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The map label for this gene is wecA [H]

Identifier: 54296789

GI number: 54296789

Start: 925876

End: 926880

Strand: Direct

Name: wecA [H]

Synonym: lpp0828

Alternate gene names: 54296789

Gene position: 925876-926880 (Clockwise)

Preceding gene: 54296788

Following gene: 54296795

Centisome position: 26.43

GC content: 28.86

Gene sequence:

>1005_bases
ATGAATATAATACTTAATGTATTTTTAATATTTGTCTCAGCAATTTTGACTAAATTATTTGCCTTGTTTGCGCAGCATAC
AAAATTGATTGATATTCCAAATGAAAGAAATTTACACTCCAGACCTACTGTCCGAGGAGGAGGGCTTGTCTTTATTGGTC
TTAGTTTATTTTGTTGGTTTTTTATTTGTAACTCACAATTTTTTTTAACATTGGATCAATTCATTTTTTCGATAGCTATT
ATTTTCATAGCAACTATAAGTTTTATAGATGATTTTTATAATTTGTCAGTTACAATTCGATTCTTTTTTCAATGTCTGAT
TGCATTCCTGATAGTTATATTTATATTGCCTTCCCAGTTAGATTTTGGTTTATTTCTATTTGAAAACACCTATTTAATTG
CTTTTTTTCTATTTTTTGCAGTTATTTGGGCAATTAATCATTTTAATTTCATGGATGGGCTTGATGGTTTTTGCGCTTCC
CAAGCGATTTTTTTGTTAGCCGCATATGCTTTGTTTTTCAACTCAGCAGGTTCATTAATTTATCAAGATTTTTGCCTGAT
TCTTATTTCTAGTTTGGCAGGGTTTTTAATTTTTAATTTCCCACCAGCCAAGATATTTATGGGAGATGTAGGGAGCGCCT
CCTTAGGATTAATTACTTTTTTCATAGCAATCATTGCTCAAAAGAATTATCAAATTCCAATTCTATATTGGTTTATCCTG
AACTCATTATTTCTCTTCGATTCTACAGTGACTTTAATTCGAAGGATTATAAAGCATGAAAAATGGTTTAGTCCCCATAA
AAAGCACGCTTATCAGAGATTAAAGCAATTGGGCATTAACTCTAGGTTTATTTTGTTAGGTCAAGCAATAATAAATGGTA
GTTTATTTCTTTCTGTCATGTTTATGCATTTTCAATTTTTTAATCTTAAAAATCTAATAATTATTCAGTTATGTTATTTA
TCTGCCATATATTTTTTCATTGAAAAAAAATATCCTATGGAATAA

Upstream 100 bases:

>100_bases
TCTTTAGAAGTAAGTAATGAGAAAATTAAATCCCAATTAGGGTGGACACCACCAGTTAGTTCTATTGATGGATTAGAAAA
GACGGTAAAATGGTATCAAA

Downstream 100 bases:

>100_bases
AGATAAGAATTTTTTTGTATTTAAGATATAAACTTTTAATTGTGATTAATTTGTCTTTAATCTTATGTAAATATTTGGTT
TAATTAATAATCATAATATA

Product: alpha-N-acetylglucosaminyltransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MNIILNVFLIFVSAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWFFICNSQFFLTLDQFIFSIAI
IFIATISFIDDFYNLSVTIRFFFQCLIAFLIVIFILPSQLDFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCAS
QAIFLLAAYALFFNSAGSLIYQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
NSLFLFDSTVTLIRRIIKHEKWFSPHKKHAYQRLKQLGINSRFILLGQAIINGSLFLSVMFMHFQFFNLKNLIIIQLCYL
SAIYFFIEKKYPME

Sequences:

>Translated_334_residues
MNIILNVFLIFVSAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWFFICNSQFFLTLDQFIFSIAI
IFIATISFIDDFYNLSVTIRFFFQCLIAFLIVIFILPSQLDFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCAS
QAIFLLAAYALFFNSAGSLIYQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
NSLFLFDSTVTLIRRIIKHEKWFSPHKKHAYQRLKQLGINSRFILLGQAIINGSLFLSVMFMHFQFFNLKNLIIIQLCYL
SAIYFFIEKKYPME
>Mature_334_residues
MNIILNVFLIFVSAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWFFICNSQFFLTLDQFIFSIAI
IFIATISFIDDFYNLSVTIRFFFQCLIAFLIVIFILPSQLDFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCAS
QAIFLLAAYALFFNSAGSLIYQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
NSLFLFDSTVTLIRRIIKHEKWFSPHKKHAYQRLKQLGINSRFILLGQAIINGSLFLSVMFMHFQFFNLKNLIIIQLCYL
SAIYFFIEKKYPME

Specific function: Catalyzes the formation of undecaprenyl-PP-N- acetylglucosamine. Involved in the synthesis of anionic cell-wall polymers as it mediates the initiation of the linkage unit formation that appears to be common to the two types of teichoic acids attached to t

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=277, Percent_Identity=25.6317689530686, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 38668; Mature: 38668

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILNVFLIFVSAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FICNSQFFLTLDQFIFSIAIIFIATISFIDDFYNLSVTIRFFFQCLIAFLIVIFILPSQL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCASQAIFLLAAYALFFNSAGSLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHH
YQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
HHHHHHHHHHHHHHHHEECCCCHHEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NSLFLFDSTVTLIRRIIKHEKWFSPHKKHAYQRLKQLGINSRFILLGQAIINGSLFLSVM
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
FMHFQFFNLKNLIIIQLCYLSAIYFFIEKKYPME
HHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNIILNVFLIFVSAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FICNSQFFLTLDQFIFSIAIIFIATISFIDDFYNLSVTIRFFFQCLIAFLIVIFILPSQL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCASQAIFLLAAYALFFNSAGSLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHH
YQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
HHHHHHHHHHHHHHHHEECCCCHHEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NSLFLFDSTVTLIRRIIKHEKWFSPHKKHAYQRLKQLGINSRFILLGQAIINGSLFLSVM
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
FMHFQFFNLKNLIIIQLCYLSAIYFFIEKKYPME
HHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12101296; 9384377 [H]