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The map label for this gene is parC [H]

Identifier: 54295818

GI number: 54295818

Start: 3319406

End: 3321661

Strand: Reverse

Name: parC [H]

Synonym: lpl2908

Alternate gene names: 54295818

Gene position: 3321661-3319406 (Counterclockwise)

Preceding gene: 54295819

Following gene: 54295816

Centisome position: 99.28

GC content: 39.89

Gene sequence:

>2256_bases
ATGAAGAAAATACCCAATATGAATGAAGTAACTGAAAAAAAGCCGCTTACTGAGTTTACAGAAAAAGCTTATCTTGATTA
TTCAATGTATGTCATTTTGGACAGAGCATTACCGAGCATCGCAGATGGACTTAAGCCTGTCCAACGCAGAATTGTTTATG
CTATGTCTGAGTTGGGTTTGAAAGCAACAGCAAAATATAAAAAATCAGCGCGTACAGTAGGGGATGTTCTTGGTAAATTC
CATCCTCATGGTGATAGTGCATGCTATGAAGCTATGGTATTAATGGCACAACCTTTCTCGTATCGTTATCCTTTTGTTGA
TGGACAAGGAAATTGGGGATCCCCGGATGATCCCAAATCATTTGCTGCAATGAGATATACAGAAGCAAGATTATCTCATT
ATGCTGATGTGTTACTTGGAGAACTGCTACAAGGAACCGTAGATTGGGTAGATAATTTTGATGGTACTTTGCAAGAGCCA
GCTCTTTTACCAGCACGTTTGCCTAATATTTTATTGAATGGTGCAACAGGTATAGCTGTTGGTATGGCTTCAGATATTCT
TCCGCACAATTTGACTGAAGTTGCTAATGCGTGTATTCATCTGCTGGATAACCCCCAAGCCGATATTAAGACTATATGTG
AATATATTAAAGGCCCTGATTTTCCAACAGAAGCAGAAATCATTAGCCCAAGTGAAACAATTAGAGCTATGTACGAGTCT
GGTAATGGCTCAATTAAAATGCGAGCAATTTATACTCAAGAAAAACAAAATATCGTCATAACCGCTTTGCCTTATCAAGT
ATCCGGAGCTAGGGTAATGGAGCAAATTGCGTTGCAGATGCAACAGAAAAAATTACCGATGGTTGAGGATTTACGTGATG
AATCAGATCACGAGCATCCAACACGGTTGGTTATTATCCCTCGTTCTAATCGAGTAGATATAGAAAGTTTAATGTCGCAT
TTATTTGCTACCACGGATTTGGAGCGTAGCTATCGAGTTAATTTTAATATGATTGGGCTTGATGGCAAGCCAAGGGTTAA
AGGACTGTTAGCAATCTTGACTGAATGGTTGGAATTTAGGCTTGCCACAGTAAAAAGACGTCTTCAATTCAGATTGGAAA
AGGTACTGGAGCGTATTCATATTCTTGAAGGATTGCTTATCGCCTATCTTAATATAGATGAAGTCATTGCAATCATCAGA
GAACATGAGCAACCAAAACAAGGATTAATTTCGCGCTTTAACTTAACCGAAAGACAGGCTGAAGCAATTTTGGAAATGAA
ACTGCGGCATTTAGCCAAATTGGAAGAGATTAAATTGCGTGGTGAACTGGACGAGCTGTCTGATGAACGTGATACTTTAC
AAAAAACGCTGGCTAGTCATTTTCTCTTAAAAGAACTGGTAAAAGAAGAGATAACGAAAGATCGAGATGAGTTTGGTGAC
CCACGCCGTTCACCCATTATTACAAGGGAGGACTCTCAGGCATTAAAAGAAGAGGATATTTTGCCTAATGAGCCTATTAC
GGTTGTATTGTCTAAAAATGGATGGGTCAGAGCGGCCAAGGGGCATGATGTCGATGGTAAGGAACTCAGCTATAAAGCTG
GAGATGAATTCAAAGCCCAAACGCTAGCTCGTACTAATCAGCAAGTTTTATTTTTTGATGGAGAGGGAAAGGTCTATTCG
CTTCCAGGACATGTATTGCCATCAGCACGTGGTCAAGGCGAGCCTTTGACCGGAAAATTAAACCCTGCTGAAGGAGTATT
GTTTGAAGCAATTGTTGGCGGAGAGCCTGAGCAAAAGGTGTTATTGGCTACTGATTCCGGGTATGGATTTATCGCCAAAA
TTGAAGATTTATATGTAAAAAATCGTAATGGAAAGGCATGCATCAAATTAAGTGAAAAAAGTCATATATTGCCGCCAAGG
CTAATACCAAATCGAGAGCAATTATTTGTTGCTTGTGCAACGAATGTAGGGCGTTTATTGATTTTTTCTCTTGAGGAGTT
GCCCGAATTATCTCGAGGAAAAGGGAATAAATTGATCAGTATCCCTGCCGCTAAAGCGGTCTCACGAGAAGAGTATATAG
TTGATATACAAGTTTTAACAACAAATGATTCACTGACAGTTCATGCCGGTAAGCGGCATTTTACTCTGAAAGGTGAGGAT
TTGACTCACTATAAGGGTGAACGGGGCAGGAGAGGAAACCGGTTGCCAAGAGGTTTACAAAATGTTTCTCAATTACATGT
TACTCAATCTGAGTAA

Upstream 100 bases:

>100_bases
GATAATACGATGATTATAATTCTAACAGCATGAATATTCTGTTAAAATTGTTTTGCATTGTCTTATACGATTCAATAGGA
TGATGGATAGCAATTAATAT

Downstream 100 bases:

>100_bases
CATGGCCGTTAGAGACTGTATGTTTCCCGTGAAACACCTTTAAGTGATGATTTGAAATCAAACAGAATAATGCACAGAGC
TGGCTTATTGTTCAATAACT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 751; Mature: 751

Protein sequence:

>751_residues
MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGLKATAKYKKSARTVGDVLGKF
HPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKSFAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEP
ALLPARLPNILLNGATGIAVGMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAMYES
GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHPTRLVIIPRSNRVDIESLMSH
LFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFRLATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIR
EHEQPKQGLISRFNLTERQAEAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHFLLKELVKEEITKDRDEFGD
PRRSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQTLARTNQQVLFFDGEGKVYS
LPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKVLLATDSGYGFIAKIEDLYVKNRNGKACIKLSEKSHILPPR
LIPNREQLFVACATNVGRLLIFSLEELPELSRGKGNKLISIPAAKAVSREEYIVDIQVLTTNDSLTVHAGKRHFTLKGED
LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE

Sequences:

>Translated_751_residues
MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGLKATAKYKKSARTVGDVLGKF
HPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKSFAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEP
ALLPARLPNILLNGATGIAVGMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAMYES
GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHPTRLVIIPRSNRVDIESLMSH
LFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFRLATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIR
EHEQPKQGLISRFNLTERQAEAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHFLLKELVKEEITKDRDEFGD
PRRSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQTLARTNQQVLFFDGEGKVYS
LPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKVLLATDSGYGFIAKIEDLYVKNRNGKACIKLSEKSHILPPR
LIPNREQLFVACATNVGRLLIFSLEELPELSRGKGNKLISIPAAKAVSREEYIVDIQVLTTNDSLTVHAGKRHFTLKGED
LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE
>Mature_751_residues
MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGLKATAKYKKSARTVGDVLGKF
HPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKSFAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEP
ALLPARLPNILLNGATGIAVGMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAMYES
GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHPTRLVIIPRSNRVDIESLMSH
LFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFRLATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIR
EHEQPKQGLISRFNLTERQAEAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHFLLKELVKEEITKDRDEFGD
PRRSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQTLARTNQQVLFFDGEGKVYS
LPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKVLLATDSGYGFIAKIEDLYVKNRNGKACIKLSEKSHILPPR
LIPNREQLFVACATNVGRLLIFSLEELPELSRGKGNKLISIPAAKAVSREEYIVDIQVLTTNDSLTVHAGKRHFTLKGED
LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=741, Percent_Identity=62.3481781376518, Blast_Score=974, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=733, Percent_Identity=36.5620736698499, Blast_Score=408, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI212645845, Length=383, Percent_Identity=23.2375979112272, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=402, Percent_Identity=22.3880597014925, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.- [C]

Molecular weight: Translated: 84418; Mature: 84418

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGL
CCCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KATAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHH
FAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEPALLPARLPNILLNGATGIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHEECCCCCEEH
GMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAMYES
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHC
GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHP
CCCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC
TRLVIIPRSNRVDIESLMSHLFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFR
EEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
LATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIREHEQPKQGLISRFNLTERQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHH
EAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHFLLKELVKEEITKDRDEFGD
HHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
PRRSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQ
CCCCCCEECCCHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCHHHH
TLARTNQQVLFFDGEGKVYSLPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKV
HHHCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHEEHHHCCCCCCEE
LLATDSGYGFIAKIEDLYVKNRNGKACIKLSEKSHILPPRLIPNREQLFVACATNVGRLL
EEEECCCCEEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHEEEEECCCCCCEE
IFSLEELPELSRGKGNKLISIPAAKAVSREEYIVDIQVLTTNDSLTVHAGKRHFTLKGED
EEEHHHCCHHHCCCCCEEEECCCHHHCCCCCEEEEEEEEEECCCEEEEECCEEEEEECCC
LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGL
CCCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KATAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHH
FAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEPALLPARLPNILLNGATGIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHEECCCCCEEH
GMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAMYES
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHC
GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHP
CCCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC
TRLVIIPRSNRVDIESLMSHLFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFR
EEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
LATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIREHEQPKQGLISRFNLTERQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHH
EAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHFLLKELVKEEITKDRDEFGD
HHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
PRRSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQ
CCCCCCEECCCHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCHHHH
TLARTNQQVLFFDGEGKVYSLPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKV
HHHCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHEEHHHCCCCCCEE
LLATDSGYGFIAKIEDLYVKNRNGKACIKLSEKSHILPPRLIPNREQLFVACATNVGRLL
EEEECCCCEEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHEEEEECCCCCCEE
IFSLEELPELSRGKGNKLISIPAAKAVSREEYIVDIQVLTTNDSLTVHAGKRHFTLKGED
EEEHHHCCHHHCCCCCEEEECCCHHHCCCCCEEEEEEEEEECCCEEEEECCEEEEEECCC
LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]