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The map label for this gene is folP [H]

Identifier: 55980160

GI number: 55980160

Start: 186516

End: 187400

Strand: Reverse

Name: folP [H]

Synonym: TTHA0191

Alternate gene names: 55980160

Gene position: 187400-186516 (Counterclockwise)

Preceding gene: 55980165

Following gene: 55980159

Centisome position: 10.13

GC content: 70.4

Gene sequence:

>885_bases
ATGGGCGCACCTCCTTTAGGACCCACTATAATCCCTCCTGTGCGGACGCTCTGGCTTCGGGACCGGGCCCTGGACCTGGA
CCGGGTGCGGCTCCTTGGGGTGCTGAACCTCACCCCCGATTCCTTCTCCGACGGGGGCCGGTACTTGGACCCGGAGCGGG
CCCTTGAGCGGGCCCGGGAGATGGTGGCCGAGGGGGCGGACATTCTGGATTTGGGGGCCGAGTCCACCCGCCCTGGGGCG
GCGCCTGTGCCCGTGGAGGAGGAGAAGCGGAGGCTTCTTCCCGTCCTCGAGGCGGTCCTTTCCCTGGGGGTGCCGGTGAG
CGTGGACACCCGCAAGCCCGAGGTGGCCGAGGAGGCCCTAAAGCTTGGGGCCCACCTTCTGAACGACGTCACCGGGCTTC
GCGACGAGCGCATGGTGGCCCTGGCCGCCCGCCACGGGGTGGCCGCCGTGGTCATGCACATGCCGGTGCCGGACCCGGCC
ACCATGATGGCCCACGCCCGCTACCGGGACGTGGTGGCCGAGGTCAAGGCCTTCCTCGAGGCCCAGGCGAGAAGGGCCCT
AAGCGCAGGGGTGCCCCAGGTGGTCCTGGACCCGGGGTTCGGCTTCGGGAAGCTCTTGGAGCACAACCTCGCCCTCCTCC
GCCGCCTGGACGAGATCGTGGCCCTGGGCCACCCGGTCTTGGTGGGGCTTTCCCGCAAGCGCACCATCGGGGAGCTTTCC
GGGGTGGAGGACCCGGCCCAGAGGGTCCACGGCTCCGTGGCCGCCCACCTCTTCGCCGTGATGAAGGGGGTGAGGTTGCT
TCGGGTCCACGACGTGCGGGCCCACCGGGAGGCCCTTGGGGTTTGGGAGGCGCTGTATGGGGGAGATCGCCCTTCTCGGG
CTTGA

Upstream 100 bases:

>100_bases
GACCAGGTGGGCCTCGAGGCCCAAGGCGGGGGCCAGGGCCCGGGCCGTGGCCACCACGCTCTCGTGGGTCAGGCCGAAGT
CTAGGGCGGCGAGAAGCCTC

Downstream 100 bases:

>100_bases
GTTCTACGGGCGCCACGGGGTCATGCCCGAGGAGGGGCGGCTTGGGGCCCGGTTCGTGGTGGACCTCTGGCTTTCCGTGC
CCTTTGAGGGCAAGGGGGAC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MGAPPLGPTIIPPVRTLWLRDRALDLDRVRLLGVLNLTPDSFSDGGRYLDPERALERAREMVAEGADILDLGAESTRPGA
APVPVEEEKRRLLPVLEAVLSLGVPVSVDTRKPEVAEEALKLGAHLLNDVTGLRDERMVALAARHGVAAVVMHMPVPDPA
TMMAHARYRDVVAEVKAFLEAQARRALSAGVPQVVLDPGFGFGKLLEHNLALLRRLDEIVALGHPVLVGLSRKRTIGELS
GVEDPAQRVHGSVAAHLFAVMKGVRLLRVHDVRAHREALGVWEALYGGDRPSRA

Sequences:

>Translated_294_residues
MGAPPLGPTIIPPVRTLWLRDRALDLDRVRLLGVLNLTPDSFSDGGRYLDPERALERAREMVAEGADILDLGAESTRPGA
APVPVEEEKRRLLPVLEAVLSLGVPVSVDTRKPEVAEEALKLGAHLLNDVTGLRDERMVALAARHGVAAVVMHMPVPDPA
TMMAHARYRDVVAEVKAFLEAQARRALSAGVPQVVLDPGFGFGKLLEHNLALLRRLDEIVALGHPVLVGLSRKRTIGELS
GVEDPAQRVHGSVAAHLFAVMKGVRLLRVHDVRAHREALGVWEALYGGDRPSRA
>Mature_293_residues
GAPPLGPTIIPPVRTLWLRDRALDLDRVRLLGVLNLTPDSFSDGGRYLDPERALERAREMVAEGADILDLGAESTRPGAA
PVPVEEEKRRLLPVLEAVLSLGVPVSVDTRKPEVAEEALKLGAHLLNDVTGLRDERMVALAARHGVAAVVMHMPVPDPAT
MMAHARYRDVVAEVKAFLEAQARRALSAGVPQVVLDPGFGFGKLLEHNLALLRRLDEIVALGHPVLVGLSRKRTIGELSG
VEDPAQRVHGSVAAHLFAVMKGVRLLRVHDVRAHREALGVWEALYGGDRPSRA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=280, Percent_Identity=44.6428571428571, Blast_Score=223, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324073, Length=317, Percent_Identity=28.0757097791798, Blast_Score=116, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31849; Mature: 31718

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPPLGPTIIPPVRTLWLRDRALDLDRVRLLGVLNLTPDSFSDGGRYLDPERALERARE
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHH
MVAEGADILDLGAESTRPGAAPVPVEEEKRRLLPVLEAVLSLGVPVSVDTRKPEVAEEAL
HHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHH
KLGAHLLNDVTGLRDERMVALAARHGVAAVVMHMPVPDPATMMAHARYRDVVAEVKAFLE
HHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AQARRALSAGVPQVVLDPGFGFGKLLEHNLALLRRLDEIVALGHPVLVGLSRKRTIGELS
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHC
GVEDPAQRVHGSVAAHLFAVMKGVRLLRVHDVRAHREALGVWEALYGGDRPSRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GAPPLGPTIIPPVRTLWLRDRALDLDRVRLLGVLNLTPDSFSDGGRYLDPERALERARE
CCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHH
MVAEGADILDLGAESTRPGAAPVPVEEEKRRLLPVLEAVLSLGVPVSVDTRKPEVAEEAL
HHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHH
KLGAHLLNDVTGLRDERMVALAARHGVAAVVMHMPVPDPATMMAHARYRDVVAEVKAFLE
HHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AQARRALSAGVPQVVLDPGFGFGKLLEHNLALLRRLDEIVALGHPVLVGLSRKRTIGELS
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHC
GVEDPAQRVHGSVAAHLFAVMKGVRLLRVHDVRAHREALGVWEALYGGDRPSRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400191; 7642493; 10710307 [H]