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The map label for this gene is relA [H]

Identifier: 54294502

GI number: 54294502

Start: 1750628

End: 1752832

Strand: Reverse

Name: relA [H]

Synonym: lpl1571

Alternate gene names: 54294502

Gene position: 1752832-1750628 (Counterclockwise)

Preceding gene: 54294503

Following gene: 54294500

Centisome position: 52.39

GC content: 40.41

Gene sequence:

>2205_bases
ATGGTAAGAGTAAAAGATACGACTCCGTTGACGGCAGATGGCAGTATTGACGTAGAGATGTGGTTACATCATCTTGGTTC
AAAAGGATATTTGGATAATCTCGAACTCGTAAGAGCTGCTTGTACTTTAAGTCAATTGGCTGGTCAGGATCATGCTACTG
AAACAGGGCAAACTTGTTTACAACAAGGGTTATCAATGGCTGATTTACTTGCTGACCTGGAAGTAGATCAGGAAACTCTG
GCCGCCGCTATTATTTTTGAAAATGTTCATTATGCGGATTTATCTATTGATGATGTTGAAGAGCAATTGGGGCACAATAT
CGCTAAATTGGTCAAAGGCATAGAAAAAATGAGTGCCATGAACAATTTCCAGGCTTTAAATAAATATCCGCAAAACAAAA
ATCAAATTGACAATATTCGCAAAATGCTTCTTGCGATGGTTGATGATGTGCGAGTTGTTTTAATCAAGCTGGCAGAGTGT
TTATGTATTTTAAGAACAGCAGGGCATCTTTCTGAAACGATACGTAAACAGCTGGCAACCGAAGCCATGGAAATTTACGC
GCCTTTAGCTAACCGCTTGGGAATAGGGGCAATCAAGTGGGAAATGGAAGATTTGGCTTTCCGGCATTTGCACCCAGAAG
AATATAAGGCGATTGCCAAGGGATTGAAGGCTAAACGATTGGAAAGGGACAGCTTTGTCAATCGCATTGTCGAACAGCTT
GAACATCAGATTCGAGCAACAGGAGCTCGCCACTTTGCCGTTTATGGTCGCTCAAAACATATCCATAGTATTTATAAAAA
GATGAAGCGTAAAAATGTATCATTAGACGAAATATATGATGCAACAGCGGTTCGTATTCTGGTAGATACTGAAGCACAAT
GTTACGAAGTGTTAGGCATGGTTCATACTTTGTGGAAGCAAATTCCAGCAGAGTTTGATGATTACATCATCAATCCAAAA
TCCAATGGCTATCAGTCTCTGCATACCGCAGTAGAGGGTCCGGAAGGAAGAGTTTTTGAAGTGCAAATCAGAACTTTTCA
TATGCATGATTTAGCAGAAATGGGTGTGGCAGCCCATTGGAAATATAAAGAGGGCGCTGTATCACAAAAAGAGAGCCATG
AGCGCAAAATAGAATGGTTAAGAGACGTTTTGGCGTGGCACCAGGAAATGGCGGCTAATAAAGGTGTCGCAGAAAACGTT
ACGACCGAGTTTCTTGAAGACAGAGTGTATGTATTTACTCCCGATGGCGATGTATTGGATTTACCCCATGGGGTGACTCC
TTTGGATTTTGCTTATCATGTGCATAGTAATTTGGGACATCGTTGCCGAGGTGCCAAGGTTAATGGTCATATTGTCCCAT
TGACTTATCAATTGAAAACAGGAGACAGGGTTGAAGTACTGACGGGAAAAGAAATCAAGCCATCAAGGGATTGGATTAAT
CCTCATCTGAATTATTTAAAGACTGCAAGAGCCAAGGCTAAAGTATTGCATTGGTTTAAAATGCAAGATTATGAAGATAA
TGTGAGAGATGGTCGTGAGTTATTGGAGAAGGAATTAAAGTCTTTAGGTATTAAATCGGATAAACTCAATGAAGTGATTA
CGGCATTGAATTATAAAAAGGCGGATGATCTTTATGCCAGTTTGGGGCGAGGTGATATTAAAATAGGTCAGATTGTTAAT
CGATTGGCACCCCCAGATGCTTCAGAACAAAATTTACAGAAGTTTGTAAGACAACAACAAAAACCAGAGGTCACAGGGAG
TGATCTTCGTATTGAGGGAGTTGGGAACTTATTGACATTTATGGCGAGATGCTGCCAACCTGTTCCTGGTGATGAAATAG
TAGGATACATCACGATTGGAAGGGGGGTTTCCGTTCATCGAAAAGATTGTCCTAATATTATACATGCCAGTGAAAAGCAA
AAGCGACGGTTTATTCAGGTGAATTGGGGTACAGCAACACGGGAAAATTATGTTGTTGATGTGCTGATTAAGGCCTTTGA
TCGTTCCGAGTTATTGAAGGATGTTACTTCGCTGCTTTCAAATGAAAAAGCCCATGTTTATGCTTTACAGACCCATAGCA
ATAAACATGAAAATATGGCTTATATCACTTTAACTGTTGAGATCGATGGTTTAAACAGTTTGTCGCGCTTATTAACTAAA
CTGGAGCAAATTCCTAACGTGCTGGAAGCAAGAAGGCAATTATAG

Upstream 100 bases:

>100_bases
ATCAAAAAGGTTACGTTTTGATAACAGCTGGGGTAATGGATATGTTTCCTCATACAGCGCATGTCGAGTCTATTGCCTTG
TTTCAAAAAGGATAATATGT

Downstream 100 bases:

>100_bases
CTTTGGTATATTTAGCCAGAGCCTTCTCAAAAAATTGATATTAGAAGATAAACCCTGCAACAACCGCTCTGTGTTCGCTC
AATAAGACGTTATAAGTTCT

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 734; Mature: 734

Protein sequence:

>734_residues
MVRVKDTTPLTADGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCLQQGLSMADLLADLEVDQETL
AAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAMNNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAEC
LCILRTAGHLSETIRKQLATEAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL
EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGMVHTLWKQIPAEFDDYIINPK
SNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHWKYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENV
TTEFLEDRVYVFTPDGDVLDLPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN
PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKKADDLYASLGRGDIKIGQIVN
RLAPPDASEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTFMARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQ
KRRFIQVNWGTATRENYVVDVLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK
LEQIPNVLEARRQL

Sequences:

>Translated_734_residues
MVRVKDTTPLTADGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCLQQGLSMADLLADLEVDQETL
AAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAMNNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAEC
LCILRTAGHLSETIRKQLATEAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL
EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGMVHTLWKQIPAEFDDYIINPK
SNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHWKYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENV
TTEFLEDRVYVFTPDGDVLDLPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN
PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKKADDLYASLGRGDIKIGQIVN
RLAPPDASEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTFMARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQ
KRRFIQVNWGTATRENYVVDVLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK
LEQIPNVLEARRQL
>Mature_734_residues
MVRVKDTTPLTADGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCLQQGLSMADLLADLEVDQETL
AAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAMNNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAEC
LCILRTAGHLSETIRKQLATEAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL
EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGMVHTLWKQIPAEFDDYIINPK
SNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHWKYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENV
TTEFLEDRVYVFTPDGDVLDLPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN
PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKKADDLYASLGRGDIKIGQIVN
RLAPPDASEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTFMARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQ
KRRFIQVNWGTATRENYVVDVLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK
LEQIPNVLEARRQL

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=747, Percent_Identity=44.8460508701473, Blast_Score=655, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=713, Percent_Identity=33.9410939691445, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83265; Mature: 83265

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVKDTTPLTADGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCL
CEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
QQGLSMADLLADLEVDQETLAAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAM
HHCCCHHHHHHHCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAECLCILRTAGHLSETIRKQLAT
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL
HHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGM
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCHHHHHHHHH
VHTLWKQIPAEFDDYIINPKSNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHW
HHHHHHHCCCCHHCEEECCCCCCHHHHHHHHCCCCCCEEEEEEEEEEHHHHHHCCHHEEE
KYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENVTTEFLEDRVYVFTPDGDVLD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCEEE
LPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHCC
PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKK
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCH
ADDLYASLGRGDIKIGQIVNRLAPPDASEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTF
HHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHH
MARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQKRRFIQVNWGTATRENYVVD
HHHHCCCCCCCCEEEEEEECCCCEECHHCCCCHHCCCCHHCCCEEEEECCCCCCCCHHHH
VLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK
HHHHHHCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHHH
LEQIPNVLEARRQL
HHHHHHHHHHHHCC
>Mature Secondary Structure
MVRVKDTTPLTADGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCL
CEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
QQGLSMADLLADLEVDQETLAAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAM
HHCCCHHHHHHHCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAECLCILRTAGHLSETIRKQLAT
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL
HHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGM
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCHHHHHHHHH
VHTLWKQIPAEFDDYIINPKSNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHW
HHHHHHHCCCCHHCEEECCCCCCHHHHHHHHCCCCCCEEEEEEEEEEHHHHHHCCHHEEE
KYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENVTTEFLEDRVYVFTPDGDVLD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCEEE
LPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHCC
PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKK
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCH
ADDLYASLGRGDIKIGQIVNRLAPPDASEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTF
HHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHH
MARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQKRRFIQVNWGTATRENYVVD
HHHHCCCCCCCCEEEEEEECCCCEECHHCCCCHHCCCCHHCCCEEEEECCCCCCCCHHHH
VLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK
HHHHHHCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHHH
LEQIPNVLEARRQL
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]