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The map label for this gene is pepA [H]

Identifier: 55980225

GI number: 55980225

Start: 243126

End: 244703

Strand: Reverse

Name: pepA [H]

Synonym: TTHA0256

Alternate gene names: 55980225

Gene position: 244703-243126 (Counterclockwise)

Preceding gene: 55980236

Following gene: 55980223

Centisome position: 13.23

GC content: 70.98

Gene sequence:

>1578_bases
GTGAGGGCCCTTTCCTCGTGGCGTTCCACGTGGATCCTTCCGTCCGGCAGGCGCACCGCCAGGGCCCAGGCCCAGGGGGC
CTTCATCATCACCCCCTCGAGGGCCGCCGCCCCCCCGAGGGCCGGTTGCTTCGCTAGAAGAAGCCACCGCATCCCTCCCA
TTCTGCCACGCCCCCGTGGTAAAACCTTGGACGTGGTCACCCTGCGCGCCGTTTCCACGGGCCTGGCCGAGGGCCAGGCC
CCCCTCAAGGTGGTCTGGGCCAAGGAAGGCGCCCTCCTCCCCCAGGGGGAGGCCCTGGACGCCCGCTTCGAGGGGCGGCT
CCGCCAGGCCCTGAAGGAGGCGGGGCTTAAGGCGGGGGAGAGCCTTCTCCTCTACACGGAGGAGGGCCCCGTCCTCCTCT
TCGGGCGGGGCGAGGACGACCGGGAAAGCGGGGGAAGGCTCGCCCAGGCCCTCCAGAGGCTCGCCTTTCCCGAGGCCCTG
GTGGAGCCTTTGGAGGACGCCTACGCCCTGGCCGAGGGCCTTCTCCTCGGGGCCTACCGCTTTGACCGGCTCAAGACGAA
AAGGGAGGAAAAGGCCCTCACCCTCCTCCTTCCGGGCGTTTCCGAGGCCCTTTTGGAGCGGGCGAGGAGGGTGGCGGAAG
GGGTCTACCTGGCCCGGGACCTGGTGAACGAGCCCCCGAACCTCCTCACCCCCGAGGCCCTGGCGGAGCGGGCCTTGGAG
CTTAGGGCCCTAGGGGTGGAGGTGGAGGTCCTGGACGAGAAGGCCATCGCCGAGCTCGGCATGGGGGCCTTCCTCGCCGT
GGCCCAGGGCTCGGAGAACCCGCCCCGGTTCATCCGCCTCCGCTACGCCCCAGAAGGGGCTAAGGCCCGGCTGGACCTGG
TGGGGAAGGGCCTCACCTTTGACTCCGGCGGCTACTCCCTAAAGCCCACGGAGAGCATGGCCACCATGAAGAGCGACATG
GCGGGGGCGGCGGCCGTGCTCGGGGCCTTCAAGGCCGCGGCCCTTTTGGGCCTTCCCGTGGAGCTGAGGGGCTACATCGC
CGCCTGCGAGAACCTGGTCTCCGGGCGGGCCTACCGGGTGGGGGACGTGCTCAAGACCCTCTCCGGCAAGACCGTGGAGG
TGATGAACACCGACGCCGAAGGCCGCCTCACCCTGGCCGACGCCCTGGCCTACGCCGAAAGGGAGGGGGCGGAGCGGATC
CTGGAGCTTTCCACCCTCACGGGGGCCGCGGTGGTGGCCCTGGGGGAGGAGGTGGCGGCCCTCTTCGCCACCGAGCCCTC
CTGGGGGGAGAGGGTGCGGGAGGCGGCGGAAAAGGCCGGGGAGAAGGTCTGGCCCATGCCCTTGGAGAAGGCCTACCGGG
AGAAGCTGAAAAGCCCGGTGGCCGACCTCAAGAACGTGGGGGACCGCTACGGCGGGGCCATCGCCGCCGCCCTCTTCTTG
GCGGAGTTCGTGCAGGTGCCCCTCGTCCACCTGGACATCGCCGGGCCCGCCTTCGCCAGGAAGGCCCACGCCCTGGGCCC
CGAGGGGGGAACGGGCTTCGGCGTGCGCACCATCCTGAAGGTGGCGGAGGCCCTGTAG

Upstream 100 bases:

>100_bases
CTCGGCGCTCCGCGCCAGGGCTCGGTAGCTCACGGAAAGGGCGTCAAAGAGGGCCACCACCCCCCGGAGGAGGGGAAGCC
TCGTCCAGGGGTAGCGCTCG

Downstream 100 bases:

>100_bases
GGCCGCCCCGTGCGGGCTTAGGTCCCGCGGGGAAGGAAAGAAGGCGCGGGCCCGGGGAACCCCCCCGGGCCTCAGGCTTA
GGCGGCTACCTCTGGCAGTT

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MRALSSWRSTWILPSGRRTARAQAQGAFIITPSRAAAPPRAGCFARRSHRIPPILPRPRGKTLDVVTLRAVSTGLAEGQA
PLKVVWAKEGALLPQGEALDARFEGRLRQALKEAGLKAGESLLLYTEEGPVLLFGRGEDDRESGGRLAQALQRLAFPEAL
VEPLEDAYALAEGLLLGAYRFDRLKTKREEKALTLLLPGVSEALLERARRVAEGVYLARDLVNEPPNLLTPEALAERALE
LRALGVEVEVLDEKAIAELGMGAFLAVAQGSENPPRFIRLRYAPEGAKARLDLVGKGLTFDSGGYSLKPTESMATMKSDM
AGAAAVLGAFKAAALLGLPVELRGYIAACENLVSGRAYRVGDVLKTLSGKTVEVMNTDAEGRLTLADALAYAEREGAERI
LELSTLTGAAVVALGEEVAALFATEPSWGERVREAAEKAGEKVWPMPLEKAYREKLKSPVADLKNVGDRYGGAIAAALFL
AEFVQVPLVHLDIAGPAFARKAHALGPEGGTGFGVRTILKVAEAL

Sequences:

>Translated_525_residues
MRALSSWRSTWILPSGRRTARAQAQGAFIITPSRAAAPPRAGCFARRSHRIPPILPRPRGKTLDVVTLRAVSTGLAEGQA
PLKVVWAKEGALLPQGEALDARFEGRLRQALKEAGLKAGESLLLYTEEGPVLLFGRGEDDRESGGRLAQALQRLAFPEAL
VEPLEDAYALAEGLLLGAYRFDRLKTKREEKALTLLLPGVSEALLERARRVAEGVYLARDLVNEPPNLLTPEALAERALE
LRALGVEVEVLDEKAIAELGMGAFLAVAQGSENPPRFIRLRYAPEGAKARLDLVGKGLTFDSGGYSLKPTESMATMKSDM
AGAAAVLGAFKAAALLGLPVELRGYIAACENLVSGRAYRVGDVLKTLSGKTVEVMNTDAEGRLTLADALAYAEREGAERI
LELSTLTGAAVVALGEEVAALFATEPSWGERVREAAEKAGEKVWPMPLEKAYREKLKSPVADLKNVGDRYGGAIAAALFL
AEFVQVPLVHLDIAGPAFARKAHALGPEGGTGFGVRTILKVAEAL
>Mature_525_residues
MRALSSWRSTWILPSGRRTARAQAQGAFIITPSRAAAPPRAGCFARRSHRIPPILPRPRGKTLDVVTLRAVSTGLAEGQA
PLKVVWAKEGALLPQGEALDARFEGRLRQALKEAGLKAGESLLLYTEEGPVLLFGRGEDDRESGGRLAQALQRLAFPEAL
VEPLEDAYALAEGLLLGAYRFDRLKTKREEKALTLLLPGVSEALLERARRVAEGVYLARDLVNEPPNLLTPEALAERALE
LRALGVEVEVLDEKAIAELGMGAFLAVAQGSENPPRFIRLRYAPEGAKARLDLVGKGLTFDSGGYSLKPTESMATMKSDM
AGAAAVLGAFKAAALLGLPVELRGYIAACENLVSGRAYRVGDVLKTLSGKTVEVMNTDAEGRLTLADALAYAEREGAERI
LELSTLTGAAVVALGEEVAALFATEPSWGERVREAAEKAGEKVWPMPLEKAYREKLKSPVADLKNVGDRYGGAIAAALFL
AEFVQVPLVHLDIAGPAFARKAHALGPEGGTGFGVRTILKVAEAL

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=455, Percent_Identity=38.9010989010989, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI47155554, Length=329, Percent_Identity=36.1702127659575, Blast_Score=176, Evalue=5e-44,
Organism=Escherichia coli, GI1790710, Length=459, Percent_Identity=38.3442265795207, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=41.3793103448276, Blast_Score=201, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=313, Percent_Identity=34.8242811501597, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=307, Percent_Identity=29.9674267100977, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24661038, Length=448, Percent_Identity=32.5892857142857, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI21355725, Length=343, Percent_Identity=36.734693877551, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI161077148, Length=454, Percent_Identity=30.6167400881057, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI20130057, Length=454, Percent_Identity=30.6167400881057, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI20129969, Length=442, Percent_Identity=29.8642533936652, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21357381, Length=310, Percent_Identity=33.5483870967742, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=33.5483870967742, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=33.5483870967742, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21355645, Length=434, Percent_Identity=29.0322580645161, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24662223, Length=434, Percent_Identity=29.0322580645161, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI20129963, Length=482, Percent_Identity=30.0829875518672, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24662227, Length=470, Percent_Identity=26.5957446808511, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19922386, Length=497, Percent_Identity=29.9798792756539, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646701, Length=229, Percent_Identity=31.0043668122271, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646703, Length=229, Percent_Identity=31.0043668122271, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358201, Length=229, Percent_Identity=31.0043668122271, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 56075; Mature: 56075

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALSSWRSTWILPSGRRTARAQAQGAFIITPSRAAAPPRAGCFARRSHRIPPILPRPRG
CCCHHHHCCEEECCCCCCHHHHHHCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
KTLDVVTLRAVSTGLAEGQAPLKVVWAKEGALLPQGEALDARFEGRLRQALKEAGLKAGE
CEEEEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
SLLLYTEEGPVLLFGRGEDDRESGGRLAQALQRLAFPEALVEPLEDAYALAEGLLLGAYR
EEEEEECCCCEEEEECCCCCHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
FDRLKTKREEKALTLLLPGVSEALLERARRVAEGVYLARDLVNEPPNLLTPEALAERALE
HHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LRALGVEVEVLDEKAIAELGMGAFLAVAQGSENPPRFIRLRYAPEGAKARLDLVGKGLTF
HHHHCCEEEECCHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCEE
DSGGYSLKPTESMATMKSDMAGAAAVLGAFKAAALLGLPVELRGYIAACENLVSGRAYRV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
GDVLKTLSGKTVEVMNTDAEGRLTLADALAYAEREGAERILELSTLTGAAVVALGEEVAA
HHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LFATEPSWGERVREAAEKAGEKVWPMPLEKAYREKLKSPVADLKNVGDRYGGAIAAALFL
HHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
AEFVQVPLVHLDIAGPAFARKAHALGPEGGTGFGVRTILKVAEAL
HHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRALSSWRSTWILPSGRRTARAQAQGAFIITPSRAAAPPRAGCFARRSHRIPPILPRPRG
CCCHHHHCCEEECCCCCCHHHHHHCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
KTLDVVTLRAVSTGLAEGQAPLKVVWAKEGALLPQGEALDARFEGRLRQALKEAGLKAGE
CEEEEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
SLLLYTEEGPVLLFGRGEDDRESGGRLAQALQRLAFPEALVEPLEDAYALAEGLLLGAYR
EEEEEECCCCEEEEECCCCCHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
FDRLKTKREEKALTLLLPGVSEALLERARRVAEGVYLARDLVNEPPNLLTPEALAERALE
HHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LRALGVEVEVLDEKAIAELGMGAFLAVAQGSENPPRFIRLRYAPEGAKARLDLVGKGLTF
HHHHCCEEEECCHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCEE
DSGGYSLKPTESMATMKSDMAGAAAVLGAFKAAALLGLPVELRGYIAACENLVSGRAYRV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
GDVLKTLSGKTVEVMNTDAEGRLTLADALAYAEREGAERILELSTLTGAAVVALGEEVAA
HHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LFATEPSWGERVREAAEKAGEKVWPMPLEKAYREKLKSPVADLKNVGDRYGGAIAAALFL
HHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
AEFVQVPLVHLDIAGPAFARKAHALGPEGGTGFGVRTILKVAEAL
HHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]