACCTGGCCCTCATCCTCTCCCTGGCCCAGGAGGGGGACTGGGACGAGCTCGCCCTGGCGGTGCGCCAGTTCCAGA
AGGCCTCCATGTCCCTCCGCTATAGCCCCTTCCCCGTGGTGGTGGCGCCCTTCGGCCTGACTTTGGGGGGCGGGGCGGAG
TTCACCCTGCACGCCGACCGGGTCCAGGCCCACGCCGAGCTCTATATGGGCCTGGTGGAGGCCGGGGTGGGGCTTTTGCC
CGCGGGAGGCGGCACCAAGGAGATGCTCCTCCGCTTCACCCAAGAGCTTGCGCCCTACGAGGAGGCCGACCCCTTTGAGG
CGGTGAAGCGGGCCTTCCAGCTCATCGCCATGGCCAGGACCTCCACGAGCGCCCTCGAGGCCCGCAAGATGGGCTTCCTC
CGGGACGGGGACGGGATCAGCATGAACCGGGACTTCCTCATCGCCGACGCCAAGAGGCGGGTTTTGGAGCTCGCCCCCGA
CTACCGCCCGCCCCTGCCCCCGAGGATCCGGGTCTTGGGGAGCGAGGCCCTGGGCAACCTCCGCTACGCCGTCTGGTCCT
TCCGCGAGGCGGGGGAGATCACGGACCACGACATGAAAATCGGCCTGGAGATCGCCTACGTCCTCTCCGGCGGGGAAGGC
CCGGCGCGGGAGGTCTCCGAGTGGGACCTTCTGGACCTGGAGCGCGAGGCCTTCTTGAAGCTCCTCGGCACCCGGAAGAC
CCAGGAGCGCATCGCCTACACCTTGAAGACGGGGAAGCCTCTCAGGAACTAA

Upstream 100 bases:

>100_bases
CCGGCCTGGGCGGGAAACAGCCTGGGGGACCCCGCCCGTGCGGCCCTTTGACAGGCGGGGCGTCTGGGGTTAAACTTTGA
CTGAGTATAAGGAGGTGCCC

Downstream 100 bases:

>100_bases
GGGGGAGAAGATGCGGGAAGCGGTCATCGTAAGCGCAGTGCGGAGCCCCGTGGCCCGGGGCAAGAAGAACGGGGCCTTGG
CCACCCTCCACCCCGTGGAC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MIKKVGVVGAGTMGSGIAALVASAGIPVVLLDIPGKEDRNEYAKRGLERALKARPAAFMDPERARYIEIGNTEDHLEKLR
DCDWVVEAIVEKPEPKQALYARLENLLKPTAIVSSNTSGIPMRVLLEGRSEGFRRRFLGTHFFNPPRYLHLLELIPTPET
DPKVLEEIRRFGERILGKGTVLAKDSPGFIANRLGVYGMVQAVRLMEKHGLTIDEVDALTGPLLGRPNSATFRTADLTGL
DVLKLVTEELAQATGEDFALPEWVHRLVEEGRLGEKAGAGFYKRVNGEIYTLDYRTLDYAPRTKLELPELRALRDLPLRE
RLAKALDLPGKYGAFLRELFARTAHYTLEKAPEIAYDLVSVDQALEWGFGWEEGPFKNMDAVGLSRVEALFAEYGLEVPE
LLGKAQGTFYKDGAYLGFDGAYHPLPKREGVISLKALKSEGKTLLEGKEAALLDLGDGVALLEFRTKMNAIGEGVIRMLQ
KSLEFVEEKGYLGLVIGNEDPRAFSAGANLALILSLAQEGDWDELALAVRQFQKASMSLRYSPFPVVVAPFGLTLGGGAE
FTLHADRVQAHAELYMGLVEAGVGLLPAGGGTKEMLLRFTQELAPYEEADPFEAVKRAFQLIAMARTSTSALEARKMGFL
RDGDGISMNRDFLIADAKRRVLELAPDYRPPLPPRIRVLGSEALGNLRYAVWSFREAGEITDHDMKIGLEIAYVLSGGEG
PAREVSEWDLLDLEREAFLKLLGTRKTQERIAYTLKTGKPLRN

Sequences:

>Translated_763_residues
MIKKVGVVGAGTMGSGIAALVASAGIPVVLLDIPGKEDRNEYAKRGLERALKARPAAFMDPERARYIEIGNTEDHLEKLR
DCDWVVEAIVEKPEPKQALYARLENLLKPTAIVSSNTSGIPMRVLLEGRSEGFRRRFLGTHFFNPPRYLHLLELIPTPET
DPKVLEEIRRFGERILGKGTVLAKDSPGFIANRLGVYGMVQAVRLMEKHGLTIDEVDALTGPLLGRPNSATFRTADLTGL
DVLKLVTEELAQATGEDFALPEWVHRLVEEGRLGEKAGAGFYKRVNGEIYTLDYRTLDYAPRTKLELPELRALRDLPLRE
RLAKALDLPGKYGAFLRELFARTAHYTLEKAPEIAYDLVSVDQALEWGFGWEEGPFKNMDAVGLSRVEALFAEYGLEVPE
LLGKAQGTFYKDGAYLGFDGAYHPLPKREGVISLKALKSEGKTLLEGKEAALLDLGDGVALLEFRTKMNAIGEGVIRMLQ
KSLEFVEEKGYLGLVIGNEDPRAFSAGANLALILSLAQEGDWDELALAVRQFQKASMSLRYSPFPVVVAPFGLTLGGGAE
FTLHADRVQAHAELYMGLVEAGVGLLPAGGGTKEMLLRFTQELAPYEEADPFEAVKRAFQLIAMARTSTSALEARKMGFL
RDGDGISMNRDFLIADAKRRVLELAPDYRPPLPPRIRVLGSEALGNLRYAVWSFREAGEITDHDMKIGLEIAYVLSGGEG
PAREVSEWDLLDLEREAFLKLLGTRKTQERIAYTLKTGKPLRN
>Mature_763_residues
MIKKVGVVGAGTMGSGIAALVASAGIPVVLLDIPGKEDRNEYAKRGLERALKARPAAFMDPERARYIEIGNTEDHLEKLR
DCDWVVEAIVEKPEPKQALYARLENLLKPTAIVSSNTSGIPMRVLLEGRSEGFRRRFLGTHFFNPPRYLHLLELIPTPET
DPKVLEEIRRFGERILGKGTVLAKDSPGFIANRLGVYGMVQAVRLMEKHGLTIDEVDALTGPLLGRPNSATFRTADLTGL
DVLKLVTEELAQATGEDFALPEWVHRLVEEGRLGEKAGAGFYKRVNGEIYTLDYRTLDYAPRTKLELPELRALRDLPLRE
RLAKALDLPGKYGAFLRELFARTAHYTLEKAPEIAYDLVSVDQALEWGFGWEEGPFKNMDAVGLSRVEALFAEYGLEVPE
LLGKAQGTFYKDGAYLGFDGAYHPLPKREGVISLKALKSEGKTLLEGKEAALLDLGDGVALLEFRTKMNAIGEGVIRMLQ
KSLEFVEEKGYLGLVIGNEDPRAFSAGANLALILSLAQEGDWDELALAVRQFQKASMSLRYSPFPVVVAPFGLTLGGGAE
FTLHADRVQAHAELYMGLVEAGVGLLPAGGGTKEMLLRFTQELAPYEEADPFEAVKRAFQLIAMARTSTSALEARKMGFL
RDGDGISMNRDFLIADAKRRVLELAPDYRPPLPPRIRVLGSEALGNLRYAVWSFREAGEITDHDMKIGLEIAYVLSGGEG
PAREVSEWDLLDLEREAFLKLLGTRKTQERIAYTLKTGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=293, Percent_Identity=34.4709897610922, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI296179427, Length=309, Percent_Identity=33.6569579288026, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI20127408, Length=287, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI68989263, Length=433, Percent_Identity=26.5588914549654, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI261878539, Length=433, Percent_Identity=26.5588914549654, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI115430219, Length=226, Percent_Identity=26.9911504424779, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1787661, Length=289, Percent_Identity=31.1418685121107, Blast_Score=100, Evalue=6e-22,
Organism=Escherichia coli, GI1790281, Length=208, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788682, Length=291, Percent_Identity=25.7731958762887, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17553560, Length=299, Percent_Identity=33.7792642140468, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17549919, Length=292, Percent_Identity=33.2191780821918, Blast_Score=145, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17558304, Length=326, Percent_Identity=30.6748466257669, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17508951, Length=327, Percent_Identity=30.2752293577982, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17508953, Length=327, Percent_Identity=30.2752293577982, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71985923, Length=294, Percent_Identity=30.952380952381, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144276, Length=305, Percent_Identity=30.8196721311475, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=29.757785467128, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71985930, Length=292, Percent_Identity=30.4794520547945, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=29.1228070175439, Blast_Score=103, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=29.1228070175439, Blast_Score=103, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=29.1228070175439, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI45549573, Length=234, Percent_Identity=29.4871794871795, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI20129993, Length=227, Percent_Identity=29.5154185022026, Blast_Score=83, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 84293; Mature: 84293

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVGVVGAGTMGSGIAALVASAGIPVVLLDIPGKEDRNEYAKRGLERALKARPAAFMD
CCCEECEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCC
PERARYIEIGNTEDHLEKLRDCDWVVEAIVEKPEPKQALYARLENLLKPTAIVSSNTSGI
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCCCCCC
PMRVLLEGRSEGFRRRFLGTHFFNPPRYLHLLELIPTPETDPKVLEEIRRFGERILGKGT
CEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
VLAKDSPGFIANRLGVYGMVQAVRLMEKHGLTIDEVDALTGPLLGRPNSATFRTADLTGL
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEECCCCHH
DVLKLVTEELAQATGEDFALPEWVHRLVEEGRLGEKAGAGFYKRVNGEIYTLDYRTLDYA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHCCCHHEECCCEEEEEEEEEECCC
PRTKLELPELRALRDLPLRERLAKALDLPGKYGAFLRELFARTAHYTLEKAPEIAYDLVS
CCCCCCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
VDQALEWGFGWEEGPFKNMDAVGLSRVEALFAEYGLEVPELLGKAQGTFYKDGAYLGFDG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEECCEEECCCC
AYHPLPKREGVISLKALKSEGKTLLEGKEAALLDLGDGVALLEFRTKMNAIGEGVIRMLQ
CCCCCCCCCCEEEEEHHHHCCCHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
KSLEFVEEKGYLGLVIGNEDPRAFSAGANLALILSLAQEGDWDELALAVRQFQKASMSLR
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHCCEE
YSPFPVVVAPFGLTLGGGAEFTLHADRVQAHAELYMGLVEAGVGLLPAGGGTKEMLLRFT
CCCCCEEEECCCEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHH
QELAPYEEADPFEAVKRAFQLIAMARTSTSALEARKMGFLRDGDGISMNRDFLIADAKRR
HHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEECCCCCCCCCCEEEEHHHHH
VLELAPDYRPPLPPRIRVLGSEALGNLRYAVWSFREAGEITDHDMKIGLEIAYVLSGGEG
HHHHCCCCCCCCCHHEEEECHHHHHHHHHHHHHHHHCCCCCCCCEEECEEEEEEEECCCC
PAREVSEWDLLDLEREAFLKLLGTRKTQERIAYTLKTGKPLRN
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEEEEECCCCCCC
>Mature Secondary Structure
MIKKVGVVGAGTMGSGIAALVASAGIPVVLLDIPGKEDRNEYAKRGLERALKARPAAFMD
CCCEECEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCC
PERARYIEIGNTEDHLEKLRDCDWVVEAIVEKPEPKQALYARLENLLKPTAIVSSNTSGI
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCCCCCC
PMRVLLEGRSEGFRRRFLGTHFFNPPRYLHLLELIPTPETDPKVLEEIRRFGERILGKGT
CEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
VLAKDSPGFIANRLGVYGMVQAVRLMEKHGLTIDEVDALTGPLLGRPNSATFRTADLTGL
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEECCCCHH
DVLKLVTEELAQATGEDFALPEWVHRLVEEGRLGEKAGAGFYKRVNGEIYTLDYRTLDYA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHCCCHHEECCCEEEEEEEEEECCC
PRTKLELPELRALRDLPLRERLAKALDLPGKYGAFLRELFARTAHYTLEKAPEIAYDLVS
CCCCCCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
VDQALEWGFGWEEGPFKNMDAVGLSRVEALFAEYGLEVPELLGKAQGTFYKDGAYLGFDG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEECCEEECCCC
AYHPLPKREGVISLKALKSEGKTLLEGKEAALLDLGDGVALLEFRTKMNAIGEGVIRMLQ
CCCCCCCCCCEEEEEHHHHCCCHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
KSLEFVEEKGYLGLVIGNEDPRAFSAGANLALILSLAQEGDWDELALAVRQFQKASMSLR
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHCCEE
YSPFPVVVAPFGLTLGGGAEFTLHADRVQAHAELYMGLVEAGVGLLPAGGGTKEMLLRFT
CCCCCEEEECCCEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHH
QELAPYEEADPFEAVKRAFQLIAMARTSTSALEARKMGFLRDGDGISMNRDFLIADAKRR
HHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEECCCCCCCCCCEEEEHHHHH
VLELAPDYRPPLPPRIRVLGSEALGNLRYAVWSFREAGEITDHDMKIGLEIAYVLSGGEG
HHHHCCCCCCCCCHHEEEECHHHHHHHHHHHHHHHHCCCCCCCCEEECEEEEEEEECCCC
PAREVSEWDLLDLEREAFLKLLGTRKTQERIAYTLKTGKPLRN
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]