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The map label for this gene is pkwA [H]

Identifier: 55980835

GI number: 55980835

Start: 826917

End: 828068

Strand: Direct

Name: pkwA [H]

Synonym: TTHA0866

Alternate gene names: 55980835

Gene position: 826917-828068 (Clockwise)

Preceding gene: 55980834

Following gene: 55980838

Centisome position: 44.7

GC content: 72.83

Gene sequence:

>1152_bases
ATGAGGGCGCTGGGTCTCCTCTTCCTACTCCTTCCGGCCCTGGCCCAGAACCTGGCCCCGGCCTTTCAACTGGACTGCCG
CTTCCGGGGGGAGGCCAGGCCCGCCCAGGTCTTCTGGGACGGGAGCCCCTTGGGGACCTGCCCCCTCGAGGTCCGGGCTG
CTCCGGGCCGCCACCTTCTCCGCCTGCGCCTCGAGGAGCCCGGGGGGACCTACCTGGCCTACGAGGCCCGGGTGGAGGTG
GGGGAGGGGGGCCTGGGGGCCTTCACCGCCGAACTCCTGCGCTATGACCCCCGGGGGGAGGCCCTGAAGGGGGGCAAGGG
CTTGGTCTACGCCCTGGCCTACGGCCCCAAGGGGGTCTTGGCCCTGGGGGACGCGGCCGGGCAGGTCCGCCTCCTCCCCC
CGGGCCGTCCCCCCTTGGACCTCAAGGGGCACGCCTCCTACGTGCGCGACCTGGCCTTTAGCCCCGACGGCCGCTACCTC
GCCTCGGCCTCGGGGGATGGGACGGTGCGCCTGTACGAGGCCCAGGGCCGCTTCCTCCGGGCTTTGGGCAAGGGCCCGGC
CTTCCTCAAGGTGGGCTTTGACGCCCAGGGCCGCCTCTTTGGCCTCCAGCTCCGGGGGAACCTCACCCTGTTTGACCCCG
CCACGGGCAAGGTCCTGGCCGCCCGCCCCCTAAGCCCCTACCTCTTCTCCGCGGCCCAGAGCCCCGGGGGGAGGGTCCTC
GCTTTGGGGCTTTCCGTGGGCCGGGTGGAGGTGTGGGACCTCGCCCTCCCGGGGAAGCGGAGGGAGGTCCGGGTCCCGGG
AGGTCCCGTCTACGCCCTGGCCTTCAGCCCCGACGGCCGCTATCTCGCCGTGGGTTCGGCGGACGGGGGAGTGAGGCTTT
TGGACCTCCTGGCCCCGGGCGGGCCCGAACCCCGGCTCCTCTACGCCCACAAGGACCTGCCCCTGGGCCTGGCCTTCAGC
CCCGACGGCCGCTATTTGGCCTCCGGAGGGCAGGACCGGGAGGTGCGCCTCTACGACCTCGATGCGGGCCTTTTGGAGCG
GGTTTACGTGGGGCATACCGGTGCGGTGTACGGGCTGGACTTTAACCCCCAAACCCCCGCCCTGGCCACGGGCGGGGGGG
AGGGTCGGGTCCTCCTCTTCCGCCTTCCCTAG

Upstream 100 bases:

>100_bases
CACGCTGTGAACGAGGAGTACTCGGGGAGGCTGCAGCTCGCCCAGATGGACACGGGCTACTGAGCCCCAAGACGCCTACG
CCTTGGGAGGAGGTGTTGGG

Downstream 100 bases:

>100_bases
GCTTATACCCTTGCTTCCGGTTTCCTTCACCCTACGGGCCCTAGGAGGCCCCTAGGAACCTTGCGCCAGGGCCCCCATGC
TGGCGCAAGCCAGCATGGGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MRALGLLFLLLPALAQNLAPAFQLDCRFRGEARPAQVFWDGSPLGTCPLEVRAAPGRHLLRLRLEEPGGTYLAYEARVEV
GEGGLGAFTAELLRYDPRGEALKGGKGLVYALAYGPKGVLALGDAAGQVRLLPPGRPPLDLKGHASYVRDLAFSPDGRYL
ASASGDGTVRLYEAQGRFLRALGKGPAFLKVGFDAQGRLFGLQLRGNLTLFDPATGKVLAARPLSPYLFSAAQSPGGRVL
ALGLSVGRVEVWDLALPGKRREVRVPGGPVYALAFSPDGRYLAVGSADGGVRLLDLLAPGGPEPRLLYAHKDLPLGLAFS
PDGRYLASGGQDREVRLYDLDAGLLERVYVGHTGAVYGLDFNPQTPALATGGGEGRVLLFRLP

Sequences:

>Translated_383_residues
MRALGLLFLLLPALAQNLAPAFQLDCRFRGEARPAQVFWDGSPLGTCPLEVRAAPGRHLLRLRLEEPGGTYLAYEARVEV
GEGGLGAFTAELLRYDPRGEALKGGKGLVYALAYGPKGVLALGDAAGQVRLLPPGRPPLDLKGHASYVRDLAFSPDGRYL
ASASGDGTVRLYEAQGRFLRALGKGPAFLKVGFDAQGRLFGLQLRGNLTLFDPATGKVLAARPLSPYLFSAAQSPGGRVL
ALGLSVGRVEVWDLALPGKRREVRVPGGPVYALAFSPDGRYLAVGSADGGVRLLDLLAPGGPEPRLLYAHKDLPLGLAFS
PDGRYLASGGQDREVRLYDLDAGLLERVYVGHTGAVYGLDFNPQTPALATGGGEGRVLLFRLP
>Mature_383_residues
MRALGLLFLLLPALAQNLAPAFQLDCRFRGEARPAQVFWDGSPLGTCPLEVRAAPGRHLLRLRLEEPGGTYLAYEARVEV
GEGGLGAFTAELLRYDPRGEALKGGKGLVYALAYGPKGVLALGDAAGQVRLLPPGRPPLDLKGHASYVRDLAFSPDGRYL
ASASGDGTVRLYEAQGRFLRALGKGPAFLKVGFDAQGRLFGLQLRGNLTLFDPATGKVLAARPLSPYLFSAAQSPGGRVL
ALGLSVGRVEVWDLALPGKRREVRVPGGPVYALAFSPDGRYLAVGSADGGVRLLDLLAPGGPEPRLLYAHKDLPLGLAFS
PDGRYLASGGQDREVRLYDLDAGLLERVYVGHTGAVYGLDFNPQTPALATGGGEGRVLLFRLP

Specific function: May play a regulatory role during the complex growth cycle and in secondary metabolite production [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 WD repeats [H]

Homologues:

Organism=Homo sapiens, GI23199987, Length=278, Percent_Identity=26.6187050359712, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI16554629, Length=261, Percent_Identity=25.2873563218391, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI16554627, Length=261, Percent_Identity=25.2873563218391, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI239787760, Length=260, Percent_Identity=26.1538461538462, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI239787754, Length=265, Percent_Identity=25.6603773584906, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI239787764, Length=260, Percent_Identity=26.1538461538462, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI113865883, Length=153, Percent_Identity=36.6013071895425, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI32189425, Length=291, Percent_Identity=24.0549828178694, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI21071067, Length=216, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI26665869, Length=291, Percent_Identity=25.4295532646048, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI115298668, Length=305, Percent_Identity=25.2459016393443, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI7657439, Length=113, Percent_Identity=38.0530973451327, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI83779014, Length=224, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI20357529, Length=345, Percent_Identity=25.7971014492754, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI62234461, Length=376, Percent_Identity=26.3297872340426, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI24431950, Length=288, Percent_Identity=26.3888888888889, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI7657381, Length=260, Percent_Identity=28.0769230769231, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI13376840, Length=137, Percent_Identity=32.8467153284672, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17552164, Length=250, Percent_Identity=24, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17568701, Length=250, Percent_Identity=24.8, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI72001544, Length=250, Percent_Identity=24.4, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17538129, Length=197, Percent_Identity=27.9187817258883, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319675, Length=255, Percent_Identity=28.2352941176471, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324322, Length=243, Percent_Identity=26.3374485596708, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319926, Length=262, Percent_Identity=24.8091603053435, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6325435, Length=246, Percent_Identity=23.5772357723577, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21356075, Length=251, Percent_Identity=29.8804780876494, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17864654, Length=250, Percent_Identity=25.6, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24654584, Length=251, Percent_Identity=27.8884462151394, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20129125, Length=299, Percent_Identity=24.4147157190635, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24663767, Length=298, Percent_Identity=27.5167785234899, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136870, Length=257, Percent_Identity=27.2373540856031, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24639729, Length=176, Percent_Identity=30.6818181818182, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639727, Length=176, Percent_Identity=30.6818181818182, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24649265, Length=245, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020472
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR015943
- InterPro:   IPR001680
- InterPro:   IPR011046
- InterPro:   IPR019782
- InterPro:   IPR019775
- InterPro:   IPR017986
- InterPro:   IPR019781 [H]

Pfam domain/function: PF00069 Pkinase; PF00400 WD40 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 40601; Mature: 40601

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50082 WD_REPEATS_2 ; PS50294 WD_REPEATS_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALGLLFLLLPALAQNLAPAFQLDCRFRGEARPAQVFWDGSPLGTCPLEVRAAPGRHLL
CCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCEEE
RLRLEEPGGTYLAYEARVEVGEGGLGAFTAELLRYDPRGEALKGGKGLVYALAYGPKGVL
EEEEECCCCCEEEEEEEEEECCCCCHHHHHHHHEECCCCCCCCCCCCEEEEEEECCCCEE
ALGDAAGQVRLLPPGRPPLDLKGHASYVRDLAFSPDGRYLASASGDGTVRLYEAQGRFLR
EEECCCCEEEECCCCCCCCCCCCCHHHHHHHEECCCCCEEEECCCCCEEEEEECCCCEEH
ALGKGPAFLKVGFDAQGRLFGLQLRGNLTLFDPATGKVLAARPLSPYLFSAAQSPGGRVL
HHCCCCEEEEECCCCCCCEEEEEEECCEEEECCCCCCEEEECCCCHHHHHHCCCCCCEEE
ALGLSVGRVEVWDLALPGKRREVRVPGGPVYALAFSPDGRYLAVGSADGGVRLLDLLAPG
EEEEEECEEEEEEEECCCCCCEEECCCCCEEEEEECCCCCEEEEECCCCCEEEEEEECCC
GPEPRLLYAHKDLPLGLAFSPDGRYLASGGQDREVRLYDLDAGLLERVYVGHTGAVYGLD
CCCCEEEEEECCCCEEEEECCCCCEEECCCCCCEEEEEECCCHHHHHEEECCCCEEEEEC
FNPQTPALATGGGEGRVLLFRLP
CCCCCCEEEECCCCCEEEEEECC
>Mature Secondary Structure
MRALGLLFLLLPALAQNLAPAFQLDCRFRGEARPAQVFWDGSPLGTCPLEVRAAPGRHLL
CCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCEEE
RLRLEEPGGTYLAYEARVEVGEGGLGAFTAELLRYDPRGEALKGGKGLVYALAYGPKGVL
EEEEECCCCCEEEEEEEEEECCCCCHHHHHHHHEECCCCCCCCCCCCEEEEEEECCCCEE
ALGDAAGQVRLLPPGRPPLDLKGHASYVRDLAFSPDGRYLASASGDGTVRLYEAQGRFLR
EEECCCCEEEECCCCCCCCCCCCCHHHHHHHEECCCCCEEEECCCCCEEEEEECCCCEEH
ALGKGPAFLKVGFDAQGRLFGLQLRGNLTLFDPATGKVLAARPLSPYLFSAAQSPGGRVL
HHCCCCEEEEECCCCCCCEEEEEEECCEEEECCCCCCEEEECCCCHHHHHHCCCCCCEEE
ALGLSVGRVEVWDLALPGKRREVRVPGGPVYALAFSPDGRYLAVGSADGGVRLLDLLAPG
EEEEEECEEEEEEEECCCCCCEEECCCCCEEEEEECCCCCEEEEECCCCCEEEEEEECCC
GPEPRLLYAHKDLPLGLAFSPDGRYLASGGQDREVRLYDLDAGLLERVYVGHTGAVYGLD
CCCCEEEEEECCCCEEEEECCCCCEEECCCCCCEEEEEECCCHHHHHEEECCCCEEEEEC
FNPQTPALATGGGEGRVLLFRLP
CCCCCCEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8631732 [H]