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The map label for this gene is adk

Identifier: 54297321

GI number: 54297321

Start: 1520874

End: 1521530

Strand: Direct

Name: adk

Synonym: lpp1366

Alternate gene names: 54297321

Gene position: 1520874-1521530 (Clockwise)

Preceding gene: 54297320

Following gene: 54297322

Centisome position: 43.41

GC content: 42.31

Gene sequence:

>657_bases
ATGCGATTAATGCTTTTAGGTGGACCGGGAGCCGGCAAAGGAACCCAAGCTTCACTTTTAATTAACCGTTATAAAATTCC
TCAAATTTCTACCGGTGACATGCTGCGTGCTGCCATAGCAAAAGGTACGCCCTTAGGATTAAGTGCCCAAAAAATCATGG
AATCAGGTGGGTTGGTGTCCGATGATATTATTATCGGGTTAGTGAAGGAAAGACTAAAAAACCCTGATTGTGATAGAGGA
TTCCTGTTTGATGGTTTTCCAAGAACATTGGTCCAGGCCGAAGCTTTAAAAGATGCAGAAATCCATTTGGATCATGTGAT
AGAAATAGCCGTTGATGACGAAGAAATAATTGAACGCATCAGCGGGCGACGCATTCACCAGCCTTCTGGTAGGGTTTATC
ACGTTGTGAATCAACCGCCGAAAAATCCAGGTGTAGATGACATCACAGGTGAGCCTCTGATTCAACGTGATGATGATAAA
GAAGAAACCATACGTAAGCGCTTGCAGGTTTACCATAGTCAAACAGCGCCATTGGTGCAATATTATAAAGAATGGGCTGA
AACTGGCTCTAAAGAAGCTCCAAAATTTCACACTATTAGTGGTACAGGTACAGTAGAGCAAATATTTGACAACATCGTAA
CGATACTCGAAACTTAG

Upstream 100 bases:

>100_bases
ATTTGTCAATGTGCACTAAATAATTATAAAATTTTATAGTGCTACTATGTTACTATATTTTAAAGTATATAATGATTATG
AATTATTTAAGGAGTTTTGG

Downstream 100 bases:

>100_bases
GAGTTAACATGCCGACCCAGACTATTAACAGCGCTGAATTTGAATCATTAATTAATGATAATGAGATAGTTTTTATTGAT
TTCTGGGCTGAGTGGTGTGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDDIIIGLVKERLKNPDCDRG
FLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDK
EETIRKRLQVYHSQTAPLVQYYKEWAETGSKEAPKFHTISGTGTVEQIFDNIVTILET

Sequences:

>Translated_218_residues
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDDIIIGLVKERLKNPDCDRG
FLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDK
EETIRKRLQVYHSQTAPLVQYYKEWAETGSKEAPKFHTISGTGTVEQIFDNIVTILET
>Mature_218_residues
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDDIIIGLVKERLKNPDCDRG
FLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDK
EETIRKRLQVYHSQTAPLVQYYKEWAETGSKEAPKFHTISGTGTVEQIFDNIVTILET

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=50.531914893617, Blast_Score=195, Evalue=2e-50,
Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=50.531914893617, Blast_Score=195, Evalue=2e-50,
Organism=Homo sapiens, GI19923437, Length=218, Percent_Identity=42.6605504587156, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI310110345, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI53832003, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI8051579, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI53832001, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI4502011, Length=216, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI28144897, Length=223, Percent_Identity=30.4932735426009, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI28144899, Length=223, Percent_Identity=30.4932735426009, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI7706497, Length=223, Percent_Identity=26.9058295964126, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=30.2158273381295, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=30.2158273381295, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=55.0925925925926, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=46.8085106382979, Blast_Score=185, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=219, Percent_Identity=32.8767123287671, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=30.8755760368664, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320432, Length=202, Percent_Identity=50.990099009901, Blast_Score=207, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6321018, Length=217, Percent_Identity=43.3179723502304, Blast_Score=148, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6322828, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=53.551912568306, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17647141, Length=217, Percent_Identity=28.110599078341, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24663208, Length=217, Percent_Identity=28.110599078341, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221459597, Length=212, Percent_Identity=24.0566037735849, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356893, Length=212, Percent_Identity=24.0566037735849, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_LEGPA (Q5X5F4)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123690.1
- HSSP:   P69441
- ProteinModelPortal:   Q5X5F4
- SMR:   Q5X5F4
- STRING:   Q5X5F4
- GeneID:   3117745
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1366
- LegioList:   lpp1366
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   LPNE297246:LPP1366-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24135; Mature: 24135

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVS
CEEEEEECCCCCCCCCHHEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DDIIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERI
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHH
SGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDKEETIRKRLQVYHSQTAPLVQ
CCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
YYKEWAETGSKEAPKFHTISGTGTVEQIFDNIVTILET
HHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVS
CEEEEEECCCCCCCCCHHEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DDIIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERI
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHH
SGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDKEETIRKRLQVYHSQTAPLVQ
CCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
YYKEWAETGSKEAPKFHTISGTGTVEQIFDNIVTILET
HHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA