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The map label for this gene is purE [H]

Identifier: 55980483

GI number: 55980483

Start: 478846

End: 479340

Strand: Reverse

Name: purE [H]

Synonym: TTHA0514

Alternate gene names: 55980483

Gene position: 479340-478846 (Counterclockwise)

Preceding gene: 55980486

Following gene: 55980482

Centisome position: 25.91

GC content: 70.91

Gene sequence:

>495_bases
ATGGCGCCGTTGGTAGGCCTGATCATGGGTTCCCGCTCCGACTGGGAGACCATGCGCCACGCGGCGGAGACCCTCGAGGC
CCTGGGCATCCCCTACGAGGTGCGCGTGGTCTCCGCCCACCGCACCCCAGACCTCATGGCGGAGTACGCCAAGACCGCCG
AGGAACGGGGGATCCAGGTGATCATCGCCGGGGCCGGGGGGGCGGCCCACCTCCCCGGCATGACCGCGGCCCACACCGCC
CTCCCCGTCCTCGGGGTGCCGGTGGAAAGCCGGGCCCTAGGGGGCTTAGACTCCCTCCTTTCCATCGTGCAGATGCCCGC
GGGCGTCCCCGTGGGCACCCTGGCCATCGGGAAAGCAGGGGCGGTGAACGCCGCTTTGCTTGCCGCAAGCATCCTGGGCC
TCAAGCACCCCGAGATCCTAAAGCGCCTCAAGGCCTACCGCAAGGCCCAGACGGAGGCCGTCCTCGCCCACCCCGACCCC
AGGGAGGAGGCGTGA

Upstream 100 bases:

>100_bases
CGAGGACCATGGGGGAGAGGAGGTTGAGGCGCAAAAGCTCCAGCGCGTCCATACCCCCACCGCTTTACCAAAGGGGGAAG
GGCTTTTACAATCCGGTACG

Downstream 100 bases:

>100_bases
TCGGGATCCTGGGCGGGGGGCAACTCGGGCGGATGCTGGCCCTTGCCGGCTACCCCTTGGGGCTTTCCTTCCGCTTCCTG
GACCCTTCCCCCGAGGCCTG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MAPLVGLIMGSRSDWETMRHAAETLEALGIPYEVRVVSAHRTPDLMAEYAKTAEERGIQVIIAGAGGAAHLPGMTAAHTA
LPVLGVPVESRALGGLDSLLSIVQMPAGVPVGTLAIGKAGAVNAALLAASILGLKHPEILKRLKAYRKAQTEAVLAHPDP
REEA

Sequences:

>Translated_164_residues
MAPLVGLIMGSRSDWETMRHAAETLEALGIPYEVRVVSAHRTPDLMAEYAKTAEERGIQVIIAGAGGAAHLPGMTAAHTA
LPVLGVPVESRALGGLDSLLSIVQMPAGVPVGTLAIGKAGAVNAALLAASILGLKHPEILKRLKAYRKAQTEAVLAHPDP
REEA
>Mature_163_residues
APLVGLIMGSRSDWETMRHAAETLEALGIPYEVRVVSAHRTPDLMAEYAKTAEERGIQVIIAGAGGAAHLPGMTAAHTAL
PVLGVPVESRALGGLDSLLSIVQMPAGVPVGTLAIGKAGAVNAALLAASILGLKHPEILKRLKAYRKAQTEAVLAHPDPR
EEA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=66.8789808917197, Blast_Score=179, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6324702, Length=155, Percent_Identity=54.8387096774194, Blast_Score=159, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17018; Mature: 16887

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPLVGLIMGSRSDWETMRHAAETLEALGIPYEVRVVSAHRTPDLMAEYAKTAEERGIQV
CCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMTAAHTALPVLGVPVESRALGGLDSLLSIVQMPAGVPVGTLAIGKAG
EEECCCCCCCCCCCHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCEECCCCC
AVNAALLAASILGLKHPEILKRLKAYRKAQTEAVLAHPDPREEA
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCC
>Mature Secondary Structure 
APLVGLIMGSRSDWETMRHAAETLEALGIPYEVRVVSAHRTPDLMAEYAKTAEERGIQV
CCHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMTAAHTALPVLGVPVESRALGGLDSLLSIVQMPAGVPVGTLAIGKAG
EEECCCCCCCCCCCHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCEECCCCC
AVNAALLAASILGLKHPEILKRLKAYRKAQTEAVLAHPDPREEA
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]