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The map label for this gene is maeA [H]

Identifier: 55980489

GI number: 55980489

Start: 482455

End: 484185

Strand: Direct

Name: maeA [H]

Synonym: TTHA0520

Alternate gene names: 55980489

Gene position: 482455-484185 (Clockwise)

Preceding gene: 55980488

Following gene: 55980490

Centisome position: 26.08

GC content: 68.63

Gene sequence:

>1731_bases
ATGCCCATAAGCCGCTACTACGACGTCAAGCGGGACGAGAAAGGCGAGCGCTACCTGGAGCCCTACGTCACGGGTTTTTT
GCTCCTTAGGCTTCCCCTCCTCAACAAGGGCACGGCCTTCACCGAGGAGGAGCGCCGCCTCTTGGGCCTCGAGGGCCTCC
TCCCCCCCCACGTCCACACCCTGGAGGAGCAGAAGGAAAGGGTCTACCGCCGCTACCGCCTGATCCAAAGTCCCTTGGAG
AAGCACATCTACCTGCGCCACCTCCAGGACCGGAACGAGGTCCTCTTCTACGCCCTTGTGGTGGACCACCTGGAGGAGAT
GCTCCCCATCCTCTACACCCCCACGGTGGGGGAGGCGGTGCGGGAGTTCTCCCACATCTACCGCTACCCCCGGGGCTTCA
CCGCGAGCACCAAAAACATTGACCGGATAGACGAGGCCCTCCAGAACGTCCCCTTGGAGGACGTGCGCCTCATCGTGGCC
ACGGACTCCTCCGCCATCCTGGGGATCGGGGACCAGGGCTACGGGGGGATGGCCATCAGCATCGGCAAGCTCACCCTCTA
CACCGCCGCGGGCGGGGTGGGCCCCGACAAGACCCTCCCCGTGGAGCTGGACGTGGGCACGGACCGGGAGGACCTCCTCA
AGGACCCCCTCTACCTCGGGGTGCGGCACCGGCGCTTGCGGGGGGAGGAGTACTTCCGCTTCCTGGACCGCTTCGTGGAG
GCGGTGAGGCGGCGCTACCCCAAGGCCCTCATCCAGTGGGAGGACTTCGCCAAGGAGACGGCCTTCCAGGTGTTGGAGCG
CTACCGCAAGGTCATCCCCTCCTTCAACGACGACATCCAGGGCACGGGGGCCGTGGCCCTGGCCGGGGTGCTCTCCGCCT
GCCGCTTAAAGGGGGAGAGGCTTTCGGACCAGGTGGTGGTGGTCTATGGGGCGGGGGCCGGGGGGATCGGGGTGGCCTGG
GCCTTGGTGGAGGGGATGAAGCGGGAGGGCCTCTCCGAGGAGGAGGCCAAGGCCCGGGTCCTCGTCCTGGACTCCAAGGG
CCTCCTCGTGGAGGGGCGGAGCATGGAGGACTACAAGAGGCCCTACGCCCAGAGGCCCGAGCGCCTATGGGGTTGGCGCT
TTGCCGGGGAGTACCCCAACCTCCTGGAGACCATCACGAACGCCCGAGCCACGGTCCTCCTCGGCCTTTCCGGCCAGGCG
GGAAGCTTCACCGAGCCCGTGGTGCGGGCCATGCTGGCGAACACGCCCCGCCCCGTGATCTTCCCCCTCTCCAACCCCAC
CTCGGCCACGGAGGCCCTTCCGGACGACCTCGTCTACTGGACGGAGGGGCGGGCCCTGGTGGCCGCGGGAAGCCCCTTCC
CCCCGGTGGGCTTCAAGGGGCGCACCGTCCCCATCGGCCAGGGGAACAACGCCTTCGTCTTCCCCGGGCTCGGCCTCGGG
GCGGTGCTCTCCCGGGCCCGGGAGGTGACGGACGGGATGGTCCTCGAGGCCGCCTACGCCCTTTACGACTACACCCGGGA
GCACTTCCCCGAGCGGATCTACCCCCCGGTGGGGCGGTTGCGGGAGGTCTCCCCCTACGTGGCCGCCCGGGTGATGCAGA
GGGCCCTGGAGGAAGGGGTGGCGGAGGAGGCTAGGGTCCAGGGGCTTACCCTCGAGGCCCTCCTGGACTTCGTCAAAAGC
CGCTTCTGGGAGCCCCGGTACCTCCCCTACCGCCCCGCCCCGGTAATCTAG

Upstream 100 bases:

>100_bases
CGTCTGGACCCCGCCCTGGACCCCCGCCCGCATGACGGAGGAGGGCAAGCGCATGATGCGCATGTTCGGCTTCAACGTCT
AGGCGTGGGAGCGTGGCCCC

Downstream 100 bases:

>100_bases
GGGCATGGCCTGGCGCCTCTTGCGCCTCGAGCCCCTGGGGCTCCAAGAAGGCCCCGCCTCCCCCCCGGAGCCCGGGGCCT
TCCGGCTCCTGGAGGAGCCC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 576; Mature: 575

Protein sequence:

>576_residues
MPISRYYDVKRDEKGERYLEPYVTGFLLLRLPLLNKGTAFTEEERRLLGLEGLLPPHVHTLEEQKERVYRRYRLIQSPLE
KHIYLRHLQDRNEVLFYALVVDHLEEMLPILYTPTVGEAVREFSHIYRYPRGFTASTKNIDRIDEALQNVPLEDVRLIVA
TDSSAILGIGDQGYGGMAISIGKLTLYTAAGGVGPDKTLPVELDVGTDREDLLKDPLYLGVRHRRLRGEEYFRFLDRFVE
AVRRRYPKALIQWEDFAKETAFQVLERYRKVIPSFNDDIQGTGAVALAGVLSACRLKGERLSDQVVVVYGAGAGGIGVAW
ALVEGMKREGLSEEEAKARVLVLDSKGLLVEGRSMEDYKRPYAQRPERLWGWRFAGEYPNLLETITNARATVLLGLSGQA
GSFTEPVVRAMLANTPRPVIFPLSNPTSATEALPDDLVYWTEGRALVAAGSPFPPVGFKGRTVPIGQGNNAFVFPGLGLG
AVLSRAREVTDGMVLEAAYALYDYTREHFPERIYPPVGRLREVSPYVAARVMQRALEEGVAEEARVQGLTLEALLDFVKS
RFWEPRYLPYRPAPVI

Sequences:

>Translated_576_residues
MPISRYYDVKRDEKGERYLEPYVTGFLLLRLPLLNKGTAFTEEERRLLGLEGLLPPHVHTLEEQKERVYRRYRLIQSPLE
KHIYLRHLQDRNEVLFYALVVDHLEEMLPILYTPTVGEAVREFSHIYRYPRGFTASTKNIDRIDEALQNVPLEDVRLIVA
TDSSAILGIGDQGYGGMAISIGKLTLYTAAGGVGPDKTLPVELDVGTDREDLLKDPLYLGVRHRRLRGEEYFRFLDRFVE
AVRRRYPKALIQWEDFAKETAFQVLERYRKVIPSFNDDIQGTGAVALAGVLSACRLKGERLSDQVVVVYGAGAGGIGVAW
ALVEGMKREGLSEEEAKARVLVLDSKGLLVEGRSMEDYKRPYAQRPERLWGWRFAGEYPNLLETITNARATVLLGLSGQA
GSFTEPVVRAMLANTPRPVIFPLSNPTSATEALPDDLVYWTEGRALVAAGSPFPPVGFKGRTVPIGQGNNAFVFPGLGLG
AVLSRAREVTDGMVLEAAYALYDYTREHFPERIYPPVGRLREVSPYVAARVMQRALEEGVAEEARVQGLTLEALLDFVKS
RFWEPRYLPYRPAPVI
>Mature_575_residues
PISRYYDVKRDEKGERYLEPYVTGFLLLRLPLLNKGTAFTEEERRLLGLEGLLPPHVHTLEEQKERVYRRYRLIQSPLEK
HIYLRHLQDRNEVLFYALVVDHLEEMLPILYTPTVGEAVREFSHIYRYPRGFTASTKNIDRIDEALQNVPLEDVRLIVAT
DSSAILGIGDQGYGGMAISIGKLTLYTAAGGVGPDKTLPVELDVGTDREDLLKDPLYLGVRHRRLRGEEYFRFLDRFVEA
VRRRYPKALIQWEDFAKETAFQVLERYRKVIPSFNDDIQGTGAVALAGVLSACRLKGERLSDQVVVVYGAGAGGIGVAWA
LVEGMKREGLSEEEAKARVLVLDSKGLLVEGRSMEDYKRPYAQRPERLWGWRFAGEYPNLLETITNARATVLLGLSGQAG
SFTEPVVRAMLANTPRPVIFPLSNPTSATEALPDDLVYWTEGRALVAAGSPFPPVGFKGRTVPIGQGNNAFVFPGLGLGA
VLSRAREVTDGMVLEAAYALYDYTREHFPERIYPPVGRLREVSPYVAARVMQRALEEGVAEEARVQGLTLEALLDFVKSR
FWEPRYLPYRPAPVI

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=522, Percent_Identity=43.4865900383142, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI62420882, Length=525, Percent_Identity=41.5238095238095, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI62420880, Length=525, Percent_Identity=41.5238095238095, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI239049447, Length=525, Percent_Identity=41.5238095238095, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI4505145, Length=559, Percent_Identity=40.9660107334526, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI270265879, Length=466, Percent_Identity=42.9184549356223, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI87081919, Length=561, Percent_Identity=46.1675579322638, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1788806, Length=387, Percent_Identity=27.1317829457364, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537199, Length=520, Percent_Identity=43.0769230769231, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322823, Length=576, Percent_Identity=42.3611111111111, Blast_Score=440, Evalue=1e-124,
Organism=Drosophila melanogaster, GI281362672, Length=526, Percent_Identity=41.254752851711, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281362674, Length=526, Percent_Identity=41.254752851711, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI21356279, Length=526, Percent_Identity=41.254752851711, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24646386, Length=556, Percent_Identity=38.1294964028777, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24646388, Length=556, Percent_Identity=38.1294964028777, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI78707242, Length=514, Percent_Identity=37.15953307393, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI78707238, Length=514, Percent_Identity=37.15953307393, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI78707240, Length=511, Percent_Identity=37.1819960861057, Blast_Score=338, Evalue=5e-93,
Organism=Drosophila melanogaster, GI78707232, Length=510, Percent_Identity=33.921568627451, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI281363505, Length=513, Percent_Identity=33.5282651072125, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI78707236, Length=513, Percent_Identity=33.5282651072125, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI281363503, Length=511, Percent_Identity=33.2681017612524, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI19922384, Length=555, Percent_Identity=31.1711711711712, Blast_Score=263, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 64814; Mature: 64683

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISRYYDVKRDEKGERYLEPYVTGFLLLRLPLLNKGTAFTEEERRLLGLEGLLPPHVHT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHH
LEEQKERVYRRYRLIQSPLEKHIYLRHLQDRNEVLFYALVVDHLEEMLPILYTPTVGEAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCHHHHH
REFSHIYRYPRGFTASTKNIDRIDEALQNVPLEDVRLIVATDSSAILGIGDQGYGGMAIS
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHEEEEEEECCCEEEECCCCCCCCEEEE
IGKLTLYTAAGGVGPDKTLPVELDVGTDREDLLKDPLYLGVRHRRLRGEEYFRFLDRFVE
ECCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHH
AVRRRYPKALIQWEDFAKETAFQVLERYRKVIPSFNDDIQGTGAVALAGVLSACRLKGER
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LSDQVVVVYGAGAGGIGVAWALVEGMKREGLSEEEAKARVLVLDSKGLLVEGRSMEDYKR
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHCCEEEEEEECCCCEEECCCCHHHHC
PYAQRPERLWGWRFAGEYPNLLETITNARATVLLGLSGQAGSFTEPVVRAMLANTPRPVI
HHHCCCHHHHCEEECCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEE
FPLSNPTSATEALPDDLVYWTEGRALVAAGSPFPPVGFKGRTVPIGQGNNAFVFPGLGLG
EECCCCCCHHHCCCCCCEEEECCCEEEECCCCCCCCCCCCCEEECCCCCCEEEECCCCHH
AVLSRAREVTDGMVLEAAYALYDYTREHFPERIYPPVGRLREVSPYVAARVMQRALEEGV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCC
AEEARVQGLTLEALLDFVKSRFWEPRYLPYRPAPVI
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PISRYYDVKRDEKGERYLEPYVTGFLLLRLPLLNKGTAFTEEERRLLGLEGLLPPHVHT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHH
LEEQKERVYRRYRLIQSPLEKHIYLRHLQDRNEVLFYALVVDHLEEMLPILYTPTVGEAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCHHHHH
REFSHIYRYPRGFTASTKNIDRIDEALQNVPLEDVRLIVATDSSAILGIGDQGYGGMAIS
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHEEEEEEECCCEEEECCCCCCCCEEEE
IGKLTLYTAAGGVGPDKTLPVELDVGTDREDLLKDPLYLGVRHRRLRGEEYFRFLDRFVE
ECCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHH
AVRRRYPKALIQWEDFAKETAFQVLERYRKVIPSFNDDIQGTGAVALAGVLSACRLKGER
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LSDQVVVVYGAGAGGIGVAWALVEGMKREGLSEEEAKARVLVLDSKGLLVEGRSMEDYKR
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHCCEEEEEEECCCCEEECCCCHHHHC
PYAQRPERLWGWRFAGEYPNLLETITNARATVLLGLSGQAGSFTEPVVRAMLANTPRPVI
HHHCCCHHHHCEEECCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEE
FPLSNPTSATEALPDDLVYWTEGRALVAAGSPFPPVGFKGRTVPIGQGNNAFVFPGLGLG
EECCCCCCHHHCCCCCCEEEECCCEEEECCCCCCCCCCCCCEEECCCCCCEEEECCCCHH
AVLSRAREVTDGMVLEAAYALYDYTREHFPERIYPPVGRLREVSPYVAARVMQRALEEGV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCC
AEEARVQGLTLEALLDFVKSRFWEPRYLPYRPAPVI
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA