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The map label for this gene is purK [H]

Identifier: 55980482

GI number: 55980482

Start: 477740

End: 478849

Strand: Reverse

Name: purK [H]

Synonym: TTHA0513

Alternate gene names: 55980482

Gene position: 478849-477740 (Counterclockwise)

Preceding gene: 55980483

Following gene: 55980481

Centisome position: 25.89

GC content: 69.37

Gene sequence:

>1110_bases
GTGATCGGGATCCTGGGCGGGGGGCAACTCGGGCGGATGCTGGCCCTTGCCGGCTACCCCTTGGGGCTTTCCTTCCGCTT
CCTGGACCCTTCCCCCGAGGCCTGCGCCGGGCAGGTGGGGGAGCTCGTGGTGGGGGAGTTTCTGGACGAAGGGGCCCTTT
TGCGCTTCGCCGAGGGGCTTGCCCTCGTCACCTACGAGTTTGAGAACGTCCCCGTGGAGGCGGCGAGGCGCCTGGAAGGG
AGGCTTCCCCTCTACCCCCCGGCGAAGGCCCTCGAGGTGGCCCAGGACCGCCTCCGGGAAAAGACCTTCTTCCAGGGCCT
CGGCGTGCCCACCCCTCCCTTCCACCCCGTGGACGGCCCCGAGGACCTGGAGGAGGGCCTAAAGCGGGTAGGCCTTCCCG
CCCTCCTCAAGACGAGGCGGGGCGGCTACGACGGCAAGGGGCAGGCCCTGGTGCGCACGGAGGAAGAGGCCCTAGAGGCT
CTGAAGGCCCTGGGGGGCAGGGGGCTTATTCTGGAGGGCTTCGTCCCCTTTGACCGGGAAGTCTCCCTGCTCGCCGTCCG
GGGCCGGACGGGGGAGGTGGCCTTCTATCCCCTGGTGGAAAACCGCCACTGGGGAGGGATCCTCAGGCTCTCCCTGGCCC
CGGCCCCCGGGGCCTCGGAGGCCCTGCAGAAGAAGGCGGAGGCCTACGCCTTGAGGGCCATGGAGGCCCTGGACTACGTG
GGCGTCCTCGCCCTGGAGTTCTTCCAGGTGGGGGAGGAACTCCTCTTCAACGAGATGGCCCCCCGGGTGCACAACTCCGG
CCACTGGACGATAGAAGGAGCGGAGACGAGCCAGTTTGAGAACCACCTCCGGGCCGTCCTGGGCCTTCCCCTGGGGAGCA
CCGCCCCCAGGGGCCAAAGCGCCATGGTGAACCTCATCGGGGAAAAGCCCCCCTTCGCCGAGGTCCTAAAGGTAGAGGGG
GCCCACCTCCACTGGTACGGCAAGGCGGTGCGCCCCGGGCGCAAGGTGGGGCACATCACCCTGAGGCGGGACGGCCTAAA
GGCCCTGGAGGAAGGCCTCGCGCGGCTTTCGCGCCTGGTCTCCGAGCTTCCCTGGGAGGGACGCGTATGA

Upstream 100 bases:

>100_bases
TCCTGGGCCTCAAGCACCCCGAGATCCTAAAGCGCCTCAAGGCCTACCGCAAGGCCCAGACGGAGGCCGTCCTCGCCCAC
CCCGACCCCAGGGAGGAGGC

Downstream 100 bases:

>100_bases
CCATCTCCGAGCTGGAGGAAACCCTTAAGGAGGAGGCCCGGCTCTTCCTCAGCCGGGCCCGGGGGCTTAGGGGCCCCCAC
ACGGAGGACCTCTTCGCCCG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MIGILGGGQLGRMLALAGYPLGLSFRFLDPSPEACAGQVGELVVGEFLDEGALLRFAEGLALVTYEFENVPVEAARRLEG
RLPLYPPAKALEVAQDRLREKTFFQGLGVPTPPFHPVDGPEDLEEGLKRVGLPALLKTRRGGYDGKGQALVRTEEEALEA
LKALGGRGLILEGFVPFDREVSLLAVRGRTGEVAFYPLVENRHWGGILRLSLAPAPGASEALQKKAEAYALRAMEALDYV
GVLALEFFQVGEELLFNEMAPRVHNSGHWTIEGAETSQFENHLRAVLGLPLGSTAPRGQSAMVNLIGEKPPFAEVLKVEG
AHLHWYGKAVRPGRKVGHITLRRDGLKALEEGLARLSRLVSELPWEGRV

Sequences:

>Translated_369_residues
MIGILGGGQLGRMLALAGYPLGLSFRFLDPSPEACAGQVGELVVGEFLDEGALLRFAEGLALVTYEFENVPVEAARRLEG
RLPLYPPAKALEVAQDRLREKTFFQGLGVPTPPFHPVDGPEDLEEGLKRVGLPALLKTRRGGYDGKGQALVRTEEEALEA
LKALGGRGLILEGFVPFDREVSLLAVRGRTGEVAFYPLVENRHWGGILRLSLAPAPGASEALQKKAEAYALRAMEALDYV
GVLALEFFQVGEELLFNEMAPRVHNSGHWTIEGAETSQFENHLRAVLGLPLGSTAPRGQSAMVNLIGEKPPFAEVLKVEG
AHLHWYGKAVRPGRKVGHITLRRDGLKALEEGLARLSRLVSELPWEGRV
>Mature_369_residues
MIGILGGGQLGRMLALAGYPLGLSFRFLDPSPEACAGQVGELVVGEFLDEGALLRFAEGLALVTYEFENVPVEAARRLEG
RLPLYPPAKALEVAQDRLREKTFFQGLGVPTPPFHPVDGPEDLEEGLKRVGLPALLKTRRGGYDGKGQALVRTEEEALEA
LKALGGRGLILEGFVPFDREVSLLAVRGRTGEVAFYPLVENRHWGGILRLSLAPAPGASEALQKKAEAYALRAMEALDYV
GVLALEFFQVGEELLFNEMAPRVHNSGHWTIEGAETSQFENHLRAVLGLPLGSTAPRGQSAMVNLIGEKPPFAEVLKVEG
AHLHWYGKAVRPGRKVGHITLRRDGLKALEEGLARLSRLVSELPWEGRV

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=212, Percent_Identity=29.2452830188679, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786733, Length=365, Percent_Identity=39.1780821917808, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1788155, Length=345, Percent_Identity=30.4347826086957, Blast_Score=111, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324702, Length=377, Percent_Identity=33.6870026525199, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651757, Length=318, Percent_Identity=27.0440251572327, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24651759, Length=252, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40099; Mature: 40099

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGILGGGQLGRMLALAGYPLGLSFRFLDPSPEACAGQVGELVVGEFLDEGALLRFAEGL
CEEECCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCE
ALVTYEFENVPVEAARRLEGRLPLYPPAKALEVAQDRLREKTFFQGLGVPTPPFHPVDGP
EEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
EDLEEGLKRVGLPALLKTRRGGYDGKGQALVRTEEEALEALKALGGRGLILEGFVPFDRE
HHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCCCCEEEECCCCCCCC
VSLLAVRGRTGEVAFYPLVENRHWGGILRLSLAPAPGASEALQKKAEAYALRAMEALDYV
EEEEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVLALEFFQVGEELLFNEMAPRVHNSGHWTIEGAETSQFENHLRAVLGLPLGSTAPRGQS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCH
AMVNLIGEKPPFAEVLKVEGAHLHWYGKAVRPGRKVGHITLRRDGLKALEEGLARLSRLV
HHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHH
SELPWEGRV
HHCCCCCCC
>Mature Secondary Structure
MIGILGGGQLGRMLALAGYPLGLSFRFLDPSPEACAGQVGELVVGEFLDEGALLRFAEGL
CEEECCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCE
ALVTYEFENVPVEAARRLEGRLPLYPPAKALEVAQDRLREKTFFQGLGVPTPPFHPVDGP
EEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
EDLEEGLKRVGLPALLKTRRGGYDGKGQALVRTEEEALEALKALGGRGLILEGFVPFDRE
HHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCCCCEEEECCCCCCCC
VSLLAVRGRTGEVAFYPLVENRHWGGILRLSLAPAPGASEALQKKAEAYALRAMEALDYV
EEEEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVLALEFFQVGEELLFNEMAPRVHNSGHWTIEGAETSQFENHLRAVLGLPLGSTAPRGQS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCH
AMVNLIGEKPPFAEVLKVEGAHLHWYGKAVRPGRKVGHITLRRDGLKALEEGLARLSRLV
HHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHH
SELPWEGRV
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]