Click here to switch to the map view.

The map label for this gene is hemK [H]

Identifier: 54295178

GI number: 54295178

Start: 2575791

End: 2576654

Strand: Direct

Name: hemK [H]

Synonym: lpl2258

Alternate gene names: 54295178

Gene position: 2575791-2576654 (Clockwise)

Preceding gene: 54295177

Following gene: 54295179

Centisome position: 76.99

GC content: 40.39

Gene sequence:

>864_bases
ATGATTGATATTCGTTCATTGCTGGAACAAGCTCTGCAACAATTCAAAGTCAAAAACCAGGAAACCAAGTTAGAGGCAGA
ACTTTTACTCTGCCATGTGCTAAACAAAAACCGAGCCTATCTTTTTGCCCATCCGGATGCCTTGGTTTCTCCTGAACAGA
TAGAAACCTATTTGCAGATGATTAAACAACGTGCTGAAGGTCTACCAATAGCCTACATTACCGGACAGCGGGAATTCTGG
TCTCTTTCGTTAAAAGTAACACCCAATGTTCTCATTCCAAGACATGAAACCGAGCATCTGGTGGAACTTGCACTGGAGCT
AATACCTGACAAGGAGAATGTTTCTGTCCTTGATCTGGGAACAGGAAGTGGTGCTATTGCCCTGGCGCTTGCAAAAGAAA
GACCTCTTTGGCGTATTGACGCCTGTGATTTCAGTAAAGAGGCATTGGAATTAGCCTGTTATAACGCTAAAACACTCGGC
TTAAACAATATTAATTTCTGTCATTCCTACTGGTTTAATAATCTCCCCCTAAAACAATACCACGCTATTGTATCTAATCC
GCCCTACATTGCTGAAAATGATCCTCATTTAAAACAAGGCGATGTCCGCTTTGAACCAACAAGTGCATTAGTCAGTAGTC
AAGATGGATTAGCTGATCTACAATATATTATTCAGCACAGTTATGAATATCTTTTGCCTGATGGACTGCTCTTGGTTGAA
CATGGTTTTGAACAAAAAAATGAGATAAGCACTATACTTAATCAATTAGGATATAAAAACATACACTGTTGGCAAGATCT
TCAAGGACATGATAGGGTAAGTGGAGGACAACGTCCAGGCAATCGGAATAACAAACCTTTGTAG

Upstream 100 bases:

>100_bases
ATCTACCAGCTTAGTGACATCATGGAAGGGAATTTATCCCTGGTCATTGACCCGTTAAAACGCGAATACCATGCTGAACT
GCTAGCCGATTTAGGTCGAC

Downstream 100 bases:

>100_bases
TGATTATTTTTTTGTTGATGATACTGACGTTTTTTGGTATACGTAGCGATTTTGTATAAAACTCAGTTTCAGATACAGAA
TGAAATATAGGGTCTGGCAG

Product: hypothetical protein

Products: NA

Alternate protein names: M.VchAHemK2P [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQMIKQRAEGLPIAYITGQREFW
SLSLKVTPNVLIPRHETEHLVELALELIPDKENVSVLDLGTGSGAIALALAKERPLWRIDACDFSKEALELACYNAKTLG
LNNINFCHSYWFNNLPLKQYHAIVSNPPYIAENDPHLKQGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HGFEQKNEISTILNQLGYKNIHCWQDLQGHDRVSGGQRPGNRNNKPL

Sequences:

>Translated_287_residues
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQMIKQRAEGLPIAYITGQREFW
SLSLKVTPNVLIPRHETEHLVELALELIPDKENVSVLDLGTGSGAIALALAKERPLWRIDACDFSKEALELACYNAKTLG
LNNINFCHSYWFNNLPLKQYHAIVSNPPYIAENDPHLKQGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HGFEQKNEISTILNQLGYKNIHCWQDLQGHDRVSGGQRPGNRNNKPL
>Mature_287_residues
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQMIKQRAEGLPIAYITGQREFW
SLSLKVTPNVLIPRHETEHLVELALELIPDKENVSVLDLGTGSGAIALALAKERPLWRIDACDFSKEALELACYNAKTLG
LNNINFCHSYWFNNLPLKQYHAIVSNPPYIAENDPHLKQGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HGFEQKNEISTILNQLGYKNIHCWQDLQGHDRVSGGQRPGNRNNKPL

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=239, Percent_Identity=28.8702928870293, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1787463, Length=270, Percent_Identity=43.7037037037037, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87082085, Length=196, Percent_Identity=34.6938775510204, Blast_Score=104, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24582226, Length=247, Percent_Identity=30.3643724696356, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 32616; Mature: 32616

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQM
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
IKQRAEGLPIAYITGQREFWSLSLKVTPNVLIPRHETEHLVELALELIPDKENVSVLDLG
HHHHHCCCCEEEEECCCEEEEEEEEECCCEEECCCCHHHHHHHHHHHCCCCCCEEEEEEC
TGSGAIALALAKERPLWRIDACDFSKEALELACYNAKTLGLNNINFCHSYWFNNLPLKQY
CCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHCCCEECCCCCCHHHHHHHCCCCCHHHH
HAIVSNPPYIAENDPHLKQGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HHHHCCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCHHHHHHHHHHCHHHCCCCCEEEEE
HGFEQKNEISTILNQLGYKNIHCWQDLQGHDRVSGGQRPGNRNNKPL
CCCCCHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIDIRSLLEQALQQFKVKNQETKLEAELLLCHVLNKNRAYLFAHPDALVSPEQIETYLQM
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
IKQRAEGLPIAYITGQREFWSLSLKVTPNVLIPRHETEHLVELALELIPDKENVSVLDLG
HHHHHCCCCEEEEECCCEEEEEEEEECCCEEECCCCHHHHHHHHHHHCCCCCCEEEEEEC
TGSGAIALALAKERPLWRIDACDFSKEALELACYNAKTLGLNNINFCHSYWFNNLPLKQY
CCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHCCCEECCCCCCHHHHHHHCCCCCHHHH
HAIVSNPPYIAENDPHLKQGDVRFEPTSALVSSQDGLADLQYIIQHSYEYLLPDGLLLVE
HHHHCCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCHHHHHHHHHHCHHHCCCCCEEEEE
HGFEQKNEISTILNQLGYKNIHCWQDLQGHDRVSGGQRPGNRNNKPL
CCCCCHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]