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The map label for this gene is hap [H]

Identifier: 54295816

GI number: 54295816

Start: 3316531

End: 3318192

Strand: Reverse

Name: hap [H]

Synonym: lpl2906

Alternate gene names: 54295816

Gene position: 3318192-3316531 (Counterclockwise)

Preceding gene: 54295818

Following gene: 54295815

Centisome position: 99.18

GC content: 38.03

Gene sequence:

>1662_bases
ATGAAAAAACGGATTGTTTCATTATTTGTCATTTCAACAGTTATTTCATCTGTAAACGCTGCAACTCAAGCAATCGTATG
GGGTGAGTCAACGAAAGCATTGCCTCAATTTATGCAAGCACATCCTTTTAAGAAACAAGGATTATTGCAAACTGTAAAAA
GTCAGCAAAGTGATTATAAACTGGAGTTACAAAATAATTCTAACCATGCGACCAGGCATGCTCGTTATCAAATAACTTAC
AAGGGGGTTCCGGTTTGGGGTTATCAAGTCATTTTTCATTCCAAAGATGGCGCCAAAGAAACTGTAACAGGTATGAATAT
TACCGGAATTGAACAGGATATTAATTCTATTGAGGGAAAATTGAGCCCGAATGATATAGAACAAAAGATTCTTGGAAAGG
TAACTGAACCGGTTAAATTTAAAAACCTTAAAAAGGTTATTTATATAGATAAAGGAAATAAAGCTCATTTGGCTTATCAT
TTGTCTTACTATTCCAATAGTGAAAAAAAACATGTGAATGCACCTAATTATCTTATTGATGCCAATAGTGGTGAGATTTT
GAAACAATGGGATGAGGTGCGTCATGAAAGAATTGGTCAGGGATTAGGAGGTAATGCGTTTACTCTCCCATACCGTCAGG
GAATGTTTCAGCATGGTAATGCTTTGCCGGGACTTCCCTCATTAGGGAAGTTTGACGTTAATGTTGAGGATGGCTTATGT
CGTGTTGAAAATGAATCCATAAAAGTAATGAATTTGGAAAATCATAATATAGGTTATGATTTCTTTCCAATTACCATATT
TGCGGAGTCTGTACTGAATTTAAGTGCTTTTTCCTACCCATGTAATGAAACCAATTTGTTTTTAAACTATGCGGATGGCA
GAACAGGTCCTGTCAATTATGCTTTTTCTCCAGTTAACGATACGATGTATTTTGCCCAACAAACGTTAGATATGTATCAA
AAAGTTTATGGTGTTAATCGTCCAATAGGTGATGATTTACCTATACGGGCTTACACCCATCTTGGTGACATGGATAACGC
TTTTGCAGTACCAACTATCAGTCTTGATGGGGTAGTTCTTGCACATCAGCAAATTGTAATCGGAAATGGTGGTGAGTTTT
TAACAGCTCCCGCCCAGAGTGTATTAGGACATGAATTATCGCACAATTTTACTGCCTTGCATTCCGGATTGATGTATGAA
GGGCAATCTGGGGGGATCAATGAATCCTTCTCTGATATGGCGGCAATTGCATTGTTAGATTATCTTAGTAAAGATTATCC
ATGGTATTGGGATGGTGAGGATTGGACCATTGGGCGTGAAGCTGTAAAAAGTGGGCAACCTATTCGTTATTTGGATGATC
CAGCCAAGGATGGAATGTCTATAGGGCATGCTAGTGAATACACTGATGCGTTAGATGTGCATATAACGAGCGGAGTATTT
AATAAAGCATTTTATTTATTAGCACATAAACCAGGCTGGTCTATACGAAAAGCATTTCAGGTTATGGTTGACGCCAATAT
GAATTATTGGTCTCCTATTGCATACTATGATTTTGCTGCATGTGGCGTCATTCAGGCAACCATAGATAAGCATTGGGATA
AAACACCTGTTATCGAGGCATTTGCCGAGGTGGGAGTTGTTTGTCCGATGCATAAAAGCTAG

Upstream 100 bases:

>100_bases
ATATAAAAAAATAAAATTTTGTCGTAATTTGTGTCTTCTGATTGTTTTTTTCTCGAATTTGTAGCAGCATGAAATTTCCA
CAAAAAATCAGGATGATATT

Downstream 100 bases:

>100_bases
TTTTAAAGTGGTTTGACTTCAATAGTTCAAGCTTCTTAAAACAACGAGAATTGCTAAGGAAGGTTGATCATTTTCTATAG
AACGCATACTGGATAAGATA

Product: hypothetical protein

Products: NA

Alternate protein names: HA/protease; Vibriolysin [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MKKRIVSLFVISTVISSVNAATQAIVWGESTKALPQFMQAHPFKKQGLLQTVKSQQSDYKLELQNNSNHATRHARYQITY
KGVPVWGYQVIFHSKDGAKETVTGMNITGIEQDINSIEGKLSPNDIEQKILGKVTEPVKFKNLKKVIYIDKGNKAHLAYH
LSYYSNSEKKHVNAPNYLIDANSGEILKQWDEVRHERIGQGLGGNAFTLPYRQGMFQHGNALPGLPSLGKFDVNVEDGLC
RVENESIKVMNLENHNIGYDFFPITIFAESVLNLSAFSYPCNETNLFLNYADGRTGPVNYAFSPVNDTMYFAQQTLDMYQ
KVYGVNRPIGDDLPIRAYTHLGDMDNAFAVPTISLDGVVLAHQQIVIGNGGEFLTAPAQSVLGHELSHNFTALHSGLMYE
GQSGGINESFSDMAAIALLDYLSKDYPWYWDGEDWTIGREAVKSGQPIRYLDDPAKDGMSIGHASEYTDALDVHITSGVF
NKAFYLLAHKPGWSIRKAFQVMVDANMNYWSPIAYYDFAACGVIQATIDKHWDKTPVIEAFAEVGVVCPMHKS

Sequences:

>Translated_553_residues
MKKRIVSLFVISTVISSVNAATQAIVWGESTKALPQFMQAHPFKKQGLLQTVKSQQSDYKLELQNNSNHATRHARYQITY
KGVPVWGYQVIFHSKDGAKETVTGMNITGIEQDINSIEGKLSPNDIEQKILGKVTEPVKFKNLKKVIYIDKGNKAHLAYH
LSYYSNSEKKHVNAPNYLIDANSGEILKQWDEVRHERIGQGLGGNAFTLPYRQGMFQHGNALPGLPSLGKFDVNVEDGLC
RVENESIKVMNLENHNIGYDFFPITIFAESVLNLSAFSYPCNETNLFLNYADGRTGPVNYAFSPVNDTMYFAQQTLDMYQ
KVYGVNRPIGDDLPIRAYTHLGDMDNAFAVPTISLDGVVLAHQQIVIGNGGEFLTAPAQSVLGHELSHNFTALHSGLMYE
GQSGGINESFSDMAAIALLDYLSKDYPWYWDGEDWTIGREAVKSGQPIRYLDDPAKDGMSIGHASEYTDALDVHITSGVF
NKAFYLLAHKPGWSIRKAFQVMVDANMNYWSPIAYYDFAACGVIQATIDKHWDKTPVIEAFAEVGVVCPMHKS
>Mature_553_residues
MKKRIVSLFVISTVISSVNAATQAIVWGESTKALPQFMQAHPFKKQGLLQTVKSQQSDYKLELQNNSNHATRHARYQITY
KGVPVWGYQVIFHSKDGAKETVTGMNITGIEQDINSIEGKLSPNDIEQKILGKVTEPVKFKNLKKVIYIDKGNKAHLAYH
LSYYSNSEKKHVNAPNYLIDANSGEILKQWDEVRHERIGQGLGGNAFTLPYRQGMFQHGNALPGLPSLGKFDVNVEDGLC
RVENESIKVMNLENHNIGYDFFPITIFAESVLNLSAFSYPCNETNLFLNYADGRTGPVNYAFSPVNDTMYFAQQTLDMYQ
KVYGVNRPIGDDLPIRAYTHLGDMDNAFAVPTISLDGVVLAHQQIVIGNGGEFLTAPAQSVLGHELSHNFTALHSGLMYE
GQSGGINESFSDMAAIALLDYLSKDYPWYWDGEDWTIGREAVKSGQPIRYLDDPAKDGMSIGHASEYTDALDVHITSGVF
NKAFYLLAHKPGWSIRKAFQVMVDANMNYWSPIAYYDFAACGVIQATIDKHWDKTPVIEAFAEVGVVCPMHKS

Specific function: May play a role in the pathogenesis of cholera. Hap nicks and activates the A subunit of cholera enterotoxin and related enterotoxins [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR007280
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C; PF04151 PPC [H]

EC number: NA

Molecular weight: Translated: 61679; Mature: 61679

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRIVSLFVISTVISSVNAATQAIVWGESTKALPQFMQAHPFKKQGLLQTVKSQQSDYK
CCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEE
LELQNNSNHATRHARYQITYKGVPVWGYQVIFHSKDGAKETVTGMNITGIEQDINSIEGK
EEEECCCCCCEEEEEEEEEEECCCEEEEEEEEECCCCCCHHCCCCEEECHHHHHHHHCCC
LSPNDIEQKILGKVTEPVKFKNLKKVIYIDKGNKAHLAYHLSYYSNSEKKHVNAPNYLID
CCHHHHHHHHHHHCCCCHHHCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCEEEE
ANSGEILKQWDEVRHERIGQGLGGNAFTLPYRQGMFQHGNALPGLPSLGKFDVNVEDGLC
CCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHCHHHCCCCCCCCCCCCEEEEECCCCEE
RVENESIKVMNLENHNIGYDFFPITIFAESVLNLSAFSYPCNETNLFLNYADGRTGPVNY
EECCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCE
AFSPVNDTMYFAQQTLDMYQKVYGVNRPIGDDLPIRAYTHLGDMDNAFAVPTISLDGVVL
EECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCEEE
AHQQIVIGNGGEFLTAPAQSVLGHELSHNFTALHSGLMYEGQSGGINESFSDMAAIALLD
EEEEEEEECCCCEEECCHHHHHHHHHCCCHHHHHCCEEEECCCCCCCCCHHHHHHHHHHH
YLSKDYPWYWDGEDWTIGREAVKSGQPIRYLDDPAKDGMSIGHASEYTDALDVHITSGVF
HHHCCCCEEECCCCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCHHCCCEEEEEEECCHH
NKAFYLLAHKPGWSIRKAFQVMVDANMNYWSPIAYYDFAACGVIQATIDKHWDKTPVIEA
CCEEEEEEECCCHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
FAEVGVVCPMHKS
HHHCCEECCCCCC
>Mature Secondary Structure
MKKRIVSLFVISTVISSVNAATQAIVWGESTKALPQFMQAHPFKKQGLLQTVKSQQSDYK
CCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEE
LELQNNSNHATRHARYQITYKGVPVWGYQVIFHSKDGAKETVTGMNITGIEQDINSIEGK
EEEECCCCCCEEEEEEEEEEECCCEEEEEEEEECCCCCCHHCCCCEEECHHHHHHHHCCC
LSPNDIEQKILGKVTEPVKFKNLKKVIYIDKGNKAHLAYHLSYYSNSEKKHVNAPNYLID
CCHHHHHHHHHHHCCCCHHHCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCEEEE
ANSGEILKQWDEVRHERIGQGLGGNAFTLPYRQGMFQHGNALPGLPSLGKFDVNVEDGLC
CCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHCHHHCCCCCCCCCCCCEEEEECCCCEE
RVENESIKVMNLENHNIGYDFFPITIFAESVLNLSAFSYPCNETNLFLNYADGRTGPVNY
EECCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCE
AFSPVNDTMYFAQQTLDMYQKVYGVNRPIGDDLPIRAYTHLGDMDNAFAVPTISLDGVVL
EECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCEEE
AHQQIVIGNGGEFLTAPAQSVLGHELSHNFTALHSGLMYEGQSGGINESFSDMAAIALLD
EEEEEEEECCCCEEECCHHHHHHHHHCCCHHHHHCCEEEECCCCCCCCCHHHHHHHHHHH
YLSKDYPWYWDGEDWTIGREAVKSGQPIRYLDDPAKDGMSIGHASEYTDALDVHITSGVF
HHHCCCCEEECCCCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCHHCCCEEEEEEECCHH
NKAFYLLAHKPGWSIRKAFQVMVDANMNYWSPIAYYDFAACGVIQATIDKHWDKTPVIEA
CCEEEEEEECCCHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
FAEVGVVCPMHKS
HHHCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2045361; 10952301; 2123831 [H]