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The map label for this gene is coxA [H]

Identifier: 54295722

GI number: 54295722

Start: 3212256

End: 3213872

Strand: Reverse

Name: coxA [H]

Synonym: lpl2810

Alternate gene names: 54295722

Gene position: 3213872-3212256 (Counterclockwise)

Preceding gene: 54295723

Following gene: 54295721

Centisome position: 96.06

GC content: 43.29

Gene sequence:

>1617_bases
ATGAAATACGCAATAGCGCATTCAGAAGATTCTCATGAAGATCATGGTCCCGAACAAGGCAAAGGCTTTATGGGATTTAT
CAAAAGGTGGCTATTTACAACCAACCACAAAGACATAGGTACTCTGTATTTATGGTTAGCATTGATAAGCTTCTTTGTTG
CAGGAGCAATGGCTTTGGTTATCAGGCTTGAGTTATTTCAACCTGGCCATCGATTCGTCGATCCTAATTTCTTTAACCAA
ATGACAACATTGCATGGATTAGTCATGCTGTTTGGTGTTGTCATGCCAGCGTTTACCGGTATGGCAAACTGGCAAATCCC
CATGATGATAGGTGCTCCCGATATGGCTTTGCCAAGACTAAACAACTGGAGCTTCTGGATTTTACCGTTTGCTTTTTGTC
TGTTGTTTTCTACCATGTTTCATGCCGGTGGCGGTCCAAATTTTGGCTGGACCATGTACGCGCCTCTCTCTACAACTTAT
GCGCCACCCAGTACTGATTTCATGATTTTTTCCATTCATATGATGGGACTCTCATCCATCATGGGATCAATTAACATCAT
AGCCACGATTTTAAACTTGAGGGCTCCAGGCATGACCTTGATGAAGATGCCCCTATTTGTCTGGACCTGGCTTATTACGG
CGTTCCTTCTGATCGCCATCATGCCTGTTCTGGCGGGTGCAGTTACTATGATGTTAGCCGATAGACACTTTGGTACTTCT
TTCTTTAATGCGGCAGGTGGTGGAGATCCTATCCTGTTTCAACACGTGTTTTGGTTCTTTGGTCACCCTGAAGTGTATGT
TCTGGTCTTGCCAGCTTTTGGGGTTATTTCAGAAATCATTCCCACTTTCAGCCGTAAACCATTATTTGGTTATCATTTTA
TGGTTTATGCCACTGTGAGCATCGCTGTATTATCCTTTATAGTTTGGGCTCACCATATGTTCACCACGGGAATTCCCCTG
GGGGCTGAATTATTCTTTATGTACACCACCATGCTGATTGCGGTACCTACCGGTATCAAGGTGTTCAACTGGGTGAGTAC
AATGTTCAAAGGGGCAATGACCTTTGAAACGCCAATGCTGTTTGCCATAGCATTTGTATTTTTATTCACTATAGGTGGAT
TTACAGGCTTAATGTTGGCATTGGTACCGGCTGATTTTCAATATCAGGACAGCTATTTTGTTGTGGCTCACTTCCATTAT
GTTCTTGTGCCCGGCGTTATCTTTGCTCTGGTAGCAGCGACTTATTATTGGTTACCCAAATGGACAGGGCATATGTACAA
TGAGCGTTTGGGTAAATGGCATTTTTGGCTTTCTGTCATTTCAGTTAATTTGACCTTTTTCCCCATGCATTTTCTGGGGC
TAGCTGGTATGCCAAGGCGAATCCCTGACTATGCTTTGCAGTTTGCCAATTTTAATATGATTGTAACAGTGGCTGCTTTT
GCTTTCGGTTTGTCGCAATTGTTGTTCCTGTACAATGTGGTAGCCACAGTAAGAAAAAGAGGCACTAATAAGGATGTAGC
AACGAGCAGGGTTTGGGAAGGGTCACATGGATTGGAATGGACTTTGCCATCTCCACCACCTTACCATACGTTTACCACTC
CACCTGAGATTAAATAA

Upstream 100 bases:

>100_bases
ATACTAATGATTTAATTCAACCCGCAGATGTTGCGGCACTGCGACATGGTACCGATATTAAACCTACCATGGTTAATAAA
GCTAAAGCTGGAGGTTTGCA

Downstream 100 bases:

>100_bases
AGGTGGAGCTTGATGATTGAAGAAAAAAAACAGAAAAAACTGCTCACCATATTAACATTATTAGTCTTAGGGATGTTTGC
TTTTGGTTTTGCTCTGGTCC

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MKYAIAHSEDSHEDHGPEQGKGFMGFIKRWLFTTNHKDIGTLYLWLALISFFVAGAMALVIRLELFQPGHRFVDPNFFNQ
MTTLHGLVMLFGVVMPAFTGMANWQIPMMIGAPDMALPRLNNWSFWILPFAFCLLFSTMFHAGGGPNFGWTMYAPLSTTY
APPSTDFMIFSIHMMGLSSIMGSINIIATILNLRAPGMTLMKMPLFVWTWLITAFLLIAIMPVLAGAVTMMLADRHFGTS
FFNAAGGGDPILFQHVFWFFGHPEVYVLVLPAFGVISEIIPTFSRKPLFGYHFMVYATVSIAVLSFIVWAHHMFTTGIPL
GAELFFMYTTMLIAVPTGIKVFNWVSTMFKGAMTFETPMLFAIAFVFLFTIGGFTGLMLALVPADFQYQDSYFVVAHFHY
VLVPGVIFALVAATYYWLPKWTGHMYNERLGKWHFWLSVISVNLTFFPMHFLGLAGMPRRIPDYALQFANFNMIVTVAAF
AFGLSQLLFLYNVVATVRKRGTNKDVATSRVWEGSHGLEWTLPSPPPYHTFTTPPEIK

Sequences:

>Translated_538_residues
MKYAIAHSEDSHEDHGPEQGKGFMGFIKRWLFTTNHKDIGTLYLWLALISFFVAGAMALVIRLELFQPGHRFVDPNFFNQ
MTTLHGLVMLFGVVMPAFTGMANWQIPMMIGAPDMALPRLNNWSFWILPFAFCLLFSTMFHAGGGPNFGWTMYAPLSTTY
APPSTDFMIFSIHMMGLSSIMGSINIIATILNLRAPGMTLMKMPLFVWTWLITAFLLIAIMPVLAGAVTMMLADRHFGTS
FFNAAGGGDPILFQHVFWFFGHPEVYVLVLPAFGVISEIIPTFSRKPLFGYHFMVYATVSIAVLSFIVWAHHMFTTGIPL
GAELFFMYTTMLIAVPTGIKVFNWVSTMFKGAMTFETPMLFAIAFVFLFTIGGFTGLMLALVPADFQYQDSYFVVAHFHY
VLVPGVIFALVAATYYWLPKWTGHMYNERLGKWHFWLSVISVNLTFFPMHFLGLAGMPRRIPDYALQFANFNMIVTVAAF
AFGLSQLLFLYNVVATVRKRGTNKDVATSRVWEGSHGLEWTLPSPPPYHTFTTPPEIK
>Mature_538_residues
MKYAIAHSEDSHEDHGPEQGKGFMGFIKRWLFTTNHKDIGTLYLWLALISFFVAGAMALVIRLELFQPGHRFVDPNFFNQ
MTTLHGLVMLFGVVMPAFTGMANWQIPMMIGAPDMALPRLNNWSFWILPFAFCLLFSTMFHAGGGPNFGWTMYAPLSTTY
APPSTDFMIFSIHMMGLSSIMGSINIIATILNLRAPGMTLMKMPLFVWTWLITAFLLIAIMPVLAGAVTMMLADRHFGTS
FFNAAGGGDPILFQHVFWFFGHPEVYVLVLPAFGVISEIIPTFSRKPLFGYHFMVYATVSIAVLSFIVWAHHMFTTGIPL
GAELFFMYTTMLIAVPTGIKVFNWVSTMFKGAMTFETPMLFAIAFVFLFTIGGFTGLMLALVPADFQYQDSYFVVAHFHY
VLVPGVIFALVAATYYWLPKWTGHMYNERLGKWHFWLSVISVNLTFFPMHFLGLAGMPRRIPDYALQFANFNMIVTVAAF
AFGLSQLLFLYNVVATVRKRGTNKDVATSRVWEGSHGLEWTLPSPPPYHTFTTPPEIK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=519, Percent_Identity=48.5549132947977, Blast_Score=448, Evalue=1e-126,
Organism=Escherichia coli, GI1786634, Length=516, Percent_Identity=41.0852713178295, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6226519, Length=531, Percent_Identity=47.6459510357815, Blast_Score=491, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=50.1538461538461, Blast_Score=329, Evalue=6e-91,
Organism=Saccharomyces cerevisiae, GI6226523, Length=249, Percent_Identity=48.5943775100402, Blast_Score=225, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 60696; Mature: 60696

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYAIAHSEDSHEDHGPEQGKGFMGFIKRWLFTTNHKDIGTLYLWLALISFFVAGAMALV
CCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IRLELFQPGHRFVDPNFFNQMTTLHGLVMLFGVVMPAFTGMANWQIPMMIGAPDMALPRL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
NNWSFWILPFAFCLLFSTMFHAGGGPNFGWTMYAPLSTTYAPPSTDFMIFSIHMMGLSSI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHH
MGSINIIATILNLRAPGMTLMKMPLFVWTWLITAFLLIAIMPVLAGAVTMMLADRHFGTS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
FFNAAGGGDPILFQHVFWFFGHPEVYVLVLPAFGVISEIIPTFSRKPLFGYHFMVYATVS
HHCCCCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
IAVLSFIVWAHHMFTTGIPLGAELFFMYTTMLIAVPTGIKVFNWVSTMFKGAMTFETPML
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHCHHHH
FAIAFVFLFTIGGFTGLMLALVPADFQYQDSYFVVAHFHYVLVPGVIFALVAATYYWLPK
HHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
WTGHMYNERLGKWHFWLSVISVNLTFFPMHFLGLAGMPRRIPDYALQFANFNMIVTVAAF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHH
AFGLSQLLFLYNVVATVRKRGTNKDVATSRVWEGSHGLEWTLPSPPPYHTFTTPPEIK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKYAIAHSEDSHEDHGPEQGKGFMGFIKRWLFTTNHKDIGTLYLWLALISFFVAGAMALV
CCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IRLELFQPGHRFVDPNFFNQMTTLHGLVMLFGVVMPAFTGMANWQIPMMIGAPDMALPRL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
NNWSFWILPFAFCLLFSTMFHAGGGPNFGWTMYAPLSTTYAPPSTDFMIFSIHMMGLSSI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHH
MGSINIIATILNLRAPGMTLMKMPLFVWTWLITAFLLIAIMPVLAGAVTMMLADRHFGTS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
FFNAAGGGDPILFQHVFWFFGHPEVYVLVLPAFGVISEIIPTFSRKPLFGYHFMVYATVS
HHCCCCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
IAVLSFIVWAHHMFTTGIPLGAELFFMYTTMLIAVPTGIKVFNWVSTMFKGAMTFETPML
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHCHHHH
FAIAFVFLFTIGGFTGLMLALVPADFQYQDSYFVVAHFHYVLVPGVIFALVAATYYWLPK
HHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
WTGHMYNERLGKWHFWLSVISVNLTFFPMHFLGLAGMPRRIPDYALQFANFNMIVTVAAF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHH
AFGLSQLLFLYNVVATVRKRGTNKDVATSRVWEGSHGLEWTLPSPPPYHTFTTPPEIK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]