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The map label for this gene is trpS [H]

Identifier: 54294521

GI number: 54294521

Start: 1771985

End: 1773199

Strand: Reverse

Name: trpS [H]

Synonym: lpl1597

Alternate gene names: 54294521

Gene position: 1773199-1771985 (Counterclockwise)

Preceding gene: 54294522

Following gene: 54294520

Centisome position: 53.0

GC content: 39.59

Gene sequence:

>1215_bases
ATGTCAGCACTGTTTACTTCCAATAAGCGAGTCGTTTCTGGAATGCGGGTCAGTGGAAAATTGCATTTAGGTCATTATCA
TGGTGTTTTAAAAAATTGGATAAAATTACAACATCAATACGATTGTTTCTTTTTTGCAGCAGATTGGCATGGCCTAACAA
CACAATATGAAGACCCCAATTTTATTGAAAAACACCTCTGGGATATGATTATTGATTGGCTAGCTTGTGGAGTTAATCCA
GGCTTATGTAAGATATTTATTCAATCCTGGGTTCCAGAGCATGCTGAATTACATTTACTTTTGTCTATGATCACTCCTTT
AGGTTGGTTGGAGCGAGTGCCTACTTATAAAGATCAGCAGGAGAAATTAAAAGAAAAAGATTTATCAACCTATGGTTTTT
TGGGATATCCATTACTACAAAGTGCTGATGTACTTTTATACCACGCGGATTATGTTCCGGTGGGTGAAGACCAAGTGGCT
CATATTGAGTTAACGCGAGAAATAGCCCGAAGATTTAACTATCTTTATGGTAGAGAGGCTAATTTTGAGGAGCTGGCTGC
TGCAGCAATCAAAAAGATGGGTAAAAAGAATGGGAAAATTTATACCGAATTACGCAGACAATTTCAGGAGCATGGCATCC
ACGAATCGATTAAGACAGCACAAGCGCTTTTAGAAGATCAGCCTAATTTGTCGATTGGAGATAAAGAGCGGTTGTTAGGA
TATTTGGAAGGAAATGGCAAAATTATATTAAGTGAACCACAGCCTTTGCTTACGGAAACTGCAAAAATGCCAGGTCTTGA
TGGGCAGAAAATGTCCAAATCTTACCATAATACGATCATGCTAAGAGATGAGCCAGCTTTAGTTGAAAAGAAAATTCTGA
CTATGCCCACGGATCCGGCGCGTGTTAAACGTACAGATCCAGGAGAGCCTGAAAAATGTCCTGTTTGGCAATTCCATAAA
GTGTATTCTAATGAGGAAGTAAAAGATTGGGTGCAAAAAGGTTGCCGAACAGCAGGAATTGGTTGCGTTGACTGTAAGAG
GCCAGTGATTGGTGCTATCCATCAAGAACTTAAACCAATACAGGAAGCGATTTCAGATTATGAAGCTGATTTAGGTTCGG
TAAAACGTATTGTAGCGGAAGGAAGCGAAGCGGCCAGAGAAGAAGGAAACAAGACTTTAAATACGGTCAGAGAAGTCATG
GGGCTTGATTATTAA

Upstream 100 bases:

>100_bases
ATAAAATATGATTGAAGCAAGCATCAGGTTAGAATTCAGGGAATAAAGAAATTTTTGTATTTGAAATAATTGATTAATTT
ATAACAAGAAGAGGAAATTG

Downstream 100 bases:

>100_bases
TGAATATCGATTTGCAGCCTGCGCCTATAGTCAAAGCAGTGGTGGATGGTAAGGAAATTACTCAGTTTCCAGAGGATTTA
TATATTCCTCCTGATGCATT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSALFTSNKRVVSGMRVSGKLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDPNFIEKHLWDMIIDWLACGVNP
GLCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQVA
HIELTREIARRFNYLYGREANFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLLG
YLEGNGKIILSEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDPARVKRTDPGEPEKCPVWQFHK
VYSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKPIQEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREVM
GLDY

Sequences:

>Translated_404_residues
MSALFTSNKRVVSGMRVSGKLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDPNFIEKHLWDMIIDWLACGVNP
GLCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQVA
HIELTREIARRFNYLYGREANFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLLG
YLEGNGKIILSEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDPARVKRTDPGEPEKCPVWQFHK
VYSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKPIQEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREVM
GLDY
>Mature_403_residues
SALFTSNKRVVSGMRVSGKLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDPNFIEKHLWDMIIDWLACGVNPG
LCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQVAH
IELTREIARRFNYLYGREANFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLLGY
LEGNGKIILSEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDPARVKRTDPGEPEKCPVWQFHKV
YSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKPIQEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREVMG
LDY

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=188, Percent_Identity=40.4255319148936, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI41352700, Length=172, Percent_Identity=42.4418604651163, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1789786, Length=167, Percent_Identity=42.5149700598802, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71982800, Length=171, Percent_Identity=35.0877192982456, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71982793, Length=171, Percent_Identity=35.0877192982456, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320474, Length=192, Percent_Identity=35.4166666666667, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24666151, Length=399, Percent_Identity=28.3208020050125, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 46034; Mature: 45903

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALFTSNKRVVSGMRVSGKLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDPN
CCCCCCCCCHHHCCEEECCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
FIEKHLWDMIIDWLACGVNPGLCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
EKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQVAHIELTREIARRFNYLYGREA
HHHHHHCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
NFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLLG
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHEE
YLEGNGKIILSEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDPA
EEECCCEEEEECCCHHHHHHHCCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCC
RVKRTDPGEPEKCPVWQFHKVYSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKPI
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
QEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREVMGLDY
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SALFTSNKRVVSGMRVSGKLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDPN
CCCCCCCCHHHCCEEECCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
FIEKHLWDMIIDWLACGVNPGLCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
EKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQVAHIELTREIARRFNYLYGREA
HHHHHHCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
NFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLLG
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHEE
YLEGNGKIILSEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDPA
EEECCCEEEEECCCHHHHHHHCCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCC
RVKRTDPGEPEKCPVWQFHKVYSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKPI
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
QEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREVMGLDY
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]