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The map label for this gene is clpP

Identifier: 55980584

GI number: 55980584

Start: 584289

End: 584873

Strand: Direct

Name: clpP

Synonym: TTHA0615

Alternate gene names: 55980584

Gene position: 584289-584873 (Clockwise)

Preceding gene: 55980583

Following gene: 55980585

Centisome position: 31.59

GC content: 65.81

Gene sequence:

>585_bases
ATGGTCATACCCTACGTCATTGAGCAGACGGCCCGCGGCGAGCGCGTCTACGACATCTACTCCCGCCTCCTCAAGGACCG
CATCATCTTCCTGGGCACCCCCATAGACGCCCAGGTGGCCAACGTGGTGGTGGCCCAGCTCCTCTTCCTGGACGCCCAGA
ACCCCAACCAGGAGATCAAGCTCTACATCAACTCCCCCGGGGGCGAGGTGGACGCGGGCCTCGCCATCTACGACACCATG
CAGTTCGTCCGGGCCCCCGTGTCCACCATCGTCATCGGCATGGCGGCCAGCATGGCCGCGGTGATCCTGGCGGCGGGGGA
GAAGGGCCGCCGCTACGCCCTTCCCCACGCCAAGGTCATGATCCATCAGCCCTGGGGTGGGGTGCGGGGGACGGCGAGCG
ACATCGCCATCCAGGCCCAGGAGATCCTGAAGGCGAAGAAGCTCCTCAACGAGATCCTGGCCAAGCACACCGGCCAGCCC
CTGGAGAAGGTGGAGAAGGACACGGACCGGGACTACTACCTCTCGGCCCAGGAGGCCCTGGAGTACGGCCTCATTGACCA
GGTGGTGACCCGTGAAGAGGCCTAG

Upstream 100 bases:

>100_bases
AGGCGGTGCAGGAGGCCCTGAAGGCCCTGGGCTGAGGGCCTGGAACATGGTGGCCCAGGGGGGTTTCCCCCCTGGGTCTG
CCGCTAAACTAAGGATTGGT

Downstream 100 bases:

>100_bases
GCCCCACTGCAGCTTCTGCGGCCTCCGCCCCCCCGAGACGGGGCGGCTTCTGGAAAGCCCCCTTGAGGACGTCTACATCT
GCGAGGACTGCGTGGAAAGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MVIPYVIEQTARGERVYDIYSRLLKDRIIFLGTPIDAQVANVVVAQLLFLDAQNPNQEIKLYINSPGGEVDAGLAIYDTM
QFVRAPVSTIVIGMAASMAAVILAAGEKGRRYALPHAKVMIHQPWGGVRGTASDIAIQAQEILKAKKLLNEILAKHTGQP
LEKVEKDTDRDYYLSAQEALEYGLIDQVVTREEA

Sequences:

>Translated_194_residues
MVIPYVIEQTARGERVYDIYSRLLKDRIIFLGTPIDAQVANVVVAQLLFLDAQNPNQEIKLYINSPGGEVDAGLAIYDTM
QFVRAPVSTIVIGMAASMAAVILAAGEKGRRYALPHAKVMIHQPWGGVRGTASDIAIQAQEILKAKKLLNEILAKHTGQP
LEKVEKDTDRDYYLSAQEALEYGLIDQVVTREEA
>Mature_194_residues
MVIPYVIEQTARGERVYDIYSRLLKDRIIFLGTPIDAQVANVVVAQLLFLDAQNPNQEIKLYINSPGGEVDAGLAIYDTM
QFVRAPVSTIVIGMAASMAAVILAAGEKGRRYALPHAKVMIHQPWGGVRGTASDIAIQAQEILKAKKLLNEILAKHTGQP
LEKVEKDTDRDYYLSAQEALEYGLIDQVVTREEA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=56.3829787234042, Blast_Score=226, Evalue=8e-60,
Organism=Escherichia coli, GI1786641, Length=189, Percent_Identity=59.7883597883598, Blast_Score=254, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=55.7894736842105, Blast_Score=236, Evalue=7e-63,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=53.1914893617021, Blast_Score=212, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_THET2 (Q72L15)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_004225.1
- ProteinModelPortal:   Q72L15
- SMR:   Q72L15
- STRING:   Q72L15
- GeneID:   2776183
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   TTHE262724:TT_C0250-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21393; Mature: 21393

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 97-97 ACT_SITE 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIPYVIEQTARGERVYDIYSRLLKDRIIFLGTPIDAQVANVVVAQLLFLDAQNPNQEIK
CCCCHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGEVDAGLAIYDTMQFVRAPVSTIVIGMAASMAAVILAAGEKGRRYALPHAKVM
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEE
IHQPWGGVRGTASDIAIQAQEILKAKKLLNEILAKHTGQPLEKVEKDTDRDYYLSAQEAL
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEECHHHHH
EYGLIDQVVTREEA
HHHHHHHHHHHCCC
>Mature Secondary Structure
MVIPYVIEQTARGERVYDIYSRLLKDRIIFLGTPIDAQVANVVVAQLLFLDAQNPNQEIK
CCCCHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGEVDAGLAIYDTMQFVRAPVSTIVIGMAASMAAVILAAGEKGRRYALPHAKVM
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEE
IHQPWGGVRGTASDIAIQAQEILKAKKLLNEILAKHTGQPLEKVEKDTDRDYYLSAQEAL
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEECHHHHH
EYGLIDQVVTREEA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA