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The map label for this gene is tkt [H]

Identifier: 55980077

GI number: 55980077

Start: 106140

End: 108095

Strand: Reverse

Name: tkt [H]

Synonym: TTHA0108

Alternate gene names: 55980077

Gene position: 108095-106140 (Counterclockwise)

Preceding gene: 55980078

Following gene: 55980076

Centisome position: 5.84

GC content: 70.25

Gene sequence:

>1956_bases
ATGAAGGAGACGCGGGACCTAGAGACCCTTTCGGTGAACGCCATCCGCTTCCTGGCCATTGACGCGGTGGAGAAGGCGCG
AAGCGGCCACCCCGGGATGCCCATGGGCATGGCGCCCCTGGCCTACCTCCTCTTCCGGGAGGTCATGCGCCACAACCCCT
TAGACCCCGACTGGCCCGACCGGGACCGGTTCGTCCTCTCGGCCGGACACGGGTCCATGCTCCTCTACGCCGTCCTCCAC
CTCACGGGCTACGACCTTCCCCTGGAGGAGCTGAAAAGCTTCCGCCAGTGGGGGTCCAAGACCCCGGGCCACCCCGAGCG
CGGCCACACCCCGGGGGTGGAGGTGACCACGGGGCCCTTGGGGCAGGGGATCTCCACCGCCGTGGGGCTTGCCCTGGCGG
AAAGGAAGCTCGCCGCCGAGTTCAACCGCCCGGGGCACGTGGTGGTGGACCACTACACCTACGTCCTCGCCTCGGACGGG
GACCTGATGGAGGGGGTCTCCGGGGAGGCCGCCTCCTTGGCGGGGCACTGGGGCCTCTCCAAGCTCATCGTCTTCTGGGA
CGACAACCGCATCTCCATTGACGGCCCCACGGACCTCGCCTTCACCGAGGACGTGCTCGCCCGTTACCGGGCCTACGGCT
GGCAGACCCTTAGGGTGGAGGACGTGAACGACCTCGAGGCCCTCCGCAAGGCCATCAAGCTCGCCAAGCTGGACGAGCGC
CCCACCCTCATCGCCGTGCGGAGCCACATCGGCTTCGGCTCCCCCAAGCAGGACTCCGCCAAGGCCCACGGGGAGCCCTT
GGGCCCGGAGGCGGTGGAGGCCACCCGGAGGAACCTGGGCTGGCCCTACCCGCCCTTCGTGGTGCCCGAGGAGGTCTACC
GCCACATGGACATGCGGGAGAAGGGGCGGGCCTGGCAGGAGGCCTGGGAAAAGGCCCTCGAGGCCTACGCCCGGGCGTAC
CCGGACCTCCACCAGGAGCTCATGCGGCGCCTGCGAGGGGAGCTTCCGCCCTTGCCCGAAGAGCCCCCATCCTTTGACAA
GCCCATCGCCACCCGGGCGGCGAGCGGCCGGGCCCTGAACCTCCTCGCCCCCCGCCTCCCCGAGCTCCTTGGGGGAAGCG
CCGACCTCACCCCCTCCAACAACACCAAGGCCGAGGGGATGGAGGACTTCTCCCGGGCGAACCCTTTGGGCCGCTATCTC
CACTTCGGGGTGCGGGAGCACGCCATGGGGGCCATCCTGAACGGCCTCAACCTCCACGGGGGGTATCGGGCCTACGGCGG
GACCTTCCTCGTCTTCTCCGACTACATGCGCCCCGCCATCCGCCTCGCCGCCCTCATGGGGGTTCCCACGGTCTTCGTCT
TCACCCACGACTCCATTGCCCTGGGCGAGGACGGCCCCACCCACCAGCCCGTGGAGCACCTCATGTCCCTCAGGGCCATG
CCCAACCTCTTTGTGATCCGCCCCGCGGACGCCTACGAGACCTTCTACGCCTGGCTCGTGGCCCTGAGGCGTAAGGAAGG
CCCCACCGCCCTCGTCCTCACCCGCCAGGCGGTGCCCCTCCTCTCCCCGGAGAAGGCCAGGGGGCTTTTGCGGGGAGGCT
ACGTCCTGGAGGACGTGGAGGAGCCCCAAGGGGTCCTCGTGGCCACGGGGAGCGAGGTGCACCTGGCCCTTAGGGCCCAG
GCCCTCCTCCGGGAGAAGGGGGTGCGGGTCCGGGTGGTGAGCCTGCCTTCCTTTGAGCTCTTCGCCGCCCAGCCCGAGGC
CTACCGGAAGGAGGTCCTGCCCCCGGGGCTTCCGGTGGTGGCCGTGGAGGCGGGGGCCAGCCTGGGGTGGGAGCGGTACG
CCCACAAGGTGGTGGCCCTGGACCGCTTCGGGGCCAGCGCCCCCTACCCCGAGGTCTACGAGCGGCTCGGCTTCACCCCG
GAGAGGGTGGCGGAGGCCTTCCTCTCCCTGGTGTAA

Upstream 100 bases:

>100_bases
CCCACAGGGAGGGATTGTACACCCTTCCTCCAAGGGAGGCAAGCCCGGCCCGCCGGGGTATAGTTTCACTGGCGGAGGGG
GTTCCCCGCCAGGAGGAAGG

Downstream 100 bases:

>100_bases
AAGGGCGGGATTTACCGGGGGAAGGCCCCCGGGGGAGGGGCTTAGGCTAGGGGCATGGGGGAGGCGTTTCGCAAAGCCGA
GGCGGCCATCTACCTCTTCG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MKETRDLETLSVNAIRFLAIDAVEKARSGHPGMPMGMAPLAYLLFREVMRHNPLDPDWPDRDRFVLSAGHGSMLLYAVLH
LTGYDLPLEELKSFRQWGSKTPGHPERGHTPGVEVTTGPLGQGISTAVGLALAERKLAAEFNRPGHVVVDHYTYVLASDG
DLMEGVSGEAASLAGHWGLSKLIVFWDDNRISIDGPTDLAFTEDVLARYRAYGWQTLRVEDVNDLEALRKAIKLAKLDER
PTLIAVRSHIGFGSPKQDSAKAHGEPLGPEAVEATRRNLGWPYPPFVVPEEVYRHMDMREKGRAWQEAWEKALEAYARAY
PDLHQELMRRLRGELPPLPEEPPSFDKPIATRAASGRALNLLAPRLPELLGGSADLTPSNNTKAEGMEDFSRANPLGRYL
HFGVREHAMGAILNGLNLHGGYRAYGGTFLVFSDYMRPAIRLAALMGVPTVFVFTHDSIALGEDGPTHQPVEHLMSLRAM
PNLFVIRPADAYETFYAWLVALRRKEGPTALVLTRQAVPLLSPEKARGLLRGGYVLEDVEEPQGVLVATGSEVHLALRAQ
ALLREKGVRVRVVSLPSFELFAAQPEAYRKEVLPPGLPVVAVEAGASLGWERYAHKVVALDRFGASAPYPEVYERLGFTP
ERVAEAFLSLV

Sequences:

>Translated_651_residues
MKETRDLETLSVNAIRFLAIDAVEKARSGHPGMPMGMAPLAYLLFREVMRHNPLDPDWPDRDRFVLSAGHGSMLLYAVLH
LTGYDLPLEELKSFRQWGSKTPGHPERGHTPGVEVTTGPLGQGISTAVGLALAERKLAAEFNRPGHVVVDHYTYVLASDG
DLMEGVSGEAASLAGHWGLSKLIVFWDDNRISIDGPTDLAFTEDVLARYRAYGWQTLRVEDVNDLEALRKAIKLAKLDER
PTLIAVRSHIGFGSPKQDSAKAHGEPLGPEAVEATRRNLGWPYPPFVVPEEVYRHMDMREKGRAWQEAWEKALEAYARAY
PDLHQELMRRLRGELPPLPEEPPSFDKPIATRAASGRALNLLAPRLPELLGGSADLTPSNNTKAEGMEDFSRANPLGRYL
HFGVREHAMGAILNGLNLHGGYRAYGGTFLVFSDYMRPAIRLAALMGVPTVFVFTHDSIALGEDGPTHQPVEHLMSLRAM
PNLFVIRPADAYETFYAWLVALRRKEGPTALVLTRQAVPLLSPEKARGLLRGGYVLEDVEEPQGVLVATGSEVHLALRAQ
ALLREKGVRVRVVSLPSFELFAAQPEAYRKEVLPPGLPVVAVEAGASLGWERYAHKVVALDRFGASAPYPEVYERLGFTP
ERVAEAFLSLV
>Mature_651_residues
MKETRDLETLSVNAIRFLAIDAVEKARSGHPGMPMGMAPLAYLLFREVMRHNPLDPDWPDRDRFVLSAGHGSMLLYAVLH
LTGYDLPLEELKSFRQWGSKTPGHPERGHTPGVEVTTGPLGQGISTAVGLALAERKLAAEFNRPGHVVVDHYTYVLASDG
DLMEGVSGEAASLAGHWGLSKLIVFWDDNRISIDGPTDLAFTEDVLARYRAYGWQTLRVEDVNDLEALRKAIKLAKLDER
PTLIAVRSHIGFGSPKQDSAKAHGEPLGPEAVEATRRNLGWPYPPFVVPEEVYRHMDMREKGRAWQEAWEKALEAYARAY
PDLHQELMRRLRGELPPLPEEPPSFDKPIATRAASGRALNLLAPRLPELLGGSADLTPSNNTKAEGMEDFSRANPLGRYL
HFGVREHAMGAILNGLNLHGGYRAYGGTFLVFSDYMRPAIRLAALMGVPTVFVFTHDSIALGEDGPTHQPVEHLMSLRAM
PNLFVIRPADAYETFYAWLVALRRKEGPTALVLTRQAVPLLSPEKARGLLRGGYVLEDVEEPQGVLVATGSEVHLALRAQ
ALLREKGVRVRVVSLPSFELFAAQPEAYRKEVLPPGLPVVAVEAGASLGWERYAHKVVALDRFGASAPYPEVYERLGFTP
ERVAEAFLSLV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=572, Percent_Identity=28.6713286713287, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI4507521, Length=572, Percent_Identity=28.6713286713287, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI133778974, Length=580, Percent_Identity=26.551724137931, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI225637459, Length=577, Percent_Identity=24.6100519930676, Blast_Score=123, Evalue=7e-28,
Organism=Homo sapiens, GI225637461, Length=549, Percent_Identity=24.5901639344262, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI225637463, Length=559, Percent_Identity=24.5080500894454, Blast_Score=113, Evalue=5e-25,
Organism=Escherichia coli, GI48994911, Length=648, Percent_Identity=50.6172839506173, Blast_Score=643, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=648, Percent_Identity=51.6975308641975, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=575, Percent_Identity=26.6086956521739, Blast_Score=141, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6325331, Length=660, Percent_Identity=50.3030303030303, Blast_Score=630, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=661, Percent_Identity=47.8063540090772, Blast_Score=606, Evalue=1e-174,
Organism=Drosophila melanogaster, GI45551847, Length=586, Percent_Identity=26.4505119453925, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI45550715, Length=586, Percent_Identity=26.4505119453925, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24666278, Length=567, Percent_Identity=26.984126984127, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645119, Length=545, Percent_Identity=26.2385321100917, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71880; Mature: 71880

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETRDLETLSVNAIRFLAIDAVEKARSGHPGMPMGMAPLAYLLFREVMRHNPLDPDWPD
CCCCCCCHHEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSAGHGSMLLYAVLHLTGYDLPLEELKSFRQWGSKTPGHPERGHTPGVEVTTGPL
CCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCC
GQGISTAVGLALAERKLAAEFNRPGHVVVDHYTYVLASDGDLMEGVSGEAASLAGHWGLS
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHCCCCCCHHHHHHHCCCE
KLIVFWDDNRISIDGPTDLAFTEDVLARYRAYGWQTLRVEDVNDLEALRKAIKLAKLDER
EEEEEECCCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCC
PTLIAVRSHIGFGSPKQDSAKAHGEPLGPEAVEATRRNLGWPYPPFVVPEEVYRHMDMRE
CCEEEEEHHCCCCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHH
KGRAWQEAWEKALEAYARAYPDLHQELMRRLRGELPPLPEEPPSFDKPIATRAASGRALN
HCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCEEE
LLAPRLPELLGGSADLTPSNNTKAEGMEDFSRANPLGRYLHFGVREHAMGAILNGLNLHG
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GYRAYGGTFLVFSDYMRPAIRLAALMGVPTVFVFTHDSIALGEDGPTHQPVEHLMSLRAM
CEECCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHCC
PNLFVIRPADAYETFYAWLVALRRKEGPTALVLTRQAVPLLSPEKARGLLRGGYVLEDVE
CCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCEEEECCC
EPQGVLVATGSEVHLALRAQALLREKGVRVRVVSLPSFELFAAQPEAYRKEVLPPGLPVV
CCCCEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHHHHHCCCCCCCEE
AVEAGASLGWERYAHKVVALDRFGASAPYPEVYERLGFTPERVAEAFLSLV
EEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKETRDLETLSVNAIRFLAIDAVEKARSGHPGMPMGMAPLAYLLFREVMRHNPLDPDWPD
CCCCCCCHHEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSAGHGSMLLYAVLHLTGYDLPLEELKSFRQWGSKTPGHPERGHTPGVEVTTGPL
CCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCC
GQGISTAVGLALAERKLAAEFNRPGHVVVDHYTYVLASDGDLMEGVSGEAASLAGHWGLS
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHCCCCCCHHHHHHHCCCE
KLIVFWDDNRISIDGPTDLAFTEDVLARYRAYGWQTLRVEDVNDLEALRKAIKLAKLDER
EEEEEECCCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCC
PTLIAVRSHIGFGSPKQDSAKAHGEPLGPEAVEATRRNLGWPYPPFVVPEEVYRHMDMRE
CCEEEEEHHCCCCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHH
KGRAWQEAWEKALEAYARAYPDLHQELMRRLRGELPPLPEEPPSFDKPIATRAASGRALN
HCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCEEE
LLAPRLPELLGGSADLTPSNNTKAEGMEDFSRANPLGRYLHFGVREHAMGAILNGLNLHG
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GYRAYGGTFLVFSDYMRPAIRLAALMGVPTVFVFTHDSIALGEDGPTHQPVEHLMSLRAM
CEECCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHCC
PNLFVIRPADAYETFYAWLVALRRKEGPTALVLTRQAVPLLSPEKARGLLRGGYVLEDVE
CCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCEEEECCC
EPQGVLVATGSEVHLALRAQALLREKGVRVRVVSLPSFELFAAQPEAYRKEVLPPGLPVV
CCCCEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHHHHHCCCCCCCEE
AVEAGASLGWERYAHKVVALDRFGASAPYPEVYERLGFTPERVAEAFLSLV
EEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]