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The map label for this gene is purD [H]

Identifier: 54294562

GI number: 54294562

Start: 1824282

End: 1825601

Strand: Reverse

Name: purD [H]

Synonym: lpl1638

Alternate gene names: 54294562

Gene position: 1825601-1824282 (Counterclockwise)

Preceding gene: 54294563

Following gene: 54294561

Centisome position: 54.57

GC content: 38.86

Gene sequence:

>1320_bases
TTGATCAATATCCTTATTGTTGGTTCAGGTGCACGTGAGCATGCAATAGCTACAGCATTGAGTAAATCAGAGAATAAACC
AAAGATTTATTGCTTTGGAACAACTCGTAATCCTGGTATCCAAAGACTCACCTCAGATTATTGGGTAGGTGATATTACAG
ACCCTGAGCAAGTTAACCAGCAAGCAAAAGAATGGGAAATTAATTTGGCCATTATTGGTCCAGAAGCGCCTTTGGAACAT
GCTGTTGCTGATGCTTTGTGGGATTGTGGAATTCCTGTTATAGGTCCCAGGAAAAATTTGGCTAAAATTGAAACCAGTAA
AGCGTTCGCCAGAGAGTTGATGGAAAAATACGGTATTCCAGGTTTGCCTAAGTATAAAGTATTTACCAGTTTAGAAGGAA
TAGGAGAGTTTTTATCAGAGTTAGGTGAAAATAATTTCGTTGTTAAGGCCAATGGTTTAATGGCGGGCAAGGGTGTAAAA
GTAGGTGGGGAACATCTGTTGTCATTTGAAGAGGCTTTGAACTATTGTAAAGAAATTTTTACTCATAATCAGTCTTTAGT
CATTGAAGAAAAATTAATAGGTCAAGAATTTTCATTTATGTGTTTTTCTGATGGCATCTCATTAGTTCCAATGCCTATTG
TGCAAGATCATAAACGAGCTTATGAGCATGATGAGGGTCCTAATACAGGTGGTATGGGGAGTTATTCAGCGGCAGATCAC
AGCTTGCCATTTTTGTCTCCAGAGGATGTTCGTGCTGCTTTTGAAATTAATCAATCAGTAATCAATGCGCTTATGACGGA
AATGTCTGATAAATACATAGGAATACTTTATGGCGGATTTATGGCCACCGCACATGGGGTGTATGTGATTGAGTTTAATG
CTCGCTTTGGAGATCCCGAGGCTCTTAATGTGCTTAGCTTGTTAGAATCTGATTTTGTTAAATTATGTGTTGCGATGGCT
AACGGCAATTTACAAAAAGAATCCGTTCGCTTTTTGAATCAAGCAACAGTTTGTAAATACGCTGTCCCTGATGGTTATCC
TGATAATCCAATGCGCCATGTTGAGATTGATATTTCTGCTGTCGAACCTAAAGATACTCTATATTTGGCTGCAGTGAATT
TTAAGGATGGCAAACTCTATGCCACAGGTTCGAGGACAGCTGCTTATGTCGGTATAGCGAATACTATCAGTGAGGCAGAA
GAAATTGCTGAACAACAGATAAAAAATATAAAAGGCCCTTTATTTCACAGAAAAGATATTGGCACATCGCCTTTAATTAA
TACACGCGTTGAAGTAATGCGTAGGTTGCGTGCCTTATGA

Upstream 100 bases:

>100_bases
GCAAATACATTTGTGGACAGATTACTGAAGAAAAAATTAAATTGTTGGAGAAAAAAAGATTAACCGAGAATGACCAAGAA
ACAGAGATAGGAGAGATGTC

Downstream 100 bases:

>100_bases
TTCGTTTAGGAATATTAGGGTCTACTCGTGGAACCAATATGTTGGCTCTTGTTGATGCAATCAATGAGGGAATTCTTAAG
GCAAAGATAGAGCTTGTTAT

Product: phosphoribosylamine-glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQQAKEWEINLAIIGPEAPLEH
AVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIPGLPKYKVFTSLEGIGEFLSELGENNFVVKANGLMAGKGVK
VGGEHLLSFEEALNYCKEIFTHNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
SLPFLSPEDVRAAFEINQSVINALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPEALNVLSLLESDFVKLCVAMA
NGNLQKESVRFLNQATVCKYAVPDGYPDNPMRHVEIDISAVEPKDTLYLAAVNFKDGKLYATGSRTAAYVGIANTISEAE
EIAEQQIKNIKGPLFHRKDIGTSPLINTRVEVMRRLRAL

Sequences:

>Translated_439_residues
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQQAKEWEINLAIIGPEAPLEH
AVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIPGLPKYKVFTSLEGIGEFLSELGENNFVVKANGLMAGKGVK
VGGEHLLSFEEALNYCKEIFTHNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
SLPFLSPEDVRAAFEINQSVINALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPEALNVLSLLESDFVKLCVAMA
NGNLQKESVRFLNQATVCKYAVPDGYPDNPMRHVEIDISAVEPKDTLYLAAVNFKDGKLYATGSRTAAYVGIANTISEAE
EIAEQQIKNIKGPLFHRKDIGTSPLINTRVEVMRRLRAL
>Mature_439_residues
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQQAKEWEINLAIIGPEAPLEH
AVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIPGLPKYKVFTSLEGIGEFLSELGENNFVVKANGLMAGKGVK
VGGEHLLSFEEALNYCKEIFTHNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
SLPFLSPEDVRAAFEINQSVINALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPEALNVLSLLESDFVKLCVAMA
NGNLQKESVRFLNQATVCKYAVPDGYPDNPMRHVEIDISAVEPKDTLYLAAVNFKDGKLYATGSRTAAYVGIANTISEAE
EIAEQQIKNIKGPLFHRKDIGTSPLINTRVEVMRRLRAL

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=433, Percent_Identity=35.1039260969977, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI209869995, Length=433, Percent_Identity=35.1039260969977, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI209869993, Length=433, Percent_Identity=35.1039260969977, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI28416899, Length=433, Percent_Identity=35.1039260969977, Blast_Score=218, Evalue=7e-57,
Organism=Escherichia coli, GI1790438, Length=438, Percent_Identity=32.4200913242009, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17567511, Length=436, Percent_Identity=33.0275229357798, Blast_Score=190, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321203, Length=455, Percent_Identity=30.1098901098901, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24582400, Length=366, Percent_Identity=36.8852459016393, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI62471619, Length=366, Percent_Identity=36.8852459016393, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 48300; Mature: 48300

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQ
CEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHH
QAKEWEINLAIIGPEAPLEHAVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIP
HHHHEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GLPKYKVFTSLEGIGEFLSELGENNFVVKANGLMAGKGVKVGGEHLLSFEEALNYCKEIF
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHH
THNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
HCCCCEEEHHHHCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
SLPFLSPEDVRAAFEINQSVINALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCEEEEEEECCCCCHH
ALNVLSLLESDFVKLCVAMANGNLQKESVRFLNQATVCKYAVPDGYPDNPMRHVEIDISA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEEEEE
VEPKDTLYLAAVNFKDGKLYATGSRTAAYVGIANTISEAEEIAEQQIKNIKGPLFHRKDI
ECCCCEEEEEEEEECCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GTSPLINTRVEVMRRLRAL
CCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQ
CEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHH
QAKEWEINLAIIGPEAPLEHAVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIP
HHHHEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GLPKYKVFTSLEGIGEFLSELGENNFVVKANGLMAGKGVKVGGEHLLSFEEALNYCKEIF
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHH
THNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
HCCCCEEEHHHHCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
SLPFLSPEDVRAAFEINQSVINALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCEEEEEEECCCCCHH
ALNVLSLLESDFVKLCVAMANGNLQKESVRFLNQATVCKYAVPDGYPDNPMRHVEIDISA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEEEEE
VEPKDTLYLAAVNFKDGKLYATGSRTAAYVGIANTISEAEEIAEQQIKNIKGPLFHRKDI
ECCCCEEEEEEEEECCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GTSPLINTRVEVMRRLRAL
CCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA