Click here to switch to the map view.

The map label for this gene is polC [H]

Identifier: 55980543

GI number: 55980543

Start: 541898

End: 542641

Strand: Direct

Name: polC [H]

Synonym: TTHA0574

Alternate gene names: 55980543

Gene position: 541898-542641 (Clockwise)

Preceding gene: 55980542

Following gene: 55980544

Centisome position: 29.3

GC content: 71.64

Gene sequence:

>744_bases
ATGGAGGCCGCCTTCCGCTACCGCATGGCCACCCGGCTCGCCCGCAGGCTCAGGGAGGCCGGGCGCCCCCTTCCCCTCCC
TGCCCTGGGGGAGGCCTTGGGGCTTCGCGGCCCCGTGGAGCGGGTGGTGCGGCCCCTTCTGGACGGGAGGTTCCTCCTGG
AGGAGGGGGTGGGGCTTTGGGAGTGGCGCTACCCCTTTCCCCTGGAGGGGGAGGCGGTGGTGGTCCTGGACCTGGAGACC
ACGGGGCTTGCCCCGGGCCTGGACGAGGTGATTGAGGTGGGCCTCCTCCGCCTGGAGGGGGGGAGGCGCCTCCCCTTCCA
GAGCCTCGTCCGCCCCTCCCGCCCGCCGAGCCCCTTCGTGGAGCGCCTCACCGGCATCCCCCGGGAGGCCCTGGAGGAGG
CCCCCTCCCTGGAGGAGGTTCTGGAGAAGGCCTACCCCCTCCTCGCCGACGCCACCTTGGTGATCCACAACGCCGCCTTT
GACCTGGGCTTCCTCCGCCCGGCCTTGGAGGGCCTGGGCTACCGCCTGGAAAACCCCGTGGTGGACTCCCTGCGCTTGGC
CAGACGGGGCTTACCAGGCCTTAGGCGCTACGGCCTGGACGCCCTCTCCGAGGTCCTGGAGCTTCCCCGAAGGACCTGCC
ACCGGGCCCTCGAGGACGTGGAGCGCACCCTCGCCGTGGTGCACGAGGTATACTATATGCTTACGTCCGGCCGTCCCCGC
ACGCTTTGGGAACTCGGGAGGTAG

Upstream 100 bases:

>100_bases
CCCCCTGGGGGGAGGACGAGAGGCTTCTTCGGGCGGCCCTCGCCTTTGAGGAGGCCACGGCCCGGGCCCACCTCAAGGCC
CCCTTGGGGGAGGCCCTCTG

Downstream 100 bases:

>100_bases
CATGACCGCGCGGTATGTGCTCACCAGCGCCTGTATCCAGACCGGTACCATGGCCTTGACCGTATCCCTCCGCCAGCGCC
TCCTCGGGCGGGAGCAGGTG

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MEAAFRYRMATRLARRLREAGRPLPLPALGEALGLRGPVERVVRPLLDGRFLLEEGVGLWEWRYPFPLEGEAVVVLDLET
TGLAPGLDEVIEVGLLRLEGGRRLPFQSLVRPSRPPSPFVERLTGIPREALEEAPSLEEVLEKAYPLLADATLVIHNAAF
DLGFLRPALEGLGYRLENPVVDSLRLARRGLPGLRRYGLDALSEVLELPRRTCHRALEDVERTLAVVHEVYYMLTSGRPR
TLWELGR

Sequences:

>Translated_247_residues
MEAAFRYRMATRLARRLREAGRPLPLPALGEALGLRGPVERVVRPLLDGRFLLEEGVGLWEWRYPFPLEGEAVVVLDLET
TGLAPGLDEVIEVGLLRLEGGRRLPFQSLVRPSRPPSPFVERLTGIPREALEEAPSLEEVLEKAYPLLADATLVIHNAAF
DLGFLRPALEGLGYRLENPVVDSLRLARRGLPGLRRYGLDALSEVLELPRRTCHRALEDVERTLAVVHEVYYMLTSGRPR
TLWELGR
>Mature_247_residues
MEAAFRYRMATRLARRLREAGRPLPLPALGEALGLRGPVERVVRPLLDGRFLLEEGVGLWEWRYPFPLEGEAVVVLDLET
TGLAPGLDEVIEVGLLRLEGGRRLPFQSLVRPSRPPSPFVERLTGIPREALEEAPSLEEVLEKAYPLLADATLVIHNAAF
DLGFLRPALEGLGYRLENPVVDSLRLARRGLPGLRRYGLDALSEVLELPRRTCHRALEDVERTLAVVHEVYYMLTSGRPR
TLWELGR

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

Organism=Escherichia coli, GI1786409, Length=187, Percent_Identity=33.6898395721925, Blast_Score=77, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 27780; Mature: 27780

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAAFRYRMATRLARRLREAGRPLPLPALGEALGLRGPVERVVRPLLDGRFLLEEGVGLW
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCCE
EWRYPFPLEGEAVVVLDLETTGLAPGLDEVIEVGLLRLEGGRRLPFQSLVRPSRPPSPFV
EECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHH
ERLTGIPREALEEAPSLEEVLEKAYPLLADATLVIHNAAFDLGFLRPALEGLGYRLENPV
HHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
VDSLRLARRGLPGLRRYGLDALSEVLELPRRTCHRALEDVERTLAVVHEVYYMLTSGRPR
HHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TLWELGR
HHHHCCC
>Mature Secondary Structure
MEAAFRYRMATRLARRLREAGRPLPLPALGEALGLRGPVERVVRPLLDGRFLLEEGVGLW
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCCE
EWRYPFPLEGEAVVVLDLETTGLAPGLDEVIEVGLLRLEGGRRLPFQSLVRPSRPPSPFV
EECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHH
ERLTGIPREALEEAPSLEEVLEKAYPLLADATLVIHNAAFDLGFLRPALEGLGYRLENPV
HHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
VDSLRLARRGLPGLRRYGLDALSEVLELPRRTCHRALEDVERTLAVVHEVYYMLTSGRPR
HHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TLWELGR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]