Click here to switch to the map view.

The map label for this gene is cdd [H]

Identifier: 55980704

GI number: 55980704

Start: 701602

End: 701976

Strand: Direct

Name: cdd [H]

Synonym: TTHA0735

Alternate gene names: 55980704

Gene position: 701602-701976 (Clockwise)

Preceding gene: 55980703

Following gene: 55980708

Centisome position: 37.93

GC content: 70.93

Gene sequence:

>375_bases
GTGAACGCCAAGGCGGTTAAGGAGGTGTTGAAGGCCCACGTGGGGCGGGCCTACGCCCCCTACTCGGGCTTCCCCGTGGT
GGCCCTGGTGGAGGCGGAAGGGGAGGTGTTCCTCGGGGTCAACGTGGAAAACGCCTCCTTCCCCCTCTCCCAGTGCGCCG
AAAGGAACGCCGTGGCGGCCATGGTCCTCGCGGGGAAGCGCCGCCTGGAGCGGGTGCACGTGTATAGCCCCAAGGGGCCC
ATCCCCCCTTGCGGGGGGTGCCGGCAGGTCCTCATGGAGTTCGGGGGGCCGGAGGTGGAGGTGGTCCTCCACGGGCCCGA
GGAGGAGGTGCGCACCACCCTGGGGGCCCTCCTCCCCCTGGCCTTCCGCCTCTAG

Upstream 100 bases:

>100_bases
AGCGTGGGGGAGAGCCTGGAGTGGCAGGGCTTCCGCTTCGTGGTGGAAAGCGCCGACCAGAGGCGCCTGGAGCGGATCCG
GGTGGAACGGGTGGTGGAGC

Downstream 100 bases:

>100_bases
AGGTCCAGGACCAGGGTCTGGCTGAGGAAGCCGGGGACCTCGAGGCGAAGCTCCAGCCGCCCCCTCCCCCGCTCAAGCCC
GGGCCTCAGGCCCACCACCT

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 124; Mature: 124

Protein sequence:

>124_residues
MNAKAVKEVLKAHVGRAYAPYSGFPVVALVEAEGEVFLGVNVENASFPLSQCAERNAVAAMVLAGKRRLERVHVYSPKGP
IPPCGGCRQVLMEFGGPEVEVVLHGPEEEVRTTLGALLPLAFRL

Sequences:

>Translated_124_residues
MNAKAVKEVLKAHVGRAYAPYSGFPVVALVEAEGEVFLGVNVENASFPLSQCAERNAVAAMVLAGKRRLERVHVYSPKGP
IPPCGGCRQVLMEFGGPEVEVVLHGPEEEVRTTLGALLPLAFRL
>Mature_124_residues
MNAKAVKEVLKAHVGRAYAPYSGFPVVALVEAEGEVFLGVNVENASFPLSQCAERNAVAAMVLAGKRRLERVHVYSPKGP
IPPCGGCRQVLMEFGGPEVEVVLHGPEEEVRTTLGALLPLAFRL

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=110, Percent_Identity=41.8181818181818, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551074, Length=109, Percent_Identity=41.2844036697248, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540514, Length=114, Percent_Identity=42.1052631578947, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323274, Length=113, Percent_Identity=37.1681415929204, Blast_Score=69, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920920, Length=140, Percent_Identity=35, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24582744, Length=99, Percent_Identity=38.3838383838384, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 13281; Mature: 13281

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAKAVKEVLKAHVGRAYAPYSGFPVVALVEAEGEVFLGVNVENASFPLSQCAERNAVAA
CCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHCCCHHHH
MVLAGKRRLERVHVYSPKGPIPPCGGCRQVLMEFGGPEVEVVLHGPEEEVRTTLGALLPL
HHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHH
AFRL
HHCC
>Mature Secondary Structure
MNAKAVKEVLKAHVGRAYAPYSGFPVVALVEAEGEVFLGVNVENASFPLSQCAERNAVAA
CCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHCCCHHHH
MVLAGKRRLERVHVYSPKGPIPPCGGCRQVLMEFGGPEVEVVLHGPEEEVRTTLGALLPL
HHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHH
AFRL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7569993; 8253680 [H]