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The map label for this gene is moaE [H]

Identifier: 55980028

GI number: 55980028

Start: 57257

End: 57928

Strand: Direct

Name: moaE [H]

Synonym: TTHA0059

Alternate gene names: 55980028

Gene position: 57257-57928 (Clockwise)

Preceding gene: 55980027

Following gene: 55980029

Centisome position: 3.1

GC content: 70.68

Gene sequence:

>672_bases
ATGCGGATTGAGGTCCGGCTCTTCGCCCTTTACCGGGAGCAGGCGGGGACGGACCGCCTCGCCCTGGAGCTCCCCGAGGG
CGCCCGGGTGCGGGAGGCCCAGAAAGCCCTGGAGGAACGCTTCCCCAGGCTTCGCCTCGAGGGCGGGATGGCGGCGGTGA
ACCAGGCCCTGGCGGGGGCGGAAACCCCCTTAAAGGAGGGGGACGAGGTGGCCTTTCTTCCCCCGGTCTCTGGCGGGCAG
GACTCCTACGGCCTGACCCAGGAGCCTCTGGACCTCGAGGCCCTCGTGGCCTGGGCCACGGCCCCGGAGTACGGGGCGGT
GGTGAGCTTCCTCGGCACCACCCGCAGCCCCAACCGGGGGGAGGAGGTGGCCTTTTTGGAGTACGAGGCCTACCCGGAGA
TGGCGGAGAAGGTGATGGCGGAAATCCTCGCCGAGATGCGCGCCCGCTGGCCCCTGGGCCGCATCGCCCTCTGGCACCGC
CTGGGCCGGGTGGACCCGGGGGAGGCCTCCATCGCCATCGTCGTCTCGGCCCGCCACCGCAAGGAGGCCTTCGCCGCCTG
CCAGTACGCCATAGACCGGGTGAAGCAGATCCTCCCCGTCTGGAAGAAGGAGCACCGCAAGGACGGGAGCTTCTGGGTGG
AGGGCTTCGCCCCGGAGGACAAGCGGCTATGA

Upstream 100 bases:

>100_bases
GAGTGGCTGGGGGAGCTCACCCTGATCGGCCCCCTGCGCATGCGCTACGCCGAGGCCCTCTCCGTGGCCTTCAGCCTCTC
CCAGGTCTATACTGGGCAGC

Downstream 100 bases:

>100_bases
GGCCACCCCCTGCGGGCGCGGGCCCAAGGGGCCCCGGGGGAAAACCCCATCGCGAAGCGGGAAAGAGGGCATGACCTCCT
TCGCCTTTACTGCCTTCCTC

Product: molybdenum cofactor biosynthesis protein D/E

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRIEVRLFALYREQAGTDRLALELPEGARVREAQKALEERFPRLRLEGGMAAVNQALAGAETPLKEGDEVAFLPPVSGGQ
DSYGLTQEPLDLEALVAWATAPEYGAVVSFLGTTRSPNRGEEVAFLEYEAYPEMAEKVMAEILAEMRARWPLGRIALWHR
LGRVDPGEASIAIVVSARHRKEAFAACQYAIDRVKQILPVWKKEHRKDGSFWVEGFAPEDKRL

Sequences:

>Translated_223_residues
MRIEVRLFALYREQAGTDRLALELPEGARVREAQKALEERFPRLRLEGGMAAVNQALAGAETPLKEGDEVAFLPPVSGGQ
DSYGLTQEPLDLEALVAWATAPEYGAVVSFLGTTRSPNRGEEVAFLEYEAYPEMAEKVMAEILAEMRARWPLGRIALWHR
LGRVDPGEASIAIVVSARHRKEAFAACQYAIDRVKQILPVWKKEHRKDGSFWVEGFAPEDKRL
>Mature_223_residues
MRIEVRLFALYREQAGTDRLALELPEGARVREAQKALEERFPRLRLEGGMAAVNQALAGAETPLKEGDEVAFLPPVSGGQ
DSYGLTQEPLDLEALVAWATAPEYGAVVSFLGTTRSPNRGEEVAFLEYEAYPEMAEKVMAEILAEMRARWPLGRIALWHR
LGRVDPGEASIAIVVSARHRKEAFAACQYAIDRVKQILPVWKKEHRKDGSFWVEGFAPEDKRL

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=134, Percent_Identity=41.7910447761194, Blast_Score=112, Evalue=3e-25,
Organism=Escherichia coli, GI1787003, Length=112, Percent_Identity=45.5357142857143, Blast_Score=104, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17509279, Length=131, Percent_Identity=38.1679389312977, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356259, Length=125, Percent_Identity=40, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 24946; Mature: 24946

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEVRLFALYREQAGTDRLALELPEGARVREAQKALEERFPRLRLEGGMAAVNQALAGA
CEEEEEEHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCC
ETPLKEGDEVAFLPPVSGGQDSYGLTQEPLDLEALVAWATAPEYGAVVSFLGTTRSPNRG
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
EEVAFLEYEAYPEMAEKVMAEILAEMRARWPLGRIALWHRLGRVDPGEASIAIVVSARHR
CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEECCHH
KEAFAACQYAIDRVKQILPVWKKEHRKDGSFWVEGFAPEDKRL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MRIEVRLFALYREQAGTDRLALELPEGARVREAQKALEERFPRLRLEGGMAAVNQALAGA
CEEEEEEHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCC
ETPLKEGDEVAFLPPVSGGQDSYGLTQEPLDLEALVAWATAPEYGAVVSFLGTTRSPNRG
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
EEVAFLEYEAYPEMAEKVMAEILAEMRARWPLGRIALWHRLGRVDPGEASIAIVVSARHR
CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEECCHH
KEAFAACQYAIDRVKQILPVWKKEHRKDGSFWVEGFAPEDKRL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]