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The map label for this gene is 55980021

Identifier: 55980021

GI number: 55980021

Start: 50953

End: 51837

Strand: Reverse

Name: 55980021

Synonym: TTHA0052

Alternate gene names: NA

Gene position: 51837-50953 (Counterclockwise)

Preceding gene: 55980023

Following gene: 55980018

Centisome position: 2.8

GC content: 69.94

Gene sequence:

>885_bases
GTGCGGGCGTACACCACGGCCCACCTCTCCCTTCCCTTGCCCGAGGGCCACCCCTTTCCCCTTTACAAGTACGGGGGCGT
GGCCGAGGCCCTTAAGGGGCTTCTTCCCGTCCTCCCCGCCCCCGAGGTGCCCCGGGAGGCCCTCTTCCTGGCCCACGAGG
CTTCCTACCTGGAGAAGCTTTTCGGGGAGGGCCTTAGCCGGGAGGAGTCCTTGAGGCTTGGCCTCCCCTTTAGCCAGGCC
CTCTTGCGGCGCGCCCTCCACGCCGCCGGGGGCACCCTGGCCGCGGCCCTGGACGCCCTTAAGACCGGCCTCGGCCTCAA
CCTCTCCGGGGGCACCCACCACGCCTTCCCCGGCCGGGCCGAGGGGTACAGCCTCTTCAACGACGTGGCCGTGGCCATTT
TCTGGCTCCGGGCCAAGGAGGGGTTTTCGGGCCGGGTCTTGGTGGTGGACCTGGACGCCCACCAGGGGAACGGCACCGCC
TTCTTCTTCCGGGAGGACCCCTCCGTCTTCACCCTCTCCCTCCACGGGGAGCGGAACTACCCTCTGAAGAAGGAAAAGAG
CGACCTGGACGTGGGCCTTCCCGATGGGACGGGGGACGAGGCCTACCTCTGGGCCCTGGAGGGGGCCTTAGAGAAGGCCC
GGGCCTTCCGCCCGGACCTCGTCTTCTACAACGCCGGGGTGGACGTCTTAAAGGGGGACCGCTTCGGCCGCCTCGCCCTA
AGCCCGGAAGGGGTGAGGCGGCGGGACGAGAGGGTCTTCCGCTTCGTCAAGGCCCTCGGGGCGCCCCTCGTGGTGGTGAT
GGGCGGGGGGTACAACCGCGACCCCCGCCTCACCGTGGAGGCCCACGCGGCGACCTACCGCCTGGCCTTGAGCTCCTTGG
CGTAG

Upstream 100 bases:

>100_bases
GGGGAAGCGGGGGGAGTGGATGTGGGGGTGGACCTGGTCGGATAGGACAAGGAGGCGCACGCTCCTTTTCATTCTGGCAA
AAAGGCGTAAGGATAGGGGC

Downstream 100 bases:

>100_bases
GTGGCCACGGCCTCCTCGAGGCTAAACCCCAGGCCCCGGTAGAGGTCTAGAGCGCCCTTTTCGTGGTCGTGGGCCCGGAC
CCGGAGGAGGTCCGCCCCCT

Product: deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MRAYTTAHLSLPLPEGHPFPLYKYGGVAEALKGLLPVLPAPEVPREALFLAHEASYLEKLFGEGLSREESLRLGLPFSQA
LLRRALHAAGGTLAAALDALKTGLGLNLSGGTHHAFPGRAEGYSLFNDVAVAIFWLRAKEGFSGRVLVVDLDAHQGNGTA
FFFREDPSVFTLSLHGERNYPLKKEKSDLDVGLPDGTGDEAYLWALEGALEKARAFRPDLVFYNAGVDVLKGDRFGRLAL
SPEGVRRRDERVFRFVKALGAPLVVVMGGGYNRDPRLTVEAHAATYRLALSSLA

Sequences:

>Translated_294_residues
MRAYTTAHLSLPLPEGHPFPLYKYGGVAEALKGLLPVLPAPEVPREALFLAHEASYLEKLFGEGLSREESLRLGLPFSQA
LLRRALHAAGGTLAAALDALKTGLGLNLSGGTHHAFPGRAEGYSLFNDVAVAIFWLRAKEGFSGRVLVVDLDAHQGNGTA
FFFREDPSVFTLSLHGERNYPLKKEKSDLDVGLPDGTGDEAYLWALEGALEKARAFRPDLVFYNAGVDVLKGDRFGRLAL
SPEGVRRRDERVFRFVKALGAPLVVVMGGGYNRDPRLTVEAHAATYRLALSSLA
>Mature_294_residues
MRAYTTAHLSLPLPEGHPFPLYKYGGVAEALKGLLPVLPAPEVPREALFLAHEASYLEKLFGEGLSREESLRLGLPFSQA
LLRRALHAAGGTLAAALDALKTGLGLNLSGGTHHAFPGRAEGYSLFNDVAVAIFWLRAKEGFSGRVLVVDLDAHQGNGTA
FFFREDPSVFTLSLHGERNYPLKKEKSDLDVGLPDGTGDEAYLWALEGALEKARAFRPDLVFYNAGVDVLKGDRFGRLAL
SPEGVRRRDERVFRFVKALGAPLVVVMGGGYNRDPRLTVEAHAATYRLALSSLA

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI217272877, Length=273, Percent_Identity=35.8974358974359, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI209862883, Length=267, Percent_Identity=35.2059925093633, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI13128860, Length=211, Percent_Identity=30.8056872037915, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13128864, Length=266, Percent_Identity=30.4511278195489, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI8923769, Length=271, Percent_Identity=28.4132841328413, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI13128862, Length=191, Percent_Identity=30.8900523560209, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI20070354, Length=264, Percent_Identity=31.4393939393939, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI293336691, Length=184, Percent_Identity=29.8913043478261, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI17158039, Length=151, Percent_Identity=35.7615894039735, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI30795204, Length=151, Percent_Identity=35.7615894039735, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI30795202, Length=151, Percent_Identity=35.7615894039735, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI169234807, Length=151, Percent_Identity=33.7748344370861, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI62750349, Length=196, Percent_Identity=31.6326530612245, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI62750347, Length=196, Percent_Identity=31.6326530612245, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI148539870, Length=151, Percent_Identity=33.7748344370861, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262073088, Length=173, Percent_Identity=28.9017341040462, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193207430, Length=287, Percent_Identity=33.4494773519164, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17508561, Length=198, Percent_Identity=32.3232323232323, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17561978, Length=231, Percent_Identity=30.7359307359307, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193206283, Length=177, Percent_Identity=31.638418079096, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540332, Length=177, Percent_Identity=31.638418079096, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534739, Length=269, Percent_Identity=26.7657992565056, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540334, Length=177, Percent_Identity=31.638418079096, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193209491, Length=219, Percent_Identity=29.6803652968037, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323999, Length=226, Percent_Identity=31.858407079646, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321244, Length=220, Percent_Identity=30.9090909090909, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324307, Length=276, Percent_Identity=29.7101449275362, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325325, Length=181, Percent_Identity=29.2817679558011, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649807, Length=191, Percent_Identity=42.4083769633508, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24657891, Length=211, Percent_Identity=31.2796208530806, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644244, Length=191, Percent_Identity=30.8900523560209, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281360899, Length=206, Percent_Identity=30.0970873786408, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24642142, Length=206, Percent_Identity=30.0970873786408, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24642146, Length=206, Percent_Identity=30.0970873786408, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24642144, Length=206, Percent_Identity=30.0970873786408, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 31909; Mature: 31909

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYTTAHLSLPLPEGHPFPLYKYGGVAEALKGLLPVLPAPEVPREALFLAHEASYLEKL
CCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FGEGLSREESLRLGLPFSQALLRRALHAAGGTLAAALDALKTGLGLNLSGGTHHAFPGRA
HCCCCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCC
EGYSLFNDVAVAIFWLRAKEGFSGRVLVVDLDAHQGNGTAFFFREDPSVFTLSLHGERNY
CCHHHHHHHHHHHHEEECCCCCCCEEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCC
PLKKEKSDLDVGLPDGTGDEAYLWALEGALEKARAFRPDLVFYNAGVDVLKGDRFGRLAL
CCCCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEEE
SPEGVRRRDERVFRFVKALGAPLVVVMGGGYNRDPRLTVEAHAATYRLALSSLA
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECHHHHHHHHHHCC
>Mature Secondary Structure
MRAYTTAHLSLPLPEGHPFPLYKYGGVAEALKGLLPVLPAPEVPREALFLAHEASYLEKL
CCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FGEGLSREESLRLGLPFSQALLRRALHAAGGTLAAALDALKTGLGLNLSGGTHHAFPGRA
HCCCCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCC
EGYSLFNDVAVAIFWLRAKEGFSGRVLVVDLDAHQGNGTAFFFREDPSVFTLSLHGERNY
CCHHHHHHHHHHHHEEECCCCCCCEEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCC
PLKKEKSDLDVGLPDGTGDEAYLWALEGALEKARAFRPDLVFYNAGVDVLKGDRFGRLAL
CCCCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEEE
SPEGVRRRDERVFRFVKALGAPLVVVMGGGYNRDPRLTVEAHAATYRLALSSLA
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7678591 [H]