Click here to switch to the map view.

The map label for this gene is nqo9

Identifier: 55980061

GI number: 55980061

Start: 91826

End: 92374

Strand: Direct

Name: nqo9

Synonym: TTHA0092

Alternate gene names: 55980061

Gene position: 91826-92374 (Clockwise)

Preceding gene: 55980060

Following gene: 55980062

Centisome position: 4.96

GC content: 67.94

Gene sequence:

>549_bases
ATGACCCTGAAGGCCCTCGCCCAAAGCCTCGGCATCACCCTGAAGTACCTCTTCTCCAAGCCGGTGACCGTCCCCTACCC
CGACGCCCCCGTGGCCCTGAAGCCCCGCTTCCACGGGCGGCACGTCCTCACCCGGCACCCGAACGGGCTAGAGAAGTGCA
TCGGCTGCTCCCTCTGCGCCGCCGCCTGCCCCGCCTACGCCATCTACGTGGAGCCGGCGGAGAACGACCCGGAAAACCCG
GTCTCCGCGGGGGAGCGGTACGCCAAGGTCTACGAGATCAACATGCTCCGGTGCATCTTCTGCGGCCTCTGCGAGGAGGC
CTGCCCCACGGGGGCCATCGTCCTGGGGTACGACTTTGAGATGGCGGACTACGAGTACTCCGACCTCGTCTACGGCAAGG
AGGACATGCTGGTGGACGTGGTGGGCACCAAGCCCCAGCGCCGCGAGGCCAAGCGGACGGGCAAGCCCGTGAAGGTGGGC
TACGTGGTGCCCTACGTGCGGCCCGAGCTGGAGGGGTTCAAGGCCCCCACGGAAGGGGGGAAGCGATGA

Upstream 100 bases:

>100_bases
TCCCCAGGACCTACCTCCTCTACCTCTCCGCCCTAAGCTTCCTCGTCCTCCTGGGAGCGGTCCTCTACACCCCCAAGCCC
GCCCGCAAAGGAGGTGGCGC

Downstream 100 bases:

>100_bases
GCCTTCTTGAAGGCCTCGCCCTCTTCCTCCTCCTCCTGAGCGGGGTCCTGGTGGTGACCCTCAGGAACGCCATCCACGCC
GCCCTGGCCCTGATCCTCAA

Product: NADH-quinone oxidoreductase subunit 9

Products: NA

Alternate protein names: NADH dehydrogenase I subunit 9; NDH-1 subunit 9

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MTLKALAQSLGITLKYLFSKPVTVPYPDAPVALKPRFHGRHVLTRHPNGLEKCIGCSLCAAACPAYAIYVEPAENDPENP
VSAGERYAKVYEINMLRCIFCGLCEEACPTGAIVLGYDFEMADYEYSDLVYGKEDMLVDVVGTKPQRREAKRTGKPVKVG
YVVPYVRPELEGFKAPTEGGKR

Sequences:

>Translated_182_residues
MTLKALAQSLGITLKYLFSKPVTVPYPDAPVALKPRFHGRHVLTRHPNGLEKCIGCSLCAAACPAYAIYVEPAENDPENP
VSAGERYAKVYEINMLRCIFCGLCEEACPTGAIVLGYDFEMADYEYSDLVYGKEDMLVDVVGTKPQRREAKRTGKPVKVG
YVVPYVRPELEGFKAPTEGGKR
>Mature_181_residues
TLKALAQSLGITLKYLFSKPVTVPYPDAPVALKPRFHGRHVLTRHPNGLEKCIGCSLCAAACPAYAIYVEPAENDPENPV
SAGERYAKVYEINMLRCIFCGLCEEACPTGAIVLGYDFEMADYEYSDLVYGKEDMLVDVVGTKPQRREAKRTGKPVKVGY
VVPYVRPELEGFKAPTEGGKR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=132, Percent_Identity=46.2121212121212, Blast_Score=127, Evalue=7e-30,
Organism=Escherichia coli, GI1788617, Length=186, Percent_Identity=41.9354838709677, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789075, Length=123, Percent_Identity=36.5853658536585, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17555194, Length=141, Percent_Identity=42.5531914893617, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17864306, Length=139, Percent_Identity=41.726618705036, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NQO9_THET8 (Q56224)

Other databases:

- EMBL:   U52917
- EMBL:   AP008226
- PIR:   T11906
- RefSeq:   YP_143358.1
- PDB:   2FUG
- PDB:   3I9V
- PDB:   3IAM
- PDB:   3IAS
- PDB:   3M9S
- PDBsum:   2FUG
- PDBsum:   3I9V
- PDBsum:   3IAM
- PDBsum:   3IAS
- PDBsum:   3M9S
- ProteinModelPortal:   Q56224
- SMR:   Q56224
- STRING:   Q56224
- GeneID:   3167944
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA0092
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   RYWSVAG
- ProtClustDB:   CLSK445099
- BioCyc:   TTHE300852:TTHA0092-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 20080; Mature: 19949

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKALAQSLGITLKYLFSKPVTVPYPDAPVALKPRFHGRHVLTRHPNGLEKCIGCSLCA
CCHHHHHHHHCCEEEEHHCCCCCCCCCCCCEEECCCCCCCEEEECCCCHHHHHHHHHHHH
AACPAYAIYVEPAENDPENPVSAGERYAKVYEINMLRCIFCGLCEEACPTGAIVLGYDFE
HHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCE
MADYEYSDLVYGKEDMLVDVVGTKPQRREAKRTGKPVKVGYVVPYVRPELEGFKAPTEGG
ECCCCCCCEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
KR
CC
>Mature Secondary Structure 
TLKALAQSLGITLKYLFSKPVTVPYPDAPVALKPRFHGRHVLTRHPNGLEKCIGCSLCA
CHHHHHHHHCCEEEEHHCCCCCCCCCCCCEEECCCCCCCEEEECCCCHHHHHHHHHHHH
AACPAYAIYVEPAENDPENPVSAGERYAKVYEINMLRCIFCGLCEEACPTGAIVLGYDFE
HHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCE
MADYEYSDLVYGKEDMLVDVVGTKPQRREAKRTGKPVKVGYVVPYVRPELEGFKAPTEGG
ECCCCCCCEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
KR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9020134