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The map label for this gene is atoB [H]

Identifier: 55980528

GI number: 55980528

Start: 520477

End: 521667

Strand: Direct

Name: atoB [H]

Synonym: TTHA0559

Alternate gene names: 55980528

Gene position: 520477-521667 (Clockwise)

Preceding gene: 55980525

Following gene: 55980531

Centisome position: 28.14

GC content: 70.03

Gene sequence:

>1191_bases
ATGCGCGAGGTGTACGTTGTCGCCGCGGTGAGGACCCCCATCGGCAAGTTCGGGGGGGTCTTCAAGGACGTAAGCCCCGT
GGACCTCGGCGCCCACGCCATGCGGGAGGCCTTGGCCCGGGCGGGGGTGGAGGGAAAGGCCTTGGACCTCTACATCTTCG
GCAACGTCCTCAGGGCCGGGCACGGGCAGCTCCTCCCCCGGCAGGCGGCCCTGAAGGCGGGCATCCCCAAGGAGGTGGAC
GGGTACCAGGTGGACATGGTCTGCGCCTCGGGGATGATGGCGGCGCTCAACGCCGTCCAGTTCCTCCGCACCGGGGAGGC
CCACCTCGTCCTCGCCGGGGGGATGGAGTCCATGAGCCAGGCGGGCTTCTACCTCTCCCACCGGGCCCGGTGGGGGTACA
AGTTCCTCCTGGGCGCCCCGGAAAACCTCCAGGACATCCTCCTGCGGGACGGGCTTTCCGACCCCTTCACCGGGGAGGCC
ATGGGGGAGCAGGCGGAAAGGCTCGCCCAGGACCACGGGGTGACGCGGCGGGAGATTGACGAGGCCGCCTACCTTTCCCA
CAAGAGGGCGGCGGAGGCCACGGAGAAGGGCCTCTTTGCCTGGGAGATCGCCCCCATGGAGGTCCAAGGGAGGAAGGGCC
CGGTGGTGGTGGACCGGGACGAGGGGATCCGGCCCGAGACCACCCTGGAGTCCCTCGCCGCCCTCAGGCCCGCCTTCAAG
AAGGACGGGGTCCTCACGGCGGGGAACTCCAGCCAGATTTCCGACGGGGCGGCGGCCCTCCTCCTCGCCTCCGAGGAGGC
GGTCAAGGCCCACGGCCTGAAGCCCATCGCCAAGGTCCTCGGAGGGGCCTGGGCCGCCGGGGAGTCCTGGCGCTTCCCCG
AGGCCCCCATCCCCGCGGCCAAAAGGCTCTTGGACCGTTTGGGGATGCGGGTTTCCGACTTCGGCCTCTTTGAGAACAAC
GAGGCCTTCGCCCTGAACAACGTCCTCTTCAGCCGCCTTCTGGACGTCCCCTACGAGCGGCTCAACGTCTTCGGAGGGGC
GGTGGCTTTAGGCCACCCCATCGGGGCGAGCGGGGCGAGGATCCTGGTCACGCTCCTCAACGCCTTGCGGGCGAAGGGGG
AGGAGCGGGGCCTCGCCGCCATCTGCCACGGGACCGGGGGCTCGGTGGCCTTTGCGGTGGAGGTGGTGTAG

Upstream 100 bases:

>100_bases
CGGCACCCGCACCTCGCCCATGGTGTCCCGCTCAATCCGGTATTCCACAGGGCACCTCCCAAGGGGATTCTACCCCCAAG
GCTCGGCGTATGATGGGGGC

Downstream 100 bases:

>100_bases
CGGGGCGCCCCTAGAGGAGCCCGTCCAGCTCAAAGGCCTCGAGGCGGAACTCCTCCAGGGCCACCTGGAACCCCCCCGCC
TCCGCCAGGAAGCGGGCCGC

Product: acetyl coenzyme A acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MREVYVVAAVRTPIGKFGGVFKDVSPVDLGAHAMREALARAGVEGKALDLYIFGNVLRAGHGQLLPRQAALKAGIPKEVD
GYQVDMVCASGMMAALNAVQFLRTGEAHLVLAGGMESMSQAGFYLSHRARWGYKFLLGAPENLQDILLRDGLSDPFTGEA
MGEQAERLAQDHGVTRREIDEAAYLSHKRAAEATEKGLFAWEIAPMEVQGRKGPVVVDRDEGIRPETTLESLAALRPAFK
KDGVLTAGNSSQISDGAAALLLASEEAVKAHGLKPIAKVLGGAWAAGESWRFPEAPIPAAKRLLDRLGMRVSDFGLFENN
EAFALNNVLFSRLLDVPYERLNVFGGAVALGHPIGASGARILVTLLNALRAKGEERGLAAICHGTGGSVAFAVEVV

Sequences:

>Translated_396_residues
MREVYVVAAVRTPIGKFGGVFKDVSPVDLGAHAMREALARAGVEGKALDLYIFGNVLRAGHGQLLPRQAALKAGIPKEVD
GYQVDMVCASGMMAALNAVQFLRTGEAHLVLAGGMESMSQAGFYLSHRARWGYKFLLGAPENLQDILLRDGLSDPFTGEA
MGEQAERLAQDHGVTRREIDEAAYLSHKRAAEATEKGLFAWEIAPMEVQGRKGPVVVDRDEGIRPETTLESLAALRPAFK
KDGVLTAGNSSQISDGAAALLLASEEAVKAHGLKPIAKVLGGAWAAGESWRFPEAPIPAAKRLLDRLGMRVSDFGLFENN
EAFALNNVLFSRLLDVPYERLNVFGGAVALGHPIGASGARILVTLLNALRAKGEERGLAAICHGTGGSVAFAVEVV
>Mature_396_residues
MREVYVVAAVRTPIGKFGGVFKDVSPVDLGAHAMREALARAGVEGKALDLYIFGNVLRAGHGQLLPRQAALKAGIPKEVD
GYQVDMVCASGMMAALNAVQFLRTGEAHLVLAGGMESMSQAGFYLSHRARWGYKFLLGAPENLQDILLRDGLSDPFTGEA
MGEQAERLAQDHGVTRREIDEAAYLSHKRAAEATEKGLFAWEIAPMEVQGRKGPVVVDRDEGIRPETTLESLAALRPAFK
KDGVLTAGNSSQISDGAAALLLASEEAVKAHGLKPIAKVLGGAWAAGESWRFPEAPIPAAKRLLDRLGMRVSDFGLFENN
EAFALNNVLFSRLLDVPYERLNVFGGAVALGHPIGASGARILVTLLNALRAKGEERGLAAICHGTGGSVAFAVEVV

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=40, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=40.5063291139241, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=37.7215189873418, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=39, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4504327, Length=432, Percent_Identity=33.1018518518519, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=29.6675191815857, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=43.6548223350254, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=39.8477157360406, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=35.9102244389027, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=40.3465346534653, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=30.8068459657702, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=41.8781725888325, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=37.6590330788804, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=35.8585858585859, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=32.4766355140187, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=31.8181818181818, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=40.0497512437811, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=33.9240506329114, Blast_Score=172, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=42.3857868020305, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=40.1015228426396, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17648125, Length=399, Percent_Identity=37.844611528822, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=30.4651162790698, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24585051, Length=433, Percent_Identity=24.4803695150115, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921506, Length=433, Percent_Identity=23.7875288683603, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42130; Mature: 42130

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVYVVAAVRTPIGKFGGVFKDVSPVDLGAHAMREALARAGVEGKALDLYIFGNVLRAG
CCEEEEEEEECCCCHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEHHHHHCC
HGQLLPRQAALKAGIPKEVDGYQVDMVCASGMMAALNAVQFLRTGEAHLVLAGGMESMSQ
CCCCCCHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
AGFYLSHRARWGYKFLLGAPENLQDILLRDGLSDPFTGEAMGEQAERLAQDHGVTRREID
CCCEEEHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHH
EAAYLSHKRAAEATEKGLFAWEIAPMEVQGRKGPVVVDRDEGIRPETTLESLAALRPAFK
HHHHHHHHHHHHHHHCCCEEEEECCEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
KDGVLTAGNSSQISDGAAALLLASEEAVKAHGLKPIAKVLGGAWAAGESWRFPEAPIPAA
CCCEEECCCCCCCCCCCEEEEEECHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCHHH
KRLLDRLGMRVSDFGLFENNEAFALNNVLFSRLLDVPYERLNVFGGAVALGHPIGASGAR
HHHHHHHCCCEECCCEECCCCCCHHHHHHHHHHHHCCHHHHHHHCCHHEECCCCCCCHHH
ILVTLLNALRAKGEERGLAAICHGTGGSVAFAVEVV
HHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MREVYVVAAVRTPIGKFGGVFKDVSPVDLGAHAMREALARAGVEGKALDLYIFGNVLRAG
CCEEEEEEEECCCCHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEHHHHHCC
HGQLLPRQAALKAGIPKEVDGYQVDMVCASGMMAALNAVQFLRTGEAHLVLAGGMESMSQ
CCCCCCHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
AGFYLSHRARWGYKFLLGAPENLQDILLRDGLSDPFTGEAMGEQAERLAQDHGVTRREID
CCCEEEHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHH
EAAYLSHKRAAEATEKGLFAWEIAPMEVQGRKGPVVVDRDEGIRPETTLESLAALRPAFK
HHHHHHHHHHHHHHHCCCEEEEECCEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
KDGVLTAGNSSQISDGAAALLLASEEAVKAHGLKPIAKVLGGAWAAGESWRFPEAPIPAA
CCCEEECCCCCCCCCCCEEEEEECHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCHHH
KRLLDRLGMRVSDFGLFENNEAFALNNVLFSRLLDVPYERLNVFGGAVALGHPIGASGAR
HHHHHHHCCCEECCCEECCCCCCHHHHHHHHHHHHCCHHHHHHHCCHHEECCCCCCCHHH
ILVTLLNALRAKGEERGLAAICHGTGGSVAFAVEVV
HHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]