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The map label for this gene is nqo2

Identifier: 55980057

GI number: 55980057

Start: 86524

End: 87069

Strand: Direct

Name: nqo2

Synonym: TTHA0088

Alternate gene names: 55980057

Gene position: 86524-87069 (Clockwise)

Preceding gene: 55980056

Following gene: 55980058

Centisome position: 4.68

GC content: 66.3

Gene sequence:

>546_bases
ATGGGGTTCTTTGACGACAAGCAGGACTTTCTGGAGGAGACCTTCGCCAAGTACCCGCCGGAAGGGCGCCGCGCCGCCAT
CATGCCCCTCCTTAGGCGGGTGCAGCAGGAGGAGGGCTGGATCCGGCCCGAGCGCATAGAGGAGATCGCCCGCCTCGTGG
GCACCACCCCCACGGAGGTCATGGGGGTGGCGAGCTTCTACTCCTACTACCAGTTCGTGCCCACGGGGAAGTACCACCTC
CAGGTCTGCGCCACCCTCTCCTGCAAGCTCGCCGGGGCCGAGGAGCTTTGGGACTACCTCACCGAGACCCTGGGCATCGG
CCCGGGGGAGGTGACCCCGGACGGGCTTTTCAGCGTGCAGAAGGTGGAGTGCCTGGGAAGCTGCCACACCGCCCCCGTGA
TCCAGGTGAACGACGAGCCCTACGTGGAGTGCGTGACCCGGGCGAGGCTCGAGGCCCTTCTTGCAGGCCTTAGGGCGGGG
AAGCGGCTTGAGGAGATTGAGCTTCCCGGAAAGTGCGGCCACCACGTGCACGAGGTGGAGGTATGA

Upstream 100 bases:

>100_bases
CTCCCCTACGCCTGCAAGGGGGAGCAGGTCCCCGACATGGTGGCCATCATCGCCAGCCTAGACCCCGTGATGGGGGACGT
GGACCGCTAAGGGAGGGAAG

Downstream 100 bases:

>100_bases
CTGGCCCCATTCTTTCCGGACTGGACCCCCGGTTTGAAAGGACCCTCTACGCCCACGTGGGGAAGGAGGGGTCCTGGACC
CTGGACTACTACCTCCGGCA

Product: NADH-quinone oxidoreductase subunit 2

Products: NA

Alternate protein names: NADH dehydrogenase I chain 2; NDH-1 subunit 2

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MGFFDDKQDFLEETFAKYPPEGRRAAIMPLLRRVQQEEGWIRPERIEEIARLVGTTPTEVMGVASFYSYYQFVPTGKYHL
QVCATLSCKLAGAEELWDYLTETLGIGPGEVTPDGLFSVQKVECLGSCHTAPVIQVNDEPYVECVTRARLEALLAGLRAG
KRLEEIELPGKCGHHVHEVEV

Sequences:

>Translated_181_residues
MGFFDDKQDFLEETFAKYPPEGRRAAIMPLLRRVQQEEGWIRPERIEEIARLVGTTPTEVMGVASFYSYYQFVPTGKYHL
QVCATLSCKLAGAEELWDYLTETLGIGPGEVTPDGLFSVQKVECLGSCHTAPVIQVNDEPYVECVTRARLEALLAGLRAG
KRLEEIELPGKCGHHVHEVEV
>Mature_180_residues
GFFDDKQDFLEETFAKYPPEGRRAAIMPLLRRVQQEEGWIRPERIEEIARLVGTTPTEVMGVASFYSYYQFVPTGKYHLQ
VCATLSCKLAGAEELWDYLTETLGIGPGEVTPDGLFSVQKVECLGSCHTAPVIQVNDEPYVECVTRARLEALLAGLRAGK
RLEEIELPGKCGHHVHEVEV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family

Homologues:

Organism=Homo sapiens, GI222080062, Length=159, Percent_Identity=37.1069182389937, Blast_Score=123, Evalue=9e-29,
Organism=Escherichia coli, GI1788621, Length=133, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17561328, Length=160, Percent_Identity=38.125, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI18859877, Length=159, Percent_Identity=35.2201257861635, Blast_Score=116, Evalue=8e-27,
Organism=Drosophila melanogaster, GI21355353, Length=159, Percent_Identity=33.9622641509434, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NQO2_THET8 (Q56221)

Other databases:

- EMBL:   U52917
- EMBL:   AP008226
- PIR:   T11902
- RefSeq:   YP_143354.1
- PDB:   2FUG
- PDB:   3I9V
- PDB:   3IAM
- PDB:   3IAS
- PDB:   3M9S
- PDBsum:   2FUG
- PDBsum:   3I9V
- PDBsum:   3IAM
- PDBsum:   3IAS
- PDBsum:   3M9S
- ProteinModelPortal:   Q56221
- SMR:   Q56221
- STRING:   Q56221
- GeneID:   3168326
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA0088
- eggNOG:   COG1905
- HOGENOM:   HBG616790
- OMA:   VMIVNNT
- ProtClustDB:   CLSK445103
- BioCyc:   TTHE300852:TTHA0088-MONOMER
- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10371
- PIRSF:   PIRSF000216
- TIGRFAMs:   TIGR01958

Pfam domain/function: PF01257 Complex1_24kDa; SSF52833 Thiordxn-like_fd

EC number: =1.6.99.5

Molecular weight: Translated: 20286; Mature: 20155

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFFDDKQDFLEETFAKYPPEGRRAAIMPLLRRVQQEEGWIRPERIEEIARLVGTTPTEV
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHH
MGVASFYSYYQFVPTGKYHLQVCATLSCKLAGAEELWDYLTETLGIGPGEVTPDGLFSVQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHH
KVECLGSCHTAPVIQVNDEPYVECVTRARLEALLAGLRAGKRLEEIELPGKCGHHVHEVE
HHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEECC
V
C
>Mature Secondary Structure 
GFFDDKQDFLEETFAKYPPEGRRAAIMPLLRRVQQEEGWIRPERIEEIARLVGTTPTEV
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHH
MGVASFYSYYQFVPTGKYHLQVCATLSCKLAGAEELWDYLTETLGIGPGEVTPDGLFSVQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHH
KVECLGSCHTAPVIQVNDEPYVECVTRARLEALLAGLRAGKRLEEIELPGKCGHHVHEVE
HHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEECC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9020134