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The map label for this gene is galE [C]

Identifier: 55980560

GI number: 55980560

Start: 558173

End: 559108

Strand: Reverse

Name: galE [C]

Synonym: TTHA0591

Alternate gene names: 55980560

Gene position: 559108-558173 (Counterclockwise)

Preceding gene: 55980562

Following gene: 55980559

Centisome position: 30.23

GC content: 69.87

Gene sequence:

>936_bases
ATGCGCGTGCTGGTGACGGGCGGCGCCGGTTTCATCGGAAGCCACATCGTGGAGGACCTCCTCGCCAGGGGCCTGGAGGT
GGCGGTCCTGGACAACCTGGCCACGGGCAAGCGGGAAAACGTGCCCAAAGGCGTCCCCTTCTTCCGGGTGGACCTAAGGG
ACAAGGAGGGGGTGGAAAGGGCCTTCCGGGAGTTCCGCCCCACCCACGTCTCCCACCAGGCGGCCCAAGCCTCGGTGAAG
GTGAGCGTGGAGGACCCGGTCCTGGACTTTGAGGTGAACCTCCTGGGGGGGCTTAACCTCCTCGAGGCCTGCCGCCAGTA
CGGCGTGGAGAAGCTCGTCTTCGCCTCCACGGGCGGGGCCATCTACGGGGAGGTGCCCGAGGGGGAAAGGGCCGAGGAGA
CCTGGCCCCCCCGCCCAAAAAGCCCCTACGCCGCGAGCAAGGCGGCCTTTGAGCACTACCTCTCCGTCTACGGGCAAAGC
TACGGGCTCAAGTGGGTCTCCCTGCGCTACGGCAACGTGTACGGCCCCAGGCAGGACCCCCACGGGGAGGCAGGGGTGGT
GGCCATCTTCGCCGAGCGGGTCCTCAAGGGCCTGCCCGTGACCCTCTACGCCCGGAAGACCCCCGGGGACGAGGGGTGCG
TGCGGGACTACGTTTACGTGGGGGACGTGGCCGAGGCCCACGCCCTCGCCCTCTTCTCCTTGGAAGGGATCTACAACGTG
GGGACCGGGGAGGGGCACACCACGAGGGAGGTCCTCATGGCGGTGGCCGAGGCCGCGGGGAAGGCCCCCGAGGTCCAGCC
CGCCCCCCCGCGCCCCGGGGACCTGGAACGGAGCGTCCTCTCCCCCCTCAAGCTCATGGCCCACGGCTGGCGGCCCAAGG
TGGGGTTCCAGGAGGGCATCCGCCTCACCGTGGACCACTTCCGGGGCGCCGTATAG

Upstream 100 bases:

>100_bases
AGACCCGGGCGAAAAGGGCCGCCAGGCGGGAAACAAACCTCACGCCCCCCATCCTAACCCAGGTGGTAGACTGCCTCCGG
GCTTCGGCCCGGGAGGTTTT

Downstream 100 bases:

>100_bases
GGCTACCCCCGGCCTCGCCGGCCTCCTTCTCCCTGGGCAAGCCCCCGCATCACCGTCCGGGAGGGCCACCATCGGACCTG
AAGCGCCGACCAAGGCACGG

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MRVLVTGGAGFIGSHIVEDLLARGLEVAVLDNLATGKRENVPKGVPFFRVDLRDKEGVERAFREFRPTHVSHQAAQASVK
VSVEDPVLDFEVNLLGGLNLLEACRQYGVEKLVFASTGGAIYGEVPEGERAEETWPPRPKSPYAASKAAFEHYLSVYGQS
YGLKWVSLRYGNVYGPRQDPHGEAGVVAIFAERVLKGLPVTLYARKTPGDEGCVRDYVYVGDVAEAHALALFSLEGIYNV
GTGEGHTTREVLMAVAEAAGKAPEVQPAPPRPGDLERSVLSPLKLMAHGWRPKVGFQEGIRLTVDHFRGAV

Sequences:

>Translated_311_residues
MRVLVTGGAGFIGSHIVEDLLARGLEVAVLDNLATGKRENVPKGVPFFRVDLRDKEGVERAFREFRPTHVSHQAAQASVK
VSVEDPVLDFEVNLLGGLNLLEACRQYGVEKLVFASTGGAIYGEVPEGERAEETWPPRPKSPYAASKAAFEHYLSVYGQS
YGLKWVSLRYGNVYGPRQDPHGEAGVVAIFAERVLKGLPVTLYARKTPGDEGCVRDYVYVGDVAEAHALALFSLEGIYNV
GTGEGHTTREVLMAVAEAAGKAPEVQPAPPRPGDLERSVLSPLKLMAHGWRPKVGFQEGIRLTVDHFRGAV
>Mature_311_residues
MRVLVTGGAGFIGSHIVEDLLARGLEVAVLDNLATGKRENVPKGVPFFRVDLRDKEGVERAFREFRPTHVSHQAAQASVK
VSVEDPVLDFEVNLLGGLNLLEACRQYGVEKLVFASTGGAIYGEVPEGERAEETWPPRPKSPYAASKAAFEHYLSVYGQS
YGLKWVSLRYGNVYGPRQDPHGEAGVVAIFAERVLKGLPVTLYARKTPGDEGCVRDYVYVGDVAEAHALALFSLEGIYNV
GTGEGHTTREVLMAVAEAAGKAPEVQPAPPRPGDLERSVLSPLKLMAHGWRPKVGFQEGIRLTVDHFRGAV

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=314, Percent_Identity=29.6178343949045, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI56237023, Length=338, Percent_Identity=30.7692307692308, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI56118217, Length=338, Percent_Identity=30.7692307692308, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI189083684, Length=338, Percent_Identity=30.7692307692308, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI7657641, Length=333, Percent_Identity=31.8318318318318, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI116268111, Length=239, Percent_Identity=27.6150627615063, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI193211614, Length=251, Percent_Identity=27.8884462151394, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI8393516, Length=251, Percent_Identity=27.8884462151394, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4504031, Length=264, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786974, Length=298, Percent_Identity=32.5503355704698, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788353, Length=349, Percent_Identity=30.3724928366762, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI48994969, Length=346, Percent_Identity=29.4797687861272, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1788366, Length=346, Percent_Identity=26.878612716763, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790049, Length=264, Percent_Identity=31.4393939393939, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788365, Length=338, Percent_Identity=26.6272189349112, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71982035, Length=333, Percent_Identity=32.7327327327327, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71982038, Length=335, Percent_Identity=33.134328358209, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17568069, Length=331, Percent_Identity=32.02416918429, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17539532, Length=326, Percent_Identity=28.2208588957055, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI115532424, Length=328, Percent_Identity=27.7439024390244, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17507723, Length=339, Percent_Identity=26.8436578171091, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=310, Percent_Identity=32.9032258064516, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321437, Length=354, Percent_Identity=24.5762711864407, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19923002, Length=331, Percent_Identity=32.6283987915408, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21356223, Length=323, Percent_Identity=28.4829721362229, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24158427, Length=270, Percent_Identity=28.5185185185185, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 33773; Mature: 33773

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVTGGAGFIGSHIVEDLLARGLEVAVLDNLATGKRENVPKGVPFFRVDLRDKEGVER
CEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHH
AFREFRPTHVSHQAAQASVKVSVEDPVLDFEVNLLGGLNLLEACRQYGVEKLVFASTGGA
HHHHHCCCHHHHHHHHCEEEEEECCCEEEEEEHHHCCCHHHHHHHHCCCCEEEEEECCCE
IYGEVPEGERAEETWPPRPKSPYAASKAAFEHYLSVYGQSYGLKWVSLRYGNVYGPRQDP
EEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
HGEAGVVAIFAERVLKGLPVTLYARKTPGDEGCVRDYVYVGDVAEAHALALFSLEGIYNV
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCEEEECCHHHHHHHHEEEECCEEEC
GTGEGHTTREVLMAVAEAAGKAPEVQPAPPRPGDLERSVLSPLKLMAHGWRPKVGFQEGI
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCC
RLTVDHFRGAV
EEEEHHHCCCC
>Mature Secondary Structure
MRVLVTGGAGFIGSHIVEDLLARGLEVAVLDNLATGKRENVPKGVPFFRVDLRDKEGVER
CEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHH
AFREFRPTHVSHQAAQASVKVSVEDPVLDFEVNLLGGLNLLEACRQYGVEKLVFASTGGA
HHHHHCCCHHHHHHHHCEEEEEECCCEEEEEEHHHCCCHHHHHHHHCCCCEEEEEECCCE
IYGEVPEGERAEETWPPRPKSPYAASKAAFEHYLSVYGQSYGLKWVSLRYGNVYGPRQDP
EEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
HGEAGVVAIFAERVLKGLPVTLYARKTPGDEGCVRDYVYVGDVAEAHALALFSLEGIYNV
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCEEEECCHHHHHHHHEEEECCEEEC
GTGEGHTTREVLMAVAEAAGKAPEVQPAPPRPGDLERSVLSPLKLMAHGWRPKVGFQEGI
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCC
RLTVDHFRGAV
EEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]