Click here to switch to the map view.

The map label for this gene is sucC [H]

Identifier: 55980507

GI number: 55980507

Start: 500445

End: 501620

Strand: Reverse

Name: sucC [H]

Synonym: TTHA0538

Alternate gene names: 55980507

Gene position: 501620-500445 (Counterclockwise)

Preceding gene: 55980509

Following gene: 55980506

Centisome position: 27.12

GC content: 66.33

Gene sequence:

>1176_bases
ATGCCCTTGACCGGGGTCGCCCGGCAAGGGAGGTGGGTCTTGAACCTGCACGAGTATCAAGCGAAGGAGATCCTGGCCCG
CTATGGGGTGCCCGTGCCGCCGGGAAAGGTGGCCTACACCCCCGAGGAGGCCAAACGGATCGCCGAGGAGTTCGGCAAGC
GGGTGGTCATCAAGGCCCAGGTGCACGTGGGAGGGAGAGGAAAGGCGGGGGGCGTCAAGCTCGCCGACACCCCCCAGGAG
GCCTACGAGAAGGCCCAGGCCATCCTGGGCATGAACATCAAGGGCCTTACCGTGAAGAAGGTCCTGGTGGCCGAGGCGGT
GGACATCGCCAAGGAGTACTACGCGGGCCTCATCCTGGACCGGGCCAAGAAGCGGGTGGTCCTGATGCTCTCCAAGGAGG
GGGGCGTGGACATTGAAGAGGTGGCCGCGGAGCGCCCCGAGGCCATCCACAAGTTCTGGATTGACCCCCACAAGGGGTTC
CGCCCCTTTGAGGCCCGGGAGATGGTGAAGCGGGCGGGGCTCGAGGGCAACCTCAACAAGCTCGCCCAGGTCCTGGTGGC
CCTCTACCGGGCCTACGAGGGCGTGGACGCCTCCATCGCCGAGATCAACCCCCTGGTGGTGACCACGGACGGCGGGATCG
TCGCCGCCGACGCCAAGATCGTCCTGGACGACAACGCCCTCTTCCGCCACCCCGACCTCGCCGAGCTCAGGGAGGTGGAG
GCCGAGCACCCCTTGGAGGTGGAGGCCAGCAACTACGGCTTCGCCTACGTGAAGCTTGATGGCAACATCGGCATCATCGG
AAACGGGGCGGGCCTCGTGATGTACACCCTGGATCTGGTGAACCGGGTAGGGGGCAAGCCCGCCAACTTCCTGGACATCG
GGGGCGGGGCCAAGGCGGATGTGGTCTACAACGCCCTCAAGGTGGTCCTCAAGGACCCCGACGTCAAGGGGGTCTTCATC
AACATCTTCGGCGGCATCACCCGGGCGGACGAGGTGGCCAAGGGGGTGATCCGCGCCCTGGAGGAGGGCCTCCTCACCAA
GCCCGTGGTGATGCGGGTGGCGGGCACCGCCGAGGAGGAGGCCAAGAAGCTTTTGGAGGGGAAGCCCGTCTACATGTACC
CCACGTCCATTGAGGCGGCCAAGGTCATCGTGGCCATGGTGGGAGGTGCGGCGTGA

Upstream 100 bases:

>100_bases
AGGCCCGTGGCCCGGCGCACCTCTTCCGCCACCTGGACCAGCGCTTCCTTGTTCACGCTCACCCCCTTTCCGGCCGTTTC
CACGGCCCAAGGCCTATATA

Downstream 100 bases:

>100_bases
TCCTGGTGAACCGCGAGACCCGCGTCCTGGTCCAGGGCATCACCGGCCGGGAGGGGCAGTTCCACACCAAGCAGATGCTT
TCCTACGGCACCAAGATCGT

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MPLTGVARQGRWVLNLHEYQAKEILARYGVPVPPGKVAYTPEEAKRIAEEFGKRVVIKAQVHVGGRGKAGGVKLADTPQE
AYEKAQAILGMNIKGLTVKKVLVAEAVDIAKEYYAGLILDRAKKRVVLMLSKEGGVDIEEVAAERPEAIHKFWIDPHKGF
RPFEAREMVKRAGLEGNLNKLAQVLVALYRAYEGVDASIAEINPLVVTTDGGIVAADAKIVLDDNALFRHPDLAELREVE
AEHPLEVEASNYGFAYVKLDGNIGIIGNGAGLVMYTLDLVNRVGGKPANFLDIGGGAKADVVYNALKVVLKDPDVKGVFI
NIFGGITRADEVAKGVIRALEEGLLTKPVVMRVAGTAEEEAKKLLEGKPVYMYPTSIEAAKVIVAMVGGAA

Sequences:

>Translated_391_residues
MPLTGVARQGRWVLNLHEYQAKEILARYGVPVPPGKVAYTPEEAKRIAEEFGKRVVIKAQVHVGGRGKAGGVKLADTPQE
AYEKAQAILGMNIKGLTVKKVLVAEAVDIAKEYYAGLILDRAKKRVVLMLSKEGGVDIEEVAAERPEAIHKFWIDPHKGF
RPFEAREMVKRAGLEGNLNKLAQVLVALYRAYEGVDASIAEINPLVVTTDGGIVAADAKIVLDDNALFRHPDLAELREVE
AEHPLEVEASNYGFAYVKLDGNIGIIGNGAGLVMYTLDLVNRVGGKPANFLDIGGGAKADVVYNALKVVLKDPDVKGVFI
NIFGGITRADEVAKGVIRALEEGLLTKPVVMRVAGTAEEEAKKLLEGKPVYMYPTSIEAAKVIVAMVGGAA
>Mature_390_residues
PLTGVARQGRWVLNLHEYQAKEILARYGVPVPPGKVAYTPEEAKRIAEEFGKRVVIKAQVHVGGRGKAGGVKLADTPQEA
YEKAQAILGMNIKGLTVKKVLVAEAVDIAKEYYAGLILDRAKKRVVLMLSKEGGVDIEEVAAERPEAIHKFWIDPHKGFR
PFEAREMVKRAGLEGNLNKLAQVLVALYRAYEGVDASIAEINPLVVTTDGGIVAADAKIVLDDNALFRHPDLAELREVEA
EHPLEVEASNYGFAYVKLDGNIGIIGNGAGLVMYTLDLVNRVGGKPANFLDIGGGAKADVVYNALKVVLKDPDVKGVFIN
IFGGITRADEVAKGVIRALEEGLLTKPVVMRVAGTAEEEAKKLLEGKPVYMYPTSIEAAKVIVAMVGGAA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI157779135, Length=378, Percent_Identity=41.7989417989418, Blast_Score=268, Evalue=5e-72,
Organism=Homo sapiens, GI294862256, Length=379, Percent_Identity=41.1609498680739, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI11321583, Length=391, Percent_Identity=39.386189258312, Blast_Score=259, Evalue=4e-69,
Organism=Escherichia coli, GI1786948, Length=387, Percent_Identity=45.7364341085271, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17567829, Length=396, Percent_Identity=39.1414141414141, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17539378, Length=377, Percent_Identity=38.7267904509284, Blast_Score=248, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6321683, Length=402, Percent_Identity=37.8109452736318, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI161078106, Length=379, Percent_Identity=41.1609498680739, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24645208, Length=379, Percent_Identity=41.1609498680739, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI281361397, Length=380, Percent_Identity=41.0526315789474, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI281361395, Length=380, Percent_Identity=41.0526315789474, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI21356231, Length=391, Percent_Identity=37.3401534526854, Blast_Score=242, Evalue=4e-64,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 42066; Mature: 41935

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTGVARQGRWVLNLHEYQAKEILARYGVPVPPGKVAYTPEEAKRIAEEFGKRVVIKAQ
CCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHCCEEEEEEE
VHVGGRGKAGGVKLADTPQEAYEKAQAILGMNIKGLTVKKVLVAEAVDIAKEYYAGLILD
EEECCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RAKKRVVLMLSKEGGVDIEEVAAERPEAIHKFWIDPHKGFRPFEAREMVKRAGLEGNLNK
CCCCEEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHH
LAQVLVALYRAYEGVDASIAEINPLVVTTDGGIVAADAKIVLDDNALFRHPDLAELREVE
HHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCEEEECCEEEEECCCEECCCCHHHHHHCC
AEHPLEVEASNYGFAYVKLDGNIGIIGNGAGLVMYTLDLVNRVGGKPANFLDIGGGAKAD
CCCCEEEEECCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHH
VVYNALKVVLKDPDVKGVFINIFGGITRADEVAKGVIRALEEGLLTKPVVMRVAGTAEEE
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHEECCCCHHH
AKKLLEGKPVYMYPTSIEAAKVIVAMVGGAA
HHHHHCCCCEEEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLTGVARQGRWVLNLHEYQAKEILARYGVPVPPGKVAYTPEEAKRIAEEFGKRVVIKAQ
CCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHCCEEEEEEE
VHVGGRGKAGGVKLADTPQEAYEKAQAILGMNIKGLTVKKVLVAEAVDIAKEYYAGLILD
EEECCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RAKKRVVLMLSKEGGVDIEEVAAERPEAIHKFWIDPHKGFRPFEAREMVKRAGLEGNLNK
CCCCEEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHH
LAQVLVALYRAYEGVDASIAEINPLVVTTDGGIVAADAKIVLDDNALFRHPDLAELREVE
HHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCEEEECCEEEEECCCEECCCCHHHHHHCC
AEHPLEVEASNYGFAYVKLDGNIGIIGNGAGLVMYTLDLVNRVGGKPANFLDIGGGAKAD
CCCCEEEEECCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHH
VVYNALKVVLKDPDVKGVFINIFGGITRADEVAKGVIRALEEGLLTKPVVMRVAGTAEEE
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHEECCCCHHH
AKKLLEGKPVYMYPTSIEAAKVIVAMVGGAA
HHHHHCCCCEEEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034208; 2204576 [H]