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The map label for this gene is iscA [H]

Identifier: 54294631

GI number: 54294631

Start: 1906408

End: 1906776

Strand: Reverse

Name: iscA [H]

Synonym: lpl1708

Alternate gene names: 54294631

Gene position: 1906776-1906408 (Counterclockwise)

Preceding gene: 54294632

Following gene: 54294630

Centisome position: 56.99

GC content: 35.77

Gene sequence:

>369_bases
ATGAGTGTAGAAATACAACAAGCGAGCAGTACCAACCCCAACATCACTTTCAGTGAATCGGCAATAAAGCACCTGGTCTC
CTATCTGGAGAAAAACCCAGGAAACAAGGGGGTAAGATTGTCTGTAAAAAAGACGGGATGCTCGGGTTTATCTTATGTAG
TGGATTATGTAAAAGAACCTTCAGAAGGAGATATGATAGCTTCTTTATCTAAAGATTATATGGTATGCGTTGATAAAACA
AGTTATCCATTTCTTAAAAATATGCAAGTTGATTATGTGAAACAAGGTTTAAATTATAAATTTATTTTTAATAATCCTAA
TCAGACGGGGCAATGTGGTTGTGGAGAGAGCTTTACTGTAAGTCAGTAA

Upstream 100 bases:

>100_bases
TTACAGATAACAAATAATCAGTATCCAGTAGCAGTCCAGGTAGAGGACATATATAAAGAAGCATTGACTTTGATGCGTAA
GAAATTTGAGAGGTAAAGCA

Downstream 100 bases:

>100_bases
AATAAGCAGAAAGTCCACGATACCTTTTTAATATTATCAATAAGCGGCTGGCTTGAAGGGCAGCCGCAATATCCAGCCTC
ATGGTTTTATATTCTTTTTA

Product: hypothetical protein

Products: NA

Alternate protein names: Iron-sulfur cluster assembly protein [H]

Number of amino acids: Translated: 122; Mature: 121

Protein sequence:

>122_residues
MSVEIQQASSTNPNITFSESAIKHLVSYLEKNPGNKGVRLSVKKTGCSGLSYVVDYVKEPSEGDMIASLSKDYMVCVDKT
SYPFLKNMQVDYVKQGLNYKFIFNNPNQTGQCGCGESFTVSQ

Sequences:

>Translated_122_residues
MSVEIQQASSTNPNITFSESAIKHLVSYLEKNPGNKGVRLSVKKTGCSGLSYVVDYVKEPSEGDMIASLSKDYMVCVDKT
SYPFLKNMQVDYVKQGLNYKFIFNNPNQTGQCGCGESFTVSQ
>Mature_121_residues
SVEIQQASSTNPNITFSESAIKHLVSYLEKNPGNKGVRLSVKKTGCSGLSYVVDYVKEPSEGDMIASLSKDYMVCVDKTS
YPFLKNMQVDYVKQGLNYKFIFNNPNQTGQCGCGESFTVSQ

Specific function: Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that iscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transi

COG id: COG0316

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesB/iscA family [H]

Homologues:

Organism=Homo sapiens, GI52426768, Length=120, Percent_Identity=35, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788877, Length=107, Percent_Identity=43.9252336448598, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1787974, Length=107, Percent_Identity=41.1214953271028, Blast_Score=94, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25146411, Length=111, Percent_Identity=29.7297297297297, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193209025, Length=120, Percent_Identity=28.3333333333333, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323001, Length=106, Percent_Identity=39.622641509434, Blast_Score=82, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24642263, Length=110, Percent_Identity=33.6363636363636, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000361
- InterPro:   IPR016092
- InterPro:   IPR017870
- InterPro:   IPR011302 [H]

Pfam domain/function: PF01521 Fe-S_biosyn [H]

EC number: NA

Molecular weight: Translated: 13483; Mature: 13352

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS01152 HESB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEIQQASSTNPNITFSESAIKHLVSYLEKNPGNKGVRLSVKKTGCSGLSYVVDYVKEP
CCEECCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCC
SEGDMIASLSKDYMVCVDKTSYPFLKNMQVDYVKQGLNYKFIFNNPNQTGQCGCGESFTV
CCCCEEEECCCCEEEEECCCCCCHHHCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCEEC
SQ
CC
>Mature Secondary Structure 
SVEIQQASSTNPNITFSESAIKHLVSYLEKNPGNKGVRLSVKKTGCSGLSYVVDYVKEP
CEECCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCC
SEGDMIASLSKDYMVCVDKTSYPFLKNMQVDYVKQGLNYKFIFNNPNQTGQCGCGESFTV
CCCCEEEECCCCEEEEECCCCCCHHHCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCEEC
SQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA